- |||||||||| loperamide / Generic mfg.
COMMENCING LOPERAMIDE FOR DIARRHOEA PRIOR TO NEGATIVE CULTURE RESULT AFTER HAEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) IS SAFE AND EFFECTIVE (CLYDE) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1166;
Background: Gut toxicity in the form of diarrhoea remains a common side effect of conditioning therapy with high-dose Melphalan among HSCT patients with no improvement over historical rates and no known prophylactic measures.As a standard practice, diarrhoea after transplant prompts stool sampling for Clostridium Difficile (C-diff) toxin as well as viral, bacterial and parasitic cultures if indicated. Commencement of Loperamide before results from stool culture in HSCT patients was safe and effective in improving diarrhoea management.
- |||||||||| loperamide / Generic mfg.
COMMENCING LOPERAMIDE FOR DIARRHOEA PRIOR TO NEGATIVE CULTURE RESULT AFTER HAEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) IS SAFE AND EFFECTIVE (CLYDE) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1165;
Background: Gut toxicity in the form of diarrhoea remains a common side effect of conditioning therapy with high-dose Melphalan among HSCT patients with no improvement over historical rates and no known prophylactic measures.As a standard practice, diarrhoea after transplant prompts stool sampling for Clostridium Difficile (C-diff) toxin as well as viral, bacterial and parasitic cultures if indicated. Commencement of Loperamide before results from stool culture in HSCT patients was safe and effective in improving diarrhoea management.
- |||||||||| loperamide / Generic mfg.
COMMENCING LOPERAMIDE FOR DIARRHOEA PRIOR TO NEGATIVE CULTURE RESULT AFTER HAEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) IS SAFE AND EFFECTIVE (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1164;
Background: Gut toxicity in the form of diarrhoea remains a common side effect of conditioning therapy with high-dose Melphalan among HSCT patients with no improvement over historical rates and no known prophylactic measures.As a standard practice, diarrhoea after transplant prompts stool sampling for Clostridium Difficile (C-diff) toxin as well as viral, bacterial and parasitic cultures if indicated. Commencement of Loperamide before results from stool culture in HSCT patients was safe and effective in improving diarrhoea management.
- |||||||||| Trodelvy (sacituzumab govitecan-hziy) / Gilead
Enrollment closed, Metastases: Preventive stRategy for IMMU132-relatED AEs in TNBC - PRIMED (clinicaltrials.gov) - Jan 31, 2024
P2, N=50, Active, not recruiting,
These findings suggested that repurposing of loperamide might have great potential as a novel and safe alternative strategy to cure melanoma via inhibiting proliferation, inducing apoptosis and cell cycle arrest, and suppressing migration and invasion. Recruiting --> Active, not recruiting
- |||||||||| Mytesi (crofelemer) / Jaguar Health, Knight Therap, Nerlynx (neratinib) / Puma, Knight Therap, Pierre Fabre
Journal: Effects of orally administered crofelemer on the incidence and severity of neratinib-induced diarrhea in female dogs. (Pubmed Central) - Jan 28, 2024
The average number of weekly loose/watery stools were not different between the crofelemer BID and QID treatment groups (p = 0.84). This study showed that crofelemer prophylaxis reduced the incidence/severity of neratinib-associated diarrhea in female beagle dogs without the need for any loperamide administration.
- |||||||||| loperamide / Generic mfg.
CHASING THE HIGH TOWARDS DEATH, A CASE OF LOPERAMIDE INDUCED CARDIAC ARREST (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_314;
This study showed that crofelemer prophylaxis reduced the incidence/severity of neratinib-associated diarrhea in female beagle dogs without the need for any loperamide administration. Clinicians should have increased awareness for potential loperamide overdose and cardiotoxicity, especially in patients with a prolonged QTc interval and be expeditious in their management to prevent malignant arrhythmia and cardiac arrest.
- |||||||||| budesonide / Generic mfg., loperamide / Generic mfg.
Journal: Diagnosis and Pharmacological Management of Microscopic Colitis in Geriatric Care. (Pubmed Central) - Jan 17, 2024
Consequently, other therapeutic options (e.g., bismuth subsalicylate, biologics, loperamide, bile acid sequestrants, and thiopurines) recommended by available guidelines may be prescribed. Herein, clinically meaningful data is provided based on the latest evidence that may aid in reaching a diagnosis and establishing rational therapy in geriatric care to control symptoms and enhance the quality of life for those affected.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma, Viberzi (eluxadoline) / AbbVie
Journal: Management of Irritable Bowel Syndrome With Diarrhea. (Pubmed Central) - Jan 16, 2024
Additional therapeutic options for the relief of global IBS symptoms include rifaximin, 5-HT3 antagonists, gut-directed psychological therapies, and eluxadoline, while tricyclic antidepressants can target abdominal pain and bile acid sequestrants diarrhea. Promising evidence exists for the use of mesalazine and fecal microbiota transplantation in IBS-D, although further evidence is needed for definitive conclusions regarding their efficacy.
- |||||||||| Journal, Adverse events, Real-world evidence, Real-world: Drug-induced QT prolongation and torsade de pointes: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database. (Pubmed Central) - Jan 8, 2024
However, the positive-negative distribution of ADR signals between different drug classes showed great differences, representing the overall risk difference of different drug classes. Our study provided a real-world overview of QT prolongation and TdP to drugs, and the presentation of the potential culprit-drug list, the proportion of reports, the detection results of ADR signals, and the distribution characteristics of ADR signals may help understand the safety profile of drugs and optimize clinical practice.
- |||||||||| nifedipine immediate release / Generic mfg., loperamide / Generic mfg.
Preclinical, Journal: Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies. (Pubmed Central) - Jan 2, 2024
In molecular docking, piperine exhibited higher binding affinities towards different inflammatory enzymes such as cyclooxygenase 1 (-7.9?kcal/mol), cyclooxygenase 2 (-8.4?kcal/mol), nitric oxide synthases (-8.9?kcal/mol), and L-type calcium channel (-8.8?kcal/mol), indicating better interaction of PP with these proteins. In conclusion, piperine showed a potent anti-diarrheal effect in castor oil-induced diarrheal chicks by suppressing the inflammation and calcium ion influx induced by castor oil.
- |||||||||| Neupogen (filgrastim) / Kyowa Kirin, Amgen
Journal, Adverse events: Update of triggers for detection of adverse drug events in hematologic patients (Pubmed Central) - Dec 21, 2023
The overall PPV of the new suggested list was 48% versus 10% of the previous list. This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.
- |||||||||| cholestyramine (A3384) / Ipsen, Somatuline Depot (lanreotide prolonged-release subcutaneous) / Ipsen, Teijin, Sutent (sunitinib) / Pfizer
Diarrhea is not a VIP guest (Sancy - Hilton Antwerp Old Town) - Dec 19, 2023 - Abstract #BWG2024BWG_45;
A combination of treatment with loperamide, pancreatic enzyme supplementation and codein syrup resulted in a mild reduction in diarrhea...For liver-dominant disease, targeted treatment is recommended, such as bland embolization, radiofrequency ablation, and radioembolization. Other treatments such as Everolimus, Sunitinib, peptide receptor radionuclide therapy (PRRT) or chemotherapy are alternatives for metastatic or unresectable disease.
- |||||||||| Trodelvy (sacituzumab govitecan-hziy) / Everest Medicines, Gilead
Review, Journal, Adverse events: Managing adverse events of sacituzumab govitecan. (Pubmed Central) - Dec 17, 2023
Fatigue occurs in approximately half of the patients receiving SG, and?<?50% of patients experience complete alopecia during treatment. The approval of SG has significantly improved treatment outcomes; however, effective management of the toxicities is critical to optimize patient care and treatment adherence.
- |||||||||| loperamide / Generic mfg.
Clinical guideline: The Mexican consensus on fecal incontinence. (Pubmed Central) - Dec 14, 2023
Treatment should also be multidisciplinary and general measures and drugs (lidamidine, loperamide) are recommended, as well as non-pharmacologic interventions, such as biofeedback therapy, in selected cases. Likewise, surgical treatment should be offered to selected patients and performed by experts.
- |||||||||| citalopram / Generic mfg., amitriptyline / Generic mfg., loperamide / Generic mfg.
Journal: Anticholinergic medications associated with falls and frailty in people with HIV. (Pubmed Central) - Dec 4, 2023
ACM are commonly prescribed for people living with HIV, and evidence exists for an association with recurrent falls and frailty. Clinicians should be alert to this and reduce ACM exposure where possible.
- |||||||||| Recentin (cediranib) / AstraZeneca
Trial completion date, Trial primary completion date, Monotherapy, Metastases: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) - Nov 29, 2023
P2, N=34, Active, not recruiting,
Clinicians should be alert to this and reduce ACM exposure where possible. Trial completion date: Mar 2024 --> Mar 2025 | Trial primary completion date: Mar 2024 --> Nov 2023
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal, Adverse events: Analysis of Opioid-Related Adverse Events in Japan Using FAERS Database. (Pubmed Central) - Nov 25, 2023
Cluster analysis based on these RORs resulted in five broad clusters based on the reported adverse events: i.e., strong opioids, weak opioids, loperamide, tapentadol, and remifentanil. This study provides a comprehensive classification of the association between ?-opioid-receptor-stimulating opioids and adverse events.
- |||||||||| loperamide / Generic mfg.
Journal: Lactobacillus paracasei Relieves Constipation by Acting on the Acetic Acid-5-HT-Intestinal Motility Pathway. (Pubmed Central) - Nov 25, 2023
In this study, we selected ten strains of two species of lactobacilli to identify whether they were effective against constipation induced by loperamide administration in BALB/c mice...Furthermore, through the detection of biological, chemical, mechanical, and immune barriers in mice, it was discovered that L. paracasei changed the relative abundance of bacteria related to the levels of acetic acid and 5-hydroxytryptamine (5-HT) (such as by increasing the relative abundance of Odoribacter and Clostridium, and reducing the relative abundance of Mucispirillum, Ruminococcus, Coprobacillus, and Dorea), increased the concentration of acetic acid in the intestine, which stimulated enterochromaffin cells, promoted 5-HT synthesis in the colon, enhanced intestinal motility, and relieved constipation. In conclusion, this study provides a theoretical foundation for the development of personalized products for the treatment of constipation.
- |||||||||| loperamide / Generic mfg.
Journal: Antidiarrheal and antioxidant activities of Ajuga iva (L.) leave extract. (Pubmed Central) - Nov 9, 2023
Wistar rats were divided and received either: castor oil (CO), CO and loperamide or CO and different doses of AIE...AIE exhibits significant anti-diarrheal activity, related in part to its antioxidant properties. Our investigation also provides experimental evidence for the traditional use of this medicinal plant in the treatment of diarrhea.
- |||||||||| loperamide / Generic mfg.
Journal: The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. (Pubmed Central) - Nov 6, 2023
Herein, after the intervention of probiotic fermented milk (FMMIX) containing Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 for 14 d in Kunming mice with loperamide-induced constipation, the results indicated that FMMIX significantly increased the secretion of serum motilin (MTL), gastrin (GAS) and 5-hydroxytryptamine (5-HT) and decreased those of peptide YY (PYY), vasoactive intestinal peptide (VIP) and nitric oxide (NO) in mice...In conclusion, FMMIX had the potential to alleviate constipation symptoms in mice by improving the secretion of serum GI regulatory peptides and neurotransmitters, increasing the expression of c-kit and SCF proteins, and modulating the gut microbiota structure and SCFAs levels, and may be associated with an increase in the above functional components in FMMIX. This suggested that FMMIX could be a promising adjunctive strategy for managing constipation symptoms and could contribute to the development of functional foods aimed at improving gut health.
- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats. (Pubmed Central) - Nov 1, 2023
Further, molecular investigations revealed increased expression of ion channels such as TRPA1, TRPM8; voltage-gated sodium channels (VGSCs) and neuroinflammatory markers in the dorsal root ganglion (DRG) and lumbar (L4-L5) spinal cord of neuropathic rats, which was significantly downregulated upon loperamide treatment. These findings collectively suggest that activation of peripheral mu-opioid receptors contributes to the amelioration of both evoked and spontaneous pain in neuropathic rats by downregulating TRP channels and VGSCs along with suppression of oxido-nitrosative stress and neuroinflammatory cascade.
- |||||||||| morphine sulphate / Generic mfg., loperamide / Generic mfg.
Observational data, Journal: Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study. (Pubmed Central) - Oct 30, 2023
These findings collectively suggest that activation of peripheral mu-opioid receptors contributes to the amelioration of both evoked and spontaneous pain in neuropathic rats by downregulating TRP channels and VGSCs along with suppression of oxido-nitrosative stress and neuroinflammatory cascade. This mini-review discusses the use of opium derivates for treatment of diarrhea, with an emphasis on opium drops as a new medicinal grade opium for the use as additional treatment of severe diarrhea, emphasizing its mechanism of action and evaluation of the risk-benefit ratio in the clinical setting.
- |||||||||| loperamide / Generic mfg., colesevelam / Generic mfg.
Review, Journal: Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment. (Pubmed Central) - Oct 28, 2023
Moreover, a new scale needs to be developed to incorporate the patient's perspective and facilitate outpatient follow-up. Though the establishment of a stepwise classification model for LARS treatment here is indispensable, the refinement of the guidelines may be improved by more standardized studies.
- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Gastrointestinal Fermentable Polysaccharide Is Beneficial in Alleviating Loperamide-Induced Constipation in Mice. (Pubmed Central) - Oct 28, 2023
Bioinformatic analysis indicated that SSP-1 upregulated bacteria such as Oscillibacter to improve SCFA metabolism and stimulate GI hormone secretion, while SSP-2 had less influence on the gut microbiota. These results suggest that the neutral polysaccharide with superior GI fermentation properties exerted beneficial effects on constipation, while the less fermentable pectic fraction might act as a stool-bulking agent.
- |||||||||| loperamide / Generic mfg.
Journal: Reply: Loperamide-Associated Ventricular Arrhythmias. (Pubmed Central) - Oct 22, 2023
These results suggest that the neutral polysaccharide with superior GI fermentation properties exerted beneficial effects on constipation, while the less fermentable pectic fraction might act as a stool-bulking agent. No abstract available
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