- |||||||||| lithium / Generic mfg., Latuda (lurasidone oral) / Sumitomo Dainippon
[VIRTUAL] Lithium toxicity following sleeve gastrectomy (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_1093;
The pathophysiology of lithium toxicity after bariatric surgery, particularly after restrictive procedures, remains unclear. We suggest that therapeutic drug monitoring be performed regularly for patients on lithium after bariatric surgery to prevent toxicity.
- |||||||||| aripiprazole / Generic mfg., bromocriptine / Generic mfg.
[VIRTUAL] Patient with bipolar disorder and prolactinoma treated with aripiprazole: a case report (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_1011;
The drugs that are effective in the treatment of hyperprolactinemia are DA agonists such as bromocriptine and cabergoline...She exhibited a manic episode and was treated with aripiprazole and lorazepam... Aripiprazole seems to be a safe choice for patients suffering from schizophrenia or BD and prolactinoma.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] Puerperal catatonia: authors´experience, diagnosis and treatment (Station 07) - Feb 20, 2020 - Abstract #EPA2020EPA_498;
Joint treatment of PC and its cause is associated with very good response rates (>95%). Even though a classification based on brain circuits and genetic biomarkers would allow an objective nomenclature, catatonia deserves a home of its own, completely differentiable from other disorders.
- |||||||||| lorazepam / Generic mfg.
Preclinical, Journal: The Challenge that Chlorine Presented during the Development of a Benzodiazepine Assay. (Pubmed Central) - Feb 19, 2020
During the routine validation of a benzodiazepine method (performed on a Liquid Chromatography - Tandem Mass Spectrometer), it was noted that lorazepam, triazolam, and α-hydroxytriazolam showed a quadratic shift/bias in the calibration curve, particularly at high concentrations...The presence of the heavy (Cl) isoforms of Cl resulted in the analyte's mass being the same as the internal standard which, in turn, caused the internal standard to appear "falsely increased", thus skewing the calibration curve. One solution to this potential issue was to take advantage of this natural phenomenon and use the Cl heavy isoforms of the respectively labeled internal standards.
- |||||||||| lorazepam / Generic mfg.
Journal: Regulation of Ovarian cancer G protein-coupled receptor (OGR1) expression and signaling. (Pubmed Central) - Feb 14, 2020
We employed model systems of heterologously expressed [human embryonic kidney 293 (HEK293) cells] or endogenous (HASM) OGR1 to assess changes in expression, subcellular localization, and signaling capabilities following acute or chronic treatment with ↓pH or the benzodiazepines lorazepam and sulazepam...In contrast to a recent study reporting OGR1 upregulation and sensitization in cardiac tissue subject to ischemic/acidic insult, chronic OGR1 activation in multiple model systems did not increase OGR1 expression or signaling capacity. The ability to induce OGR1 internalization and desensitization was activator-dependent, reflecting the ability of different activators to induce specific receptor confirmations and engagement of specific heterotrimeric G proteins.
- |||||||||| olanzapine / Generic mfg., fluoxetine / Generic mfg.
Clinical, Journal: A case of an unusual presentation of obsessive compulsive disorder in an adolescent. (Pubmed Central) - Feb 14, 2020
This case shows that in contrast to adults, children may not recognize that their obsessional thoughts are irrational and may not be able to resist the obsessions as a result. It stresses the importance of being mindful of the atypical presentations of OCD in children to avoid misdiagnosis.
- |||||||||| lorazepam / Generic mfg.
Focal Sustained Facial Seizure Following an Arteriovenous Malformation, Todd's Paralysis with a Twitch. A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_963;
On his third day of rehabilitation, the patient was noted to have sustained facial twitching, refractory to his anti-epileptic medication regimen including STAT doses of Ativan...Conclusions : We thus present a case of Todd’s Paralysis secondary to a seizure originating from a surgically clipped arteriovenous malformation. Although seizures are a common sequela of this type of malformation, proper diagnosis and management of all medical and functional complications in these patient's are important.
- |||||||||| Imperan (metoclopramide) / Generic mfg.
Case of Intractable Hiccups in Lateral Wallenberg Syndrome relieved with Baclofen and Speech Therapy () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_582;
Reglan was also used with minimal relief...NMES focused on direct stimulation of muscles, including the epiglottis which is a spasmodic muscle seen with hiccups. Conclusions : Hiccups are an unusual and difficult to treat symptom associated with Lateral Wallenberg Syndrome, the use of Baclofen in conjunction with modalities used in Speech Therapy such as NEMS device helped abate the symptoms with improvement of dysphagia as well.
- |||||||||| risperidone / Generic mfg., Egis, cyclophosphamide intravenous / Generic mfg., Rituxan (rituximab) / Roche, Biogen
Anti-NMDAR Encephalitis in a 9-year-old boy () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_486;
Patient was diagnosed with Anti-NMDA receptor encephalitis (ANRE) and treated with a regimen of high-dose pulse solumedrol followed by steroid taper, IVIG, rituximab, and cytoxan...He had a lengthy rehabilitation course which was complicated by severe agitation requiring risperidone and ativan...Early recognition of this condition is important to prevent treatment delay and to improve prognosis. Prompt treatment and proper agitation management allows for improved rehabilitation progress and clinical outcomes.Conclusions : Early recognition of ANRE allows for prompt treatment and improved patient recovery, rehabilitation, and clinical outcomes.
- |||||||||| lorazepam / Generic mfg.
A Case of Catatonia in a Patient with Severe Traumatic Brain Injury () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_328;
Case Diagnosis : Catatonia Diagnosed with Lorazepam Trial in a Patient with Severe Traumatic Brain Injury Case Description : Following a severe traumatic brain injury, a 46-year-old caucasian female was admitted to a freestanding rehabilitation institution in a minimally conscious state...Conclusions : Catatonia is an uncommonly, and likely under-diagnosed sequela of traumatic brain injury that can easily be misdiagnosed as other common neurological deficits, such as aphasia. Recognition of catatonia in a patient after traumatic brain injury and the use of a benzodiazepine both diagnostically and therapeutically is critical in allowing for the patients’ maximal functional recovery.
- |||||||||| quetiapine / Generic mfg.
The Impact of Anxiety on the Successful Management of a Type I Diabetic Patient (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_1956;
The above case sheds light on the profound medical consequences and setbacks that poorly controlled anxiety can have on diabetic patients. Therefore, recognizing the impact of anxiety on our patients with diabetes is critical in preventing further complications, especially microvascular, macrovascular and potentially other life-threatening events.
- |||||||||| Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance, lorazepam / Generic mfg., hydrocortisone / Generic mfg.
Newly Diagnosed Schmidt’s Syndrome and Steroid Induced Psychosis (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_1322;
However, five days after steroid therapy, patient was admitted for suicidal ideation and catatonia which resolved quickly with Ativan and steroid taper to physiologic dose...Although SIP in AI patients is not frequently reported, we should be mindful about this potential event especially in patients with underlying psychiatric illness. It is postulated that prolonged hypocortisolism in undiagnosed AI might lead to upregulation of central glucocorticoid receptors and hence glucocorticoid replacement might elicit a relative supraphysiological response in these patients.3.
- |||||||||| Onsolis (BEMA fentanyl) / Viatris, Collegium Pharma, NN1213 / Novo Nordisk
Trial completion, Trial completion date, Trial primary completion date: Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) (clinicaltrials.gov) - Feb 5, 2020
P=N/A, N=109, Completed,
It is postulated that prolonged hypocortisolism in undiagnosed AI might lead to upregulation of central glucocorticoid receptors and hence glucocorticoid replacement might elicit a relative supraphysiological response in these patients.3. Active, not recruiting --> Completed | Trial completion date: Oct 2020 --> Sep 2019 | Trial primary completion date: May 2020 --> Sep 2019
- |||||||||| lorazepam / Generic mfg.
Journal: Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam. (Pubmed Central) - Feb 1, 2020
Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress.
- |||||||||| bupropion / Generic mfg.
Journal: Massive lamotrigine and bupropion overdose resulting in status epilepticus without cardiovascular collapse. (Pubmed Central) - Jan 28, 2020
An 18 year-old woman presented to an outside hospital with seizure activity after a massive ingestion of lamotrigine, bupropion, trazodone, buspirone, and possibly isoretinoin...For treatment of status epilepticus, she received a total of 12 mg of IV lorazepam along with a lorazepam infusion titrated to 15 mg/hr, a propofol infusion of unknown dosing, and phenobarbital 650 mg...Her bupropion concentration was 92 ng/mL (reference 50-100 ng/mL). She was extubated on hospital day 5 and discharged to a psychiatric facility on hospital day 13.
- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: Atropine toxicity caused by erroneous intranasal administration in a pediatric patient: case report. (Pubmed Central) - Jan 24, 2020
The child presented with a tonic-clonic seizure lasting for a few minutes, followed by a brief loss of consciousness, vomiting, agitation, and irritability, all of which were stabilized by a dose of intravenous lorazepam...To the best of our knowledge, only one similar case has been reported in the literature. SIMILAR CASES PUBLISHED: 1.
- |||||||||| Onsolis (BEMA fentanyl) / Viatris, Collegium Pharma, NN1213 / Novo Nordisk
Trial primary completion date: Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) (clinicaltrials.gov) - Jan 22, 2020
P=N/A, N=109, Active, not recruiting,
SIMILAR CASES PUBLISHED: 1. Trial primary completion date: Dec 2019 --> May 2020
- |||||||||| ropinirole IR / Generic mfg., lorazepam / Generic mfg., duloxetine delayed release / Generic mfg.
Serotonin Syndrome with Exposure from Tetrahydrocannabinol: a Case Report to Highlight the Side Effects of Increasing Use of CBD Products () - Jan 21, 2020 - Abstract #AAN2020AAN_1810;
This endocannabinoid system is known to regulate serotonergic system through several mechanisms: modulation of 5-HT release, receptor expression, and regulation of excitability of 5-HT neurons. With the legalization of marijuana and increasing access to cannabinoid-containing products, it is imperative to raise awareness of the serotonergic effects of these products and to educate patients to avoid use of these products if they are currently taking a serotonergic agent.
- |||||||||| aripiprazole / Generic mfg., sertraline / Generic mfg., bupropion / Generic mfg.
Catatonia Misdiagnosed as Creutzfeldt–Jakob disease () - Jan 21, 2020 - Abstract #AAN2020AAN_1648;
Infrequent presentation of catatonia to neurology service limits accurate diagnosis. Without prompt treatment catatonia has a significant morbidity and mortality, mainly from sequelae of the prolonged stupor and immobility.
- |||||||||| pregabalin / Generic mfg., clobazam / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Efficacy of clobazam as an add-on therapy in brain tumor-related epilepsy. () - Jan 21, 2020 - Abstract #AAN2020AAN_889;
Our analysis shows clobazam to be an effective agent in BTRE. A comparative study between clobazam and other anti-epileptics in BTRE could be considered in the future.
- |||||||||| lorazepam / Generic mfg.
Catatonia Resolved, Now What? () - Jan 21, 2020 - Abstract #APA2020APA_488;
Once resolved, questions about next steps often arise such as how to treat underlying conditions or when to taper lorazepam...We will conclude with a discussion on maintenance treatment and the importance of timely treatment of catatonia. Time will be allocated at the end of the presentation for comments and questions from our audience.
- |||||||||| Clinical, Review, Journal: Treatment Options for Acute Agitation in Psychiatric Patients: Theoretical and Empirical Evidence. (Pubmed Central) - Jan 1, 2020
Clinical trials evaluating the efficacy of different treatment options have been conducted but they are extremely heterogenous and most have numerous methodological flaws, leading to a poor overall quality of evidence upon which guidelines for the appropriate treatment could be based. The combination of haloperidol and promethazine, which combines the sedative properties of the antihistamine with the more selective calming action of haloperidol (with a reduced risk of extrapyramidal effects compared to haloperidol alone because of the anticholinergic properties of promethazine) may be the best choice based on empirical evidence.
- |||||||||| lorazepam / Generic mfg., Seizalam (midazolam intramuscular) / Pfizer
Preclinical, Journal: Intranasal co-administration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats. (Pubmed Central) - Dec 25, 2019
Enzyme kinetics incorporated into a physiologically based pharmacokinetic model enabled estimation of the first order absorption rate constants: 0.0689±0.0080 min for diazepam and 0.122±0.022 min for the intermediate. Our results demonstrate that diazepam, which is practically insoluble, can be delivered intranasally with rapid and complete absorption by co-administering avizafone with aminopeptidase B. Furthermore, even faster rates of absorption might be attained simply by increasing the enzyme concentration, potentially supplanting intravenous diazepam or lorazepam or intramuscular midazolam in the treatment of seizure emergencies.
- |||||||||| olanzapine / Generic mfg.
Clinical, Review, Journal: Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. (Pubmed Central) - Dec 23, 2019
Also presented is a case of a 23-year-old male with an acute phenibut abstinence syndrome. This patient exhibited severe psychomotor agitation requiring physical restraints, dexmedetomidine, lorazepam, haloperidol, diphenhydramine, cyproheptadine, melatonin, olanzapine, and baclofen for symptom control.
- |||||||||| lorazepam / Generic mfg.
Journal: Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. (Pubmed Central) - Dec 23, 2019
3-FPM, pyrazolam, diclazepam, lorazepam and lormetazepam did apparently not exhibit any PMR. The cause of death, in conjunction with autopsy findings was concluded as a positional asphyxia promoted by poly-drug intoxication by arising from designer benzodiazepines and the presence of synthetic stimulants.
- |||||||||| Adasuve (staccato loxapine) / AOP Orphan Pharma, Teva, Ferrer International, Galen, Medivir, lorazepam / Generic mfg., haloperidol / Generic mfg.
Clinical, Journal: Joint BAP NAPICU evidence-based consensus guidelines for the clinical management of acute disturbance: De-escalation and rapid tranquillisation. (Pubmed Central) - Dec 21, 2019
We conclude that the variety of options available for the management of acute disturbance goes beyond the standard choices of lorazepam, haloperidol and promethazine and includes oral-inhaled loxapine, buccal midazolam, as well as a number of oral antipsychotics in addition to parenteral options of intramuscular aripiprazole, intramuscular droperidol and intramuscular olanzapine. Intravenous options, for settings where resuscitation equipment and trained staff are available to manage medical emergencies, are also included.
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