letrozole / Generic mfg. 
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  • ||||||||||  letrozole / Generic mfg.
    Review, Journal:  Constitutional delay of puberty versus congenital hypogonadotropic hypogonadism: Genetics, management and updates. (Pubmed Central) -  Feb 20, 2020   
    Other causes of DP include permanent hypogonadotropic hypogonadism, functional hypogonadotropic hypogonadism (due to chronic diseases and conditions), and gonadal failure. In this review we discuss these themes along with the latest achievements in the field of puberty research, and include a brief synopsis on the differential diagnosis and management of patients with CDGP and congenital hypogonadotropic hypogonadism.
  • ||||||||||  letrozole / Generic mfg.
    Hyperandrogenic effects on female fertility and pregnancy outcome (Lorenese 7) -  Feb 20, 2020 - Abstract #ISGE2020ISGE_471;    
    Widely used stimulation protocols for patients with hyperandrogenism and PCOS are Letrozole, Сlomiphene, as well as mini stimulation with recombinant gonadotropins...In patients with PCOS, in 70% of cases, non-receptive endometrium was detected, with premature maturation in most cases. The correct assessment of patients before the IVF treatment, as well as the preliminary preparation and normalization of hormonal levels and metabolism, positively affect the amount of mature oocytes, therefore the amount of euploid embryos and the maturity of the endometrium, significantly increase the chance of pregnancy in IVF cycles.
  • ||||||||||  letrozole / Generic mfg.
    Aromatase inhibitors (AOI) in ART (HALL 8 HIPPOCRATES) -  Feb 20, 2020 - Abstract #ISGE2020ISGE_467;    
    However, such a disruption of sex steroid synthetic pathways may have detrimental effects on the oocyte and clinical outcomes. This presentation focus on the functional endocrine changes in normal ovulatory women during COS with letrozole intervention.
  • ||||||||||  letrozole / Generic mfg.
    Letrozole versus clomiphene citrate: which is better for ovulation induction? (HALL 8 HIPPOCRATES) -  Feb 20, 2020 - Abstract #ISGE2020ISGE_239;    
    For many years, drug of choice has been CC. However, this concept has been changing, making room for the use of LTZ, especially in PCOS patients, which is already considered by many authors a drug of choice in this pathology.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Enrollment open, Trial completion date, Trial primary completion date:  LACOG1018: Palbociclib Plus Letrozole Treatment After Progression to Second Line Chemotherapy for Women With ER/PR-positive Ovarian Cancer (clinicaltrials.gov) -  Feb 20, 2020   
    P2,  N=39, Recruiting, 
    However, this concept has been changing, making room for the use of LTZ, especially in PCOS patients, which is already considered by many authors a drug of choice in this pathology. Not yet recruiting --> Recruiting | Trial completion date: Feb 2021 --> Mar 2023 | Trial primary completion date: Feb 2020 --> Apr 2021
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Enrollment closed, Trial completion date, Trial primary completion date, Metastases:  Alternative Dosing Schedule of Palbociclib in Metastatic Hormone Receptor Positive Breast Cancer (clinicaltrials.gov) -  Feb 19, 2020   
    P2,  N=55, Active, not recruiting, 
    Not yet recruiting --> Recruiting | Trial completion date: Feb 2021 --> Mar 2023 | Trial primary completion date: Feb 2020 --> Apr 2021 Recruiting --> Active, not recruiting | Trial completion date: Jul 2021 --> Feb 2022 | Trial primary completion date: Jan 2021 --> Mar 2020
  • ||||||||||  letrozole / Generic mfg., Arimidex (anastrozole) / AstraZeneca, Remedica, exemestane / Generic mfg.
    Structure-guided design of competitive isoflavanone inhibitors of aromatase for the treatment of endometriosis (Exhibit Hall A, Pennsylvania Convention Center) -  Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_16228;    
    Furthermore, free energy calculations quantify the inhibitor’s effectiveness using conformations generated from MD. Preliminary data has shown that several isovflavanone derivatives may be promising aromatase inhibitors.
  • ||||||||||  Trial completion date, Trial primary completion date:  STAPOVER: Signal TrAnsduction Pathway Activity Analysis in OVarian cancER (clinicaltrials.gov) -  Feb 10, 2020   
    P3,  N=50, Not yet recruiting, 
    Compared to physician’s choice SOC, TRAM was associated with significantly improved PFS and ORR in women with recurrent LGSOC. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Aug 2022 --> Aug 2023
  • ||||||||||  letrozole / Generic mfg., flutamide / Generic mfg.
    Preclinical, Journal:  Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition. (Pubmed Central) -  Feb 7, 2020   
    Co-administration of both drugs blocked object placement and object recognition memory consolidation, demonstrating that letrozole impairs memory in intact males only if androgen receptors are blocked. Together, these data suggest that DH-synthesized E and androgen receptor activation may work in concert to mediate memory consolidation in intact males, such that androgen receptor activation protects against memory impairments caused by aromatase inhibition.
  • ||||||||||  Anthropometric and Reproductive Outcomes of Patients with Gonadotropin-Independent Precocious Puberty Due to McCune-Albright Syndrome After Treatment with Distinct Therapeutic Agents (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_2478;    
    All patients were treated with one or more of the following agents: tamoxifen, medroxyprogesterone acetate, aromatase inhibitors (anastrozole or letrozole) and anti-androgens (cyproterone), and, in cases with secondary gonadotropic axis activation, depot GnRHa was used...Tamoxifen plus medroxyprogesterone, or cyproterone, or leuprorelin were used (each one) as the first choice in 1 patient (7.6%)...Despite a reasonable number of treatment options for peripheral PP in MAS, none of them showed proven effective results in stopping vaginal bleeding, reduce pubertal progression and preserving potential genetic adult height. Therefore, due to the extremely heterogeneous nature of PPP of MAS, the clinical treatment remains a challenge.
  • ||||||||||  letrozole / Generic mfg., Faslodex (fulvestrant) / AstraZeneca
    A Prospective Non-surgical Treatment for Inguinal Hernias (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_1822;    
    Ablation of estrogen production or its signaling not only completely prevents this phenotype but also reverses mild to moderate-sized hernias. Our findings pave the pathway for developing the first potential preventive and therapeutic pharmacological approach for combating recurrent inguinal hernias in elderly men through modulation of estrogen signaling in abdominal muscle tissue.
  • ||||||||||  samotolisib (LY3023414) / Eli Lilly
    Trial completion date, Metastases:  A Study of LY3023414 in Participants With Advanced Cancer (clinicaltrials.gov) -  Feb 5, 2020   
    P1,  N=156, Active, not recruiting, 
    Recruiting --> Completed | Trial completion date: May 2021 --> Dec 2019 Trial completion date: Mar 2020 --> Dec 2020
  • ||||||||||  Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date, Surgery:  PLATO: PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate (clinicaltrials.gov) -  Feb 5, 2020   
    P2,  N=122, Recruiting, 
    Active, not recruiting --> Completed | Trial completion date: Dec 2020 --> Feb 2019 | Trial primary completion date: Sep 2019 --> Feb 2019 Not yet recruiting --> Recruiting | Trial completion date: May 2025 --> Dec 2025 | Initiation date: May 2019 --> Nov 2019 | Trial primary completion date: May 2021 --> Dec 2021
  • ||||||||||  Biomarker, Trial primary completion date, PARP Biomarker, PD(L)-1 Biomarker:  I-SPY 2: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (clinicaltrials.gov) -  Jan 22, 2020   
    P2,  N=1920, Recruiting, 
    The results suggest that brain changes produced by estrogens along early development and stimuli coming from the partner are essential for shaping sex preference. Trial primary completion date: Dec 2020 --> Dec 2025
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Testicular estradiol and the pattern of Sertoli cell proliferation in prepuberal bulls. (Pubmed Central) -  Jan 21, 2020   
    To evaluate the regulatory role of testicular estrogens, Jersey bull caves were treated twice weekly with the aromatase inhibitor, letrozole, from 2 to 22 wk of age and control animals were treated with the canola oil vehicle...Inhibition of aromatase had no effect on testosterone or circulating LH; testosterone increased with age as expected. Inhibition of aromatase and consequent reduced testicular estradiol did not alter Sertoli cell numbers.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Journal:  Are testicular cortisol and WISP2 involved in estrogen-regulated Sertoli cell proliferation? (Pubmed Central) -  Jan 18, 2020   
    Local administration beginning at 1.5 weeks of age (osmotic pump and catheter (n = 3) or a silastic implant (n = 5)) reduced Sertoli cell numbers at 6.5 weeks of age compared with littermates that received the vehicle treatment (P< 0.05). In summary, testicular glucocorticoid concentration was inversely correlated with Sertoli cell numbers during the first wave of Sertoli cell proliferation.
  • ||||||||||  letrozole / Generic mfg.
    Extracorporeal retrieval and vitrification of oocytes for fertility preservation () -  Jan 16, 2020 - Abstract #Fertility2020FERTILITY_265;    
    Method(s): Ovarian stimulation of patient using flare protocol with 450IU of Menotrophin (FSH/LH) and letrozole...No ovarian cortex tissue cryopreserved, oophorectomized tissue sent to histology post-aspiration. Conclusion(s): This case demonstrates that extracorporeal oocyte retrieval in patients with ovarian cancer can lead to successful fertility preservation without the risk of malignant cell spillage and cancer upstaging.