mupirocin / Generic mfg. 
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  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Chitosan and hyaluronic-based hydrogels could promote the infected wound healing. (Pubmed Central) -  Mar 9, 2023   
    And the mupirocin-loaded GA-QCS/OHA hydrogels had inhibitory effects on E. coli (Gram-negative bacterium) and S. aureus (Gram-positive bacterium) in vitro...This study proposed an effective strategy based on antioxidant, antibacterial, self-healing multifunctional hydrogel for wound healing under various infectious complications. This natural macromolecular hydrogel could act as an effective reactive oxygen species scavenger to promote the wound healing in the future.
  • ||||||||||  mupirocin / Generic mfg.
    Opportunist turns pathogen: Multidrug resistant Staphylococcus epidermidis is associated with the wound chronicity () -  Mar 4, 2023 - Abstract #ISID2023ISID_1245;    
    We show that major fitness traits of S. epidermis from chronic VLU involve multi-drug resistance genes including resistance to methicillin and mupirocin...Our data suggests that the chronic wound influenced selection of S. epidermidis strains with the prevalence of antimicrobial resistance facilitating wound biofilm formation. This underscores the importance of the emergence of treatment resistant S. epidermidis in patients with chronic wounds.
  • ||||||||||  Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
    Inhibition of IARS alleviates skin inflammation in psoriasis through JAK2/STAT3 pathway () -  Mar 4, 2023 - Abstract #ISID2023ISID_1223;    
    Furthermore, we observed silencing IARS inhibited cell proliferation and promoted apoptosis via the JAK2/STAT3 signaling pathway. Taken together, this study identifies the critical role of IARS in the pathogenesis of psoriasis and proposes IARS as a potential therapeutic target for psoriasis.
  • ||||||||||  chlorhexidine gluconate / Generic mfg., mupirocin / Generic mfg.
    Enrollment open, Surgery:  DECREASE SSI: Decolonization to Reduce After-Surgery Events of Surgical Site Infection (clinicaltrials.gov) -  Mar 2, 2023   
    P4,  N=2700, Recruiting, 
    Our study also indicates the importance of continuous monitoring of the genotypes of MDR-MRSA isolates to prevent nosocomial outbreaks and the spread of MDR isolates. Not yet recruiting --> Recruiting
  • ||||||||||  clindamycin phosphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Optimal Treatment of MRSA Throat Carriers (clinicaltrials.gov) -  Mar 1, 2023   
    P3,  N=80, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Dec 2022 --> Sep 2025 | Trial primary completion date: Dec 2022 --> Sep 2025
  • ||||||||||  Trial completion date, Trial primary completion date:  STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) (clinicaltrials.gov) -  Feb 27, 2023   
    P2,  N=42, Recruiting, 
    Trial completion date: Dec 2022 --> Sep 2025 | Trial primary completion date: Dec 2022 --> Sep 2025 Trial completion date: Jun 2023 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Aug 2023
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Development of Nanoemulsions for Topical Application of Mupirocin. (Pubmed Central) -  Feb 25, 2023   
    Inclusion of EU led to a two-fold increase in permeation of MUP compared to the control, while EO increased the percentage by 48% compared to the control. Additionally, more MUP was detected in the skin after 8 h following MUP-NE EU application, although MUP deposition from MUP-NE EO was higher after 24 h. It may be possible, through choice of essential oil to design nanoformulations for both acute and prophylactic management of topical infections.
  • ||||||||||  cephalexin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., mupirocin / Generic mfg.
    A novel STAT3 splice site variant resulting in autosomal Hyper-IgE Syndrome () -  Feb 4, 2023 - Abstract #AAAAI2023AAAAI_1280;    
    Taken together, our patient demonstrates a likely pathogenic STAT3 variant. Since discharge the patient has only developed mild pustules and folliculitis well maintained with routine bleach baths, as needed topical mupirocin and daily trimethoprim/sulfamethoxazole prophylaxis.
  • ||||||||||  mupirocin / Generic mfg.
    Observational data, Journal:  Prevention of acquired invasive fungal infection with decontamination regimen in mechanically ventilated ICU patients: a pre/post observational study. (Pubmed Central) -  Jan 26, 2023   
    It consists of amphotericin B four times daily in the oropharynx and the gastric tube along with topical antibiotics, chlorhexidine body wash and nasal mupirocin...Acquired fungal infection is a rare event, but accounts for a large proportion of ICU-acquired infections. Our study showed a preventive effect of decontamination against acquired fungal infection, especially candidemia.Take home messageAcquired fungal infection (AFI) incidence is close to 4% in mechanically ventilated patients without antifungal prophylaxis (3% for pulmonary aspergillosis and 1% for candidemia).Aspergillosis accounts for 14% of ventilator-associated pneumonia and candidemia for 9% of acquired bloodstream infections.Immunocompromised patients, those infected with SARS-COV 2 or influenza virus, males and patients admitted during the fall season are at higher risk of AFI.Mechanically ventilated patients receiving multiple site decontamination (MSD) have a lower risk of AFI.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Effective decolonization strategy for mupirocin-resistant Staphylococcus aureus by TPGS-modified mupirocin-silver complex. (Pubmed Central) -  Jan 24, 2023   
    Results of in vivo experiments demonstrate that TPGS/Mup-Ag can effectively inhibit the progression of skin infection and accelerate wound healing, as well as alleviate systemic inflammation in both the subcutaneous infection model and the wound infection model. Furthermore, this study may contribute to the development of therapeutic agents for antibiotic-resistant bacteria and offer ideas for silver-based bactericides.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Effectiveness of topical administration of platelet-rich plasma on the healing of methicillin-resistant Staphylococcus aureus-infected full-thickness wound model. (Pubmed Central) -  Jan 15, 2023   
    After wound induction, the rats were divided into three groups: noninfected animals treated with PRP (PRP group), MRSA-infected animals treated with mupirocin (standard control group), and MRSA-infected animals treated with PRP (MRSA+PRP group)...Moreover, positive expressions of macrophage colony-stimulating factor (M-CSF), CD31, collagen type 1 and cytokeratin proteins keratinocyte proliferation, and re-epithelization were significantly (P<0.05) increased in both PRP and MRSA+PRP-treated groups compared with the control groups on days 7 and 14. Topical administration of PRP accelerated the wound healing in MRSA-infected wound by decreasing the inflammation and improving the proliferative phase.
  • ||||||||||  mometasone furoate / Generic mfg., mupirocin / Generic mfg.
    Trial initiation date, Trial primary completion date, HEOR:  Topical Steroids & Bacterial Decolonization for Radiation Dermatitis (clinicaltrials.gov) -  Jan 3, 2023   
    P2,  N=216, Not yet recruiting, 
    In a previous study, the proportion of MRSA strains with high-level mupirocin resistance in a Canadian hospital increased from 1.6% in the first 5 years of surveillance (1995 to 1999) to 7.0% (2000 to 2004). Initiation date: Dec 2022 --> Mar 2023 | Trial primary completion date: Dec 2024 --> Mar 2025
  • ||||||||||  Human Amniotic Fluid / University of Utah
    Enrollment closed, Enrollment change:  Processed Amniotic Fluid (pAF) for the Treatment of Chronic Wounds (clinicaltrials.gov) -  Dec 23, 2022   
    P1/2,  N=1, Active, not recruiting, 
    Considering that mupirocin is of chemical origin and may lead to drug resistance whereas propolis is of plant origin and does not produce drug resistance, the use of propolis is recommended. Recruiting --> Active, not recruiting | N=60 --> 1
  • ||||||||||  Review, Journal:  Interventions for the eradication of meticillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis. (Pubmed Central) -  Dec 14, 2022   
    One trial administered this combination for two weeks alongside nasal, skin and oral decontamination and a three-week environmental decontamination, while the second trial administered this drug combination for 21 days with five days intranasal mupirocin...One trial (45 participants) defined MRSA eradication as negative MRSA respiratory cultures at day 28, and reported that oral trimethoprim and sulfamethoxazole combined with rifampicin may lead to a higher proportion of negative cultures compared to control (odds ratio (OR) 12.6 (95% confidence interval (CI) 2.84 to 55.84; low-certainty evidence)...Nebulised vancomycin with oral antibiotics versus nebulised placebo with oral antibiotics The third trial (29 participants) defined eradication as a negative respiratory sample for MRSA at one month following completion of treatment...Using GRADE methodology, we judged the certainty of the evidence provided by this review to be very low to low, due to potential biases from the open-label design, high rates of attrition and small sample sizes. Based on the available evidence, we believe that whilst early eradication of respiratory MRSA in people with cystic fibrosis is possible, there is not currently enough evidence regarding the clinical outcomes of eradication to support the use of the interventions studied.
  • ||||||||||  mupirocin / Generic mfg.
    Review, Journal:  Surgical Site Infection in Cardiac Surgery. (Pubmed Central) -  Dec 12, 2022   
    Perioperative management also involves antibiotic prophylaxis, surgical site preparation, topical antibiotic administration and the maintenance of normal glucose levels. SSI treatment involves surgical intervention, NPWT application and antibiotic therapy.
  • ||||||||||  tigecycline / Generic mfg.
    Journal:  Concentration-Dependent Global Quantitative Proteome Response of Staphylococcus epidermidis RP62A Biofilms to Subinhibitory Tigecycline. (Pubmed Central) -  Nov 16, 2022   
    Interestingly, in addition to tetracycline resistance, proteins involved in resistance of various antibiotics, including aminoglycosides, antimicrobial peptides, β-lactams, erythromycin, fluoroquinolones, fusidic acid, glycopeptides, lipopeptides, mupirocin, rifampicin and trimethoprim were differentially expressed. Our study demonstrates that global protein expression profiling of biofilm cells to antibiotic pressure may improve our understanding of the mechanisms of antibiotic resistance in biofilms.