- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Effect of laxative polyherbal paste for loperamide induced constipation in rats. (Pubmed Central) - Oct 14, 2024
In cases of unjustifiable pancytopenia or adrenal dysfunction in MTC-positive patients, these possibilities should be considered and ruled out by some specific evaluations, such as bone marrow biopsy and contrast-enhanced imaging. The PHP showed promising therapeutic potential for loperamide-induced constipation in rats.
- |||||||||| loperamide / Generic mfg.
Journal: Loperamide induced acute pancreatitis in pediatrics. (Pubmed Central) - Oct 8, 2024
This causes spasms and dysfunction of the sphincter of Oddi resulting in obstruction of the pancreatic drainage and leading to acute pancreatitis. This case report shows the first case of loperamide induced acute pancreatitis in pediatrics.
- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Efficacy of Lacticaseibacillus paracasei fermented milk on a model of constipation induced by loperamide hydrochloride in BALB/c mice. (Pubmed Central) - Oct 3, 2024
Fermented milk effectively reduced defecation time, increased the rate of small intestinal propulsion in constipated mice, and alleviated colonic inflammation, safeguarding the normal function of the intestinal tract. In addition, it can regulate the intestinal flora, downregulate the abundance of Proteobacteria, upregulate the abundance of species of Firmicutes and Actinobacteriota, and improve the overall abundance level of intestinal flora in mice.
- |||||||||| loperamide / Generic mfg.
Journal, Metabolomic study: Metabolomics and gut microbiota analysis reveal the differential efficacy of areca nut and charred areca nut in treating constipation. (Pubmed Central) - Sep 30, 2024
Constipation was induced by intragastric administration of loperamide hydrochloride, followed by 14-day treatment with mosapride, AN, or CAN...In summary, this study revealed that AN may protect GI mucosa, enhance GI motility, and alleviate constipation symptoms by regulating the relative abundance of specific gut microbiota (Bacillus, UCG-005, norank_f_Muribaculaceae, Candidatus_Saccharimonas, Ruminococcus) as well as citrate cycle or tyrosine, alanine, aspartate, and glutamate metabolic pathways. Furthermore, CAN was observed to promote gastric emptying and intestinal propulsion, thereby alleviating constipation, by modulating the relative abundance of specific gut microbiota (Lactobacillus, Bacillus, norank_f_Muribaculaceae, Ruminococcus, unclassified_f_Oscillospiraceae, unclassified_f_Prevotellaceae) as well as steroid and primary bile acid biosynthesis, as well as pyrimidine and purine metabolic pathways.
- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Overweight/bowel dysmotility crosslinking and analogous laxative actions of two edible wild fruits in obese/constipated rats. (Pubmed Central) - Sep 30, 2024
Furthermore, CAN was observed to promote gastric emptying and intestinal propulsion, thereby alleviating constipation, by modulating the relative abundance of specific gut microbiota (Lactobacillus, Bacillus, norank_f_Muribaculaceae, Ruminococcus, unclassified_f_Oscillospiraceae, unclassified_f_Prevotellaceae) as well as steroid and primary bile acid biosynthesis, as well as pyrimidine and purine metabolic pathways. Our results experimentally confirmed the crosslink between overweight and constipation and both fruits have potential as functional foods to reduce metabolic risk of the obesity associated with bowel dysmotility.
- |||||||||| loperamide / Generic mfg.
UNMASKING COMMON VARIABLE IMMUNODEFICIENCY: A CASE OF CHRONIC DIARRHEA (Monitor 12; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1113;
He was discharged with loperamide treatment but returned a week later with persistent abdominal pain and new-onset bloody diarrhea...Red arrows indicate plasma cells. (Inset=100x)
- |||||||||| loperamide / Generic mfg.
Journal, Metabolomic study: Metabolomic and transcriptomic basis of photoperiodic response regulation in broomcorn millet (Panicum miliaceum L.). (Pubmed Central) - Sep 20, 2024
The main metabolites, including L-malic and fumaric acids, were identified in the negative mode, whereas brucine and loperamide were identified in the positive mode...One photoperiod candidate gene (C2845_PM11G01290), annotated as ATP6B, significantly increased the levels of L-malic and fumaric acids. In conclusion, our study provides a theoretical basis for understanding the molecular mechanisms of photoperiodic response regulation and can be used as a reference for marker development and resource identification in Panicum miliaceum L..
- |||||||||| loperamide / Generic mfg.
Journal: Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency. (Pubmed Central) - Sep 14, 2024
The upregulation of ALPI expression treated with acetate recovered the expression level of mucin-related genes in primary epithelial cells of C3 KO mice as well as most phenotypes of constipation in C3 KO mice. These results indicate that ALPI plays an important role as the novel gene associated with C3 deficiency-induced constipation.
- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Golden Flower Tibetan Tea Polysaccharides Alleviate Constipation in Mice by Regulating Aquaporins-Mediated Water Transport System and Gut Microbiota. (Pubmed Central) - Sep 14, 2024
At a 400 mg/kg dosage, GFTTPs notably improved colonic tissue alterations and serum levels of excitatory neurotransmitters caused by loperamide hydrochloride...Importantly, GFTTPs at 200 and 400 mg/kg doses exhibited comparable effects to the normal control group in key parameters, such as gastrointestinal transit rate and fecal moisture. These findings suggest that GFTTPs may serve as a potent natural remedy for constipation, offering significant therapeutic potential within the context of gut health and with promising implications for human applications.
- |||||||||| Votrient (pazopanib) / Novartis
Journal: Case 332. (Pubmed Central) - Aug 27, 2024
A comprehensive metabolic panel was performed, indicating a serum chloride level of 98 mmol/L (normal, 100-108 mmol/L) and alkaline phosphatase level of 121 U/L (2.02 ?kat/L) (normal, 45-115 U/L [0.75-1.92 ?kat/L]). The patient underwent surveillance imaging with contrast-enhanced CT of the abdomen and pelvis in the venous phase (Figure).
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
Eosinophilic Gastroenteritis, An Underrecognized Source of Chronic Diarrhea (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5461;
She was trialed on budesonide and loperamide without improvement...The patient was subsequently treated with an oral prednisone taper for 7 weeks until repeat endoscopy with biopsy was performed and demonstrated resolution of gastritis and eosinophilia...A high level of clinical suspicion for EGE in patients presenting with chronic diarrhea will aid in early diagnosis and treatment of the disease. Figure: CT A/P depicting bowel wall thickening.
- |||||||||| prednisone / Generic mfg., loperamide / Generic mfg.
A Case of Olmesartan-Induced Enteropathy in Patient With Persistent Watery Diarrhea (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5449;
The mechanism for ARB-induced enteropathy is unclear, but one proposed theory is via angiotensin II mediated over-expression of TGF-beta, which can damage the intestinal mucosa. Treatment includes removal of the offending medication (such as Olmesartan), but steroids such as budesonide and prednisone are effective and can be prescribed in hospitalized patients.
- |||||||||| ceftriaxone / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., loperamide / Generic mfg.
Whipple's Disease: A Rare Endoscopic Appearance of Rare Disease (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5445;
The patient had tried lactose and gluten-free diet, and loperamide and pancreatic enzyme supplementation without relief...The patient was started on 2 weeks of IV Ceftriaxone followed by Bactrim for several months, leading to the resolution of symptoms...Endoscopists should be aware of endoscopic findings of Whipple disease, which may affect distal small bowel. Figure: Figure 1: Endoscopic and histologic findings of Whipple's disease A) Duodenum: white-tipped villi with granular appearance B&C) Terminal Ileum: white-tipped villi with granular appearance D) Terminal ileum H&E stain: infiltration of the lamina propria by histiocytes which contain pale nucleus with abundant cytoplasm E) Terminal ileum PAS stain: histiocytes containing PAS-positive intracytoplasmic granules
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Viberzi (eluxadoline) / AbbVie
Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for Irritable Bowel Syndrome (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4580;
Eluxadoline was not tried due to his status post cholecystectomy...There is no standardized protocol for FMT such as pre-op preparation, dosing, method of delivery, anatomical sites to instill the donor stool, and follow up. Clinical trials with standardization of the FMT protocol for treating IBS are needed to achieve optimal outcomes.
- |||||||||| Gavreto (pralsetinib) / Rigel
Pralsetinib-Induced Lymphocytic Colitis: A Case Report (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4302;
Discontinuation of the offending agent is suggested, but if not possible, budesonide 9mg can be used in conjunction. Further studies are needed to elucidate the mechanisms underlying pralsetinib induced LC.
- |||||||||| aztreonam / Generic mfg., loperamide / Generic mfg.
Shigella, Shigella! A Rare Case of Shigellemia in an Immunocompetent Woman (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4275;
At this time, the leading suspicion was viral gastroenteritis and loperamide was initiated to quell the symptoms...Blood cultures were initially positive for gram-negative bacilli; an assumption of gut translocation was made based on an asymptomatic urine culture growing E. coli , and Aztreonam was started based on susceptibilities...3 Our patient was immunocompetent, unlike over 50% of patients in that cohort. This case has instructive value for gastroenterologists, who should be aware that shigellemia can cause bloody diarrhea despite negative stool cultures.
- |||||||||| Eosinophilic Colitis: A Novel Aggressive Endoscopic Presentation and Its Successful Therapeutic Management (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4258;
Case Description/ A 57-year-old male with a history of invasive adenocarcinoma of the appendix, post-appendectomy, right hemicolectomy, and treatment with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) two years ago...Initially, he was treated with mesalamine 4.8 g daily plus loperamide and diphenoxylate with limited clinical benefit...While confirming corticosteroid therapy's high sensitivity and patient response, it also demonstrates the potential benefits of combining mesalamine and PureStat. Therefore, this case emphasizes two key points: the presence of aggressive endoscopic findings associated with EoC, and the potential benefits of incorporating PureStat and mesalamine with corticosteroid therapy to achieve rapid and sustained clinical and endoscopic response.
- |||||||||| colchicine / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
Mesalamine Induced Myopericarditis in Patient with Collagenous Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4210;
Introduction : While loperamide and budesonide are first-line therapies for collagenous colitis, recurrent symptoms often require additional therapy for which mesalamine has been utilized...Given her collagenous colitis, she was not a candidate for colchicine and was discharged after symptom resolution...Although the offending agent was not initially confirmed, a subsequent workup uncovered that mesalamine was the common denominator in her presenting symptoms given that the patient improved with discontinuation of the medication. It is important to maintain a high level of suspicion for mesalamine-induced pericarditis in patients treated with mesalamine for IBD or collagenous colitis and demonstrating cardiac symptoms.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
A Case of Pembrolizumab-Induced Duodenitis Mimicking Celiac Disease (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3752;
She reported up to 15 episodes daily , not relieved by loperamide or trial of gluten-free diet...Her diarrhea resolved after completion of a prednisone taper...(B) Duodenal mucosa showing moderate villous blunting, and lamina propria expansion by acute and chronic inflammation, with focal foveolar mucin cell metaplasia (green arrow) (100x; H&E stain). (C) High power view of duodenal mucosa, showing mixed acute and chronic lamina propria inflammation with increased intraepithelial lymphocytes (200x; H&E stain).
- |||||||||| loperamide / Generic mfg.
Eosinophilic Gastroenterocolitis in an Elderly Patient Presented With Persistent Diarrhea (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2929;
This case of exceptionally rare eosinophilic gastroenterocolitis highlights the importance of considering it in the differential diagnosis and the need for comprehensive diagnostic evaluation, including EGD, colonoscopy, and biopsy, to achieve accurate diagnosis and effective treatment. It also emphasizes the need for further studies to better understand eosinophilic gastrointestinal disease.
- |||||||||| carbidopa/levodopa / Generic mfg.
A Rare Case of Carbidopa-Levodopa Induced Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2591;
Timely recognition and appropriate management with medication discontinuation or dose reduction is paramount. Figure: Hepatic flexure of the colon
- |||||||||| budesonide / Generic mfg., loperamide / Generic mfg.
When Imaging Looks Like SCAD But Pathology Shows Collagenous Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2493;
Case Description/ A n 88-year-old woman with a history of breast cancer and depression presented to the hospital due to one week of campy, non-bloody diarrhea for one week that did not improve with loperamide...Treatment with Budesonide was initiated, which quickly improved her diarrhea, and she returned to her nursing facility with close gastroenterology follow-up...Figure: CT findings (A and B, arrows) favor acute rectosigmoid colitis or segmental colitis associated with diverticulosis (SCAD) over diverticulitis. At the junction of the descending and sigmoid colon, there is an abrupt change in luminal caliber with upstream fluid-filled large bowel.
- |||||||||| prednisone / Generic mfg., loperamide / Generic mfg., sulfasalazine / Generic mfg.
Prescriber Practices and their Impact on Recurrence Rates in Microscopic Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2441;
Additional treatments included 22 (12%) patients who received loperamide, 2 (5%) patients who received bismuth subsalicylate and 3 (8%) patients who received bile acid sequestrants. Other treatments included prednisone, sulfasalazine , and diphenoxylate/atropine which were prescribed in 7 (19%) of patients.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Creon (pancrelipase delayed-release) / AbbVie, Eisai
Intravenous Immunoglobulin (IVIG) for Chronic Norovirus (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2040;
Small intestinal bacterial overgrowth was considered, and she was trialed on rifaximin, only to provide one week of symptom relief...Until anti-noroviral therapies are developed, recognizing norovirus as a chronic infection in immunocompromised patients should prompt increased preventive measures to avoid infection and subsequent transmission. While there is no consensus on a definitive treatment for immunosuppressed patients with chronic norovirus, this case displays the use of increased frequency of IVIG as a therapeutic option.
- |||||||||| Creon (pancrelipase delayed-release) / AbbVie, Eisai
Pancreatic Insufficiency With Arteriovenous Malformation: A Case Report (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_693;
The patient disclosed her use of loperamide, one tablet daily, to manage the diarrheal symptoms...Pancreatic AVMs can grow, leading to portal hypertension, which may become resistant to treatment even if the AVM is completely removed along with arterioportal communication. Transarterial embolization is the recommended treatment for small lesions, while larger lesions may require surgical resection for optimal management.
- |||||||||| loperamide / Generic mfg.
Journal: Loperamide-Induced Torsades de Pointes. (Pubmed Central) - Aug 12, 2024
At supratherapeutic doses, loperamide can cause severe cardiac toxicity, resulting in wide QRS rhythms, severe bradycardia, prolonged QTc, polymorphic ventricular tachycardia, and cardiac arrest. We present the case of a 27-year-old female with a history of heroin abuse who suffered torsades de pointes resulting in cardiac arrest in the setting of a loperamide overdose.
- |||||||||| clobetasol propionate topical / Generic mfg., loperamide / Generic mfg., azathioprine / Generic mfg.
vulvar pyoderma gangrenosum in a woman with ulcerative colitis a case report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5222;
When patient manifest systemic inflammatory diseases that have been associated with PG physicians have the obligation to suspect this dermatological disorder. Other causes of ulcers exclusion and early biopsy make set a precedent for timely start management.
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
OVERCOMING THE ANCHORING BIAS: A CASE OF MICROSCOPIC COLITIS INITIALLY PERCEIVED AS MESENTERIC ISCHEMIA (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5278;
Antidiarrheal agents including loperamide can be utilized for symptom management... Given the significant overlap of symptoms, any patient with diarrhea should be approached with a broad differential and appropriate diagnostics should be performed in a timely manner to provide patient-centered and evidence-based care.
- |||||||||| diltiazem / Generic mfg., loperamide / Generic mfg.
UNVEILING THE SILENT MENACE: A JOURNEY FROM DIARRHEA TO DYSARRTHYMIA, CULMINATING IN TRAGIC MYSTERY (Convention Center Exhibit Hall: Poster Area 1) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1161;
The patient had new-onset AF, with rapid ventricular response, which did not respond to either diltiazem or metoprolol... Future research should refine risk stratification methods and explore novel therapeutic options, like somatostatin-analogues, to improve rate control in CS-induced AF.
- |||||||||| loperamide / Generic mfg.
Journal: Single-cell RNA sequencing reveals cellular dynamics and therapeutic effects of astragaloside IV in slow transit constipation. (Pubmed Central) - Jul 30, 2024
STC mouse models were developed using loperamide, with subsequent treatment using AS-IV...The status of fibroblasts in STC undergoes alterations, and the FB_C4_Adamdec1 subset, associated with angiogenesis and the Wingless-related integration (Wnt) pathway, emerges. Our comprehensive analysis identifies perturbations of epithelial cells and tissue microenvironment cells in STC and elucidates mechanisms underlying the therapeutic efficacy of AS-IV.
- |||||||||| loperamide / Generic mfg.
Preclinical, Journal: Soluble Dietary Fiber of Hawthorn Relieves Constipation Induced by Loperamide Hydrochloride by Improving Intestinal Flora and Inflammation, Thereby Regulating the Aquaporin Ion Pathway in Mice. (Pubmed Central) - Jul 27, 2024
In addition, HSDF can reduce the levels of inflammatory factors such as IL-6 and PL-1 ?, increase the content of various short-chain fatty acids, alleviate intestinal inflammation, maintain intestinal integrity, and promote defecation. It can also promote the growth of probiotics such as Bacteroides, inhibit the growth of harmful bacteria such as Bifidobacterium and Lactobacillus, and alter the diversity of gut microbiota.
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