- |||||||||| fentanyl citrate / generics, lorazepam / generics
Journal: Sedative Plasma Concentrations and Delirium Risk in Critical Illness. (Pubmed Central) - Oct 9, 2019
In critically ill patients, higher lorazepam plasma concentrations were associated with delirium, whereas dexmedetomidine plasma concentrations were not. This implies that the reduced delirium risk seen in patients sedated with dexmedetomidine may be a result of avoidance of benzodiazepines, rather than a dose-dependent protective effect of dexmedetomidine.
- |||||||||| lorazepam / generics
Clinical, Journal: Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial. (Pubmed Central) - Oct 2, 2019
P3
Initiatives to improve the delivery of prolonged sedatives and analgesic infusions should be informed by PK parameters (Vd, context-sensitive t, and elimination t) and data derived from critically ill patients. Although enteral sedation of critically ill patients is cheaper and permits a lighter sedation target, it is not superior to intravenous sedation for reaching the RASS target.
- |||||||||| lorazepam / generics
Review, Journal: Benzodiazepines for catatonia in people with schizophrenia or other serious mental illnesses. (Pubmed Central) - Sep 27, 2019
No data were available for benzodiazepines compared to placebo or standard care. The lack of usable data and very low quality of data available makes it impossible to draw firm conclusions and further studies with a high-quality methodology and reporting are required in order to determine more definitively the outcomes associated with benzodiazepine use in the clinical management of catatonia in persons with schizophrenia and other SMI.
- |||||||||| lorazepam / generics
CARDIOPULMONARY SYNDROMES: A HYPOXEMIC LINK BETWEEN COPD AND TAKOTSUBO CARDIOMYOPATHY (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 3) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3769;
The case-population approach using a registry of cases and a primary health care database proved feasible and efficient for the active surveillance of SJS/TEN. She received 1mg of lorazepam for delirium tremens and decompensated...This classification of cardiopulmonary syndromes is meant to recognize and categorize coexisting pathology, and encourage guideline production for dual treatment modalities.
- |||||||||| tacrolimus / Generic Mfg., quetiapine / Generic Mfg.
FENTANYL ACCUMULATION IN RENAL DISEASE CAUSING SEROTONIN SYNDROME (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3515;
These patients are often on numerous medications and are at risk for interaction with drugs required in the intensive care setting. Use of alternative agents like remifentanil, alfentanil which have shorter half lives or use of intermittent pushes of fentanyl is a simple measure which can decrease the burden of this complication.
- |||||||||| aripiprazole / Generic Mfg.
STATUS EPILEPTICUS FOLLOWING ECT IN AN ELDERLY PATIENT: A CASE REPORT AND REVIEW OF THE LITERATURE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3511;
Home medications were isosorbide dinitrate, chlorpromazine and aripiprazole...In the ED she received intravenous lorazepam and was sedated with Propofol and intubated...Neuroleptics have diverse effects on initial seizure threshold for ECT but chlorpromazine is reported to increase the likelihood of seizures in patients such as ours. Another contributing factor for our patient may be cerebrovascular steal phenomenon associated with ECT which could trigger seizures in the area surrounding her previous infarcts.
- |||||||||| lorazepam / generics
ACUTE ALCOHOL WITHDRAWAL-INDUCED TAKOTSUBO CARDIOMYOPATHY: A RARE PRESENTATION (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3426;
Another contributing factor for our patient may be cerebrovascular steal phenomenon associated with ECT which could trigger seizures in the area surrounding her previous infarcts. In the ICU he was started on treatment for alcohol withdrawal with benzodiazepines- lorazepam, oxazepam along with thiamine, folate supplementation...Clinicians should consider the possibility of TCM in patients with signs and symptoms of chest pain or LV dysfunction in the setting of alcohol withdrawal.
- |||||||||| quetiapine / Generic Mfg.
QUETIAPINE- AND RIVASTIGMINE-INDUCED NEUROLEPTIC MALIGNANT SYNDROME IN LEWY BODY DEMENTIA (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3390;
NMS diagnosis requires a high index of suspicion and early identification improves outcomes. Rivastigmine use should raise suspicion of NMS with autonomic dysfunction, bland infectious work up, and concomitant neuroleptic use.
- |||||||||| lorazepam / generics
NON-TRAUMATIC ACUTE SUBDURAL HEMATOMA IN A PATIENT WITH ALCOHOLIC LIVER CIRRHOSIS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3377;
Appropriate prevention such as cautious use of anticoagulants and fall prevention is necessary for cirrhotic patients. Clinicians should keep SDH in mind as one of the differential diagnoses when cirrhotic patients present with altered consciousness even in the absence of trauma.
- |||||||||| lorazepam / generics
HYPONATREMIA-INDUCED EXPRESSIVE APHASIA: AN ATYPICAL STROKE MIMIC (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3323;
He was given lorazepam for presumed panic attack...Acute hyponatremia can present with a focal neurologic deficit, mimicking stroke. In addition to the more common culprits discussed above, electrolyte disturbance is an important consideration in the differential of stroke like symptoms.
- |||||||||| Imperan (metoclopramide) / Generic Mfg.
A RARE CASE OF SHINGLES WITH PERSISTENT SINGULTUS AND RESPIRATORY FAILURE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2794;
He was diagnosed with shingles and started on oral valacyclovir...In the ER, he was started on intravenous acyclovir for herpes zoster; however, the hiccups were refractory to haloperidol, metoclopramide, and lorazepam...Pharmacological therapies include chlorpromazine, metoclopramide and muscle relaxants. Physicians should closely monitor the respiratory status of patients who present with persistent singultus in the setting of shingles.
- |||||||||| Afinitor (everolimus) / Novartis
GASPING ON THIN AIR: SUPPLEMENTAL OXYGEN USAGE IN PALLIATIVE CARE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 3) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2689;
Providing supplemental oxygen may unexpectedly prolong life expectancy while causing undesired caregiver stress, undue financial burden, and psychological burnout on the family. Early discussion with family members regarding its use will set realistic expectations regarding prognosis and outcomes.
- |||||||||| fluoxetine / generics
TAKOTSUBO CARDIOMYOPATHY SECONDARY TO BENZODIAZEPINE TAPERING: AN UNDERREPORTED COMPLICATION (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1393;
There are approximately four published cases of TCM following abrupt cessation or tapering of either clonazepam, delorazepam, or lorazepam [1-3]...Her home medications consisted of alprazolam, lisinopril, and inhaled albuterol...She was intubated then started on midazolam and fentanyl drips...This clonazepam taper also included a concurrent fluoxetine taper [3]...TCM is known to be precipitated by a variety of stressors and should be considered in patients on benzodiazepine therapy. Until future studies provide further insight, it would be prudent for physicians tapering benzodiazepine regimens to follow a conservative approach.
- |||||||||| Duragesic (fentanyl) / J&J
TCAS-ASSOCIATED WITH PERSISTENT WIDE COMPLEX VENTRICULAR TACHYCARDIA (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1383;
Until future studies provide further insight, it would be prudent for physicians tapering benzodiazepine regimens to follow a conservative approach. Pertinent home medications included Amitriptyline, fentanyl patch, and hydromorphone...Patient was started on bicarbonate gtt and Ativan gtt...Early recognition and aggressive intervention is warranted in patients presenting with TCA overdose in order to improve patient outcomes.
- |||||||||| Clinical, Journal: Linking microbial diversity and population dynamics to the removal efficiency of pharmaceutically active compounds (PhACs) in an anaerobic/anoxic/aerobic (AO) system. (Pubmed Central) - Sep 20, 2019
Biota-environment (BIO-ENV) analysis revealed strong correlations between population shifts of the activated sludge community and the REs of PhACs of the different pharmaceutical families. Increased REs of clarithromycin, furosemide, bezafibrate and gemfibrozil were concomitant to higher relative abundances of bacterial phylotypes classified within the Rhodobacteraceae and Sphingomonadaceae (Alphaproteobacteria), while those of Betaproteobacteria, Chloroflexi and Methanomethylovorans (Euryarchaea) correlated positively with the REs of up to seven PhACs belonging to different therapeutic groups.
- |||||||||| ketamine / Generic mfg., phenobarbital / Generic mfg.
Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date: PKAT: Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine (clinicaltrials.gov) - Sep 18, 2019
P4, N=0, Withdrawn,
Increased REs of clarithromycin, furosemide, bezafibrate and gemfibrozil were concomitant to higher relative abundances of bacterial phylotypes classified within the Rhodobacteraceae and Sphingomonadaceae (Alphaproteobacteria), while those of Betaproteobacteria, Chloroflexi and Methanomethylovorans (Euryarchaea) correlated positively with the REs of up to seven PhACs belonging to different therapeutic groups. N=222 --> 0 | Trial completion date: Mar 2021 --> Apr 2019 | Not yet recruiting --> Withdrawn | Trial primary completion date: Mar 2021 --> Apr 2019
- |||||||||| ketamine / Generic mfg.
Trial completion date, Trial primary completion date: Treatment Resistant Depression (Pilot) (clinicaltrials.gov) - Sep 18, 2019
P=N/A, N=40, Active, not recruiting,
N=222 --> 0 | Trial completion date: Mar 2021 --> Apr 2019 | Not yet recruiting --> Withdrawn | Trial primary completion date: Mar 2021 --> Apr 2019 Trial completion date: Jun 2019 --> Jun 2020 | Trial primary completion date: Jun 2019 --> Jun 2020
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: A Case of Hyper Sexuality Probably Associated with Clozapine. (Pubmed Central) - Sep 14, 2019
Due to non-compliance and relapse of symptoms, she was started on clozapine 450 mg which was further increased to 650 mg along with an injectable antipsychotic zuclopenthixol 400 mg...Poor understanding of the condition by the patient could lead to marital discord and suffering. WHO scale indicates clozapine as the probable cause of sexual dysfunction in our patient.
- |||||||||| Adasuve (staccato loxapine) / AOP Orphan Pharma, Teva, Ferrer Internacional, Galen, Medivir, olanzapine / Generic Mfg.
Clinical, Review, Journal: Examining the safety, efficacy, and patient acceptability of inhaled loxapine for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults. (Pubmed Central) - Sep 10, 2019
Additionally, the use of inhaled loxapine can be associated with dysgeusia and throat irritation. Inhaled loxapine requires some degree of patient cooperation, and therefore may not be appropriate for all agitated patients.
- |||||||||| propranolol / Generic Mfg.
Use of intralipid in a case of beta-blocker overdose with prolonged cardio-pulmonary resuscitation. () - Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1600;
A 29-year-old female was admitted to hospital following a mixed drug overdose consisting of 5.6g Propranolol, 135mg Zopiclone, and 30mg Temazepam consumed as a single acute overdose, resulting in a prolonged resuscitation...Seizures were terminated with lorazepam, however bradycardia persisted, prompting treatment with atropine, adrenaline and glucagon...Current thinking is that propranolols highly lipophilic state means it can be cleared using Intralipid. Reflecting on this case the use of Intralipid during resuscitation was observed to be beneficial with an immediate response to treatment.
- |||||||||| lorazepam / generics
Journal: Fixed Drug Eruption Due to Lorazepam. (Pubmed Central) - Sep 7, 2019
Reflecting on this case the use of Intralipid during resuscitation was observed to be beneficial with an immediate response to treatment. No abstract available
- |||||||||| risperidone / Generic Mfg., Egis, carbamazepine / Generic Mfg.
Journal: Pharmacotherapy of Down Syndrome. (Pubmed Central) - Sep 6, 2019
If ineffective, we use memantine or clozapine...We treat "regression" with symptoms of MDD± psychosis, with an antidepressant and an antipsychotic if needed. Randomized controlled trials of medications for co-morbid psychiatric disorders in DS are warranted.
- |||||||||| Omeprazole RBX (omeprazole) / Generic Mfg.
Clinical, PK/PD data, Journal: Development of a Korean-specific virtual population for physiologically-based pharmacokinetic modeling and simulation. (Pubmed Central) - Sep 6, 2019
Furthermore, we found some drug models within the SimCYP® library can be improved, e.g., the minor allele frequency of ABCG2 and the fraction metabolized by UGT2B15 should be incorporated for rosuvastatin and lorazepam, respectively. The Korean-specific population can be used to evaluate the impact of ethnicity on the pharmacokinetics of a drug, particularly in various stages of drug development.
|
