- |||||||||| Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
[VIRTUAL] Refractory Morvan Syndrome Responding Dramatically to Rituximab (ePoster) - Apr 9, 2020 - Abstract #EAN2020EAN_690;
The diffuse fasciculations associated with severe pain required treatment with morphine, gabapentin and duloxetine and failed to respond to intravenous pulse steroid and to 2 courses of IVIG... Rituximab appears to be a very promising therapy for patients with anti-Caspr2 syndrome who failed to respond to steroids or IVIG.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Lacosamide as add-on in combination with other sodium channel blocker (Room: Screen B8) - Apr 9, 2020 - Abstract #EAN2020EAN_522;
Rituximab appears to be a very promising therapy for patients with anti-Caspr2 syndrome who failed to respond to steroids or IVIG. Lacosamide, as was previously known, is effective in polytherapy, and more if is combined with other drugs with a mechanism of action other than SCB so we must take this into consideration when prescribing lacosamide to a patient.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, levetiracetam / Generic mfg.
[VIRTUAL] Seizure freedom in patients treated with lacosamide and levetiracetam (ePoster) - Apr 9, 2020 - Abstract #EAN2020EAN_512;
The addition of lacosamide and levetiracetam in our series achieve a tendency of greater proportion of seizure free patients in comparison to other treatments, which is important to consider in our daily medical practice. It is necesary to have studies with greater sample to confirm the results.
- |||||||||| lacosamide / Generic mfg.
Trial completion date, Trial suspension: Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers (clinicaltrials.gov) - Apr 7, 2020
P1, N=28, Suspended,
DFT-Computational studies uncover clues for the understanding of the remarkable stereocontrol of the addition of a nickel(II) enolate to a putative oxocarbenium intermediate from trimethyl orthoformate. Trial completion date: Aug 2020 --> Dec 2020 | Recruiting --> Suspended
- |||||||||| Vimpat (lacosamide) / UCB
Clinical, Journal: Lacosamide Overdose: A Case of QRS Prolongation and Seizure. (Pubmed Central) - Mar 31, 2020
WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: After lacosamide overdosage, the emergency physician must be capable of acute management of subsequent lacosamide toxicity. Understanding the mechanisms of action causing toxicity due to this drug can help the clinician to anticipate the interventions that may be needed or useful to treat this potentially toxic ingestion.
- |||||||||| Vimpat (lacosamide) / UCB
Clinical, Journal: Lacosamide in children with drug-resistant epilepsy. (Pubmed Central) - Mar 24, 2020
Most children continued treatment with lacosamide, suggesting effectiveness and tolerability. Lacosamide may prove to be a useful, 'broad-spectrum' antiepileptic medication in children for focal and generalised epilepsies and in association with comorbidities.
- |||||||||| pregabalin / Generic mfg., cyclophosphamide intravenous / Generic mfg., Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
A Journey Through the Endless Pursuit: Challenges with Refractory Status Epilepticus (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_9617;
Patients with NORSE/FIRES present as both a diagnostic and therapeutic challenge, which is illustrated in this case. The paucity of data on these syndromes translates into a lack of data on treatment options, highlighting the need for increased awareness among medical providers, the importance of the existence of a registry and publications of individual case reports that contribute to the literature and foster further investigation.
- |||||||||| Vimpat (lacosamide) / UCB, prednisone / Generic mfg., levetiracetam / Generic mfg.
A Case of Eosinophilic Pneumonia Induced by Levetiracetam (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_7888;
Eosinophilic pneumonia is a relatively rare cause of hypoxemic respiratory failure...We detail the time course of drug exposure with peripheral and pulmonary eosinophilia and show resolution of his syndrome with corticosteroids. Additionally, our case includes follow-up imaging to demonstrate time to radiographic improvement.
- |||||||||| Vimpat (lacosamide) / UCB
Suppressing All the Electricity: A Case of Lacosamide Induced Atrioventricular Block (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_6807;
The object of this clinical case report is to highlight an important side effect that can be detrimental in this patient population.Description of case reportA 58-year-old female with a history of juvenile rheumatoid arthritis requiring chronic Prednisone and multiple orthopedic procedures was admitted to the hospital for acute blood loss anemia secondary to a post-operative infected wound following a left hip disarticulation.During her extended hospitalization, a rapid response was called for acute encephalopathy concerning for nonconvulsive status epilepticus...Lacosamide was discontinued and topiramate was started...The adjustment in medications quickly results in resolution of the AV block. It is important to always consider medication side effect as the etiology for heart block.
- |||||||||| Vimpat (lacosamide) / UCB, ketamine / Generic mfg., levetiracetam / Generic mfg.
Baclofen Overdose Associated with Prolonged Super-Refractory Status Epilepticus (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_5409;
EEG continued to show ictal activity over the next several days despite additional therapy with phenobarbital and lacosamide...Propofol and midazolam were weaned on hospital day 8, and EEG progressed to NCSE that resolved with initiation of ketamine...The etiology of our patient’s prolonged NCSE was unclear but may be related to her temporal lobe venous abnormality. With increased prescribing of baclofen, it is important for critical care physicians to be aware of the clinical characteristics of overdose including the potential for an extended duration of symptoms.
- |||||||||| Vimpat (lacosamide) / UCB
Lacosamide and Metoprolol: An Uncommon Yet Potentially Deadly Combination (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_5403;
He again developed atrial fibrillation with RVR that improved with amiodarone...It is crucial that clinicians are acutely aware of potentially deadly interactions to prevent adverse patient outcomes. This remains especially true in the ICU where DDI can easily be overlooked with the tremendous cocktails of medications patients receive on a daily basis.
- |||||||||| lacosamide / Generic mfg.
Journal, Adverse events: The adverse-effect profile of lacosamide. (Pubmed Central) - Mar 2, 2020
The review showed that lacosamide is safe and effective in antiepileptic treatment, and its common side effects are dizziness, headache, drowsiness, diplopia, and cardiovascular abnormalities. Skin rashes, hematotoxicity and heart damage, psychological symptoms and suicide risk have also been reported and emphasized.
- |||||||||| Clinical, Journal: Relationship of antiepileptic drugs to generic brittleness in patients with epilepsy. (Pubmed Central) - Feb 25, 2020
The lower number of different generics for these six drugs may result in greater patient certainty in medication identity, due to greater consistency in medication color, shape, and size, and hence less generic skepticism or generic brittleness. Also, patients taking more AEDs showed increased odds of a switch problem.
- |||||||||| lacosamide / Generic mfg.
Preclinical, Journal: The Impact of Prophylactic Lacosamide on LPS-Induced Neuroinflammation in Aged Rats. (Pubmed Central) - Feb 21, 2020
Western analysis revealed increased brain tissue levels of TNF-α, NF-Kβ, and caspase-3 following LPS. Prophylactic LCM treatment reversed these parameters including oxidative stress, inflammation, and apoptosis in the cortex, hippocampus, and cerebellum.
- |||||||||| Vimpat (lacosamide) / UCB, levetiracetam / Generic mfg., levetiracetam low dose (AGB101) / AgeneBio
[VIRTUAL] Peri-ictal psychosis associated with neurocysticercosis: a case report. (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_1330;
The diagnosis of psychotic states associated with epilepsy could be difficoult because of the very different clinical manifestations and. It is important to consider the high prevalence of psychiatric comorbility in patients with epilepsy to administer them a multidisciplinary treatment.
- |||||||||| lacosamide / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Efficacy and Safety of Rapid Titration Protocols of Lacosamide (clinicaltrials.gov) - Feb 18, 2020
P4, N=75, Completed,
It is important to consider the high prevalence of psychiatric comorbility in patients with epilepsy to administer them a multidisciplinary treatment. Not yet recruiting --> Completed | Trial completion date: Jan 2020 --> Jun 2019 | Trial primary completion date: Jan 2020 --> Jun 2019
- |||||||||| lacosamide / Generic mfg.
Clinical, Journal: Lacosamide in patients with intellectual disability and refractory epilepsy. (Pubmed Central) - Feb 14, 2020
Adjunctive LCM may provide an antiepileptic treatment option for patients with ID with or without additional psychiatric diagnosis. The occurrence of AEs and the LCM retention rate were affected by concomitant SCB use but not by psychiatric comorbidity.
- |||||||||| leucovorin calcium / Generic mfg.
Mitochondrial Polymerase Gamma Gene Mutation Presenting as Status Epilepticus and Liver Failure () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1210;
His POLG mutation was managed with an IV mitochondrial cocktail consisting of N-Acetylcysteine, carnitine, riboflavin, thiamine, and folinic acid...There is a lack of research regarding management of POLG mutations in the post-acute setting.Conclusions : Early diagnosis of POLG mutations can have a significant difference on the management and goals of rehabilitation therapy. More research needs to be conducted on the post acute management of POLG mutation.
- |||||||||| lacosamide / Generic mfg., Fycompa (perampanel) / Eisai, Briviact (brivaracetam) / UCB
Review, Journal: Intractable Generalized Epilepsy: Therapeutic Approaches. (Pubmed Central) - Feb 9, 2020
Resective surgical options have demonstrated success in carefully selected patients despite generalized electrographic findings on electroencephalogram. The current literature reflects a widening range of clinical experience with newer anticonvulsant medications including cannabinoids, dietary therapies, surgical approaches, and neurostimulation devices for patients with intractable generalized epilepsy.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: A Rare Case of Prolonged Ictal Aphasia. (Pubmed Central) - Feb 7, 2020
In this case, aphasia was determined to be an ictal semiology, as patient had complete resolution of his symptoms supported by a normal EEG after receiving seizure medications. We suggest keeping high suspicion for an ictal process in patients with sudden-onset aphasia supported by EEG findings of LPDs.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Ospolot (sultiam) / AOP Orphan Pharma, Diacomit (stiripentol) / Biocodex, Meiji Seika
Trial completion date, Trial primary completion date: EPIPOP: Population Pharmacokinetics of Antiepileptic in Pediatrics (clinicaltrials.gov) - Feb 5, 2020
P=N/A, N=1000, Recruiting,
Active, not recruiting --> Completed Trial completion date: Jun 2019 --> Jun 2022 | Trial primary completion date: Jun 2019 --> Jun 2022
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, carbamazepine / Generic mfg.
Review, Journal: Therapy in Sleep-Related Hypermotor Epilepsy (SHE). (Pubmed Central) - Jan 31, 2020
The increasing understanding of the role of neuronal nicotinic acetylcholine receptor (nAChR) in SHE pathophysiology has led to the evaluation of compounds able to modulate this receptor system, including nicotine patches and fenofibrate...Therefore, a prospective study in a large cohort of sporadic SHE patients is necessary in order to provide clinicians with an evidence-based treatment for this rare form of epilepsy. An early and effective anti-epileptic treatment is mandatory for SHE patients, in order to prevent the risk of increasing seizure frequency throughout the disease course with relevant impact on patients' cognitive profile and daytime performances.
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