lorazepam / Generic mfg. 
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  • ||||||||||  clonazepam / Generic mfg., lorazepam / Generic mfg.
    [VIRTUAL] Use of Benzodiazepines in People with Autism Spectrum Disorder in the United States () -  Jul 8, 2020 - Abstract #INSAR2020INSAR_1213;    
    Our analysis shows benzodiazepine use among people with ASD in the US is lower than previous reports and more frequently prescribed for acute/short-term use. This report sheds new light on the recent patterns of benzodiazepine prescriptions in ASD.
  • ||||||||||  lorazepam / Generic mfg., epinephrine / Generic mfg.
    [VIRTUAL] Tracheal Ulceration After Endotracheal Intubation (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_6909;    
    Critical care physicians should be vigilant of cuff pressures as a common culprit of ETT related tracheal injuries. Direct visualization is the best method for the detection of early phases of tracheal injury such as ulceration.
  • ||||||||||  Ryanodex (dantrolene) / Eagle Pharma, lorazepam / Generic mfg.
    [VIRTUAL] 2,4 DNP, A Lethal Slimming Pill (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_3056;    
    Within a few minutes of arrival to ER, the patient became extremely agitated and had to be given 8 mg of lorazepam in 2 doses and was later intubated...Fever and diaphoresis should be promptly treated with active cooling measures such as cooling blankets, IV Tylenol and Dantrolene can be considered if first line cooling measures fail...Because of extremely high mortality, an intensive approach should be adopted early in symptomatic patients who present after taking a potentially fatal dose. These patients should be managed in ICU with early intubation and mechanical ventilation and physicians should be aware that deterioration can be rapidly fatal.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] Phencyclidine and Triple C Overdose Leading to Serotonin Syndrome in the Absence of Selective Serotonin Reuptake Inhibitors (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_3021;    
    He was then treated with lorazepam 2mg as needed for his neurological symptoms along with supportive care, including intravenous fluids...Because prompt recognition is needed, a useful diagnostic tool such as the Hunter's decision rules for diagnosis of serotonin toxicity helps quickly assess a patient with symptoms concerning for serotonin syndrome. Given the availability of over-the-counter medications such as Triple C and street drugs like PCP, physicians should consider the possibility of serotonin syndrome in those who present with physical exams that meet criteria even in the absence of SSRI consumption.
  • ||||||||||  Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
    [VIRTUAL] Blocking the Wrong Channel - Bradyasystolic Arrest Following Fosphenytoin Infusion (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_3018;    
    She developed seizures, requiring administration of lorazepam and intubation for airway protection...Keppra was initiated for seizure prophylaxis...Possible mechanisms include rapid conversion to phenytoin and other metabolites with prodysrhythmic properties and transient hypocalcemia and consequent QTc prolongation due to the presence of phosphate causing a predisposition to arrhythmia. While the incidence of dysrhythmia appears to be less frequent than with phenytoin, healthcare providers should remain vigilant for their occurence when administering fosphenytoin.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] Chronic Lorazepam-Induced Pro-Relaxant Signaling in ASM Cells Is Cyclooxygenase Dependent (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_832;    
    Chronic, but not necessarily acute, treatment of human ASM cells with lorazepam activates both COX-1 and COX-2-mediated pathway. Future studies will be aimed at examining downstream synthesis of prostaglandin E2 and the role of E-type prostanoid receptor subtypes in mediating lorazepam-induced pro-relaxant signals in ASM cells.
  • ||||||||||  lorazepam / Generic mfg.
    Clinical, Journal:  Efficacy of SM-1 in a transient insomnia model. (Pubmed Central) -  Jul 2, 2020   
    SM-1 provided a robust and statistically significant increase in TST compared with placebo in a circadian model of transient insomnia, without evidence of next-day impairment. Diphenhydramine contributed to the effect.
  • ||||||||||  Trial completion date, Trial primary completion date:  Multimodal Analgesia Effect on Post Surgical Patient (clinicaltrials.gov) -  Jul 2, 2020   
    P=N/A,  N=60, Not yet recruiting, 
    Diphenhydramine contributed to the effect. Trial completion date: Oct 2020 --> Oct 2021 | Trial primary completion date: Oct 2020 --> Oct 2021
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Differentiating anxiety from fear: an experimental-pharmacological approach. (Pubmed Central) -  Jul 1, 2020   
    Overall, this study demonstrates anxiolytic effects of lorazepam in dosages ≤1 mg in the absence of a drug effect on fear using a translational behavioural task. However, a putative moderating role of personality on defensive behaviour has to be clarified in future research.
  • ||||||||||  lorazepam / Generic mfg., haloperidol / Generic mfg.
    Journal:  Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. (Pubmed Central) -  Jun 28, 2020   
    The theoretical CSS of diphenhydramine hydrochloride, haloperidol, and lorazepam were much lower than required therapeutic concentrations for antiemetic activity to relieve chemotherapy-induced nausea and vomiting. From the percutaneous absorption data, it was evident that ABH gel failed to achieve required systemic levels of lorazepam, diphenhydramine hydrochloride, and haloperidol following topical application.
  • ||||||||||  Recentin (cediranib) / AstraZeneca
    Trial completion date, Trial primary completion date, Monotherapy, Metastases:  Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) -  Jun 26, 2020   
    P2,  N=34, Active, not recruiting, 
    However, in adults the single dose of i.v. diazepam is as successful as the completely used MTAS-EMS and seems to be superior to the single dose iv and nasal midazolam. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  quetiapine / Generic mfg.
    [VIRTUAL] The Impact of Anxiety on the Successful Management of a Type I Diabetic Patient () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_894;    
    The above case sheds light on the profound medical consequences and setbacks that poorly controlled anxiety can have on diabetic patients. Therefore, recognizing the impact of anxiety on our patients with diabetes is critical in preventing further complications, especially microvascular, macrovascular and potentially other life-threatening events.
  • ||||||||||  Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance, lorazepam / Generic mfg., hydrocortisone / Generic mfg.
    [VIRTUAL] Newly Diagnosed Schmidt’s Syndrome and Steroid Induced Psychosis () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_329;    
    However, five days after steroid therapy, patient was admitted for suicidal ideation and catatonia which resolved quickly with Ativan and steroid taper to physiologic dose...Although SIP in AI patients is not frequently reported, we should be mindful about this potential event especially in patients with underlying psychiatric illness. It is postulated that prolonged hypocortisolism in undiagnosed AI might lead to upregulation of central glucocorticoid receptors and hence glucocorticoid replacement might elicit a relative supraphysiological response in these patients.3
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Single dose phenobarbital in addition to symptom-triggered lorazepam in alcohol withdrawal. (Pubmed Central) -  Jun 19, 2020   
    More patients were discharged within three days if they received a single parenteral dose of phenobarbital on hospital day one, in addition to symptom-triggered lorazepam for the acute management of AWS. Emergency Medicine physicians should consider ordering one parenteral phenobarbital dose on hospital day one to patients presenting with AWS.
  • ||||||||||  risperidone / Generic mfg., Egis, olanzapine / Generic mfg.
    Clinical, Review, Journal:  Drug therapy for delirium in terminally ill adults. (Pubmed Central) -  Jun 14, 2020   
    We found moderate- to low-quality evidence that haloperidol and risperidone may slightly increase extrapyramidal adverse events for people with mild- to moderate-severity delirium. Given the small number of studies and participants on which current evidence is based, further research is essential.
  • ||||||||||  olanzapine / Generic mfg., ziprasidone / Generic mfg.
    Journal:  The Use of Rapid Tranquilization in Aggressive Behavior. (Pubmed Central) -  Jun 10, 2020   
    All of these drugs, if accepted by the patient, can also have an additional, beneficial placebo effect, with the patient calming down more rapidly than could be explained on pharmacological grounds alone. It is, therefore, important in emergencies (as at other times) for the patient to be involved in treatment decisions to the greatest possible extent.
  • ||||||||||  remifentanil / Generic mfg.
    Journal:  GABA Receptor Subtypes and the Reinforcing Effects of Benzodiazepines in Remifentanil-Experienced Rhesus Monkeys. (Pubmed Central) -  Jun 1, 2020   
    Prospective and interventional studies should evaluate causal associations between NCI and BZD use and explore treatment alternatives to BZDs in PLWH. Our findings suggest that relatively high efficacy at one or more GABA receptor subtypes is required for a compound to have reinforcing effects in monkeys with a history of remifentanil self-administration, in contrast to monkeys with benzodiazepine or stimulant self-administration histories.
  • ||||||||||  Recentin (cediranib) / AstraZeneca
    Enrollment closed, Enrollment change, Monotherapy, Metastases:  Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) -  May 31, 2020   
    P2,  N=34, Active, not recruiting, 
    Our findings suggest that relatively high efficacy at one or more GABA receptor subtypes is required for a compound to have reinforcing effects in monkeys with a history of remifentanil self-administration, in contrast to monkeys with benzodiazepine or stimulant self-administration histories. Recruiting --> Active, not recruiting | N=70 --> 34
  • ||||||||||  olanzapine / Generic mfg., Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
    Journal:  133 Toxic Psychosis: Follow-up After One Year of Treatment. (Pubmed Central) -  Apr 28, 2020   
    C one year follow-up, no evidence of psychotic symptoms were appreciated. Family members reported that she had returned to her baseline cognitive function.
  • ||||||||||  bupropion / Generic mfg.
    Journal:  174 Catatonia Complicated by Encephalopathy-Diagnostic and Treatment Challenges. (Pubmed Central) -  Apr 28, 2020   
    This case reflects the intricacy in diagnosing Catatonia complicated by Encephalopathy and the challenges in its treatment. We want to add on to the current literature on Catatonia masked by multiple medical comorbidities and the challenges of treatment.
  • ||||||||||  ondansetron / Generic mfg., Suboxone (buprenorphine/naloxone sublingual film) / Indivior
    Clinical, Journal:  120 Laryngeal Dystonia and Buccolingual Crisis: Dystonic Reactions in 2 Patients Receiving Prochlorperazine During Suboxone Therapy. (Pubmed Central) -  Apr 28, 2020   
    His symptoms resolved with repeated intramuscular doses of diphenhydramine, benztropine, and lorazepam.A 31-year-old Caucasian female developed laryngeal dystonia (stridor) and buccolingual crisis (dysphagia, grimacing, and tongue protrusion) within thirty minutes of receiving ten milligrams of prochlorperazine intramuscularly...A small study in 2000 showed that 3.9% of patients receiving prochlorperazine for nausea in an emergency room setting experienced acute dystonia.2)Could patients receiving intramuscular prochlorperazine during Suboxone therapy have increased risk for severe acute dystonic reactions? According to the European Medicines Agency, hypertonicity is a "common" side effect of Suboxone, occurring in 1% to 10% of patients.3)Could there be potential interactions between Suboxone and prochlorperazine or between prochlorperazine and substances detected (or undetectable, such as designer drugs) via routine toxicology screening?4)Could the acute dystonia be unrelated to medication interaction, but instead result from use of prochlorperazine in patients having rapid electrolyte shifts and exhibiting dehydration during acute opioid withdrawal?Given the known risk of opioids, with or without prochlorperazine, to cause respiratory depression and these case reports of acute dystonia with the potential to cause airway impairment due to prochlorperazine administration, we encourage prescribers to exercise caution when utilizing prochlorperazine for the management of nausea and vomiting in patients receiving Suboxone for acute opioid withdrawal.