pizotifen malate / Generic mfg. 
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 0 Diseases   2 Trials   2 Trials   29 News 
  • ||||||||||  Reyvow (lasmiditan) / Eli Lilly, Daiichi Sankyo
    Review, Journal:  What is new in migraine management in children and young people? (Pubmed Central) -  Nov 22, 2022   
    There have been new developments in pharmaceuticals recently, including a more selective 5-HT1F agonist, lasmiditan, an effective acute treatment with no vasoconstrictor activity in adults, currently being tested in children...So, there has been much progress, but mostly for adults. We are in urgent need of more migraine trials in children.
  • ||||||||||  pizotifen malate / Generic mfg.
    Journal:  Gastrulation Screening to Identify Anti-metastasis Drugs in Zebrafish Embryos. (Pubmed Central) -  Nov 1, 2022   
    A previous study subjected 1,280 FDA-approved drugs to the screen and identified adrenosterone and pizotifen as epiboly-interrupting drugs...Therefore, this screen could be converted into a chemical genetic screening platform for identification of metastasis-promoting genes. Graphical abstract.
  • ||||||||||  pizotifen malate / Generic mfg.
    Preclinical, Journal:  Intrathecally administered pizotifen alleviates neuropathic and inflammatory pain in mice by enhancing GABAergic inhibition. (Pubmed Central) -  Apr 14, 2022   
    Furthermore, high dose of pizotifen (5μg) weakly affected motor performance and did not influence the locomotor activity in normal animals. In summary, our findings suggest that pizotifen strengthens the inhibitory synaptic transmission and exerts antinociceptive effect on both neuropathic pain and inflammatory pain in the spinal cord, and may serve as a promising remedy for chronic pain.
  • ||||||||||  pizotifen malate / Generic mfg.
    Journal:  Fishing for drugs. (Pubmed Central) -  Feb 15, 2022   
    Taken together, our concept offers a novel platform for discovery of anti-metastasis drugs. Screening for drugs that disrupt embryonic development in zebrafish can help identify treatments that suppress metastasis.
  • ||||||||||  verapamil / Generic mfg.
    Retrospective data, Review, Journal:  Systematic literature review and Bayesian network meta-analysis of episodic cluster headache drugs. (Pubmed Central) -  Sep 16, 2021   
    The results suggest that galcanezumab is more effective compared to verapamil as a prophylaxis treatment for reducing eCH attacks in adults. Further, head-to-head RCTs of galcanezumab vs. treatments using in clinical practice are needed to better assess its comparative efficacy and benefit-risk profile.
  • ||||||||||  verapamil / Generic mfg., sumatriptan succinate / Generic mfg.
    Review, Journal:  Pharmacotherapy for Cluster Headache. (Pubmed Central) -  Jun 10, 2021   
    If all these drugs fail, other options with lower levels of evidence are available (e.g. melatonin, clomiphene, dihydroergotamine, pizotifen)...A new addition to the preventive treatment options in episodic cluster headache is galcanezumab, although the long-term effects remain unknown...At present, greater occipital nerve injection is the most proven transitional treatment. Other options are high-dose prednisone or frovatriptan.