- |||||||||| risperidone / Generic mfg., lorazepam / Generic mfg.
[VIRTUAL] What does static electricity has to do with schizophrenia? (e-Poster Gallery) - Apr 26, 2021 - Abstract #EPA2021EPA_47;
A clinician should refrain from any strictly unnecessary physical contact with an exceedingly paranoid patient, particularly when the latter claims that is the object of "medical experiments". The elaborative "ability" of such patients could be, simply, astounding.
- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: Iatrogenic Propylene Glycol Intoxication Due to High-Dose Pentobarbital for Refractory Intracranial Hypertension: A Case Report. (Pubmed Central) - Apr 24, 2021
Propylene glycol is a rarely reported toxicity from high-dose administration of certain intravenous drugs, including lorazepam and pentobarbital...In patients who develop lactic acidosis and acute renal failure after initiation of high-dose pentobarbital, propylene glycol toxicity should be higher up in the differential diagnosis. Monitoring the serum osmolality while on pentobarbital could help provide valuable information to prevent iatrogenic propylene glycol toxicity.
- |||||||||| trazodone ER / Generic mfg., lorazepam / Generic mfg.
Review, Journal: Therapeutic Interventions for Adjustment Disorder: A Systematic Review. (Pubmed Central) - Apr 22, 2021
Psychotherapy seems indicated for mildly symptomatic adjustment disorder. Given the fact that adjustment disorder with severe symptoms is associated with a high risk of suicidal ideation and suicide attempts, clinicians must consider the potential benefit of using psychotropic agents such as benzodiazepines, antidepressants, or etifoxine.
- |||||||||| lorazepam / Generic mfg., carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: REMOVAL and environmental risk assessment of contaminants of emerging concern from irrigation waters in a semi-closed microalgae photobioreactor. (Pubmed Central) - Apr 22, 2021
For the rest of the CECs evaluated, attenuation was similar to that obtained after conventional wastewater treatment, ranging from basically no elimination (carbamazepine (CBZ) and tris-(2-chloroethyl) phosphate (TCEP)) to medium efficiencies (DCF and tributyl phosphate (TBP) (50%))...The most sensitive trophic levels were green algae, whereas fish and aquatic plants were the most resilient. Our results suggest that microalgae-based treatments could become a green, cost-effective alternative to conventional wastewater treatment regarding the efficient elimination of these contaminants.
- |||||||||| lorazepam / Generic mfg., topiramate / Generic mfg.
Journal: An association between resting state EEG parameters and the severity of topiramate-related cognitive impairment. (Pubmed Central) - Apr 20, 2021
Droperidol was more effective than lorazepam or either dose of ziprasidone for the treatment of acute agitation in the emergency department and caused fewer episodes of respiratory depression. We showed for the first time that parameters of the rsEEG are associated with the severity of TPM-related WM deficits; this suggests that rsEEG measures may have novel clinical applications in the future.
- |||||||||| dexamethasone / Generic mfg., lorazepam / Generic mfg., alprazolam / Generic mfg.
Clinical, Journal: The Effect of Patient Volume and Experience on Management of Menière's Disease. (Pubmed Central) - Apr 15, 2021
Physicians who see more MD patients annually are more likely to use these treatment modalities: diet and lifestyle modification, intratympanic steroids, intratympanic gentamycin, surgical labyrinthectomy, vestibular nerve section, acetazolamide, alprazolam, lorazepam, dexamethasone, and prednisone. Physicians with a longer length of time in practice are more likely to use only endolymphatic sac procedures, and they are less likely to use intratympanic steroids.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] OVARIAN TERATOMA MASCARADING AS ENCEPHALITIS IN AN ADOLESCENT () - Apr 14, 2021 - Abstract #ASPHO2021ASPHO_517;
Early recognition is important to prevent long term sequaeala. This case highlights the importance of a thorough clinical evaluation in young female patients with new onset neuropsychiatric manifestations and consideration for ovarian teratoma-associated NMDAR-E.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Treatment of Status Epilepticus: What Are the Guidelines and Are We Following Them? (Pubmed Central) - Apr 7, 2021
This retrospective review demonstrates how guidelines and recommendations for SE are not consistently followed. Under dosing of AEDs and aggressive weaning of anesthetic agents may result in higher morbidity and mortality.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg., alprazolam / Generic mfg.
Journal: Supramolecular Solvent Extraction-Gas Chromatography-Tandem Mass Spectrometry for Detection of Benzodiazepines in Urines. (Pubmed Central) - Apr 6, 2021
The mass concentrations of alprazolam in urine samples obtained from 8 volunteers who took alprazolam tablets orally within 8-72 h after ingestions ranged from 6.54 to 88.28 ng/mL. Conclusion The supramolecular solvent extraction GC-MS/MS method for analysis of 9 benzodiazepines in urines provided by this study is simple, fast, accurate and sensitive, which can provide technical support for monitoring of poisoning by benzodiazepines for clinical treatment and judicial identification.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] Pharmacists’ Impact on Optimization of Benzodiazepine Use and Polypharmacy at Oregon State Hospital () - Apr 4, 2021 - Abstract #CPNP2021CPNP_222;
Through the cooperation of the Pharmacy and Therapeutic (P&T) Committee, recommendations were made to providers for appropriate prescribing of benzodiazepines along with concomitant use with opioids and tramadol to comply with FDA warnings. Outcomes: All accepted recommendations will be recorded and compared to initial audit data to determine the pharmacist impact on optimizing benzodiazepine use in a state psychiatric hospital.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] Seizure secondary to Fluzone Quadrivalent vaccination in a patient with severe mental illness: A case report () - Apr 4, 2021 - Abstract #CPNP2021CPNP_115;
At the time of the seizure, the patient was receiving haloperidol per institution protocol...During her admission at the emergency department, she sustained a second seizure and was placed on levetiracetam, cefepime and lorazepam... In our case report, a temporal relationship was seen between the administration of the 2019-2020 Fluzone® Quadrivalent vaccine and a seizure in a patient with no known history of seizure disorder.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] Effect of Phenobarbital on Benzodiazepine Usage for Alcohol Withdrawal () - Apr 4, 2021 - Abstract #CPNP2021CPNP_28;
Phenobarbital lowers the need for scheduled chlordiazepoxide and may lower the overall use of benzodiazepines for alcohol withdrawal. Future studies should be performed in a prospective manner and analyze other patient outcomes, including patient safety and alcohol withdrawal assessment scores.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Diagnosing Status Epilepticus (Pubmed Central) - Apr 1, 2021
Abnormal cEEG findings during status epilepticus vary from rhythmic delta activity and epileptiform and generalized periodic discharges to ictal discharges. Accurate diagnosis of status epilepticus using MRI and cEEG can offer earlier intervention, such as prompt administration of benzodiazepines, midazolam, lorazepam, ultimately resulting in a good recovery.
- |||||||||| lorazepam / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric Convulsive Status Epilepticus: A Randomized Double-blind Controlled Clinical Trial. (Pubmed Central) - Mar 31, 2021
Accurate diagnosis of status epilepticus using MRI and cEEG can offer earlier intervention, such as prompt administration of benzodiazepines, midazolam, lorazepam, ultimately resulting in a good recovery. Phenytoin, valproate, and levetiracetam were equally effective in controlling pediatric convulsive status epilepticus.
- |||||||||| Nitredon (nitrazepam) / Remedica, Lendormin (brotizolam) / Boehringer Ingelheim, Ozalin (midazolam) / Primex Pharma, Sintetica
Benzodiazepine: Alprazolam, Bromazepam, Brotizolam, Clobazam, Clonazepam, Clorazepat, Diazepam, Flunitrazepam, Flurazepam, Lorazepam, Lormetazepam, Medazepam, Midazolam, Nitrazepam, Oxazepam, Prazepam, Temazepam und Triazolam (Twitter) - Mar 24, 2021
- |||||||||| lorazepam / Generic mfg., alprazolam / Generic mfg.
[VIRTUAL] Designer Benzodiazepines: A Dangerously Unregulated Market () - Mar 20, 2021 - Abstract #ASAM2021ASAM_192;
Lastly, the case highlights a professional with a substance use disorder. It is important to keep designer substances in mind when assessing individuals who may have an interest in evading “illegal” activities.
- |||||||||| chlorpromazine / Generic mfg., lorazepam / Generic mfg.
Journal: Changes in Stereotypical Behavior Following Chlorpromazine Termination: Polypharmcy Effects on Response Class Membership. (Pubmed Central) - Mar 20, 2021
We observed a statistically significant decrease in walking in circles, but no changes in the other topographies of stereotypy. The results suggest that the gross motor activity was differentially affected by the chlorpromazine discontinuation and also suggests that alterations in dopamine receptor binding may have selectively influenced changes in stereotypical responding.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] COVID-19 associated Posterior Reversible Encephalopathy Syndrome () - Mar 18, 2021 - Abstract #AAN2021AAN_1200;
Our case suggests that PRES is another neurological complication that can be caused by COVID-19 infection. PRES occurs due to blood-brain barrier disruption and endothelial dysfunction which may be one of the COVID-19 pathophysiological mechanisms that can affect the nervous system.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
[VIRTUAL] Pediatric Phencyclidine (PCP) Intoxication: First Reported Human MRI and EEG Findings () - Mar 18, 2021 - Abstract #AAN2021AAN_904;
The patient’s EEG and late MRI findings are analogous to animal models of PCP intoxication, including high voltage frontally predominant delta waves, and global volume loss. Early diffusion restriction and T2 hyperintensity in white matter seen in our patient are unique findings not previously described.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg., bupropion / Generic mfg.
[VIRTUAL] Bupropion Overdose Induced Reversible Burst Suppression and Myoclonic Seizures () - Mar 18, 2021 - Abstract #AAN2021AAN_854;
Usually, burst suppression is consistent with a severe diffuse disturbance of cerebral function and typically indicates a poor prognosis. However, the burst suppression pattern associated with bupropion overdose is completely reversible, and treatment with anti-seizure medication may result in faster recovery.
- |||||||||| ketamine / Generic mfg., lorazepam / Generic mfg.
[VIRTUAL] Tracheostomy Is Associated with a Decrease in Sedation Requirements for Intubated COVID-19 Patients () - Mar 14, 2021 - Abstract #ATS2021ATS_3659;
Benzodiazepines, opiates, antipsychotics and other hypnotics (e.g. propofol, ketamine, etc) were recorded...The average daily use of benzodiazepines decreased by 17.5 mg lorazepam equivalents (SD=34.2, p=.01) and opiates by 157.5 mg morphine equivalents (sd=339.3, p=.01)...Limiting sedation in these patients has the potential to lower the incidence of delirium, improve mobility and shorten the duration of ventilation. These improvements may translate into shorter ICU stays and improved survival.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] Not-So-Routine Pre-Operative Evaluation: An Unexpected Diagnosis of Disseminated Tuberculosis () - Mar 14, 2021 - Abstract #ATS2021ATS_577;
Unfortunately, the patient became unresponsive after receiving lorazepam for her MRI and was intubated for presumed aspiration...Nucleic acid amplification testing has a higher sensitivity than AFB smear and can be helpful in cases such as this with negative smears on BAL. Additionally, if there is concern for disseminated tuberculosis, sampling from multiple sites should be attempted to increase diagnostic yield.
- |||||||||| lorazepam / Generic mfg.
Clinical, Review: Treatment of Agitation With Lorazepam in Clinical Practice: A Systematic Review. (Pubmed Central) - Mar 12, 2021
As expected, the safety of lorazepam among the different studies was consistent with its well-characterized profile with dizziness, sedation, and somnolence being the most common adverse events. Based on this structured review, lorazepam can be considered to be a clinically effective means of treating the acutely agitated patient.
- |||||||||| gabapentin / Generic mfg.
Trial completion, Enrollment change, Trial completion date: Gabapentin for Alcohol Withdrawal Syndrome (clinicaltrials.gov) - Mar 5, 2021
P4, N=89, Completed,
Based on this structured review, lorazepam can be considered to be a clinically effective means of treating the acutely agitated patient. Recruiting --> Completed | N=400 --> 89 | Trial completion date: Dec 2021 --> Mar 2021
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Review, Journal: Update on Anticonvulsant Therapy in the Emergent Small Animal Patient. (Pubmed Central) - Mar 4, 2021
The benzodiazepine class of drugs (diazepam, midazolam, and lorazepam) often are the drug class of choice; however, levetiracetam and propofol also have been gaining favor as anticonvulsant drugs for acute seizure management. After cessation of seizures, practitioners then can discuss long-term seizure control on a case-by-case basis with clients.
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