- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: Benzodiazepines vs barbiturates for alcohol withdrawal: Analysis of 3 different treatment protocols. (Pubmed Central) - Dec 21, 2019
During benzodiazepine shortages, phenobarbital is a safe and effective treatment alternative for alcohol withdrawal. Incorporating phenobarbital into a benzodiazepine based protocol or as sole agent led to similar rates of ICU admission, length of stay, and need for mechanical ventilation in patients treated for alcohol withdrawal in the emergency department.
- |||||||||| lorazepam / Generic mfg.
Enrollment open, Trial initiation date: LORA-PITA IV General Investigation (clinicaltrials.gov) - Dec 18, 2019
P=N/A, N=200, Recruiting,
Further study of the antiepileptic properties of PF-06372865 is warranted. Active, not recruiting --> Recruiting | Initiation date: Jul 2019 --> Nov 2019
- |||||||||| lorazepam / generics, haloperidol / generics
Journal: Cannabinoid hyperemesis syndrome: An unrecognized cause of nausea and vomiting. (Pubmed Central) - Dec 6, 2019
Although the definitive treatment of cannabinoid hyperemesis syndrome is discontinuing the causative agent, medical management that includes rehydration is important to prevent complications. Common antiemetic medications are ineffective, but some studies have shown haloperidol and lorazepam to be effective in treating acute symptoms.
- |||||||||| Tisercin (levomepromazine) / Egis
Retrospective data, Journal: Sedatives and sedation at the end of life: a nursing home retrospective cohort study. (Pubmed Central) - Dec 1, 2019
Compared with published data on continuous deep sedation, moderate or deep sedation was less frequent in this nursing home and never labelled as 'sedation'. Multicentre mixed-methods research is needed to gain representative and more detailed data on sedation practices at the end of life in nursing homes.
- |||||||||| clonazepam / Generic mfg., lorazepam / Generic mfg., clobazam / Generic mfg.
Understanding Seizure Clusters: Epidiary Text Notes Compared with Diary Events (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1535;
Conclustions Free-text comments in the digital seizure diary provided additional information about the seizure clusters. More sophisticated lexical and grammatical models will likely improve accuracy of relevant comment identifications in the future.
- |||||||||| risperidone / Generic mfg., Egis, quetiapine / Generic mfg.
Implications of Psychiatric Comorbidities and Chronic Cannabis Use in Patients Undergoing Intracranial Monitoring for Medication Resistant Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1519;
The patient ultimately responded to quetiapine with addition of lorazepam following seizure provocation.Case 2: Patient is a 24-year-old right-handed woman with a learning disability, adjustment disorder with anxiety, methamphetamine use disorder in early remission, and right temporal lobe epilepsy in the setting of periventricular nodular heterotopia...She required physical restraint, haldol and lorazepam IM...The patient’s mood and agitation improved with scheduled risperidone and resumption of her antiseizure medications including gabapentin and clobazam...Cannabis withdrawal with added acute stress of brain surgery and seizure provocation should be taken very seriously as the consequences may be life threatening. We recommend that the presurgical process for epilepsy surgery involves a designation of a medical power of attorney, extensive patient education surrounding the hospitalization, and period of abstinence from cannabis, confirmed by urine toxicology.
- |||||||||| Standardized Pathway Implementation for the Treatment of Pediatric Status Epilepticus (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1492;
Intranasal midazolam and intravenous lorazepam were specified as first line benzodiazepines (BZD), second line medication options were expanded (see Figure 1), and midazolam was recommended as the initial third line continuous infusion...Considering all second line medications given (with and without SE), more valproic acid (p=0.0001) and less levetiracetam (p=0.008) were provided post-pathway, but this was not associated with reduced frequency of fosphenytoin and phenobarbital dosing (p=0.957)...While different second line medications were prescribed post-pathway, the overall incidence of requiring one and two doses of second-line medication was unchanged. Further analyses will evaluate whether these changes were associated with changes in patient outcome.
- |||||||||| lorazepam / Generic mfg.
Assessment of Seizure Outcomes During Rapid Discontinuation of Anticonvulsants During Invasive EEG Monitoring (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1269;
Of these patients 36 (58%) required intravenous lorazepam or other rescue anticonvulsants while 26 (42%) had spontaneous resolution of seizures...The acute cessation of all AED leads to seizure clustering in more than 70% of patients; however, seizures subside spontaneously in nearly 40% of these patients. The rapid and more gradual cessation of AED precipitates similar rates of SC and SE.
- |||||||||| pregabalin / Generic mfg., carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Levetiracetam Versus Sodium Channel Blockers as First Prescribed Antiepileptic Drug: Data from the Human Epilepsy Project (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1095;
Results 157 (59.5%) initiated levetiracetam (LEV), 49 (18.6%) lamotrigine (LTG), 21 (8%) oxcarbazepine (OXC), 11 (4.2%) phenytoin, 5 (1.9%) topiramate, 12 (4.5%) carbamazepine, (CBZ) 2 (0.8%) lacosamide, 5 (1.9%) valproic acid, 1 (0.4%) pregabalin, and 1 (0.4%) zonisamide.Of the 157 started on LEV, 63 (31.6%) remained on the drug in monotherapy, 76 (48%) switched to another AED, 12 (7.6%) added an AED in conjunction, and 6 (3.8%) ceased AED usage...By the end of the study, pts were receiving the following AEDs alone or in combination: LEV 36.0%, LTG 37.5%, CBZ 6.8%, OXC 17.0%, PHT 0.8%, topiramate 2.3%, lacosamide 7.2%, valproic acid 1.9%, zonisamide 4.9%, lorazepam 0.8%, clobazam 0.4%, clonazepam 0.4%...The likelihood of remaining on initial monotherapy was twice as high for a sodium channel blocker as for LEV in the first 2 years of treatment. (P=.001)
- |||||||||| lorazepam / Generic mfg.
The Effect of Ultrasound on Chronic Seizure in Kainic Acid Model of Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_983;
If severe epileptiform activity persisted beyond 24 hours post injection then Lorazepam (2 mg/kg) was administered...Immediately following the lesioning, seizures were observed for 24 hours, which we attribute to lysing of neurons causing them to release potassium inducing seizures. Upon recovery, animals became seizure free for the duration of experimental observation.
- |||||||||| lacosamide / Generic mfg., lorazepam / Generic mfg., levetiracetam / Generic mfg.
An Unusual Case of Subacute Encephalopathy with Seizures in Alcoholics (SESA) Syndrome (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_815;
He was given intravenous (IV) lorazepam and levetiracetam which resulted in cessation of clinical seizure activity, however he remained poorly responsive and unable to follow commands...He was continued on levetiracetam, lacosamide and valproic acid and was discharged to a rehabilitation facility...The evolution into super-refractory NCSE makes this case particularly unusual and highlights the importance of continuous EEG monitoring in this condition. Unlike alcohol withdrawal seizures, SESA syndrome typically requires chronic treatment with AEDs as recurrence is common.
- |||||||||| carbamazepine / Generic mfg.
Paradoxical Worsening of Frontal Lobe Seizures with Benzodiazepines (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_752;
Patient’s seizure medications were held, and on the third night, he was noted to have a cluster of seven nocturnal seizures prompting IV diazepam use for a total of 15mg.The patient continued to have seizures requiring additional BZDs, total of 12mg of IV lorazepam and 4mg of IV midazolam over the course of 7 – 8 hours...His ASDs were continued at home doses (brivaracetam 100mg TID, carbamazepine 600-400-400, and perampanel 18mg QHS)...At that point his clobazam was stopped and switched to zonisamide and his seizure frequency decreased to 0-1 per night...Conclustions Paradoxical worsening of frontal lobe seizures with benzodiazepine usage can occur. BZDs still remain the first line for acute seizure treatment, however additional precautions should be taken when used for sleep activated frontal lobe seizures.
- |||||||||| lorazepam / Generic mfg., topiramate / Generic mfg.
Predicting Drug-Induced Cognitive Impairment Using Resting-State EEG (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_603;
We showed for the first time that rsEEG measures are predictive of the severity of TPM-induced VWM deficits. Unlike other expensive or computationally burdensome methods used to predict treatment response or disease progression, the rsEEG measures analyzed here are quick and easy to acquire and thus may be clinically useful.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Mortality in Children with Sturge Weber Syndrome (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_558;
Seizures were not controlled despite adding levetiracetam and lorazepam, and she underwent right functional hemispherectomy at 6 months; however, resection was limited by blood loss...At 4 months, he developed left-sided focal seizures treated with phenobarbital, levetiracetam, and phenytoin, later responding to oxcarbazepine...No death directly related to prolonged seizures or SUDEP was seen in this cohort. Further studies will be necessary to identify the risk factors for mortality in children with SWS.
- |||||||||| lorazepam / Generic mfg.
Rescue Medications in Seizure Clusters: A Systematic Review of Treatment Patterns and Treatment Impact (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_534;
Rationale Benzodiazepines, including diazepam, lorazepam, and midazolam are used as rescue medications (RMs) in patients with epilepsy...The role of RMs in SC management is characterized differently by clinicians and patients. RMs effectively terminate SCs and are associated with improved clinical, humanistic and economic outcomes; therefore, addressing the issue of RM under-utilization in SC patients is critical.
- |||||||||| lorazepam / Generic mfg.
Lorazepam as a Rescue Seizure Medication in the Epilepsy Monitoring Unit (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_488;
None of the patients developed status epilepticus. Conclustions Our protocol for using lorazepam as a rescue medication in the EMU was not only simple for the nurses to follow but also beneficial to prevent status epilepticus.
- |||||||||| lorazepam / Generic mfg.
Lorazepam Timing for Acute Convulsive Seizure Control (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_282;
The increased vital instability among selective groups might be due to hyperactive or more labile autonomic responses among these populations. Acute convulsive seizures (lasting < 5 minutes) are usually self-limiting and require no intervention other than supportive measures.
- |||||||||| olanzapine / Generic Mfg.
Clinical, Journal: Autism Spectrum Disorder and Mental Health Comorbidity Leading to Prolonged Inpatient Admission. (Pubmed Central) - Nov 21, 2019
Sam began to show improvement in his overall agitation and aggression, requiring less clonazepam, and his mother then maintained outpatient follow-up.The day before discharge, you visit him in the hospital, and a medical student asks you why he was in the hospital for so long. How would you answer the question?
- |||||||||| Imperan (metoclopramide) / Generic Mfg.
Potentially inappropriate medications in older adults with HIV in the region of Madrid, Spain (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_1751;
Consistent with data in uninfected elderly, the most frequently observed PIMs were benzodiazepines and NSAIDs (Eur J Clin Pharmacol 2018; 74:679-700). Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
- |||||||||| Imperan (metoclopramide) / Generic Mfg.
Potentially inappropriate medications in older adults with HIV in the region of Madrid, Spain (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_941;
Consistent with data in uninfected elderly, the most frequently observed PIMs were benzodiazepines and NSAIDs (Eur J Clin Pharmacol 2018; 74:679-700). Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
- |||||||||| Imperan (metoclopramide) / Generic Mfg.
Potentially inappropriate medications in older adults with HIV in the region of Madrid, Spain (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_248;
Consistent with data in uninfected elderly, the most frequently observed PIMs were benzodiazepines and NSAIDs (Eur J Clin Pharmacol 2018; 74:679-700). Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
- |||||||||| ketamine / generics
Clinical, Journal: Treatment of Behavior Disturbances with Ketamine in a Patient Diagnosed with Major Neurocognitive Disorder. (Pubmed Central) - Nov 15, 2019
Although ketamine has been used recently in pre-hospital settings and EDs to reduce agitated behavior, there has been little if any investigation of its potential for reducing behavior disturbances in patients who suffer from major neurocognitive disorders. Ketamine could potentially be a promising treatment option for this population, but more research is needed.
- |||||||||| Journal: Drugs for anxiety disorders. (Pubmed Central) - Nov 13, 2019
Ketamine could potentially be a promising treatment option for this population, but more research is needed. No abstract available
- |||||||||| lorazepam / generics
Journal: Effects of lorazepam and baclofen on short- and long-latency afferent inhibition. (Pubmed Central) - Nov 6, 2019
This is the first study to report that LAI is reduced by the GABA positive allosteric modulator lorazepam, and that both SAI and LAI are not modulated by the GABA agonist baclofen. These findings advance the understanding of neural mechanisms that underlie afferent inhibition.
- |||||||||| lorazepam / generics
Clinical, PK/PD data, Journal: Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus. (Pubmed Central) - Oct 29, 2019
The model was developed using prospective data from a pediatric clinical trial comparing diazepam to lorazepam for treatment of SE...No significant or clinically important relationships were observed between diazepam PKs and safety or efficacy. Simulations demonstrated that, compared with label dosing, the study dose (0.2 mg/kg i.v., maximum 8 mg) resulted in greater frequency in rapidly achieving the target therapeutic range of 200-600 ng/mL.
- |||||||||| Tarlige (mirogabalin) / Daiichi Sankyo
Clinical, PK/PD data, Journal: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Mirogabalin When Coadministered With Lorazepam, Zolpidem, Tramadol, or Ethanol: Results From Drug-Drug Interaction Studies in Healthy Subjects. (Pubmed Central) - Oct 24, 2019
Mirogabalin/lorazepam and mirogabalin/zolpidem increased occurrence of somnolence. Increased incidence of nausea and headache was noted with mirogabalin/tramadol and mirogabalin/ethanol, respectively.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic Mfg., Precedex (dexmedetomidine) / Orion, Pfizer
SEPTICEMIA FROM URINARY TRACT INFECTION WITH NEGATIVE URINARY CULTURE: AEROCCOCUS URINAE IN AN OLDER ADULT (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Oct 23, 2019 - Abstract #CHEST2019CHEST_4801;
The patient remained very agitated and violent so a precedex infusion was started and the patient was transferred to the ICU...Aeroccocus urinae is common genitourinary pathogen that is widely underreported as a cause of septicemia given difficulties obtaining positive urine cultures. Intensivists should consider systemic infection with A. urinae in patients with positive urinalysis but negative urine cultures.
- |||||||||| dexmedetomedine sublingual (BXCL501) / BioXcel
Dexmedetomidine Highly Favorable Pharmacokinetic and Pharmacological Features for a CNS Therapeutic Drug (Floridian Ballroom) - Oct 17, 2019 - Abstract #ACNP2019ACNP_799;
• Dexmedetomidine is highly CNS penetrant after dosing as shown by near 1:1 ratios between free brain and free plasma levels. • Dexmedetomidine is more potent than other agonists tested at all 3 alpha adrenergic receptors , alpha2-A, B and C as measured by potency in increasing GTPS binding.
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