griseofulvin / Generic mfg. 
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  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles. (Pubmed Central) -  Nov 6, 2020   
    Zero-order kinetics described the griseofulvin release rate from 1.8% up to 82%. Overall, this study has successfully demonstrated that the electro-hydrodynamic drop-on-demand printing of an aqueous drug nanosuspension enables accurate and controllable drug dosing in porous polymer films, which exhibited acceptable content uniformity and reproducible drug release.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  The Sensitivity Modifying Activity of Nerolidol and α-Bisabolol Against Trichophyton spp. (Pubmed Central) -  Oct 26, 2020   
    In association with griseofulvin: nerolidol and α-bisabolol respectively presented synergism and additivity. Finally, the results of our study suggest using α-bisabolol and nerolidol compounds as potential antifungal agents and griseofulvin sensitivity modulators for Trichophyton spp.
  • ||||||||||  fluconazole / Generic mfg., Sebifin (terbinafine HCL) / Generic mfg.
    Preclinical, Journal:  Comparison of Four Methods for the in vitro Susceptibility Testing of Dermatophytes. (Pubmed Central) -  Aug 8, 2020   
    Twenty-two isolates (8 Trichophyton interdigitale, 8 T. rubrum, and 6 Microsporum canis) were tested against the antifungal agents of griseofulvin, terbinafine, fluconazole, and itraconazole...The EUCAST method was found to be the more reliable one, whereas the addition of resazurin sodium salt solution facilitates the reading and provides a reliable and objective evaluation. The fragmented mycelia method could serve as an alternative that should be applied only in cases of poor or no sporulating dermatophytes.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  Elaborated regulation of griseofulvin biosynthesis in Penicillium griseofulvum and its role on conidiation and virulence. (Pubmed Central) -  Jul 7, 2020   
    The analysis of gsfR1 promoter revealed that the regulation of griseofulvin biosynthesis is also controlled by global regulators in response to many environmental stimuli, such as carbon and nitrogen. The influence of carbon and nitrogen on griseofulvin production was further investigated and verified, revealing a complex network of response and confirming the central role of gsfR1 in many processes in P. griseofulvum.
  • ||||||||||  Zalain (sertaconazole) / Elder Pharma, clotrimazole / Generic mfg., Sebifin (terbinafine HCL) / Generic mfg.
    Journal:  Low in vitro activity of sertaconazole against clinical isolates of dermatophyte. (Pubmed Central) -  May 19, 2020   
    However, sertaconazole, a third-generation imidazole, did not show any significant effect. Furthermore, M. canis and E. floccosum showed the best response to the antifungal agents.
  • ||||||||||  fluconazole / Generic mfg., Sebifin (terbinafine HCL) / Generic mfg.
    Clinical, Journal:  Dermatomycoses in the Israeli Defense Forces- Epidemiological and Clinical Aspects. (Pubmed Central) -  May 17, 2020   
    (b) Susceptibility tests: to ketoconazole, fluconazole, itraconazole, terbinafine and griseofulvin of ~ 100 Dermatophyte and Candida isolates, using E test and/or disc diffusion assays...3. logistic regression, Chi square, ANOVA RESULTS AND 1.Incidence in male soldiers higher than in female soldiers (35% vs. 28%) 2.Incidence in combat soldiers higher than in non-combat soldiers (39% vs 32%)) 3.The major site of involvement - nails 4.Infections peaked during summer months 5.Dermatophytes constitute close to 90% of the etiological agents (87 & 86%) 6.Trichophyton rubrum the dominant species 7.Terbinafine was the most active antifungal drug The most significant conclusion of relevance of this study is the finding of higher morbidity rate among combat soldiers, as this may affect the activity of this group.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms. (Pubmed Central) -  Apr 26, 2020   
    Dynamic vapour sorption data showed that HPMCAS formed most stable solvate structure preventing recrystallization and solvate expulsion, which could explain the disruptive effect of the biofilms. This could be explained by the formed hydrogen bonds as revealed by the solid and liquid state NMR data, which was further confirmed via thermal and FTIR analyses.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  Antibacterial activity of griseofulvin analogs as example of drug repurposing. (Pubmed Central) -  Mar 26, 2020   
    Similarity analysis for all 42 compounds with the about 470 thousand drug-like compounds indexed by Clarivate Analytics Integrity database confirmed the significant novelty of the antibacterial activity for the compounds from this chemical class. Therefore, our study demonstrated that by computer-aided prediction of biological activity spectra for a particular chemical series it is possible to identify typical biological activities, which may be used for discovery of new applications for those molecules, e.g., drug repurposing.
  • ||||||||||  griseofulvin / Generic mfg.
    Clinical, Journal:  A case report of tinea capitis in infant in first year of life. (Pubmed Central) -  Mar 5, 2020   
    Once diagnosed, treatment of tinea capitis can pose a dilemma because different factors may influence the choice between equally effective therapies (i.e. safety, age, formulation, cost). This case report suggests that it is important to establish an accurate diagnosis and  treatment for this dermatophytosis to avoid recurrences or therapeutic failures, especially in infants.
  • ||||||||||  mycophenolate sodium / Generic mfg.
    PK/PD data, Preclinical, Journal:  Determination and validation of mycophenolic acid by a UPLC-MS/MS method: Applications to pharmacokinetics and tongue tissue distribution studies in rats. (Pubmed Central) -  Mar 4, 2020   
    The matrix effect was non-significant and extraction recovery rates were within 87.99% and 109.69% in plasma and tongue homogenates, respectively. The validity of this assay has been confirmed by measuring MPA in rat plasma for pharmacokinetics following intravenous administration of 0.5 mg/kg of mycophenolate sodium, as well as monitoring MPA in rat tongues for tissue distribution and detecting MPA that diffused into systemic circulation following a 4-h transmucosal delivery of 357 μg/cm of mycophenolate sodium.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  First report of tinea corporis caused by Arthroderma benhamiae in Brazil. (Pubmed Central) -  Feb 8, 2020   
    The etiological agent was identified only by ITS sequencing of the isolates aligned with reference strains to A. benhamiae. This report highlights the importance of ITS sequencing in the identification of isolates from some cases of dermatophytosis, because conventional morphological diagnosis may result in misdiagnosis of the agent and delay proper treatment.
  • ||||||||||  praziquantel (MSC2499550A) / Merck (MSD), griseofulvin / Generic mfg.
    Clinical, Journal:  The impact of cinnarizine and griseofulvin on juvenile and adult stages of Schistosoma mansoni. (Pubmed Central) -  Jan 31, 2020   
    The current work suggests the possibility of using cinnarizine and griseofulvin, mainly in late S. mansoni infection, especially cinnarizine, which showed similar results to PZQ and surpassed it in early infection. Further studies are required to elucidate their exact mechanisms of action and particularly their synergistic effect with PZQ.
  • ||||||||||  Sebifin (terbinafine HCL) / Generic mfg.
    Clinical, Journal:  Griseofulvin versus Terbinafine for pediatric Tinea Capitis: when and for how long. (Pubmed Central) -  Jan 29, 2020   
    Further studies are required to elucidate their exact mechanisms of action and particularly their synergistic effect with PZQ. Twelve-weeks treatment with oral griseofulvin was significantly more effective than 4-week treatment with oral terbinafine for TC caused by MA and TS.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  Preparation of Submicron Drug Particles via Spray Drying from Organic Solvents. (Pubmed Central) -  Jan 1, 2020   
    API particles were successfully produced in the submicron size-range, characterized and the dissolution behaviour was investigated. The dissolution time to dissolve 80% of the drug, t, was reduced from 21.5 min for the micronized grade API to 8.5 min for the submicron product.
  • ||||||||||  griseofulvin / Generic mfg.
    Preclinical, Journal:  Nano- and microcrystals of griseofulvin subcutaneously administered to rats resulted in improved bioavailability and sustained release. (Pubmed Central) -  Dec 25, 2019   
    The extended appearance in the circulation may depend on the physicochemical properties of the compound and the physiological conditions at the injection site. The bioavailability was improved for both formulations compared with an orally administered nanosuspension, suggesting the s.c. route to be a preferred administration option for compounds with low oral bioavailability regarding both overall exposure and extended efficacy.
  • ||||||||||  griseofulvin / Generic mfg.
    Journal:  Impact of Polymer Enrichment at the Crystal-Liquid Interface on Crystallization Kinetics of Amorphous Solid Dispersions. (Pubmed Central) -  Dec 21, 2019   
    This study provides the direct evidence of physical mechanisms that contribute to the local phase separation occurred at the crystal-liquid interface, which governs the kinetics of crystal growth in amorphous solid dispersions. These findings are relevant for understanding the crystallization behavior of amorphous solid dispersions and beneficial for the rational design of robust amorphous formulations.
  • ||||||||||  griseofulvin / generics
    Journal:  Griseofulvin derivatives: Synthesis, molecular docking and biological evaluation. (Pubmed Central) -  Oct 11, 2019   
    Forty-two giseofulvin derivatives were designed, synthesized and evaluated for antimicrobial activity. These derivatives revealed good antifungal activity, better than reference drugs ketoconazole, bifonazole, and griseofulvin as well.
  • ||||||||||  Sebifin (terbinafine HCL) / Generic Mfg.
    Clinical, Retrospective data, Journal:  Utility of Laboratory Test Result Monitoring in Patients Taking Oral Terbinafine or Griseofulvin for Dermatophyte Infections. (Pubmed Central) -  Sep 28, 2019   
    Routine interval laboratory test result monitoring appears to be unnecessary in adults and children without underlying hepatic or hematologic conditions taking terbinafine or griseofulvin for dermatophyte infections. Abandoning frequent laboratory monitoring can decrease unnecessary health care spending, decrease patient psychological angst associated with blood draws, and allow for expanded use of these effective oral medications.