letrozole / Generic mfg. 
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  • ||||||||||  letrozole / Generic mfg.
    Review, Journal:  Letrozole for Female Infertility. (Pubmed Central) -  Dec 25, 2021   
    In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified. This mini review focuses on our current knowledge of the applications and mechanisms of letrozole for female infertility and various questions are put forward about how letrozole could be more effectively used.
  • ||||||||||  Kisqali (ribociclib) / Novartis
    Clinical, PK/PD data, Journal:  Ribociclib Population Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Analysis of Neutrophils in Cancer Patients. (Pubmed Central) -  Dec 23, 2021   
    The PK/PD analysis confirmed reversibility of ribociclib effect on ANC; it also suggested that lowering dose of ribociclib would mitigate ANC decrease and neutropenia risk. The popPK and ANC PK/PD analyses support the use of ribociclib in combination with an aromatase inhibitor or fulvestrant in patients with HR+, HER2- advanced or metastatic breast cancer without dose adjustment in subpopulations, and the use of dose interruption/reduction to mitigate potential treatment-emergent neutropenia.
  • ||||||||||  Verzenio (abemaciclib) / Eli Lilly
    Enrollment change, Combination therapy, Metastases:  A Study of Abemaciclib in Indian Women With Advanced Breast Cancer (clinicaltrials.gov) -  Dec 21, 2021   
    P4,  N=200, Recruiting, 
    The neonatal outcomes were similar between the two groups. N=100 --> 200
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Estrogens Regulate Placental Angiogenesis in Horses. (Pubmed Central) -  Dec 17, 2021   
    Administration of letrozole, a potent and specific inhibitor of aromatase, during the first trimester (D30 to D118), decreased circulatory estrone sulfate concentrations, increased circulatory testosterone and androstenedione concentrations, and tended to reduce the weight of the fetus (p < 0.1)...We further demonstrated that 17β-estradiol increases the expression of ANGPT1 and VEGF and increases the angiogenic activity of equine endothelial cells in vitro. Our results from the estrogen-suppressed group demonstrated an impaired placental vascular network, suggesting an estrogen-dependent vasculogenesis in the equine CA during the first trimester.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Clinical, Journal:  Prolonged benefit from palbociclib plus letrozole in heavily pretreated advanced male breast cancer: case report and literature overview. (Pubmed Central) -  Dec 16, 2021   
    We present a clinical case of prolonged benefit from palbociclib in combination with letrozole and LHRH analogue in a man who had previously been treated with six lines of endocrine therapies and chemotherapy regimens but was still in excellent clinical condition. This clinical case demonstrates that male breast cancer stands out as an endocrine-sensitive disease, which could potentially benefit from CDK 4/6 inhibitors in combination with endocrine agents even in very heavily pretreated settings of disease, underscoring both the importance of an accurate selection of patients for later treatment lines, taking into account disease history and previous treatment responses, and the peculiarity of breast cancer in men, which deserves dedicated clinical trials to tailor future recommendations.
  • ||||||||||  letrozole / Generic mfg.
    Preclinical, Journal:  Comparison of IVF cycles stimulated with 20mg letrozole daily vs. high dose gonadotropins in Rotterdam Consensus ultra-poor responders: A proof of concept. (Pubmed Central) -  Dec 16, 2021   
    This clinical case demonstrates that male breast cancer stands out as an endocrine-sensitive disease, which could potentially benefit from CDK 4/6 inhibitors in combination with endocrine agents even in very heavily pretreated settings of disease, underscoring both the importance of an accurate selection of patients for later treatment lines, taking into account disease history and previous treatment responses, and the peculiarity of breast cancer in men, which deserves dedicated clinical trials to tailor future recommendations. Letrozole (20 mg daily) may be used to reduce the cost of ovarian stimulation in ultra-poor responders, significantly reducing the cost of the IVF cycle with probably at least similar outcomes to high-dose gonadotropins.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Biomarker, Clinical, Journal:  Mutation analysis using cell-free DNA for endocrine therapy in patients with HR+ metastatic breast cancer. (Pubmed Central) -  Dec 16, 2021   
    In contrast, PIK3CA mutations were significantly associated with longer TTP in patients receiving EverX treatment (median TTP of EverX: 15.9 months vs. 5.2 months, p = 0.01) and remained a significant factor in multivariable analysis for TTP of EverX in this subgroup (hazard ratio = 0.2, 95% CI = 0.1- 0.8, p = 0.03). ESR1 and PIK3CA mutations in cfDNA were associated with clinical efficacies of ET in HR+ MBC patients.
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Gene expression of Takifugu rubripes gonads during AI or MT- induced masculinization and E2-induced feminization. (Pubmed Central) -  Dec 16, 2021   
    Here, fugu larvae were treated with AI (letrozole), MT, or E2 from 25 to 80 days after hatching (dah), and gonadal transcriptomic analysis at 80 dah was performed...The shared response following AI, MT, and E2 treatment suggested that these genes are essential for sex differentiation. This finding offers some insight into AI or MT-induced masculinization, and E2-induced femininization in fugu.
  • ||||||||||  letrozole / Generic mfg.
    Preclinical, Journal:  Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin. (Pubmed Central) -  Dec 16, 2021   
    Next, female and male wax stripped C57BL/6J mice were topically treated with E2, the estrogen receptor antagonist ICI 182,780 (ICI), letrozole, E2 plus letrozole, or vehicle control (acetone) during mid-anagen...These results suggest that estrogen regulates vitamin A metabolism in the skin. Interactions between E2 and vitamin A have implications in acne treatment, hair loss, and skin immunity.
  • ||||||||||  tamoxifen / Generic mfg.
    Review, Journal:  Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects. (Pubmed Central) -  Dec 7, 2021   
    In particular, nanoformulated hesperidin and hesperetin possess greater chemotherapeutic and chemosensitising activities than free compounds. Despite promising preclinical results, further safety and efficacy evaluation of hesperidin and hesperetin as well as their nanoformulations in clinical trials is required to ascertain their potentials to be developed as clinically useful agents for BC treatment.