letrozole / Generic mfg. 
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  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  Impact of Omega 3 Fatty Acid Supplementation on Aromatase in Obese Subjects (clinicaltrials.gov) -  Jan 13, 2020   
    P1,  N=60, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Dec 2019 --> Jun 2021 | Trial primary completion date: Sep 2019 --> Jun 2020
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Tissue steroid levels in response to reduced testicular estrogen synthesis in the male pig, Sus scrofa. (Pubmed Central) -  Jan 10, 2020   
    Boars were treated with the aromatase inhibitor, letrozole from 11 to 16 weeks of age and littermate boars received the canola oil vehicle...Hence, the distribution of estrogens between the free and conjugated forms was altered in a tissue-specific manner following inhibition of aromatase. The results suggest sulfated testicular estrogens are important estrogen precursors for the prostate, potentially enabling peripheral target tissues to synthesize free estrogens in the male pig.
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Concentrations of sulphated estrone, estradiol and dehydroepiandrosterone measured by mass spectrometry in pregnant mares. (Pubmed Central) -  Jan 8, 2020   
    The results suggest sulfated testicular estrogens are important estrogen precursors for the prostate, potentially enabling peripheral target tissues to synthesize free estrogens in the male pig. Dependent on methods of extraction and chromatography, and the specificity of primary antisera, immunoassays may underestimate oestrogen conjugate concentrations in blood from pregnant mares and may detect androgen conjugates (neither testosterone sulphate nor DHEAS were detected here by LC-MS/MS) that probably peak coincident with oestrogen conjugates between 6 and 7 months of equine gestation.
  • ||||||||||  letrozole / Generic mfg., cyclophosphamide / Generic mfg.
    Trial completion date, Trial primary completion date:  Study in Letrozole Combined With Metronomic Oral Cyclophosphamide in Elderly Metastasis Breast Cancer Patients (clinicaltrials.gov) -  Jan 3, 2020   
    P=N/A,  N=200, Recruiting, 
    Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Sep 2020 Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Sep 2019 --> Dec 2020
  • ||||||||||  letrozole / Generic mfg., paclitaxel / Generic mfg.
    Biomarker, Clinical, Journal:  ER+ breast cancers resistant to prolonged neoadjuvant letrozole exhibit an E2F4 transcriptional program sensitive to CDK4/6 inhibitors. (Pubmed Central) -  Dec 24, 2019   
    In tumors resistant to prolonged neoadjuvant letrozole, we identified a gene expression signature of E2F4 target activation. CDK4/6 inhibition suppressed E2F4 target gene expression in estrogen-deprived ER+ BC cells and in patients' ER+ tumors, suggesting a potential benefit of adjuvant CDK4/6 inhibitors in patients with ER+ breast cancer who fail to respond to preoperative estrogen deprivation.
  • ||||||||||  letrozole / Generic mfg., exemestane / Generic mfg.
    Journal:  Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. (Pubmed Central) -  Dec 23, 2019   
    We also show that five derivatives of luciferin are metabolized by CYP8B1 and established a rapid and convenient inhibitor test system. In this way we were able to identify four new CYP8B1 inhibitors, which are aminobenzotriazole, exemestane, ketoconazole, and letrozole.
  • ||||||||||  letrozole / Generic mfg., cisplatin / Generic mfg.
    Journal:  Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1. (Pubmed Central) -  Dec 23, 2019   
    In this way we were able to identify four new CYP8B1 inhibitors, which are aminobenzotriazole, exemestane, ketoconazole, and letrozole. Our findings clearly demonstrate that letrozole improves cisplatin sensitivity of breast cancer cells overexpressing aromatase via down-regulation of FEN1 and suggest that a combined use of letrozole and cisplatin may be a potential treatment protocol for relieving cisplatin resistance in human breast cancer.
  • ||||||||||  letrozole / Generic mfg.
    Clinical, Journal:  Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome. (Pubmed Central) -  Dec 23, 2019   
    Our findings clearly demonstrate that letrozole improves cisplatin sensitivity of breast cancer cells overexpressing aromatase via down-regulation of FEN1 and suggest that a combined use of letrozole and cisplatin may be a potential treatment protocol for relieving cisplatin resistance in human breast cancer. The use of letrozole for ovulation induction in polycystic ovarian syndrome patients has a better effect on endometrial receptivity markers when compared to clomiphene citrate.
  • ||||||||||  valsartan / Generic mfg.
    Journal:  Angiotensin blockade attenuates diabetic nephropathy in hypogonadal adult male rats. (Pubmed Central) -  Dec 23, 2019   
    In HG-D rats, valsartan reduced renal collagen IV and TGF-β1, especially when the testosterone level was corrected by letrozole. Thus, normalizing testosterone and inhibiting renal angiotensin II have a renoprotective effect against DN in HG male rats.
  • ||||||||||  letrozole / Generic mfg.
    Journal, Adverse events:  Adverse effects of aromatase inhibition on the brain and behavior in a non-human primate. (Pubmed Central) -  Dec 21, 2019   
    We used a primate model of human cognitive aging, the common marmoset, to examine the effects of a 4-week daily administration of the AI letrozole (20 μg, p.o.) on cognition, anxiety, thermoregulation, brain estrogen content, and hippocampal pyramidal cell physiology...We show that AI-treated male and female marmosets exhibit behavioral changes consistent with these CNS symptoms, and elevated hippocampal estradiol and compromised hippocampal physiology. These findings illustrate the need for 1) a greater understanding of the precise mechanisms by which AIs impact brain function, and 2) the development of new treatment approaches for breast cancer patients that minimize adverse effects on the brain.
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model. (Pubmed Central) -  Dec 20, 2019   
    Using 16S rRNA gene sequencing, we also observed that the overall composition of the gut microbiome and the relative abundance of Coprobacillus and Lactobacillus differed in letrozole-treated mice co-housed with placebo mice compared to letrozole mice housed together. These results suggest that dysbiosis of the gut microbiome may play a causal role in PCOS and that modulation of the gut microbiome may be a potential treatment option for PCOS.
  • ||||||||||  letrozole / Generic mfg.
    Clinical, Journal:  Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. (Pubmed Central) -  Dec 20, 2019   
    In patients with PCOS undergoing FET, letrozole use for endometrial preparation was associated with higher LBR compared with artificial cycles, albeit after statistical adjustment for confounding factors. Future prospective randomized studies are needed to verify our findings.