loperamide / Generic mfg. 
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 0 Diseases   29 Trials   29 Trials   1503 News 


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  • ||||||||||  Recentin (cediranib) / AstraZeneca
    Trial completion date, Trial primary completion date, Monotherapy, Metastases:  Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) -  Jun 26, 2020   
    P2,  N=34, Active, not recruiting, 
    Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Study on the ability of partially hydrolyzed guar gum to modulate the gut microbiota and relieve constipation. (Pubmed Central) -  Jun 15, 2020   
    Treatment was administered intragastrically for 15 days, and constipation model was induced by loperamide lavage at d 16...PRACTICAL APPLICATIONS: In this study, partially hydrolyzed guar gum (PHGG) produced by mannanase hydrolysis was applied for the relieving constipation in mice. The medium-molecular-weight product (Mw 2,000-10,000 Da) could elicit constipation relief and modulate the gut microbiota in mice, which shows the potential to act as dietary fiber for constipation treatment.
  • ||||||||||  Recentin (cediranib) / AstraZeneca
    Enrollment closed, Enrollment change, Monotherapy, Metastases:  Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (clinicaltrials.gov) -  May 31, 2020   
    P2,  N=34, Active, not recruiting, 
    Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting | N=70 --> 34
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Clinical, Journal:  Controlling faecal incontinence in women by performing anal exercises with biofeedback or loperamide: a randomised clinical trial. (Pubmed Central) -  May 26, 2020   
    P3
    In women with normal stool consistency and faecal incontinence bothersome enough to seek treatment, we were unable to find evidence against the null hypotheses that loperamide is equivalent to placebo, that anal exercises with biofeedback is equivalent to an educational pamphlet, and that loperamide and biofeedback are equivalent to oral placebo and biofeedback or loperamide plus an educational pamphlet. Because these are common first-line treatments for faecal incontinence, clinicians could consider combining loperamide, anal manometry-assisted biofeedback, and a standard educational pamphlet, but this is likely to result in only negligible improvement over individual therapies and patients should be counselled regarding possible constipation.
  • ||||||||||  vancomycin / Generic mfg., bisacodyl / Generic mfg., loperamide / Generic mfg.
    Trial initiation date:  Clinical Trial to Evaluate the Efficacy of Fecal Microbiota Transplantation in Patients With Alopecia Areata (clinicaltrials.gov) -  May 26, 2020   
    P2,  N=40, Recruiting, 
    Because these are common first-line treatments for faecal incontinence, clinicians could consider combining loperamide, anal manometry-assisted biofeedback, and a standard educational pamphlet, but this is likely to result in only negligible improvement over individual therapies and patients should be counselled regarding possible constipation. Initiation date: Mar 2020 --> Aug 2020
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. (Pubmed Central) -  May 24, 2020   
    The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts of Ruta chalepensis and Vernonia amygdalina in Mice. (Pubmed Central) -  May 1, 2020   
    The test groups were treated with 100, 200, and 400 mg/kg body weight (bw) of the crude extract of each plant, while the positive controls and negative controls were given loperamide (3 mg/kg.bw) and 2% Tween 80 (10 ml/kg.bw), respectively...Contrastingly, the crude extract of Vernonia amygdalina had a significant effect in delaying the onset of time of diarrhea and reduction of the frequency of stool and the weight of feces only at the maximum tested dose (400 mg/kg.bw). The present study demonstrated that the crude leaves extract of Ruta chalepensis (200 and 400 mg/kg.bw) and Vernonia amygdalina (400 mg/kg.bw) possessed significant antidiarrheal activity in the castor oil-induced diarrheal model.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Lactobacillus paracasei subsp. paracasei NTU 101 lyophilized powder improves loperamide-induced constipation in rats. (Pubmed Central) -  Apr 28, 2020   
    and decreased the Clostridium perfringens content in feces; it increased short-chain fatty acid levels, reduced fecal pH value, enhanced the thickness of the colonic mucosa, and increased the number of mucin-producing goblet cells and interstitial cells of Cajal. Thus, NTU 101 powder was found to alleviate loperamide-induced constipation and improve gastrointestinal tract function.
  • ||||||||||  Journal:  Treatment-resistant severe capecitabine-induced diarrhoea resolved with oral budesonide. (Pubmed Central) -  Apr 26, 2020   
    Small case reports have shown benefit with budesonide in CID secondary to 5-FU and irinotecan, but there is no literature base addressing budesonide use in CID secondary to capecitabine. We describe a case of a patient with severe capecitabine-induced diarrhoea that was refractory to guideline based therapy but resolved with the use of budesonide.
  • ||||||||||  Trial completion, Surgery, Metastases:  PRECISO: Observational Study of Perioperative Chemotherapy in Gastric Cancer (clinicaltrials.gov) -  Apr 24, 2020   
    P=N/A,  N=61, Completed, 
    We describe a case of a patient with severe capecitabine-induced diarrhoea that was refractory to guideline based therapy but resolved with the use of budesonide. Active, not recruiting --> Completed
  • ||||||||||  Review, Journal:  The unsuspected threat of three opioid-like substitutes. (Pubmed Central) -  Apr 24, 2020   
    Healthcare clinicians and patients might not be aware of the potential risks involved with misusing or abusing these opioid substitutes. This article discusses the increased usage of kratom, gabapentin, and loperamide, the abuse potential, adverse effects and withdrawal symptoms of each drug, and nursing implications that impact inpatient safety and management.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Clinical, Journal:  An unusual case of loperamide anaphylaxis. (Pubmed Central) -  Apr 23, 2020   
    This article discusses the increased usage of kratom, gabapentin, and loperamide, the abuse potential, adverse effects and withdrawal symptoms of each drug, and nursing implications that impact inpatient safety and management. No abstract available
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Syncope And Wide Complex Rhythm Triggered By Therapeutic Loperamide Use And Hypokalemia (Poster Hall) -  Apr 22, 2020 - Abstract #RHYTHM2020RHYTHM_189;    
    In our patient, chronic loperamide 20 mg daily consumption was associated with a likely arrhythmogenic syncope due to pathologic QT prolongation and PMVT. IV magnesium infusion resulted in rapid suppression of AIVR and normalization of QRS
  • ||||||||||  SPX-106T / Spherix
    Journal:  The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota. (Pubmed Central) -  Apr 10, 2020   
    Moreover, the 16S rRNA sequencing analysis revealed that the changes in the gut microbiota caused by constipation were restored by d-tagatose treatment. In conclusion, this study indicated that the administration of d-tagatose as a dietary supplement can effectively prevent and relieve constipation in Kunming mice, and it is a promising prebiotic candidate with constipation-relieving properties.
  • ||||||||||  pregabalin / Generic mfg.
    Trial completion:  Pregabalin for Opiate Withdrawal Syndrome (clinicaltrials.gov) -  Apr 7, 2020   
    P4,  N=100, Completed, 
    Additionally, these findings correlate with changes observed in 15 metabolites during the laxative effects of EtRLP. Active, not recruiting --> Completed
  • ||||||||||  Herceptin (trastuzumab) / Roche, Nerlynx (neratinib) / Puma, Knight Therap, Pierre Fabre
    Clinical, Journal:  Neratinib in HER2-Positive Breast Cancer Patients. (Pubmed Central) -  Mar 31, 2020   
    Active, not recruiting --> Completed Neratinib significantly improves treatment outcomes and has manageable toxicity in stage I to III HER2+ BC patients.
  • ||||||||||  loperamide hydrochloride / Generic mfg., sertraline / Generic mfg.
    A Rare Case of Acute Kidney Injury Caused by Loperamide-Induced Urinary Retention () -  Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_86;    
    Outpatient medications included pantoprazole, sertraline, ramelteon and tamsulosin. This report should raise awareness of a potentially serious renal complication with a medication that is widely available over-the counter.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Evaluation of the Antispasmodic and Antisecretory Activities of the 80% Methanol Extracts of Verbena officinalis L: Evidence From In Vivo Antidiarrheal Study. (Pubmed Central) -  Mar 24, 2020   
    In each test, group I and group II (controls) received 10 mL/kg distilled water and standard drug (5 mg/kg loperamide), respectively, whereas groups III, IV, and V (test groups) received 100, 200, and 400 mg/kg of the 80ME, respectively...The maximum in vivo antidiarrheal index was determined to be 95.25 at dose of 400 mg/kg R-80ME. This study demonstrated that the 80ME, mainly the root extract, produced promising antidiarrheal activity and hence provides a scientific support for acclaimed traditional use of the plant material for treatment of diarrheal diseases.