lorazepam / Generic mfg. 
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  • ||||||||||  lorazepam / Generic mfg.
    Carotis Stenosis Presenting as Hemichorea (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3297;    
    No improvements were observed after Lorazepam was administered... -Movement disorders are uncommon presentation of cerebrovascular diseases and often mistaken for epilepsy.-Recognizing hemichorea as a potential manifestation of cerebral hypoperfusion is critical to prevent permanent ischemic injuries.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    Assessment of Adherence to Status Epilepticus Treatment Guidelines at a Single Institution (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2978;    
    Our study reveals room for improvement in our institution’s SE guideline execution, including timing and dosing of recommended medications. Targeted quality improvements at the institutional level are needed to increase adherence and possibly improve patient outcomes.
  • ||||||||||  lorazepam / Generic mfg.
    A rare pediatric case of hemichorea-hemiballismus secondary to vein of Galen thrombosis (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2967;    
    In children, the most common causes of genetic and acquired chorea are benign hereditary chorea and Sydenham chorea respectively. Benign hereditary chorea is typically characterized by a more chronic course and generalized choreiform movements.
  • ||||||||||  Piqray (alpelisib) / Novartis
    Alpelisib induced diabetes ketoacidosis and resultant status epilepticus ([VIRTUAL]) -  Mar 6, 2022 - Abstract #AAN2022AAN_1674;    
    Design/ A 60-year-old Caucasian female with history of breast cancer with metastasis to brain, bone,and thyroid, was admitted following syncope.She was taking alpelisib with fulvestrant as the tumor was ER/PR positive, HER-2/neu negative, and PIK3CA mutation-positive.Her disease had progressed on previous endocrine therapy.She was on metformin for prediabetes.On admission, she was afebrile, hemodynamically stable, and had no neurological deficits.MRI brain showed focal extra-axial density along the right anterior frontal lobe and mottled appearance of skull representing known multifocal bony metastases(figures 1& 2).During hospitalization, she developed DKA- glucose 513mg/dL, bicarbonate14, anion gap21, and pH7.3 resulting in status epilepticus with generalized tonic-clinic seizures, requiring intravenous levetiracetam and lorazepam.She was intubated for airway protection.Subsequent electroencephalogram showed prolonged study with presence of burst suppression activity and phase reversals in right temporal region. PI3KCA inhibitors are promising drugs in patients with metastatic breast cancer who have not responded to previous treatment;the SOLAR-1 trial showed 35% risk reduction in cancer progression and death.However, these patients are at risk of metabolic derangement with hyperglycemia and DKA, a potential limiting side-effect.The optimal management of hyperglycemia-induced by alpelisib warrants further research.
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  Eclampsia with RCVS: Postpartum seizure provoked by methergine. (Pubmed Central) -  Feb 26, 2022   
    RCVS isapregnancy-related cause of seizure that should remain on the differential for any patient presenting with a seizure in the peripartum period, especially with use of vasoconstrictive agents. Management is controversial but involves calcium channel blockers and magnesium sulfate, as well as avoidance of vasoconstrictive agents.
  • ||||||||||  lorazepam / Generic mfg.
    Fatal familial insomnia: a case report (Concourse / Mezzanine) -  Feb 26, 2022 - Abstract #WSS2022WSS_839;    
    In the presented clinical case, insomnia is the first typical clinical manifestation of FFI, but periodic legs movement syndrome is not usual and could indicate a dopaminergic dysfunction. Combined PSG findings and genetic testing are crucial to making the diagnosis.
  • ||||||||||  lorazepam / Generic mfg., sertraline / Generic mfg.
    Clinical, Journal:  Pharmacotherapy of 1,044 inpatients with posttraumatic stress disorder: current status and trends in German-speaking countries. (Pubmed Central) -  Feb 23, 2022   
    The use of drugs approved for PTSD was low (sertraline 11.1%; paroxetine 3.7%)...High prescription rates and extensive use of sedative medication suggest a symptom-driven prescription (e.g., hyperarousal, insomnia) that can only be explained to a minor extent by existing comorbidities. The observed discrepancy with existing guidelines underlines the need for effective pharmacological and psychological treatment options in psychiatric inpatient settings.
  • ||||||||||  lorazepam / Generic mfg.
    Journal:  GABAergic modulation of performance in response inhibition and interference control tasks. (Pubmed Central) -  Feb 22, 2022   
    This study examined the effects of lorazepam (0.5 mg and 1 mg), a positive allosteric modulator at the GABA receptor, on response inhibition and interference control...Furthermore, our findings highlight the diversity of the broader construct of inhibitory control while also pointing out similarities between different inhibitory control tasks. In contrast to RT and error rates, the cognitive processes indexed by delta plots may not be sensitive to GABAergic modulation.
  • ||||||||||  dexmedetomidine / Generic mfg.
    Dexmedetomidine as a Potential Cause of Central Sleep Apnea (Area J, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_4880;    
    The temporal association between higher doses of dexmedetomidine and the onset of central sleep apnea in our patient suggests there may be a subset of patients who might be predisposed to this effect. Whether this is a consistently noticed phenomenon and what patient factors affect the threshold dose needs further investigation.
  • ||||||||||  Pneumothorax, Pneumomediastinum and Subcutaneous Emphysema as Complications of Asthma (Area J, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_4455;    
    Since pneumothorax can be missed by a chest X-ray, patients considered at risk should undergo CT scan. If patients fail to respond to medical therapy, evaluating for occult pneumothoraces or recognizing the deep sulcus sign in this clinical context should also be considered.
  • ||||||||||  lorazepam / Generic mfg., levetiracetam / Generic mfg.
    Air Rises: A Unique Case of Pneumocephalus Secondary to Intrapleural Fibrinolytic Therapy (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_2875;    
    Ativan was provided due to concern for seizure but provided no benefit...She was urgently transferred to the ICU and treated with levetiracetam for seizure prophylaxis.She was placed in Trendelenburg position and treated with 15L nonrebreather mask to facilitate gaseous diffusion...Hyperbaric oxygenation therapy is important, aimed at establishing a diffusion gradient to eliminate gaseous bubbles. This case highlights the importance of considering air embolism as a cause of neurologic deterioration in patients receiving intrapleural fibrinolytics.
  • ||||||||||  lorazepam / Generic mfg., diazepam / Generic mfg.
    SIADH as the Initial Presentation of COVID-19 in the Absence of Respiratory Illness (Area J, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1278;    
    and Yousaf et al., symptomatology and evaluation revealed no evidence of respiratory illness. Our case is unique in terms of the dramatic neurologic presentation of hyponatremia in the absence of respiratory illness.
  • ||||||||||  bupropion / Generic mfg.
    Bupropion Induced Dystonia (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1191;    
    Subsequently, she was sedated and intubated with ketamine and succinylcholine...Further workup included negative urine drug screen, normal serum osmolality, creatine kinase, iron studies, acetaminophen, salicylate, and ethanol levels... A high degree of suspicion is required for early detection and appropriate management of drug-induced adverse reactions.
  • ||||||||||  A Unique Case of Serotonin Syndrome of Unknown Etiology (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1180;    
    We are still unsure of the etiology or the diagnosis but we are inclined towards the diagnosis of SS, which may be atypical given the timeline of onset of symptoms. Here, we present a unique case of AMS with resolution likely SS or SS-like syndrome in a patient with no prior usage of serotonergic/MAOI agents but responsive to Cyproheptadine.
  • ||||||||||  bupropion / Generic mfg.
    Serotonin Syndrome in a Patient with Bupropion Toxicity (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1178;    
    He was started on Labetalol drip and was admitted to the ICU with Lorazepam as needed...Multiple cases have been reported with Bupropion causing serotonin syndrome on its own and is possibly related to affecting serotonin levels at toxic doses. Prompt recognition of serotonin syndrome early during the course of the illness can result in better outcomes for the patient as delaying treatment is associated with higher morbidity and mortality.
  • ||||||||||  tizanidine / Generic mfg.
    Tizanidine Withdrawal Syndrome: A Case Report (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1169;    
    Introduction:Tizanidine is an α2-receptor stimulant, central muscle relaxant, structurally related to clonidine...She was re-started on Tizanidine 4 mg every six hours with slow taper for the next 14 days and lorazepam 2 mg PRN for agitation, Quetiapine was added at night...Clinician must be aware of current prescriptions and OTC drugs taken by patients. Prompt recognition is imperative and therapy must be started immediately.
  • ||||||||||  lorazepam / Generic mfg.
    Fulminant hepatic failure secondary to Wilsons disease () -  Feb 7, 2022 - Abstract #WSMRF2022WSMRF_646;    
    He was treated with diuretics, thiamine, and Ativan for alcohol withdrawal...Liver biopsy would be needed for confirmation. Early recognition and liver transplant evaluation are imperative in these patients
  • ||||||||||  lorazepam / Generic mfg.
    Ativan 1 mg (Twitter) -  Feb 2, 2022   
  • ||||||||||  lorazepam / Generic mfg.
    Clinical, Review, Journal:  Management of status epilepticus in patients with liver or kidney disease: a narrative review. (Pubmed Central) -  Feb 1, 2022   
    In patients with liver disease, the authors suggest the use of lorazepam as drug of choice in pre-hospital and intra-hospital early-stage SE, lacosamide in definite SE, propofol in refractory or super-refractory SE. A list of preferred drugs for all SE stages is provided.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  High-Dose Benzodiazepines Positively Modulate GABA Receptors via a Flumazenil-Insensitive Mechanism. (Pubmed Central) -  Jan 29, 2022   
    Pentylenetetrazol and Fa173 antagonized the diazepam-induced LORR. These findings support the existence of non-classical BZD binding sites on certain GABAR subtypes and indicate that the flumazenil-insensitive effects depend on the chemical structures of BZD ligands.
  • ||||||||||  lorazepam / Generic mfg.
    CANNABIS AND THE WOLF, A RISKY COMBINATION (Poster Hall_Hall C) -  Jan 28, 2022 - Abstract #ACC2022ACC_782;    
    Cannabinoids can induce arrhythmias through various receptor activation but can also include autonomic nervous stimulation modulation. It is important to know that cannabinoids can provoke WPW syndrome.
  • ||||||||||  cefepime hydrochloride / Generic mfg., lorazepam / Generic mfg.
    Review, Journal:  Prolonged Cefepime-Induced Neurotoxicity in a Patient with End-Stage Renal Disease. (Pubmed Central) -  Jan 26, 2022   
    She was stabilized on levetiracetam and lorazepam, but developed hypotension in the Neurological Intensive Care Unit (Neuro-ICU), delaying hemodialysis...She was discharged on levetiracetam and meropenem...Prolonging hemodialysis in patients with signs of cefepime neurotoxicity can pose a danger for more serious sequelae, such as status epilepticus. Close monitoring of patients at high risk of developing adverse events from cefepime administration can ensure patient safety and well-being.
  • ||||||||||  lorazepam / Generic mfg., carbamazepine / Generic mfg.
    Preclinical, Journal:  Assessment of triage DOA®, status DS10, and DRIVEN-FLOW® M8-Z on-site drug screening kits for postmortem urine. (Pubmed Central) -  Jan 19, 2022   
    However, lorazepam detection with Status was difficult...In the TCA false-positive cases, tricyclic psychotics such as quetiapine, chlorpromazine, and carbamazepine existed...There were no samples containing cocaine, THC, phencyclidine, or methadone. Based on the above, we conclude that Status and DF8 are comparable or slightly better than Triage, with fewer false-positive and fewer false-negative cases, except for TCA.
  • ||||||||||  lorazepam / Generic mfg., methamphetamine / Generic mfg.
    Clinical, Retrospective data, Journal:  Sedation and analgesia needs in methamphetamine intoxicated patients: much ado about nothing. (Pubmed Central) -  Jan 11, 2022   
    This could lead to specific recommendations for pharmacological treatment for depressed patients undergoing rTMS. To achieve the same level of pain control and depth of sedation, intubated TICU patients with a M+ UDS do not require more analgesia and sedation than patients with a M- UDS during the first 48 hours of admission.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  Assessment of 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants Receiving Opioids and Benzodiazepines. (Pubmed Central) -  Jan 4, 2022   
    In contrast, BSID-III scores for infants with short exposure to both opioids and benzodiazepines were not different than those of infants without exposure. In this study, prolonged combined use of opioids and benzodiazepines was associated with a risk of poorer neurodevelopmental outcomes as measured by BSID-III at 2 years' corrected age.