- |||||||||| carbamazepine / generics
Journal: Removal of pharmaceutically active compounds from synthetic and real aqueous mixtures and simultaneous disinfection by supported TiO/UV-A, HO/UV-A, and TiO/HO/UV-A processes. (Pubmed Central) - Apr 17, 2019 ...In this study, the degradation of alprazolam, clonazepam, diazepam, lorazepam, and carbamazepine was evaluated through TiO/UV-A, HO/UV-A, and TiO/HO/UV-A, using sunlight and artificial irradiation...The combination of both processes was shown to be an adequate approach, since removal increased up to 90%. HO/UV-A was used for disinfecting the aqueous matrices, while mineralization was obtained by TiO-photocatalysis.
- |||||||||| lorazepam / generics
Journal: Catatonia is not schizophrenia and it is treatable. (Pubmed Central) - Apr 10, 2019 Eighty percent of the patients are relieved by the use of barbiturates or benzodiazepines, while in those who fail, an improvement is achieved by electroconvulsive therapy (ECT). With more than 60years of use in catatonic patients, ECT has proven to be an effective and safe tool for the treatment of this frequent and sometimes forgotten syndrome.
- |||||||||| ketamine / Generic mfg., phenobarbital / Generic mfg.
Trial initiation date: PKAT: Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine (clinicaltrials.gov) - Apr 4, 2019 P4, N=222, Not yet recruiting, With more than 60years of use in catatonic patients, ECT has proven to be an effective and safe tool for the treatment of this frequent and sometimes forgotten syndrome. Initiation date: Mar 2019 --> Jun 2019
- |||||||||| gabapentin / Generic mfg.
Trial completion date, Trial primary completion date: Gabapentin for Alcohol Withdrawal Syndrome (clinicaltrials.gov) - Feb 27, 2019 P4, N=400, Recruiting, Phase classification: P2 --> P1 Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Feb 2019 --> Feb 2021
- |||||||||| lorazepam / Generic mfg., diazepam / Generic mfg., alprazolam / Generic mfg.
Trial primary completion date: Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free) (clinicaltrials.gov) - Aug 15, 2018 P1, N=480, Recruiting, Active, not recruiting --> Completed Trial primary completion date: Apr 2018 --> Aug 2018
- |||||||||| Recentin (cediranib) / AstraZeneca
Trial completion date, Trial primary completion date, Monotherapy, Metastases: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) - Jul 19, 2018 P2, N=70, Recruiting, Trial primary completion date: Apr 2018 --> Aug 2018 Trial completion date: Jun 2019 --> Dec 2019 | Trial primary completion date: Jun 2019 --> Dec 2019
- |||||||||| Gralise (gabapentin) / Alvogen
Trial termination: Stanford Accelerated Recovery Trial (START) (clinicaltrials.gov) - Jun 28, 2018 P3, N=422, Terminated, Trial completion date: Jun 2019 --> Dec 2019 | Trial primary completion date: Jun 2019 --> Dec 2019 Active, not recruiting --> Terminated; Trial met futility stopping point
- |||||||||| Recentin (cediranib) / AstraZeneca
Trial primary completion date, Monotherapy, Metastases: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) - Jun 28, 2018 P2, N=70, Recruiting, Active, not recruiting --> Terminated; Trial met futility stopping point Trial primary completion date: Jun 2018 --> Jun 2019
- |||||||||| ketamine / Generic mfg.
Enrollment closed, Trial primary completion date: Treatment Resistant Depression (Pilot) (clinicaltrials.gov) - Jun 20, 2018 P=N/A, N=40, Active, not recruiting, Trial primary completion date: Jun 2018 --> Jun 2019 Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2018 --> Jun 2019
- |||||||||| OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
Trial completion date, Trial primary completion date: OSDI: Oral Sedation During Cervical Dilator Placement (clinicaltrials.gov) - Jun 6, 2018 P4, N=60, Recruiting, Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2018 --> Jun 2019 Trial completion date: Oct 2018 --> Jul 2019 | Trial primary completion date: Sep 2018 --> Jun 2019
- |||||||||| Onsolis (BEMA fentanyl) / Viatris, Collegium Pharma, NN1213 / Novo Nordisk
Trial primary completion date: Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) (clinicaltrials.gov) - Jun 4, 2018 P=N/A, N=109, Active, not recruiting, Trial completion date: Oct 2018 --> Jul 2019 | Trial primary completion date: Sep 2018 --> Jun 2019 Trial primary completion date: May 2018 --> Dec 2019
- |||||||||| Adasuve (staccato loxapine) / AOP Orphan Pharma, Teva, Ferrer International, Galen, Medivir
Enrollment change, Trial completion date, Trial termination, Trial primary completion date, Head-to-Head: Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation (clinicaltrials.gov) - Apr 6, 2018 P4, N=2, Terminated, Trial completion date: Dec 2017 --> Jun 2018 | Trial primary completion date: Dec 2017 --> Jun 2018 N=140 --> 2 | Trial completion date: Aug 2019 --> Apr 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2019 --> Apr 2018; Sponsor Withdrawal
- |||||||||| Recentin (cediranib) / AstraZeneca
Trial completion date, Monotherapy, Metastases: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) - Mar 12, 2018 P2, N=70, Recruiting, N=140 --> 2 | Trial completion date: Aug 2019 --> Apr 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2019 --> Apr 2018; Sponsor Withdrawal Trial completion date: Jun 2018 --> Jun 2019
- |||||||||| OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
Trial primary completion date: OSDI: Oral Sedation During Cervical Dilator Placement (clinicaltrials.gov) - Jan 29, 2018 P4, N=60, Recruiting, Trial completion date: Jun 2018 --> Jun 2019 Trial primary completion date: Feb 2018 --> Sep 2018
- |||||||||| Adasuve (staccato loxapine) / AOP Orphan Pharma, Teva, Ferrer International, Galen, Medivir
Phase classification: ADASUVE-Lorazepam Drug-Drug Interaction (clinicaltrials.gov) - Dec 13, 2017 P4, N=22, Completed, Trial primary completion date: Feb 2018 --> Sep 2018 Phase classification: P1 --> P4
- |||||||||| lorazepam / Generic mfg., diazepam / Generic mfg., alprazolam / Generic mfg.
Enrollment open, Trial initiation date: Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free) (clinicaltrials.gov) - Nov 20, 2017 P1, N=480, Recruiting, Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting | Initiation date: Sep 2017 --> Apr 2017
- |||||||||| Enrollment change, Trial termination, Trial primary completion date, Adverse events: Pharmacovigilance in Gerontopsychiatric Patients (clinicaltrials.gov) - Oct 19, 2017
P3, N=407, Terminated, Not yet recruiting --> Recruiting | Initiation date: Sep 2017 --> Apr 2017 N=2000 --> 407 | Recruiting --> Terminated | Trial primary completion date: Feb 2017 --> Jun 2017
- |||||||||| Adasuve (staccato loxapine) / AOP Orphan Pharma, Teva, Ferrer International, Galen, Medivir
Enrollment open, Head-to-Head: Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation (clinicaltrials.gov) - Oct 19, 2017 P4, N=140, Recruiting, N=2000 --> 407 | Recruiting --> Terminated | Trial primary completion date: Feb 2017 --> Jun 2017 Not yet recruiting --> Recruiting
- |||||||||| Onsolis (BEMA fentanyl) / Viatris, Collegium Pharma
Phase classification, Trial primary completion date: Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) (clinicaltrials.gov) - Aug 22, 2017 P=N/A, N=109, Active, not recruiting, Not yet recruiting --> Recruiting Phase classification: P1 --> P=N/A | Trial primary completion date: Apr 2017 --> May 2018
- |||||||||| Adasuve (staccato loxapine) / AOP Orphan Pharma, Teva, Ferrer International, Galen, Medivir
Trial initiation date, Trial primary completion date, Head-to-Head: Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation (clinicaltrials.gov) - Jul 11, 2017 P4, N=140, Not yet recruiting, Phase classification: P1 --> P=N/A | Trial primary completion date: Apr 2017 --> May 2018 Initiation date: May 2017 --> Aug 2017 | Trial primary completion date: Apr 2019 --> Aug 2019
- |||||||||| OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
Enrollment open: OSDI: Oral Sedation During Cervical Dilator Placement (clinicaltrials.gov) - Jul 2, 2017 P4, N=60, Recruiting, Initiation date: May 2017 --> Aug 2017 | Trial primary completion date: Apr 2019 --> Aug 2019 Not yet recruiting --> Recruiting
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