||||||||||RG7667 / Roche Preclinical, Journal: Resolution of unexpected pregnancy-related findings in a rat embryofetal development and toxicokinetic study of monoclonal antibodies specific for hCMV. (Pubmed Central) - Jun 23, 2019 The results of the Pivotal study confirmed the lack of overt toxicity, teratogenicity, or effects on litter size and viability when human or humanized monoclonal antibodies that lack an endogenous target are administered IV to rats during pregnancy. With these additional data, we concluded that the unexpected pathology findings in the Pilot study were not specific to RG7667, but rather highlight some clinical pathology and macroscopic/microscopic findings that can occur during pregnancy in rats.
||||||||||RG7667 / Roche Trial completion: A Study of RG7667 in Healthy Volunteers (clinicaltrials.gov) - Mar 31, 2013 P1, N=170, Completed, Sponsor: Genentech ClinicalTrials.gov, NCT01753167. Active, not recruiting --> Completed