- |||||||||| alprazolam / Generic mfg.
Journal: Case report on melatonin overdose: Cause and concern. (Pubmed Central) - Jun 7, 2024
The authors present a case of 16-year-old male intentionally overdosed on 900mg of melatonin (180 tablets) and 10 tablets of 0.5mg alprazolam...Although melatonin has a low toxicity potential, side effects and interactions with other drugs can be severe. Supportive measures and vital sign control are crucial in overdose treatment.
- |||||||||| alprazolam / Generic mfg.
Preclinical, Journal: In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth. (Pubmed Central) - May 30, 2024
Next, we show that the estimated E/I ratio marker is sensitive to the gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI...This result is replicated across North American (8.2 to 23.0 y old) and Asian (7.2 to 7.9 y old) cohorts, suggesting that a more mature E/I ratio indexes improved cognition during normative development. Overall, our findings open the door to studying how disrupted E/I trajectories may lead to cognitive dysfunction in psychopathology that emerges during youth.
- |||||||||| Retrospective data, Review: Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis. (Pubmed Central) - Apr 18, 2024
Interestingly, commonly used synthetic drugs such as Fluoxetine, Escitalopram, Amitriptyline, Sertraline, Flupentixol and Melitracen, and Venlafaxine, not only appeared to be less effective than specific Chinese herbal medicines (Gan Mai Da Zao Decoction, Chaihu Jia Longgu Muli Decoction, Chai Hu Shu Gan San, Danzhi-Xiaoyao-San, and Xingnao Jieyu Decoction), but they were also related to substantially higher risk of adverse events...However, it underscores the necessity for larger, methodologically robust trials to further validate and refine these preliminary findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023452109.
- |||||||||| venlafaxine / Generic mfg., pilocarpine / Generic mfg., alprazolam / Generic mfg.
Journal: A relatively rare traditional Chinese medicine pattern of primary Sj (Pubmed Central) - Apr 16, 2024
Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023452109. This case report demonstrates that TCHM can effectively treat Primary Sj
- |||||||||| alprazolam / Generic mfg.
Journal: Risk of suicide attempts and intentional self-harm on alprazolam. (Pubmed Central) - Apr 15, 2024
The increased risk extends to benzodiazepines in general, regardless of half-life and risk of withdrawal seizure. Buspirone appears to be a safer treatment than benzodiazepines, particularly in patients at increased risk for suicide.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
New P4 trial: Detoxification From the Lipid Tract (clinicaltrials.gov) - Apr 9, 2024
P4, N=1, Completed,
- |||||||||| alprazolam / Generic mfg.
Journal, Adverse events: Signal mining and risk analysis of Alprazolam adverse events based on the FAERS database. (Pubmed Central) - Apr 3, 2024
This study highlights the risks of suicide and misuse of Alprazolam. Other potential severe or fatal AEs, such as those related to the cardiovascular system, platelet function, and others, require further research to determine their precise mechanisms and risk factors.
- |||||||||| paroxetine / Generic mfg., alprazolam / Generic mfg.
Journal: Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder. (Pubmed Central) - Mar 4, 2024
This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.
- |||||||||| alprazolam / Generic mfg.
Observational data, Journal: Insomnia among coronavirus disease 2019 survivors: A single-center cross-sectional study. (Pubmed Central) - Feb 20, 2024
Additionally, of the 107 insomnia patients with drug therapy, 17 (15.89%) took estazolam, 16 (14.95%) took alprazolam, 39 (36.45%) took zopiclone, and 35 (32.71%) took other drugs to improve insomnia symptoms...Education level and occupation may be the influencing factors. Unfortunately, most patients with insomnia do not take corresponding treatment measures.
- |||||||||| desmopressin / Generic mfg., alprazolam / Generic mfg., memantine / Generic mfg.
Sodium Dyscrasia: A Case of Central Diabetes Insipidus Unmasked by the Resolution of Vasopressin-Induced Hyponatremia (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3329;
Further studies are required to determine the incidence, prevalence as well as time of onset, time of resolution and duration of vasopressin induced hyponatremia and subsequent CDI. But, more importantly, establishing the reason why certain patients are predisposed or acutely develop this condition will allow for optimal monitoring and evidence-based guidelines for management, prevention and treatment to improve overall prognosis and reduce morbidity and mortality rates.
- |||||||||| alprazolam / Generic mfg.
Crisis in the Lungs: EVALI Unveiled in a Young Male Patient (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1695;
Patient relatives state abuse of Alprazolam and daily cannabis products, mostly vaping...This case underscores the need for continued public health awareness campaigns and educational initiatives targeting young individuals and healthcare professionals. Early diagnosis and intervention are crucial in preventing severe respiratory complications associated with vaping, and further research is necessary to better understand the specific factors contributing to EVALI.
- |||||||||| alprazolam / Generic mfg.
Whippet Too Hard: Nitrous Inhalant Abuse Leading to Acute Lung Injury (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1607;
In emergency department, patient was more awake, endorsed consuming 1-2 pills of oxycodone, 2 pills of xanax, and 1 joint of marijuana along with inhaling 6-8 aerosolized cans of whipped cream for recreational use...Although our patient also consumed other substances, none have been reported to cause these image findings. We hope to raise awareness of WCC inhalant abuse as a potential cause of respiratory failure and crazy-paving pattern in young adults.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Biomarker, Trial completion date, Trial primary completion date: LUSZ_CTS_COVID: LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients (clinicaltrials.gov) - Feb 15, 2024
P1, N=1000, Recruiting,
We hope to raise awareness of WCC inhalant abuse as a potential cause of respiratory failure and crazy-paving pattern in young adults. Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
- |||||||||| Journal: Diagnostic psychiatric and somatic comorbidity in patients with depression in the Western Balkan countries. (Pubmed Central) - Jan 7, 2024
The results of the study confirm the results of previous research studies about the high prevalence of psychiatric and non-psychiatric comorbidities in patients with depression that were conducted in the past. It would be important if future studies could prove the importance of those comorbidities on clinical severity, choice of treatment, and its outcome in patients with depression.
- |||||||||| alprazolam / Generic mfg.
Journal: Benzodiazepine Use During Pregnancy and Risk of Miscarriage. (Pubmed Central) - Dec 27, 2023
This nationwide case-time-control study revealed an increased risk of miscarriage associated with benzodiazepine use during pregnancy after accounting for measurable confounders, and results were unlikely to be due to unmeasured confounding. These findings underscore the necessity for health care professionals to meticulously balance the risk-benefit ratio when considering the use of benzodiazepines to treat psychiatric and sleep disorders during pregnancy.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
UNCOVERING THE REAL NON-PSYCHIATRIC DIAGNOSIS: A RARE NEUROLOGICAL DISORDER (Chapman #4 (Sunset Center)) - Dec 13, 2023 - Abstract #WRMC2024WRMC_173;
The patient went to a psychiatrist and was diagnosed with somatic symptom disorder, bipolar affective disorder, and anxiety, and started on alprazolam...She was started on clonazepam 1.5 mg three times daily and baclofen 10 mg twice daily...9 months after diagnosis, rituximab 1000 mg every 2 weeks, was added...More advanced work-up with specialized CSF biomarkers may be required such as in our patient - lumbar puncture and CSF analysis finally showed elevated GAD-65 antibody levels. Ultimately, somatic symptom disorder/functional psychiatric illnesses should be a diagnosis of exclusion; one must always have even a remote suspicion for rare disorders like Stiff-Person Syndrome.
- |||||||||| alprazolam / Generic mfg.
Journal: Short-term effects of etifoxine on human gut microbiome in healthy men. (Pubmed Central) - Dec 11, 2023
We performed a crossover study with 36 healthy male volunteers who received etifoxine versus alprazolam and placebo in a balanced Williams design...These species are currently seen as beneficial components of a healthy intestinal microbiome. This reduction in abundances may be related to elevated endogenous neurosteroids.
- |||||||||| alprazolam / Generic mfg.
Journal: Alprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study. (Pubmed Central) - Nov 3, 2023
Finally, we uncover spatial relationships (i) between regional variation in differential control energy (alprazolam versus placebo) and (ii) both serotonin and dopamine neurotransmitter systems, indicating that alprazolam may exert its effects by altering neuromodulatory systems. Together, these findings provide a new perspective on the distributed emotion processing network and the effect of GABAergic modulation on this network, in addition to identifying an association between schizophrenia risk and abnormal GABAergic effects on persistence energy during threat processing.
- |||||||||| morphine sulphate / Generic mfg., alprazolam / Generic mfg.
Alprazolam (Xanax) exposure during adolescence exacerbates spontaneous morphine withdrawal (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_13520;
, jumping, chewing/licking, paw tremors, headshakes) when compared to the VEH-MOR-treated controls. Overall, our findings have critical implications for the perpetuation of SUD's during adolescence as potentiated withdrawal symptoms can drive the continuation of drug use.
- |||||||||| alprazolam / Generic mfg.
Flualprazolam, a designer benzodiazepine, induces psychological and physical dependence in rodents (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_8079;
Although flualprazolam is structurally similar to alprazolam, a single fluorine atom of it increases pharmacokinetic parameters including half-life and volume of distribution leading to a potential for greater toxicity and drug addiction than alprazolam...All data were analyzed using ANOVA with Fisher's LSD post hoc test. The findings of this study demonstrate that flualprazolam has reinforcing effect and dependence in rodent models.
- |||||||||| Nitredon (nitrazepam) / Remedica
Journal: Intralipid as Matrix Additive for Evaluating Hyperlipidemic Postmortem Blood. (Pubmed Central) - Oct 23, 2023
Both Intralipid and pooled postmortem lipids showed marked effects on the analytical results. Intralipid gave a good indication of the effects of lipemia and could be a useful tool for making meaningful evaluation of hyperlipidemic postmortem samples during method development and validation.
- |||||||||| alprazolam / Generic mfg.
Preclinical, Journal: A brain-tumor neural circuit controls breast cancer progression in mice. (Pubmed Central) - Oct 17, 2023
Furthermore, we showed that manipulation of CeMCRH?LPGi circuit directly regulates the activity of the intratumoral sympathetic nerves and peripheral nerve-derived norepinephrine, then affecting tumor progression by modulating the antitumor immunity. Together, these findings reveal a brain-tumor neural circuit contributing to breast cancer progression and provide new therapeutic insights for breast cancer.
- |||||||||| alprazolam / Generic mfg.
Preclinical, Journal: Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice. (Pubmed Central) - Oct 6, 2023
Furthermore, in vivo behavioral experiments including IntelliCage System (ICS) and nover object recognition (NOR), hippocampal neuronal pathological changes with HE staining, and the expression levels of brain-deprived neuron factor (BDNF) with immunohistochemistry showed a significant decrease in memory consolidation in mice with repeated administration of Alp, which could be rescued by the co-administration of the mitochondrial protector NSI-189. To the best of our knowledge, this is the first study to identify a link between repeated administration of Alp and mitochondrial dysfunction and that mitochondrial impairment directly causes the attenuation of memory consolidation in mice.
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