loperamide / Generic mfg. 
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 0 Diseases   29 Trials   29 Trials   1503 News 


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  • ||||||||||  Flagyl (metronidazole) / SLA, Entyvio (vedolizumab) / Takeda
    [VIRTUAL] Duodenal IBD in an Elderly Female () -  Sep 15, 2020 - Abstract #ACG2020ACG_3327;    
    She was admitted to the hospital one week prior with similar symptoms, and was treated presumptively for acute diverticulitis with a 14-day course of oral ciprofloxacin and metronidazole without resolution of symptoms...Symptoms were unresponsive to empiric loperamide, diphenoxylate with atropine, and octreotide...The patient was started on IV corticosteroids and vedolizumab with normalization of bowel movements within 2 weeks of initiation of therapy...Despite an atypical presentation, upper tract CD can be a cause of voluminous diarrhea in elderly patients and should be considered in the differential diagnosis. Diagnosis requires a high index of suspicion and exclusion of alternate explanations to include malignancy and other infectious etiologies.
  • ||||||||||  Viberzi (eluxadoline) / AbbVie
    [VIRTUAL] Acute on Chronic Mesenteric Ischemia: A Unique Presentation () -  Sep 15, 2020 - Abstract #ACG2020ACG_3275;    
    The patient presented to the emergency room prior to the final diagnosis of acute on chronic mesenteric ischemia, which is usually made by CT or MR angiography. In a patient with risk factors for mesenteric ischemia, including atherosclerosis and splenic infarcts, this should prompt additional work-up accordingly.
  • ||||||||||  Remicade (infliximab) / Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda
    [VIRTUAL] Immune Checkpoint Inhibitor-Induced Colitis or Ulcerative Colitis: A Histopathological Dilemma () -  Sep 15, 2020 - Abstract #ACG2020ACG_2306;    
    However, even with loperamide use, he had numerous non-bloody diarrheal bowel movements daily...For >7 stools daily (grade 3 or 4) therapy is discontinued permanently. In some cases, when patients are steroid refractory, infliximab and vedolizumab have been utilized.
  • ||||||||||  Remicade (infliximab) / Mitsubishi Tanabe, J&J, Opdivo (nivolumab) / Ono Pharma, BMS, Entyvio (vedolizumab) / Takeda
    [VIRTUAL] Immune Checkpoint Inhibitor-Induced Colitis in Patients With Malignancy () -  Sep 15, 2020 - Abstract #ACG2020ACG_1264;    
    Combination Ipilimumab-Nivolumab, while effective against metastatic melanoma, results in increased frequency and severity of gastrointestinal toxicity than monotherapy...We present a case of severe (grade 4) ICI-induced colitis with hemodynamic instability, which warrants early recognition and timely treatment with IV fluid resuscitation and high dose corticosteroids while discontinuing immunotherapy. Those refractory to steroids may benefit from Infliximab, Vedolizumab, or a newer therapy involving extracorporeal photopheresis through expansion of natural killer cells.
  • ||||||||||  nintedanib / Generic mfg.
    [VIRTUAL] Nintedanib-Associated Colitis () -  Sep 15, 2020 - Abstract #ACG2020ACG_1159;    
    She was initially on pirfenidone, but had a significant dermatologic reaction, so was switched to nintedanib 150 mg twice daily...Her symptoms have since improved with use of Bifidobacterium infantis and loperamide...Diarrhea can be reversed by dose reduction, drug discontinuation, or use of anti-diarrheal agents. Addition of prednisolone to nintedanib therapy may also decrease the risk of diarrhea.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    [VIRTUAL] The Nerves of the Colon () -  Sep 15, 2020 - Abstract #ACG2020ACG_1113;    
    The patient had attempted loperamide, probiotics and multiple dietary modifications without improvement...No current guidelines exist for surveillance of recurrence. For cases with multiple polyps or diffuse bowel wall involvement, genetic screening may be indicated to screen for associated syndromes, such as neurofibromatosis 1 , MEN 2B, NFAP or Cowden’s disease.
  • ||||||||||  budesonide / Generic mfg.
    [VIRTUAL] Cannabidiol Oil-Associated Microscopic Colitis () -  Sep 15, 2020 - Abstract #ACG2020ACG_1087;    
    This case demonstrates a temporal relationship between exposure to CBD oil and onset of diarrhea, resolution of diarrhea after withdrawal of CBD oil, and reoccurrence of diarrhea with two re-challenge attempts with CBD oil while taking budesonide...To our knowledge there are currently no other case reports that describe such a relationship between CBD and MC. We recommend that physicians educate themselves on CBD containing products, and encourage open communication with patients regarding dietary supplements and their potential clinical adverse effects.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    [VIRTUAL] Mantle Cell Lymphoma Mimicking Ulcerative Colitis () -  Sep 15, 2020 - Abstract #ACG2020ACG_1063;    
    The diarrhea was not associated with meals, fever, chills or any other gastrointestinal symptom and was controlled until recently with loperamide...The patient completed 6 cycles of lenalidomide and rituximab...In this case, isolated chronic non bloody diarrhea for 8 years was the initial manifestation of the disease. Furthermore, endoscopic recognition is challenging, as gastrointestinal involvement may present with non-specific mild inflammatory changes that mimic other conditions and require biopsy for definite diagnosis.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Amylase-Producing Maltooligosaccharide Provides Potential Relief in Rats with Loperamide-Induced Constipation. (Pubmed Central) -  Sep 12, 2020   
    MOS treatment also improved the mucosal thickness as well as mucin secretion and increased the area of intestinal Cajal cells compared to that in the control group (P < 0.001). These findings suggest that MOS relieves constipation and has beneficial effect on the gastrointestinal tract, and, therefore, it can be used as an ingredient in functional foods for treating constipation or improving intestinal health.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice. (Pubmed Central) -  Sep 5, 2020   
    In addition, we found that the colon level of neurotransmitters SP and VIP was significantly related to microbial variations. Our results indicate that gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice, and it could be considered as an evaluating parameter in constipation therapy strategies.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Anti-diarrhoeal activity of a polyherbal formulation in rats and elucidation of its cellular mechanisms. (Pubmed Central) -  Aug 28, 2020   
    Loperamide was used as a reference control for in vivo studies...In vitro studies indicated that PHF inhibits cAMP release in HT-29 cells corroborating the anti-secretory effects observed in aforesaid studies. The results suggest that the PHF possesses anti-diarrhoeal activity, evident through reduced faecal output, decreased intestinal transit and anti-secretory activities.
  • ||||||||||  Xermelo (telotristat etiprate) / Lexicon Pharma, Ipsen
    Clinical, Journal:  Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome. (Pubmed Central) -  Aug 2, 2020   
    Across five clinical trials in patients with carcinoid syndrome, telotristat ethyl has been well tolerated and efficacious, providing clinicians with a new approach to help control carcinoid syndrome diarrhea, in addition to somatostatin analog therapy. By reducing the stool frequency in patients with carcinoid syndrome whose diarrhea is refractory to anticholinergics, such as loperamide and atropine/diphenoxylate, and somatostatin analog dose escalation, improvement in quality of life becomes an achievable goal.
  • ||||||||||  Nerlynx (neratinib) / Puma, Knight Therap, Pierre Fabre
    Clinical, P2 data, Journal, Pan tumor:  Neratinib in patients with HER2-mutant, metastatic cervical cancer: Findings from the phase 2 SUMMIT basket trial. (Pubmed Central) -  Jul 30, 2020   
    P2
    Neratinib monotherapy showed evidence of activity in heavily pretreated patients with HER2-mutant cervical cancer, with no new safety signals. Given the few effective options for cervical cancer after platinum-based therapy failure, neratinib warrants further investigation in this molecularly defined patient population.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Laxative and antioxidant effects of ramie (Boehmeria nivea L.) leaf extract in experimental constipated rats. (Pubmed Central) -  Jul 30, 2020   
    Loperamide decreased the antioxidant enzyme activity, including that of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), while RLE administration increased the antioxidant activity. These results suggest that RLE exerts potent laxative and antioxidant effects in model rats with loperamide-induced constipation.
  • ||||||||||  loperamide / Generic mfg.
    Review, Journal:  Loperamide: A Readily Available but Dangerous Opioid Substitute. (Pubmed Central) -  Jul 29, 2020   
    Although naloxone may ameliorate the neurological and respiratory adverse events, it is ineffective at reversing loperamide-induced arrhythmias. Even magnesium might provide less efficacy in loperamide-induced Torsade de Pointes necessitating the use of cardiac pacing and electrical cardioversion.
  • ||||||||||  loperamide / Generic mfg.
    Trial completion date:  Gut Transit Effect on Enterohepatic Circulation (clinicaltrials.gov) -  Jul 20, 2020   
    P=N/A,  N=19, Active, not recruiting, 
    Even magnesium might provide less efficacy in loperamide-induced Torsade de Pointes necessitating the use of cardiac pacing and electrical cardioversion. Trial completion date: Dec 2019 --> Dec 2020
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Trends in potentially abused medications returned during medication take-back days. (Pubmed Central) -  Jul 16, 2020   
    The rate of potentially abused medications returned steadily rose over the period of the study. Heightened awareness and increased opportunities for proper disposal including the placement of permanent drug disposal locations may account for the decreased number of prescriptions returned following 2013.
  • ||||||||||  methoxyamine (TRC102) / Tracon Pharma
    Trial completion date, Trial primary completion date, Combination therapy:  TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas (clinicaltrials.gov) -  Jul 9, 2020   
    P1/2,  N=140, Recruiting, 
    Heightened awareness and increased opportunities for proper disposal including the placement of permanent drug disposal locations may account for the decreased number of prescriptions returned following 2013. Trial completion date: Feb 2021 --> Feb 2022 | Trial primary completion date: Dec 2020 --> Feb 2022
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Torsade de pointes following repeated massive loperamide ingestions (Pubmed Central) -  Jul 8, 2020   
    We hereby describe a patient with syncope who displayed wide QRS complexes and prolonged QTc intervals on ECG upon arrival to hospital. The patient developed typical bursts of torsade de pointes during a prolonged hospital course.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    [VIRTUAL] Loperamide Abuse Presenting with Life-Threatening Arrhythmias (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_3020;    
    For QTc prolongation, intravenous isoproterenol and overdrive transvenous pacing should be used. 3) If present, the underlying opioid use disorder must be addressed
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Impact of treatment for Fecal Incontinence on Constipation Symptoms. (Pubmed Central) -  Jul 2, 2020   
    Loperamide treatment for FI does not worsen constipation symptoms among women with normal consistency stool. Women with clinically significant improvement in FI symptoms report greater improvement in constipation symptoms.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Loperamide-Associated Opioid Use Disorder and Proposal of an Alternative Treatment with Buprenorphine. (Pubmed Central) -  Jun 29, 2020   
    To our knowledge, this is the first description of the use of buprenorphine for treatment of loperamide-associated opioid use disorder. Non-medical use of loperamide requires increased recognition by the health care community, including both physicians and pharmacists, because it can result in marked and life-threatening toxicity.