- |||||||||| Ozempic (semaglutide SC once-weekly) / Novo Nordisk, tirzepatide (LY3298176) / Eli Lilly
Clinical, Journal: Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. (Pubmed Central) - Aug 22, 2021 P3 In patients with type 2 diabetes, tirzepatide was noninferior and superior to semaglutide with respect to the mean change in the glycated hemoglobin level from baseline to 40 weeks. (Funded by Eli Lilly; SURPASS-2 ClinicalTrials.gov number, NCT03987919.).
- |||||||||| Victoza (liraglutide) / Novo Nordisk, Ozempic (semaglutide SC once-weekly) / Novo Nordisk
Journal: Potential kidney protection with liraglutide and semaglutide - exploratory mediation analysis. (Pubmed Central) - Aug 13, 2021 Our results suggest that HbA and systolic BP may moderately mediate kidney benefits of liraglutide and semaglutide, with all other variables having a small to no effect. Potential kidney benefits may be driven by other mediators or potentially by direct mechanisms.
- |||||||||| Ozempic (semaglutide SC once-weekly) / Novo Nordisk
Enrollment closed, HEOR, Real-world evidence, Real-world: Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial (clinicaltrials.gov) - Jul 20, 2021 P4, N=1387, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Feb 2023 --> Feb 2021 Recruiting --> Active, not recruiting
- |||||||||| Ozempic (semaglutide SC once-weekly) / Novo Nordisk
[VIRTUAL] Reduced glycaemic variability with once-weekly semaglutide vs active comparators in post hoc analysis of the SUSTAIN programme (Rome Hall) - Jul 13, 2021 - Abstract #EASD2021EASD_806; P3 As glucose-dependent action of once-weekly semaglutide may translate to reduced glycaemic variability, we compared within-day glycaemic variability of once-weekly semaglutide vs active comparators (sitagliptin, exenatide extended release, insulin glargine, dulaglutide, canagliflozin and liraglutide) in people with type 2 diabetes (T2D).Materials and This post hoc analysis was based on individual subject data in the full analysis set from the on-treatment without rescue medication period in the SUSTAIN 2 (n=1,225), 3 (n=809), 4 (n=1,082), 7 (n=1,199), 8 (n=788) and 10 (n=577) trials... The reduction of within-day glycaemic variability from baseline to end of treatment was significantly greater with once-weekly semaglutide vs all active comparators, providing supporting evidence for the improvement in clinically relevant outcomes with semaglutide treatment for T2D management.
- |||||||||| Ozempic (semaglutide SC once-weekly) / Novo Nordisk
[VIRTUAL] Real-world use of once-weekly semaglutide in diverse patient populations with type 2 diabetes: pooled analysis of four SURE studies (Rome Hall) - Jul 13, 2021 - Abstract #EASD2021EASD_733; P=N/A The proportion of patients achieving glycaemic and weight-loss targets was similar in the overall population and in the subset of patients who had a baseline HbA1c ≥7%. In a pooled analysis of real-world data from Canada, Denmark/Sweden, Switzerland and the UK, patients with T2D initiating semaglutide experienced significant reductions in HbA1c and body weight, in the overall population and in subgroups based on various BL characteristics, including switching from another GLP-1RA.
- |||||||||| Victoza (liraglutide) / Novo Nordisk, Ozempic (semaglutide SC once-weekly) / Novo Nordisk
[VIRTUAL] Efficacy and safety of GLP-1RAs with or without baseline SGLT-2i: post hoc analysis of the SUSTAIN 10 trial (Madrid Hall) - Jul 13, 2021 - Abstract #EASD2021EASD_506; P3 Our results suggest that addition of a GLP-1RA to SGLT-2i treatment was associated with further reductions from baseline in HbA1c, BW and SBP without additional safety concerns. As SGLT-2is and GLP-1RAs are often used together in clinical practice, our data on the safety and efficacy of combining these two classes are meaningful to clinical decision-making.
- |||||||||| Ozempic (semaglutide SC once-weekly) / Novo Nordisk
What about wegovy? (Twitter) - Jul 11, 2021
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