- |||||||||| trifluoperazine / Generic mfg., chlorpromazine / Generic mfg.
Preclinical, Journal: Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Attenuate Ca Responses in Rat Peritoneal Macrophages. (Pubmed Central) - Jun 8, 2022
The data obtained indicate the participation of sigma-1 receptors in a complex signaling cascade caused by Glutoxim or Molixan and leading to an increase in intracellular Ca concentration in macrophages. The results also indicate the involvement of sigma-1 receptors in the regulation of store-dependent Caentry in macrophages.
- |||||||||| Molixan (glutathione/inosine) / Cellectar
Trial completion date, Trial primary completion date: Clinical Study in the Treatment of Patients With COVID-19 (clinicaltrials.gov) - Oct 10, 2021
P3, N=330, Recruiting,
The results also indicate the involvement of sigma-1 receptors in the regulation of store-dependent Caentry in macrophages. Trial completion date: Oct 2021 --> Sep 2022 | Trial primary completion date: Aug 2021 --> May 2022
- |||||||||| Molixan (glutathione/inosine) / Cellectar
Enrollment open: Clinical Study in the Treatment of Patients With COVID-19 (clinicaltrials.gov) - Mar 15, 2021
P3, N=330, Recruiting,
Trial completion date: Oct 2021 --> Sep 2022 | Trial primary completion date: Aug 2021 --> May 2022 Not yet recruiting --> Recruiting
- |||||||||| chlorpromazine / Generic mfg.
Journal: Neuroleptic Chlorpromazine Modulates Ca Responses in Macrophages. (Pubmed Central) - Jan 27, 2021
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist neuroleptic chlorpromazine significantly inhibits glutoxim- and molixan-induced Ca responses and Ca responses induced by endoplasmic reticulum Са-ATPase inhibitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca concentration increase and in the regulation of store-dependent Ca entry in macrophages.
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