- |||||||||| lorazepam / Generic mfg., levetiracetam / Generic mfg., topiramate / Generic mfg.
Screening of Conventional Anticonvulsants in an Alzheimer's Disease-associated Mouse Model (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_2421;
Young adult PSEN2 KO mice were more susceptible to KA-induced seizures and SE vs WT mice. Our study demonstrates that increased seizure susceptibility in this AD-associated mouse model may be well-suited to ASM screening, thereby expanding the potential to uncover novel therapeutic treatments for seizures in AD.
- |||||||||| Relationships Between Electroclinical Variables and Semiology of Status Epilepticus (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_2398;
Our study demonstrates that increased seizure susceptibility in this AD-associated mouse model may be well-suited to ASM screening, thereby expanding the potential to uncover novel therapeutic treatments for seizures in AD. The response to the 2nd-line ASM was defined as refractory if seizures continued after the trial of the 1st
- |||||||||| lorazepam / Generic mfg.
Minimal Complication Rate in Immediate Full Withdrawal of Anti-seizure Medications in Select Patients in the Epilepsy Monitoring Unit (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_2292;
Immediate full withdrawal of anti-seizure medications in select patients who do not have frequent seizures despite multiple antiseizure medications at home is a safe and effective method of diagnosing epilepsy in adults greater than 18 years old when monitoring properly in an inpatient epilepsy monitoring unit as long as rapid rescue medications are given for prolonged seizures and anti-seizure medication regimens are restarted in a reasonable period of time. None of the patients with prolonged seizures in this study had clinically significant complications.
- |||||||||| Xcopri (cenobamate) / SK Bio
Efficacy of Cenobamate in the Treatment of Refractory Seizures in Patients with Chromosome 8 Partial Deletion: A Case Report (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_2111;
Our report aims to emphasize the therapeutic potential of Cenobamate in managing refractory seizures, particularly in patients with genetic abnormalities such as Chromosome 8p deletion. These results highlight the need for continued investigation into Cenobamate's efficacy and safety profile, as well as its role in optimizing seizure management strategies for this patient population.
- |||||||||| metformin / Generic mfg., lorazepam / Generic mfg., furosemide / Generic mfg.
Cocktail Approach for Assessment of Drug-drug-interaction Potential of Bexicaserin as a Perpetrator on the Pharmacokinetics of Substrates for Renal, Hepatic, Efflux Transporters, and CYP/UGT Enzymes (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_2070;
These data support the low likelihood of bexicaserin acting as a perpetrator for clinically relevant DDIs via CYP1A2, UGT, liver transporters (BCRP, OATP1B1 and OATP1B3), and/or renal transporters (OCT1, OCT2, MATE-2K, MATE1, OAT1, and OAT3). Dosage adjustments of co-administered drugs that are metabolized via the metabolic/transporter pathways evaluated in this study appears unlikely.
- |||||||||| Seizure Management in Creutzfeldt-jakob Disease (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_1912;
Benzodiazepines showed some efficacy on EEG, with limited clinical benefit. Considering ASMs such as Clonazepam, Lorazepam, and probably try Clobazam as possible options.
- |||||||||| Calm Before the Storm: Thyrotoxic Status Epilepticus (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_1504;
A case of status epilepticus secondary to thyroid storm in an adult is being reported. This is a reminder to consider unusual yet curable differential diagnoses of generalized seizures in routine practice.
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
A Case of Focal Neurologic Deficits, Seizure, and Lateralized EEG Findings After ECT (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_1444;
Post-ECT seizures and complications are an uncommon occurrence, with only few reports in the literature, and our case is unique with left LPDs and LRDA being seen on the EEG following the procedure. This case adds further information to the limited knowledge and reporting of post-ECT complications.
- |||||||||| lorazepam / Generic mfg.
Journal: Exploring the Association Between Intravenous Lorazepam and Mortality Among Older Hospitalized Patients With and Without Cognitive Impairment. (Pubmed Central) - Nov 22, 2024
Even when ICU and palliative care patients were excluded, aOR for mortality remained high for those with (4.09; 95% CI: 2.17-7.69) and without cognitive impairment, 18.82 (95% CI: 13.39-26.46). Conclusion Despite the limitations of this exploratory study, including a lack of data on the dosage and duration of IV lorazepam, further research is warranted to examine the possible association between IV lorazepam and increased mortality among older hospitalized patients, both with and without cognitive impairment.
- |||||||||| ziprasidone / Generic mfg.
PK/PD data, Journal: Ziprasidone population pharmacokinetics and co-medication effects in Chinese patients. (Pubmed Central) - Nov 21, 2024
This study successfully established and validated a PPK model for ziprasidone in Chinese patients with psychiatric disorders. The model provides a scientific reference for individualized dosing of ziprasidone and holds the potential to optimize treatment strategies, thereby enhancing therapeutic efficacy and safety.
- |||||||||| Journal: Association between psychopharmacotherapy and postpartum hemorrhage. (Pubmed Central) - Nov 15, 2024
Prenatal PPT exposure is associated with increased odds of clinically significant PPH+pRBC after adjusting for other hemorrhage risk factors. Combination PPT was associated with greater odds of PPH+pRBC than monotherapy.
- |||||||||| lorazepam / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study (clinicaltrials.gov) - Nov 8, 2024
P2, N=25, Not yet recruiting,
In inpatients, the use of lithium has decreased in patients with bipolar disorder and also with various other psychiatric diagnoses. Trial completion date: Oct 2024 --> Mar 2025 | Initiation date: Sep 2024 --> Dec 2024 | Trial primary completion date: Oct 2024 --> Mar 2025
- |||||||||| Nitredon (nitrazepam) / Remedica
Journal: Repeated lyophilization: A neo-method for urine-based reference materials preparation. (Pubmed Central) - Nov 5, 2024
Conducting repeated lyophilizations resulted in a denser powder with reduced susceptibility to collapse and improved the quality of lyophilized urine samples. Lyophilized urine mRMs could be stored at room temperature for one month or under refrigeration conditions (4 ?) for six months.
- |||||||||| ketamine / Generic mfg.
Enrollment open, Trial initiation date: Ketamine for Sedation in Severe Traumatic Brain Injury (clinicaltrials.gov) - Nov 3, 2024
P4, N=50, Recruiting,
The patient provided written and verbal consent to publish the information in this case report. Not yet recruiting --> Recruiting | Initiation date: Jun 2024 --> Sep 2024
- |||||||||| lorazepam / Generic mfg.
Journal: Evaluation of a Benzodiazepine Immunoassay for Urine Drug Testing in Clinical Specimens. (Pubmed Central) - Nov 3, 2024
The Benzodiazepines II immunoassay demonstrated the greatest clinical and analytical sensitivity compared to the Benzodiazepines Plus and LDT immunoassays. The incorporation of beta-glucuronidase was crucial, as the Benzodiazepines II and LDT immunoassays demonstrated superior clinical sensitivity when compared to the Benzodiazepines Plus immunoassay that does not incorporate a beta-glucuronidase hydrolysis step.
- |||||||||| lorazepam / Generic mfg.
Trial completion date, Trial primary completion date: Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression (clinicaltrials.gov) - Nov 1, 2024
P4, N=165, Recruiting,
The incorporation of beta-glucuronidase was crucial, as the Benzodiazepines II and LDT immunoassays demonstrated superior clinical sensitivity when compared to the Benzodiazepines Plus immunoassay that does not incorporate a beta-glucuronidase hydrolysis step. Trial completion date: Apr 2027 --> Nov 2027 | Trial primary completion date: Apr 2027 --> Nov 2027
- |||||||||| lorazepam / Generic mfg., alprazolam / Generic mfg.
Journal: Benzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends. (Pubmed Central) - Oct 28, 2024
Rates were highest in the southeast (5.1% [95% CI, 4.8%-5.3%]) and lowest in the midwest (4.0% [95% CI, 3.8%-4.3%]), with a modest nationwide initiation decline from 2013 to 2021 (cumulative incidence difference, 1.6%). Despite a gradual decline in benzodiazepine initiation from 2013 to 2021, we noted excessive supplies in prescriptions post-acute ischemic stroke discharge, underscoring the need for improved policies.
- |||||||||| clozapine / Generic mfg.
Journal: Clozapine-induced acute akathisia: A case report. (Pubmed Central) - Oct 28, 2024
A 34-year-old woman with a 7-year history of schizophrenia exhibited positive and negative symptoms, initially treated with haloperidol and clonazepam...Propranolol and a gradual reduction in clozapine alleviated akathisia, supplemented by lorazepam...This case highlights the challenges of managing schizophrenia and the importance of tailored medication strategies. The use of clozapine should be customized based on each patient's needs to prevent clozapine-induced akathisia.
- |||||||||| fentanyl citrate / Generic mfg., lorazepam / Generic mfg.
Review, Journal: Post-operative delirium in different age groups and subtypes: a systematic review of case reports. (Pubmed Central) - Oct 25, 2024
This underscores the need for increased attention to post-operative delirium patients under 65 and highlights the necessity of rapid identification and early intervention for these populations at risk of poor outcomes. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023473383, Identifier [Registration ID: CRD 42023473383].
- |||||||||| lorazepam / Generic mfg.
Journal: Acute Catatonia Following a Cerebellar Stroke: A Case Report. (Pubmed Central) - Oct 21, 2024
However, her symptoms of variable rigidity, mutism, and marked psychomotor slowing were not attributable to the small left-sided cerebellar infarction on imaging. A dramatic response to a lorazepam challenge confirmed a diagnosis of acute catatonia secondary to a medical condition.
- |||||||||| lorazepam / Generic mfg., diazepam / Generic mfg.
Journal: Implementing an Updated Alcohol Withdrawal Symptom Management Order Set Focused on Patient Safety. (Pubmed Central) - Oct 2, 2024
Implications for leaders include having a multidisciplinary team, sufficient resources to answer clinical questions, and regular discussions by all involved disciplines to review any adverse events as well as newly published evidence. Close monitoring of patients early in implementation is recommended to detect adverse events.
- |||||||||| clonazepam / Generic mfg., lorazepam / Generic mfg., alprazolam / Generic mfg.
Journal: Benzodiazepine receipt in adults with psychogenic non-epileptic seizures in the USA. (Pubmed Central) - Sep 24, 2024
Baseline BZD receipt and anxiety disorders, but not baseline ES diagnoses, were strong independent predictors of post-PNES BZD receipt. While new BZD initiation is rare after PNES, most individuals with BZD scripts 1?month before PNES continue scripts after diagnosis.
- |||||||||| Abilify Maintena (aripiprazole extended release) / Otsuka, Lundbeck, chlorpromazine / Generic mfg., lorazepam / Generic mfg.
Journal: Medication burden reduction and early clinical benefit through aripiprazole once monthly in schizophrenia patients with polypharmacy. (Pubmed Central) - Sep 15, 2024
Total 12-month antipsychotic doses calculated in chlorpromazine equivalents (CPE) were reduced by 32.6%...Additionally, the quantity of benzodiazepine tablets/capsules, total benzodiazepine doses calculated in lorazepam equivalents, and quantity of tablets/capsules of mood stabilizers, anticholinergics, and beta blockers were significantly reduced...In conclusion, this study demonstrated the early effectiveness of AOM in treating Korean patients with schizophrenia on polypharmacy. AOM improved function and clinical symptoms in patients with schizophrenia from treatment onset and caused a decrease in the quantity and dosage of drugs taken by the patients.
- |||||||||| tranexamic acid oral / Generic mfg.
STATUS EPILEPTICUS INDUCED BY TRANEXAMIC ACID IRRIGATION (Convention Center Exhibit Hall: Rapid Fire Area 2C) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6888;
TXA has been shown to cause hyperexcitability and convulsions when applied directly onto the central nervous system. This case is unique since TXA was used for hemostasis via irrigation topically in addition to an IV load.
- |||||||||| lorazepam / Generic mfg.
Trial completion: PSILOCD: Psilocybin for Treatment of Obsessive Compulsive Disorder (clinicaltrials.gov) - Aug 30, 2024
P1, N=15, Completed,
In reporting this clinical case, we want to emphasise the importance of taking into account the catatonic syndrome in our differential diagnoses in patients with altered mental status. Active, not recruiting --> Completed
- |||||||||| hydromorphone hydrochloride / Generic mfg., lorazepam / Generic mfg.
Journal: A Case of Lung Cancer during Home Care with Suspected Chemical Coping (Pubmed Central) - Aug 27, 2024
As chemical coping with opioid analgesics was suspected, the visiting nurse listened to the patient's perspective, and the patient was subsequently prescribed an anxiolytic(lorazepam)for insomnia and anxiety. Thereafter, the frequency of using hydromorphone hydrochloride tablets decreased.
- |||||||||| lorazepam / Generic mfg.
Journal: Catatonia in Preadolescent Children. (Pubmed Central) - Aug 27, 2024
Similar to previous observations in adolescents, prepubescent catatonia seems strongly associated with neurodevelopmental disorders, secondary regression, variability in presentation, and comorbidity with other neurological conditions. Delayed recognition of catatonia can hinder rapid and effective treatment in young children.
- |||||||||| lorazepam / Generic mfg., memantine / Generic mfg.
Large-scale Dynamical Fingerprints of Distributed Synaptic Alterations in Early-Stage Psychosis (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_12834;
Individual similarity to GABA-A effects was related to positive symptoms (e.g. delusions).We conclude that early-stage psychosis is associated with large-scale patterns of changes in cortical dynamics which result from alterations in GABA-A or NMDA receptor functions and differentially related to symptoms severity. Our approach opens new perspectives for a neurophysiological-biomarker assay of psychotic disorders.
- |||||||||| lorazepam / Generic mfg., tofacitinib / Generic mfg.
Interim analysis results of an open-label trial for Down Syndrome Regression Disorder (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_11762;
The interim findings suggest that each of the three treatment arms could be safe interventions for DSRD. The study will continue to enrollment towards a total of 66 participants to investigate differences between therapy arms.
- |||||||||| lorazepam / Generic mfg., memantine / Generic mfg.
Imaging the changes in cortex-wide human circuit dynamics under pharmacological manipulation of GABA-A and NMDA receptors (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_9185;
For the slope of the aperiodic component, these spatial patterns reflected not the anatomical hierarchy, but the cortical distribution of GABA-A receptor densities, with opposite directions for lorazepam and memantine effects.We conclude that controlled manipulations of specific synaptic receptors alter cortical dynamics along reliable and distinctive large-scale spatial patterns, which are partially explained by synaptic properties. These spatial patterns provide a reference for interpreting the patterns of corresponding changes due to the same manipulation during cognitive tasks or due to cognitive disorders in our ongoing work.
- |||||||||| lorazepam / Generic mfg., tetrabenazine / Generic mfg., haloperidol / Generic mfg.
Journal: Unraveling Nonketotic Hyperglycemia Hemichorea-Hemiballismus Syndrome: A Case Report of Diagnosis and Management. (Pubmed Central) - Aug 22, 2024
Management included insulin, tetrabenazine, haloperidol, lorazepam, and other adjunctive therapies, resulting in symptom resolution by the fourth day. This case underscores the importance of considering NHH in patients with uncontrolled DM presenting with abnormal movements, highlighting the challenges in imaging due to involuntary movements and emphasizing the need for aggressive glycemic control and treatment strategies.
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