- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Clinical, Journal: Sedation Usage in COVID-19 Acute Respiratory Distress Syndrome: A Multicenter Study. (Pubmed Central) - Jan 1, 2022
There was no difference in 30-day mortality. Patients with COVID-19 ARDS required higher doses of propofol and benzodiazepines than patients with non-COVID-19 ARDS to achieve the same median levels of sedation.
- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults. (Pubmed Central) - Jan 1, 2022
We found that this reduced brain signal variability could be boosted through GABA agonism in older adults to the levels of young adults and that this boost was largest in the poorer performing older adults. These results provide the first evidence that brain signal variability can be restored by increasing GABAergic activity and suggest the promise of developing interventions targeting inhibitory systems to help slow cognitive declines in healthy aging.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Determination of drugs in exhumed liver and brain tissue after over 9 years of burial by liquid chromatography-tandem mass spectrometry Part 2: Benzodiazepines, opioids, and further drugs. (Pubmed Central) - Dec 30, 2021
Only the benzodiazepines lorazepam, nitrazepam, flunitrazepam, and its metabolite norflunitrazepam, and the drugs butylscopolamine, metronidazole, and omeprazole were not detectable at all...Correlation of detectability depending on postmortem period and condition of tissue are presented exemplarily for midazolam...Despite a long time of burial, most benzodiazepines, opioids, and further drugs were detectable in the examined tissue samples. Our results may be a good support for future exhumations in which toxicological analyses are relevant.
- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: Ornithine Transcarbamylase Deficiency Presenting with Symptoms of Mania in a Young Adult Male. (Pubmed Central) - Dec 30, 2021
In conclusion, partial ornithine transcarbamylase deficiency may manifest with psychiatric symptoms in early adulthood. In young patients with elevated ammonia and mental status change, OTCD is an important diagnosis to consider, as it is the most common inherited cause of hyperammonemia.
- |||||||||| lorazepam / Generic mfg.
Journal: Neurochemical and behavioral effects of lorazepam: A dose related study. (Pubmed Central) - Dec 21, 2021
Rats were decapitated and whole brain samples were collected and stored at -70°C until neurochemical analysis by HPLC-EC. Findings from the present study could be implicated to increased therapeutic utility of lorazepam and related benzodiazepines.
- |||||||||| lorazepam / Generic mfg.
Benzos and Booze: Effects of Adolescent Exposure to Benzodiazepine on Adult Alcohol Consumption (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_6968;
Beginning at Postnatal Day (PND) 35, 48 male and female long-evans rats were injected with either 3.2 mg/kg lorazepam (experimental group, N=24) or vehicle (control group, N=24) every other day until PND50...Preliminary tissue analysis indicates that the benzodiazepine-treated rats had higher neural activity levels in response to alcohol, which suggests that cross-tolerance was developed due to adolescent benzodiazepine exposure. Based on the results of this study, it appears that adolescent exposure to or abuse of benzodiazepines causes persisting and long-lasting changes to the brain, ultimately resulting in higher adulthood stress levels and a distorted behavioral response to alcohol.; Grant Support: Miami University Honors Program Research Grant; Miami University Undergraduate Research Award; Miami University Undergraduate Summer Scholars Award
- |||||||||| lorazepam / Generic mfg.
Physiologically-based pharmacokinetic and pharmacodynamic modeling of lorazepam: predicted brain concentrations with implications for neuronal excitability (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1509;
Based on the results of this study, it appears that adolescent exposure to or abuse of benzodiazepines causes persisting and long-lasting changes to the brain, ultimately resulting in higher adulthood stress levels and a distorted behavioral response to alcohol.; Grant Support: Miami University Honors Program Research Grant; Miami University Undergraduate Research Award; Miami University Undergraduate Summer Scholars Award PBPK modeling can be applied to compounds that target the central nervous system to determine pharmacodynamic effects at clinically relevant levels.; Grant Support: Crozer Health Department of Psychiatry
- |||||||||| lorazepam / Generic mfg.
Long-Term Outcomes Of Outpatient Management Of Pediatric Catatonia () - Dec 18, 2021 - Abstract #AACAP2021AACAP_204;
Lorazepam was used and was effective for 100% of patients (mean dose [SD]: 7 [4.5] mg)...In this study, all patients had complete remission or a partial response to treatment. Further studies are needed to create a more complete picture of the long-term trajectories of child and adolescent patients diagnosed with catatonia.RCR, SP, ASD
- |||||||||| lorazepam / Generic mfg., memantine / Generic mfg.
Journal: Misdiagnosis of Catatonia. (Pubmed Central) - Dec 16, 2021
Multidisciplinary prescription review and PIM screening in patients aged ≥75 years who have ≥3 chronic diseases or polypharmacy should be implemented in primary care and supportive computerized PIMs alert system is needed. No abstract available
- |||||||||| ketamine / Generic mfg., lorazepam / Generic mfg.
Clinical, Journal: Approach to Sedation and Analgesia in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation. (Pubmed Central) - Dec 16, 2021
Historically, sedation and analgesia management in patients requiring ECMO support have posed a challenge for bedside clinicians given the unique physiological and pharmacokinetic changes in this patient population. A multimodal strategy to managing analgesia and sedation should be used, and the use of enteral agents may play a role in reducing parenteral agent requirements.
- |||||||||| lorazepam / Generic mfg.
Journal: OGR1-dependent regulation of the allergen-induced asthma phenotype. (Pubmed Central) - Dec 16, 2021
Treatment of WT mice with sulazepam also resulted in significant inhibition of HDM-induced collagen accumulation in the lung tissue. These findings suggest OGR1 expression is not a requirement for development of the allergen-induced asthma phenotype, but OGR1 can be targeted by the Gs-biased OGR1 agonist sulazepam (but not the balanced agonist lorazepam) to protect from allergen-induced AHR, possibly mediated via suppression of chronic bronchoconstriction and airway remodeling in the absence of effects on airway inflammation.
- |||||||||| lorazepam / Generic mfg.
Retrospective data, Review, Journal: Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis. (Pubmed Central) - Dec 16, 2021
These findings suggest OGR1 expression is not a requirement for development of the allergen-induced asthma phenotype, but OGR1 can be targeted by the Gs-biased OGR1 agonist sulazepam (but not the balanced agonist lorazepam) to protect from allergen-induced AHR, possibly mediated via suppression of chronic bronchoconstriction and airway remodeling in the absence of effects on airway inflammation. In children with acute seizures, IN midazolam is equally effective in aborting seizure and decreases the total time from hospital arrival and cessation of seizures, eventually leading to faster cessation of seizure as compared to IV/rectal BDZ.
- |||||||||| lorazepam / Generic mfg.
Blue Lotus-Induced Seizures in Active Duty Soldier () - Dec 12, 2021 - Abstract #AES2021AES_1403;
The trend of Blue Lotus drug abuse is anticipated to become more widespread in the coming months. As use of Blue Lotus becomes more pervasive, it’s critical for medical providers to recognize the drug and understand its devastating complications.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group
Interaction Between Cenobamate and Clobazam: A Single Center Clinical Experience () - Dec 12, 2021 - Abstract #AES2021AES_806;
It is rarely practical to obtain CLB/N-CLB levels, thus a preemptive decrease in CLB after CNB initiation should be strongly considered for CNB dosages of 100 mg and above. While seizure reduction was present in our small cohort, a CLB reduction of 50% or more was required to resolve toxicity.
- |||||||||| lorazepam / Generic mfg., levetiracetam / Generic mfg.
Multifocal Myoclonus as a Presentation of Levetiracetam Toxicity () - Dec 12, 2021 - Abstract #AES2021AES_646;
One may hypothesize a dose-dependent effect on myoclonus with more effective binding activation of SV2A receptors at low concentrations and possible quiescence at higher concentrations. Detailed review of additional cases of and risks of potential levetiracetam toxicity would be integral in further understanding its properties and mechanisms of action.References1) Abou-Khalil B. Levetiracetam in the treatment of epilepsy.
- |||||||||| dexamethasone / Generic mfg., lorazepam / Generic mfg.
A Unique Case of Focal Nonconvulsive Status Epilepticus - Unilateral Independent Cyclic Seizures () - Dec 12, 2021 - Abstract #AES2021AES_618;
The cyclic nature of the seizures is clearly demonstrated on the quantitative measures of Persyst 14, which is a very useful tool in analyzing cyclic seizures. A previous retrospective study indicates that most of the cyclic seizures occur in the setting of acute or progressive brain injury and typically carry a poor prognosis.
- |||||||||| lorazepam / Generic mfg., metoclopramide / Generic mfg., ibuprofen / Generic mfg.
Clinical, Journal: Potentially inappropriate medications in older adults living with HIV. (Pubmed Central) - Dec 2, 2021
Consistent with data in uninfected elderly people, the most frequently observed PIMs were benzodiazepines and nonsteroidal anti-inflammatory drugs . Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
- |||||||||| lorazepam / Generic mfg.
Clinical, Review, Journal: Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges. (Pubmed Central) - Nov 30, 2021
The treatment of catatonia often involves the use of benzodiazepines, such as lorazepam, that can be used in combination therapy with antipsychotics...There are many clinical challenges that come with catatonia and, as early treatment is associated with better outcomes, it becomes imperative to understand these challenges. The purpose of this manuscript is to provide an overview of these challenges and to look at clinical studies regarding the pathophysiology, diagnosis, and treatment of as well as the complications and risk factors associated with catatonia.
- |||||||||| lorazepam / Generic mfg.
Journal: Effects of lorazepam on prosaccades and saccadic adaptation. (Pubmed Central) - Nov 24, 2021
At higher doses, however, increasing fatigue may facilitate adaptation and thus counteract the adverse effects observed at lower doses. With regards to prosaccades, our findings confirm peak velocity as well as latency and spatial measures as sensitive biomarkers of GABAergic effects.
- |||||||||| Review, Journal: Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences. (Pubmed Central) - Nov 17, 2021
Acute anxiety or suicidality may warrant benzodiazepine treatment with lorazepam...Therapeutic drug monitoring, pharmacogenomic testing, a more restrictive use of "pro re nata" (PRN) medication, an interdisciplinary treatment approach, shared decision making (SDM) and the formulation of common treatment goals by the patients, their family or carers and clinicians could improve treatment success and safety. Novel genetic, immunological, microbiome and brain imaging research as well as new pharmacological developments like the use of psychedelics, stimulants, novel monoaminergic drugs, hormone analogues and drugs which enhance the effects of psychotherapy may extend our therapeutic options in the near future.
- |||||||||| lorazepam / Generic mfg.
Journal: Experience and prospects for the use of off-label drugs in oncology. (Pubmed Central) - Nov 17, 2021
Low doses of naltrexone are applied to treat cancer and autoimmune diseases...American oncologists are of the opinion that if all the drugs prescribed by the International Recommendations failed in the treatment of cancer, doctors can prescribe off-label medications, but only if their effectiveness and safety are clearly established. The problem of the off-label use of drugs in oncology has not yet been studied in detail, however, this direction has certain promising prospects.
- |||||||||| ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Acacia Pharma
Review, Journal: A comprehensive review of remimazolam for sedation. (Pubmed Central) - Nov 10, 2021
For instance, diazepam is used for the treatment of seizures and anxiety...Lorazepam is beneficial for anxiety and status epilepticus...Its addictive potential closely resembles that of its parent compound, midazolam...It has the potential to equip anesthesiologists and other medical practitioners with a more predictable medication that has a good safety profile. However, further large clinical trials will provide us with a better understanding of the advantages and disadvantages of remimazolam.
- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: A clinical method of evaluating simple reaction time and reaction accuracy is sensitive to a single dose of lorazepam. (Pubmed Central) - Nov 6, 2021
As compared with placebo, lorazepam increased simple reaction time variability (range = 43 ± 18 vs. 60 ± 23 ms, respectively; p = 0.004 and standard deviation = 14.6 ± 5.7 vs. 19.7 ± 7.3 ms, respectively; = 0.006) and decreased reaction accuracy (90 ± 7% vs. 84 ± 11%, respectively; p = 0.010). Given prior work demonstrating associations between simple reaction time and reaction accuracy and functional outcomes such as self-protection, response to perturbations, and fall risk, these clinically available measures may have a role in identifying subtle, functionally significant cognitive changes related to short-term benzodiazepine use.
- |||||||||| lorazepam / Generic mfg.
Randomized Study of Digital Life Coaching during Autologous Stem Cell Transplantation (GWCC - Hall B5, Level 1) - Nov 5, 2021 - Abstract #ASH2021ASH_5730;
P2
In summary, our randomized Phase 2 study of DLC versus usual care is ongoing. If shown to reduce PIM prescription rates while improving wellbeing-related PRO trajectories longitudinally, DLC may become a standard of care for patients with hematologic malignancies undergoing ASCT.
- |||||||||| lorazepam / Generic mfg.
Clinical, Journal: Delirious mania in a patient with COVID-19 pneumonia. (Pubmed Central) - Nov 4, 2021
The case shows that severe neuropsychiatric symptoms can complicate otherwise mild COVID-19 pneumonia with neuroinflammation being a possible mechanism. A diagnosis of delirious mania appears to better capture the complexity of the presentation than a diagnosis of mania or delirium alone.
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