lorazepam / Generic mfg. 
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  • ||||||||||  Enrollment open:  Multimodal Analgesia Effect on Post Surgical Patient (clinicaltrials.gov) -  Feb 24, 2021   
    P=N/A,  N=60, Recruiting, 
    There is a need for more research on this association. Not yet recruiting --> Recruiting
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Impact of academic detailing on benzodiazepine use among veterans with posttraumatic stress disorder. (Pubmed Central) -  Feb 23, 2021   
    Although benzodiazepine use has been decreasing in veterans with PTSD, opportunities to improve prescribing continue to exist at the VA. In this quality improvement evaluation, AD-exposed providers were associated with a greater reduction in the prevalence of veterans with PTSD and a benzodiazepine prescription compared with AD-unexposed providers.
  • ||||||||||  lorazepam / Generic mfg., metoclopramide / Generic mfg.
    [VIRTUAL] FIRST DESCRIBED CASE OF TORSADES DE POINTES TRIGGERED BY CANNABIS HYPEREMESIS SYNDROME (eAbstract site) -  Feb 17, 2021 - Abstract #ACC2021ACC_7545;    
    Classically, cannabinoid hyperemesis is defined by severe nausea, vomiting, and abdominal pain relieved by hot water with resolution of symptoms within days of marijuana cessation. One potentially fatal complication, is the electrolyte derangements, mainly hypomagnesemia, and hypokalemia, that can trigger TdP.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] POST-ICTAL AND PAROXYSMAL ATRIAL FIBRILLATION DURING EPILEPTIC SEIZURES (eAbstract site) -  Feb 17, 2021 - Abstract #ACC2021ACC_7518;    
    It is essential to monitor for PIAF in epileptic patients as development increases their risk of developing SUDEP. Post-ictal atrial fibrillation may play a significant role in SUDEP's pathophysiology, with treatment requiring collaboration with cardiology and epileptology.
  • ||||||||||  amitriptyline / Generic mfg., lorazepam / Generic mfg.
    [VIRTUAL] TRICYCLIC ANTIDEPRESSANT TOXICITY REFRACTORY TO STANDARD THERAPIES (eAbstract site) -  Feb 17, 2021 - Abstract #ACC2021ACC_6881;    
    It can also cause decreased cardiac contractility and hypotension. Sodium bicarbonate is indicated in patients who have a QRS >100ms, develop hypotension or ventricular arrhythmias.
  • ||||||||||  lorazepam / Generic mfg., alprazolam / Generic mfg.
    Preclinical, Journal:  Pharmacological Characteristics of Anxiolytics on Acetylcholine-Induced Contractions in Rat Detrusor Smooth Muscle. (Pubmed Central) -  Feb 7, 2021   
    These findings suggest that most clinically used anxiolytics are not likely to result in anticholinergic-induced urination disorders within their clinically achievable blood concentration ranges. However, clotiazepam and diazepam may induce urination disorders within their clinical dose ranges via nonanticholinergic inhibition of DSM contractility.
  • ||||||||||  lorazepam / Generic mfg., alprazolam / Generic mfg.
    Journal:  Postmortem Analysis of Benzodiazepines in Human Bone by Gas Chromatography-Mass Spectrometry. (Pubmed Central) -  Feb 5, 2021   
    Lorazepam was detected in bone in the range of 0.3-0.7 ng/mg, nordiazepam at 1.3-4.2 ng/mg and oxazepam at 1.1-1.2 ng/mg. To our knowledge, this protocol for the simultaneous analysis of these benzodiazepines is the first performed and validated using human ribs.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] Generalized Spike-And-Wave Discharges In Anoxic Brain Injury () -  Feb 4, 2021 - Abstract #AFMRER2021AFMR_ER_73;    
    It is accepted that GSWDs seen on electroencephalography (EEG) recordings are not associated with underlying structural brain lesions. However, we postulate that absence status epilepticus (ASE) electrographically associated with GSWD can occur in nongenetic cases and in older patients with acute encephalopathy from drug etiologies such as overdose/withdrawal, fluid/electrolyte imbalance, or systemic infections as well with acute underlying structural brain lesion such as diffuse cerebral anoxic ischemic injury.
  • ||||||||||  Fetroja (cefiderocol) / Shionogi
    Journal:  Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration. (Pubmed Central) -  Feb 3, 2021   
    Similarly, the 5% dextrose admixtures of either ciprofloxacin or polymyxin B sulfate with 2% cefiderocol were incompatible, whereas data for phenylephrine hydrochloride morphine sulfate, or undiluted sodium bicarbonate were inconclusive. Overall, the 2% cefiderocol solution was physically compatible with 63 of 91 drugs challenged at 1:1 volume ratio in both 0.9% sodium chloride and 5% dextrose diluents for at least 4 hours at the concentrations tested in this study.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] A Cross-Sectional Study to Evaluate the Safety and Efficacy of the Insulin Tolerance Test (On-Demand) -  Feb 2, 2021 - Abstract #ENDO2021ENDO_1369;    
    Based on our findings the clinical safety concerns of the ITT test are minimal compared with the benefit of obtaining an accurate diagnosis in this patient cohort, if done within the correct protocol. Using IGF-1 measures as a determinant of GHD is wildly inaccurate as seen in our results.
  • ||||||||||  lorazepam / Generic mfg., gabapentin / Generic mfg.
    [VIRTUAL] Hyperglycemia With Use of Vagal Nerve Stimulator (On-Demand) -  Feb 2, 2021 - Abstract #ENDO2021ENDO_1115;    
    His antiepileptic drug regimen consisted of gabapentin and as needed lorazepam...We optimized therapy by adding once daily glargine, pioglitazone and continued glipizide...The few available, showed variation in blood glucose based on output current and length of on/off period. This should be factored in during glycemic evaluation and management and close collaboration with neurology is essential.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] Unfortunate Case of Hypoglycemia Induced Seizures Resulting in Anoxic Encephalopathy (On-Demand) -  Feb 2, 2021 - Abstract #ENDO2021ENDO_1084;    
    She received Ativan and was intubated for airway protection...Patient received IV mannitol and IV dexamethasone for cerebral edema and Keppra for seizure prophylaxis, but was unable to be weaned from the ventilator and had to undergo tracheostomy and PEG tube placement, and was eventually discharged to inpatient rehabilitation...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] Severe Hypoglycemia in a Non-Diabetic Patient (On-Demand) -  Feb 2, 2021 - Abstract #ENDO2021ENDO_1080;    
    She was given Ativan and 10% Dextrose IV followed by 5% Dextrose Normal Saline (D5NS) drip...HG drug screen performed at Mayo Clinic lab by highly sensitive LC/MS/MS assay was positive for Glimepiride...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
  • ||||||||||  lorazepam / Generic mfg.
    Clinical, Journal:  Oral sedation for pain with cervical dilator placement: a randomized controlled trial. (Pubmed Central) -  Jan 29, 2021   
    We randomized participants presenting for dilation and evacuation to lorazepam 1 mg/oxycodone 5 mg or placebo 45 min before cervical dilator placement...We had difficulty with study recruitment because many patients desired oral sedation for pain management for cervical dilator placement and declined randomization. Randomized trials of pain management with a placebo arm may find recruitment challenging especially if default clinical care already includes a pain management option that patients would have to opt out of.
  • ||||||||||  lorazepam / Generic mfg., alprazolam / Generic mfg.
    Journal:  In Brief: New benzodiazepine warnings. (Pubmed Central) -  Jan 26, 2021   
    Although AED monotherapies require attention for SJS and TEN, some AED combinations require extra caution. No abstract available
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Contracture in chronic catatonia and its response to lorazepam. (Pubmed Central) -  Jan 23, 2021   
    All the results point toward a poor prescription pattern in the residents of OAHs compared to those receiving care from a tertiary care hospital. No abstract available
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Benzodiazepines co-crystals screening using FTIR and Raman spectroscopy supported by differential scanning calorimetry. (Pubmed Central) -  Jan 15, 2021   
    The detailed spectral and thermal characteristics of these systems are presented in this work. Thus, the proposed methodology of co-crystal screening based on FTIR and Raman data supported by the DSC examination of phase transitions facilitates the screening and detection of benzodiazepine co-crystal prepared by short time components ground with a slight additional volume of solvent.
  • ||||||||||  lorazepam / Generic mfg., alprazolam / Generic mfg.
    Journal:  In Brief: New benzodiazepine warnings. (Pubmed Central) -  Jan 14, 2021   
    Thus, the proposed methodology of co-crystal screening based on FTIR and Raman data supported by the DSC examination of phase transitions facilitates the screening and detection of benzodiazepine co-crystal prepared by short time components ground with a slight additional volume of solvent. No abstract available
  • ||||||||||  lorazepam / Generic mfg., methadone / Generic mfg.
    Clinical, Journal:  Exposure-Based Methadone and Lorazepam Weaning Protocol Reduces Wean Length in Children. (Pubmed Central) -  Jan 12, 2021   
    These results do not support the use of scheduled gabapentin as an augmentation to benzodiazepines during inpatient treatment of AWS. A methadone and lorazepam weaning protocol based on patient's exposure to opioids and benzodiazepines (dose and duration) reduces weaning length.
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder. (Pubmed Central) -  Jan 7, 2021   
    For discharged patients, the 1-week ED return visit rate of nearly 25% could warrant enhanced follow-up and community support. These results demonstrate for the first time that the function of disorder-relevant neural circuits in generalized anxiety disorder can be beneficially altered through modulation of cholinergic neurotransmission and suggest potential for this system as a novel target for anxiolytic pharmacotherapy.
  • ||||||||||  lorazepam / Generic mfg.
    Preclinical, Journal:  In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus. (Pubmed Central) -  Jan 7, 2021   
    The in-vivo findings showed that compared with the control group and the group that received LZM-Gel, the occurrence of PTZ-induced seizures in the rats was significantly reduced by LZM-NLCs-Gel after intranasal administration. These results, therefore, suggested that the LZM-NLCs-Gel system could have potential applications for brain targeting through nasal route and might increase LZM therapeutic efficacy in the treatment of epilepsy.