loperamide / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 0 Diseases   29 Trials   29 Trials   1503 News 


«12...910111213141516171819...2324»
  • ||||||||||  loperamide / Generic mfg.
    Preclinical, Journal:  Effect of Durio zibethinus rind polysaccharide on functional constipation and intestinal microbiota in rats. (Pubmed Central) -  Apr 10, 2021   
    In this study, the improvement of functional constipation by Durio zibethinus Murr rind polysaccharide (DZMP) and the effects of DZMP on intestinal microbiota were investigated in a constipation model of Sprague-Dawley (SD) rats established by loperamide hydrochloride...Principal co-ordinates analysis (PcoA) revealed a significant difference in intestinal microbiota composition between the model group and the high-dose DZMP group (200 mg/kg). The results demonstrated that DZMP has a regulatory effect of treating functional constipation and regulating intestinal flora in rats.
  • ||||||||||  funapide (XEN-402) / Xenon
    Clinical, Review, Journal:  Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain-Narrative Review. (Pubmed Central) -  Apr 7, 2021   
    For topical amitriptyline, menthol, and gabapentin, evidence comes from case reports and case series...The discussed data from clinical studies and observations support the usefulness of topical treatments in neuropathic pain management. This review may help clinicians in making decisions regarding whether and which topical treatment may be a beneficial option, particularly in frail patients not tolerating systemic pharmacotherapy.
  • ||||||||||  loperamide / Generic mfg.
    New P1/2 trial:  4FMFES-PET Imaging of Endometrial and Ovarian Cancers (clinicaltrials.gov) -  Mar 29, 2021   
    P1/2,  N=72, Recruiting, 
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    [VIRTUAL] COLONIC AMYLOIDOSIS: A CAUSE OF RECURRENT HYPOVOLEMIA () -  Mar 25, 2021 - Abstract #CDDW2021CDDW_290;    
    AL amyloid has a classic appearance on special stains and mass spectrometry that distinguishes it from most subtypes, however, given elevated lysozyme levels further genetic analysis is needed to guide management. In the appropriate clinical context, gastrointestinal amyloidosis can be considered as a rare cause of recurrent unexplained diarrhea.Open in new tabDownload slideImage 1: Colonic UlcerationOpen in new tabDownload slideImage 1: Colonic Ulceration
  • ||||||||||  Mylotarg (gemtuzumab ozogamicin) / UCB, PDL, Pfizer
    [VIRTUAL] SEVERE CHEMOTHERAPY-INDUCED SECRETORY DIARRHEA () -  Mar 25, 2021 - Abstract #CDDW2021CDDW_152;    
    This was a challenging case of CID that did not respond to Loperamide or octreotide and caused a lot of emotional distress for the patient and her providers. Since she responded well to cholestyramine, we recommend its use when the loperamide and octreotide have failed, or in addition to octreotide in severe cases.
  • ||||||||||  sirolimus / Generic mfg.
    Preclinical, Journal:  Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro. (Pubmed Central) -  Mar 18, 2021   
    Similarly, among the three drugs with an anti-HCoV-229E activity, namely lopinavir/ritonavir, chloroquine and resveratrol, only the latter showed a reduction of the viral titer on SARS-CoV-2 with reduced cytotoxicity. This opens the door to further evaluation to fight Covid-19.
  • ||||||||||  cisplatin / Generic mfg., loperamide hydrochloride / Generic mfg.
    Journal:  Evaluation of the anti-diarrheal effects of the whole plant extracts of Cuscuta reflexa Roxb in pigeons. (Pubmed Central) -  Mar 16, 2021   
    In these experiments, loperamide (2 mg/kg, IM) was used as a positive control, whereas JCR (1 mL/kg (1%) and 1 mL/kg (2%), CRAE (50, 100 and 200 mg/kg) and CRME (50, 100 and 200 mg/kg) were administered intramuscularly at different doses into each pigeon in the test groups...Taken all together, results from this study reveal that the juice, aqueous, and methanol extract of C. reflexa exhibit significant anti-motility and anti-secretory potential. These findings may explain the medicinal use of C. reflexa in folk medicine as an antidiarrheal medicinal plant.
  • ||||||||||  Linzess DR (linaclotide DR) / Ironwood Pharma, AbbVie
    [VIRTUAL] IMPACT OF MD-7246 ON IRRITABLE BOWEL SYNDROME WITH DIARRHEA: PHASE 2 RESULTS (DDW Virtual) -  Mar 15, 2021 - Abstract #DDW2021DDW_4487;    
    MD-7246 did not show significant benefit when compared to placebo in patients with IBS-D. The effect seen in the subset of patients with longer diagnosis time is intriguing and should be explored further.
  • ||||||||||  loperamide / Generic mfg.
    Trial completion date, Trial termination, Trial primary completion date:  Safety and Efficacy of FMT in Individuals With One or More Recurrences of Clostridium Difficile Associated Disease (CDAD) (clinicaltrials.gov) -  Mar 15, 2021   
    P1/2,  N=10, Terminated, 
    In our cohort, diabetes was the only risk factor associated with early IMT failure. Trial completion date: Sep 2022 --> Feb 2021 | Active, not recruiting --> Terminated | Trial primary completion date: Sep 2021 --> Feb 2021; Low enrollment
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Review, Journal:  Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse. (Pubmed Central) -  Mar 13, 2021   
    Among them are opioids such as codeine, dihydrocodeine, and loperamide...OTC opioids are generally safe when consumed in accordance with medical guidelines. However, the intake of supratherapeutic amounts of these substances may reveal surprising traits of common medications.
  • ||||||||||  Viberzi (eluxadoline) / AbbVie
    Clinical, Journal:  In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal. (Pubmed Central) -  Mar 9, 2021   
    Therefore, we hypothesize that fatty meal causes the "closure" of the eluxadoline molecule to prevent the exposure of the polar groups and their interaction with water, necessary for the drug absorption. Based on our results, this work could be a reasonable "case study", useful for future investigation of the drug pharmacokinetic profile.
  • ||||||||||  ibuprofen / Generic mfg.
    Biomarker, Clinical, Journal:  Dataset of the first report of pharmacogenomics profiling in an outpatient spine setting. (Pubmed Central) -  Mar 2, 2021   
    In supplemental spreadsheets, the raw and analysed pharmacogenomics data for all 30 patients evaluated in the primary research article are additionally provided. Collectively, the presented data offer significant reuse potential in future investigations of pharmacogenomics for pain management.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice (Pubmed Central) -  Mar 2, 2021   
    Shouhui Tongbian Capsules was used to explore the therapeutic effect and potential mechanism on slow transit constipation model mice induced by loperamide hydrochloride...Shouhui Tongbian Capsules obviously shortened the time of discharging black stool for the first time, improved the intestinal propulsion rate, increased the water content and amount of feces, and improved the constipation symptoms. Mechanism study revealed that Shouhui Tongbian Capsules increased ATP synthase activity and mitochondrial isocitrate dehydrogenase activity in intestinal tissue, and up-regulated c-Kit/SCF signaling pathway to promote interstitial Cajal cells proliferation, intestinal nerve transmission, intestinal motility and transport capacity.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Laxative effect and mechanism of Tiantian Capsule on loperamide-induced constipation in rats. (Pubmed Central) -  Feb 26, 2021   
    Mechanism study revealed that Shouhui Tongbian Capsules increased ATP synthase activity and mitochondrial isocitrate dehydrogenase activity in intestinal tissue, and up-regulated c-Kit/SCF signaling pathway to promote interstitial Cajal cells proliferation, intestinal nerve transmission, intestinal motility and transport capacity. Our findings demonstrated that the laxative effect of TTC in constipation rats is probably due to the regulation of bowel movement and intestinal fluid secretion.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Preclinical, Journal:  Evaluation of In Vivo Antidiarrheal Activity of Solvent Fractions of Hagenia abyssinica (Rosaceae) in Swiss Albino Mice. (Pubmed Central) -  Feb 26, 2021   
    In all animal models, the solvent fractions treated groups were treated with three different doses (100 mg/kg, 200 mg/kg, and 400 mg/kg) of the solvent fractions, while the negative control group was treated with a vehicle (distilled water), and positive control group was treated with loperamide...The extract fractions obtained from different solvents have shown significant antidiarrheal activity. Thus, this finding supports the claimed traditional use of H. abyssinica leaves for the treatment of diarrhea.
  • ||||||||||  loperamide / Generic mfg.
    [VIRTUAL] Mechanisms underlying MOR-DOR analgesic synergy in epidermal nerve fibers () -  Feb 12, 2021 - Abstract #SID2021SID_494;    
    We recently published electrophysiological data showing that the combination of the mu-opioid (MOR) agonist loperamide and the delta-opioid (DOR) agonist oxymorphindole (Lo-OMI), applied topically to mouse toe pads, prevents activation of nociceptive epidermal nerve fibers with high potency and efficacy (Uhelski et al., 2020)...The data demonstrate that D24M was significantly more potent in antagonizing the Lo-OMI combination (p<0.01) than either drug alone, supporting the heterodimeric opioid receptor hypothesis, and that pertussis toxin significantly reduces the anti-hyperalgesic effect of the combination (p<0.05), supporting the Gai/o signaling hypothesis. Finally, both pharmacologic and genomic inhibition of GIRK2 function results in a significant reduction of the combination’s anti-nociceptive effect (p<0.0001), supporting the requirement for GIRK channels.
  • ||||||||||  Nerlynx (neratinib) / Puma
    Enrollment closed, Trial completion date, Trial primary completion date:  A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib (clinicaltrials.gov) -  Feb 10, 2021   
    P2,  N=6, Active, not recruiting, 
    Future studies should aim to identify subpopulations of patients with IBS and need to evaluate the long-term safety of these therapies.PROSPERO registration number: CRD42020141597. Recruiting --> Active, not recruiting | Trial completion date: Sep 2021 --> Apr 2022 | Trial primary completion date: Mar 2021 --> Oct 2021
  • ||||||||||  loperamide hydrochloride / Generic mfg., methadone / Generic mfg.
    [VIRTUAL] Parallel Pharmaceutical & Alternative Opioid Agonist Therapies to Treat Opioid Use Disorder () -  Feb 6, 2021 - Abstract #ASAM2021ASAM_61;    
    Describe the similarities and differences between the full opioid agonists methadone and loperamide and the partial opioid agonists buprenorphine and mitragynine. Conduct a discussion with a patient or client regarding the risks and benefits of using FDA-approved opioid agonist therapy drugs as well as alternative opioid agonist therapies.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    Journal:  Loperamide Abuse and Its Sequelae. (Pubmed Central) -  Jan 27, 2021   
    Because of reduced central nervous system activity and associated euphoria at therapeutic doses, loperamide abuse is rarely reported. This case demonstrates that an overdose on loperamide can occur in patients seeking symptom alleviation, and may mimic the presentation of opioid overdose.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Clinical, Journal:  Can You Diagnose the Cause of This Patient's Diarrhea? (Pubmed Central) -  Jan 26, 2021   
    Labs and CT chest, abdomen, and pelvis did not reveal a definitive cause. Dietary modification with a bland diet and loperamide did not significantly improved her symptoms.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Les colites microscopiques. (Pubmed Central) -  Jan 23, 2021   
    After a first course of budesonide, recurrence of diarrhea is frequent and a maintenance therapy can be prescribed for several months. In case of intolerance or refractoriness, second-line therapy (immunosuppressants, biological therapy, surgery) should be discussed in multidisciplinary team meeting.
  • ||||||||||  loperamide hydrochloride / Generic mfg.
    And loperamide (Twitter) -  Jan 23, 2021   
  • ||||||||||  loperamide hydrochloride / Generic mfg., prazosin / Generic mfg., propranolol / Generic mfg.
    Preclinical, Journal:  Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models. (Pubmed Central) -  Jan 21, 2021   
    In the former case, PHY showed interaction with hydroxyl group of Ser192 at a distance of 2.91Å, while in the latter it showed hydrogen bond interactions with Thr170 and Lys297 with a distance of 2.65 and 2.72Å, respectively. PHY exerted significant anti-diarrheal effect in Swiss mice, possibly through blocking α- and β-adrenergic receptors.