- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. (Pubmed Central) - May 31, 2024
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas...Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Spatiotemporal Evolution of the Yellow Fever Epidemic in Southeast Brazil from 2016 to 2019. (Pubmed Central) - May 30, 2024
Despite differences in sociodemographic profiles between the Southeast and North of Brazil (the latter region considered endemic), the epidemiological profile was similar, except for patients' occupation, which was not related to rural work in the Southeast. The results contributed to our understanding of the paths by which YF spread across Southeast Brazil and the epidemiological profile in an area that had gone decades without autochthonous cases.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil. (Pubmed Central) - Dec 17, 2023
Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study. (Pubmed Central) - Dec 11, 2023
ZIKV RNA clearance was associated with several factors, including age, sex, education level, body mass index, non-purulent conjunctivitis, joint pain, and whether the participant had a history of yellow fever vaccination...Recurrent ZIKV detection events after total viral clearance were observed in the cohort. Our findings provide valuable insights into the persistence and potential recurrence of ZIKV infection, highlighting the need for continued monitoring and follow-up of individuals infected with ZIKV and for effective prevention measures to reduce the risk of transmission.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: The Importance of Entomo-Virological Investigation of Yellow Fever Virus to Strengthen Surveillance in Brazil. (Pubmed Central) - Jun 27, 2023
albopictus from Minas Gerais were clustered within the 2016-2018 outbreak clade, indicating YFV spread from Midwest and its infection in a main and likely novel bridging vector species. Entomo-virological surveillance is critical for YFV monitoring in Brazil, which could highlight the need to strengthen YFV surveillance, vaccination coverage, and vector control measures.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Enrollment open, Trial completion date, Trial primary completion date, Adverse events, Serious adverse event: Investigation of Serious Adverse Events Following Vaccination Against Yellow Fever: Emphasis on Genetic Basis and Biological Markers (clinicaltrials.gov) - Jun 15, 2023
P=N/A, N=10, Recruiting,
Entomo-virological surveillance is critical for YFV monitoring in Brazil, which could highlight the need to strengthen YFV surveillance, vaccination coverage, and vector control measures. Unknown status --> Recruiting | Trial completion date: Jan 2022 --> Dec 2023 | Trial primary completion date: Jan 2022 --> Jun 2023
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Characterization and investigation of risk factors for Late-relapsing hepatitis after yellow fever. (Pubmed Central) - Apr 26, 2023
These findings indicate that the 1,2,4-oxadiazole derivatives are inhibitors of the HKT enzyme not only from A. aegypti but also from A. gambiae. These findings provide new data on the clinical course of late relapsing hepatitis during the convalescent phase of YF and highlight the need for extended patient follow-up after acute YF.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: The protein disulfide isomerase inhibitor 3-methyltoxoflavin inhibits Chikungunya virus. (Pubmed Central) - Apr 4, 2023
These findings provide new data on the clinical course of late relapsing hepatitis during the convalescent phase of YF and highlight the need for extended patient follow-up after acute YF. We have additionally screened 3-methyltoxoflavin against a panel of 17 viruses and showed that it only additionally demonstrated inhibition of the yellow fever virus (EC 370
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: A comparative analysis of Aedes albopictus and Aedes aegypti subjected to diapause-inducing conditions reveals conserved and divergent aspects associated with diapause, as well as novel genes associated with its onset. (Pubmed Central) - Jan 24, 2023
Aedes albopictus and Aedes aegypti are mosquito species that are distributed worldwide and transmit diverse arboviruses of medical importance, such as those causing yellow fever, dengue, chikungunya and Zika...Upon exposure to diapause-inducing conditions, all three genes were upregulated in the A. albopictus embryos from the tropical region, but only idgf4 was upregulated in the temperate climate embryos. This represents a new gene associated with diapause that can be used as a target to evaluate and prevent embryonic dormancy, a possible new vector control strategy for mosquito species from temperate areas, such as A. albopictus.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Potent hydroxyethylamine based drug candidates against Zika virus infection: Bioactivity and pharmacological evaluation (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1421;
Zika virus (ZIKV) is a vector-borne disease and primarily transmitted by a bite of daytime-active Aedes mosquitoes, mainly Aedes aegypti, also responsible for the transmission of dengue, chikungunya, and yellow fever...To study the toxic effect of the compound as per the observed accumulation, acute and subacute cytotoxicity of compound was evaluated in mice at different oral doses, and the biochemical/histopathological results indicated a negligible sign of toxicity. In nutshell, the study supports this compound as a prime antiviral contender for the preclinical evaluation against ZIKV disease.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Yellow Fever Molecular Diagnosis Using Urine Specimens during Acute and Convalescent Phases of the Disease. (Pubmed Central) - Aug 22, 2022
The detection of YFV RNA in urine is an indicative of YFV infection; however, the results of RT-PCR using urine as sample should be interpreted with care, since a negative result does not exclude the possibility of YFV infection. With a possible prolonged period of detection beyond the viremic phase, the use of urine samples coupled with serological tests, epidemiologic inquiry, and clinical assessment could provide a longer diagnostic window for laboratory YF diagnosis.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach. (Pubmed Central) - Jul 30, 2022
Aedes aegypti is the main vector that transmits viral diseases such as dengue, hemorrhagic dengue, urban yellow fever, zika, and chikungunya...Compounds M01-M05 were selected, showing significant differences in pharmacokinetic and toxicological parameters in relation to positive controls and interaction with catalytic residues among key protein sites reported in the literature. For this reason, the molecules investigated here are dual inhibitors of the enzymes chitin synthase and juvenile hormonal protein from insects and humans, characterizing them as potential insecticides against the Aedes aegypti mosquito.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Clinical, Journal: Immunogenicity and safety of primary fractional-dose yellow fever vaccine in autoimmune rheumatic diseases. (Pubmed Central) - Dec 22, 2021
P=N/A
This vaccine was immunogenic, safe and did not induce flares in ARD under low immunosuppression and may be indicated in YF outbreak situations and for patients who live or travel to endemic areas. This clinical trial was registered with Clinicaltrials.gov (#NCT03430388).
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever. (Pubmed Central) - Nov 4, 2021
No cross-reactivity was observed with serum from seropositive individuals for dengue, chikungunya, yellow fever, Zika, and other infectious diseases as well as healthy individuals. Our data suggest that this bioengineered antigen could be used to develop high-performance serological tests for MAYV infections.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Engaging local health research communities to enhance long-term capacity building in Brazil. (Pubmed Central) - Nov 1, 2021
As a result, REDe has become a highly dynamic community of practice for health researchers in the region, strengthening the research culture and improving connectivity. Here, we describe the design and implementation of this initiative and demonstrate the value of integrating local expertise, and a practical workshop series format with digital dissemination of research resources and training materials to generate a vibrant and robust community of practice.
- |||||||||| [VIRTUAL] A Rare Case of Shared Paralysis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6862;
Treatment modalities for all forms of Flavivirus encephalitis are the same with ongoing research demonstrating some role of ribavirin, interferon alpha and IVIG. Prognosis is usually guarded which emphasizes more on the early recognition and timely initiation of appropriate treatment.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
[VIRTUAL] A Case of Imported Falciparum Malaria and How Procalcitonin Can Aid in Critical Care Decision Making (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6770;
According to the available literature none of the patients with severe malaria showed PCT levels within normal limits (<0.5 ng/ml). PCT has also been shown to correlate with parasitemia, which is important because of the role of parasitemia in establishing severity and response to therapy.
- |||||||||| vancomycin / Generic mfg.
Journal: Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity. (Pubmed Central) - Jul 3, 2020
Two of them exerted strong and selective inhibition of influenza A and B virus replication, while antibacterial activity was successfully eliminated by removing the critical N-terminal moiety. In addition, these two molecules offered protection against several other viruses, such as herpes simplex virus, yellow fever virus, Zika virus, and human coronavirus, classifying these glycopeptides as broad antiviral molecules with a favorable therapeutic index.
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Journal: Vaccine impact on antimicrobial resistance to inform Gavi, the Vaccine Alliance's 2018 Vaccine Investment Strategy: report from an expert survey. (Pubmed Central) - Jun 14, 2020
Lowest value relative to AMR was estimated for Japanese encephalitis, hepatitis A, yellow fever, rabies and human papilloma virus vaccine. In the future, more evidence-based, data-driven, robust methodologies should be developed to guide coordinated, rational decision making on priority actions aimed at strengthening the use of vaccines against AMR.
- |||||||||| yellow Fever Vaccine - iBio, Bio / Manguinhos, Fraunhofer Institute for Molecular Biology and Applied Ecology, levamisole / Generic mfg.
Journal: Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence. (Pubmed Central) - May 10, 2020
In countries like Nepal, with a high burden of infectious and parasitic diseases, and a current health system unable to combat the burden of diseases, evaluation of local plants as a treatment or potential source of drugs can help expand treatment options. Screening plants against a broad range of pathogens (bacteria, viruses, fungi, and parasites) will support bioprospecting in Nepal, which may eventually lead to new drug development.
- |||||||||| A Rare Case of Shared Paralysis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_9593;
Treatment modalities for all forms of Flavivirus encephalitis are the same with ongoing research demonstrating some role of ribavirin, interferon alpha and IVIG. Prognosis is usually guarded which emphasizes more on the early recognition and timely initiation of appropriate treatment.
- |||||||||| yellow Fever Vaccine - iBio, Bio / Manguinhos, Fraunhofer Institute for Molecular Biology and Applied Ecology
A Case of Imported Falciparum Malaria and How Procalcitonin Can Aid in Critical Care Decision Making (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_9487;
According to the available literature none of the patients with severe malaria showed PCT levels within normal limits (<0.5 ng/ml). PCT has also been shown to correlate with parasitemia, which is important because of the role of parasitemia in establishing severity and response to therapy.
- |||||||||| ceftriaxone / generics
Journal: Community-acquired acute meningitis and encephalitis: a narrative review. (Pubmed Central) - Aug 1, 2019
Empiric therapy for encephalitis should be directed at the most frequently identified infectious pathogen, herpes simplex virus type 1 (ie, intravenous aciclovir). Vaccines can protect against the major pathogens of childhood infections (measles, mumps, rubella, polio, varicella viruses), influenza viruses, and exotic pathogens that cause meningitis and encephalitis (rabies, Japanese encephalitis, dengue, yellow fever, tick-borne encephalitis viruses, Mycobacterium tuberculosis).
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Enrollment closed: Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study) (clinicaltrials.gov) - Jul 18, 2018
P4, N=4761, Active, not recruiting,
Vaccines can protect against the major pathogens of childhood infections (measles, mumps, rubella, polio, varicella viruses), influenza viruses, and exotic pathogens that cause meningitis and encephalitis (rabies, Japanese encephalitis, dengue, yellow fever, tick-borne encephalitis viruses, Mycobacterium tuberculosis). Recruiting --> Active, not recruiting
- |||||||||| yellow fever vaccine / iBio, Fraunhofer Institute for Molecular Biology and Applied Ecology, Oswaldo Cruz Foundation
Enrollment open, Trial initiation date, Trial primary completion date: Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study) (clinicaltrials.gov) - Jul 11, 2016
P4, N=4761, Recruiting,
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting | Initiation date: Mar 2016 --> Jul 2016 | Trial primary completion date: Dec 2026 --> Jun 2026
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