letrozole / Generic mfg. 
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 114 Diseases   361 Trials   361 Trials   7200 News 


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  • ||||||||||  Kisqali (ribociclib) / Novartis
    Trial initiation date:  NEOLETRIB: Neoadjuvant Treatment of Locally-advanced Breast Cancer Patients With Ribociclib and Letrozole (clinicaltrials.gov) -  Jul 23, 2022   
    P2,  N=100, Not yet recruiting, 
    Dalp is the 4 th CDK4/6 inhibitor showing survival benefit with letrozole or anastrozole in untreated HR+/HER2- ABC, or with fulvestrant in pretreated HR+/HER2- ABC, in addition to palbociclib, ribociclib and abemaciclib. Initiation date: Apr 2022 --> Dec 2022
  • ||||||||||  AiRuiKang (dalpiciclib) / Jiangsu Hengrui Pharma
    New P2 trial, Metastases:  Dalpiciclib Plus Letrozole and Capecitabine (clinicaltrials.gov) -  Jul 23, 2022   
    P2,  N=48, Not yet recruiting, 
  • ||||||||||  letrozole / Generic mfg.
    Preclinical, Journal:  Endogenous Hippocampal Estrogen Is Involved in Stress-induced Depression-like Behaviors and Spine Plasticity in Male Rats. (Pubmed Central) -  Jul 23, 2022   
    We delivered letrozole (a selective aromatase inhibitor that blocks the conversion of testosterone to estradiol) and estrogen into the hippocampus of rats and found that letrozole treatment induced the same depression-like behaviors in control rats as observed in chronic unpredictable mild stress (CUMS) rats...In conclusion, nE2 in the hippocampus plays an important role in CUMS-induced depression-like behaviors in male rats and Kalirin-7 is involved in this process. GluN1 and PSD-95 possibly mediate the regulation of Kalirin-7 by nE2, which ultimately leads to changes in spine density and depression-like behaviors.
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Benign metastasising leiomyoma: a rare disease and a diagnostic challenge. (Pubmed Central) -  Jul 23, 2022   
    The patient declined letrozole treatment as she had just undergone bilateral oophorectomy...CT imaging 7 months postsurgery showed disease regression. She will require long-term surveillance scans to detect disease progression.
  • ||||||||||  letrozole / Generic mfg.
    PSEUDOACHALASIA – MEETING AN OLD FRIEND (Science Lounge) -  Jul 20, 2022 - Abstract #UEGW2022UEGW_2649;    
    She was referred to Oncology, having initiated letrozole with favourable clinical and imaging response at 6 months.Pseudoachalasia is associated with several neoplasms, including, most frequently, breast cancer...Despite the suspicion of ad initio malignancy, pseudoachalasia preceded the diagnosis of metastatic breast cancer (lung + lymph nodes). The absence of a direct invasion or extrinsic compression, in addition with dysphonia, raise the hypothesis of pseudoachalasia in relation to neurologic paraneoplastic syndrome.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Trial primary completion date:  Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS) (clinicaltrials.gov) -  Jul 18, 2022   
    P2,  N=195, Active, not recruiting, 
    The absence of a direct invasion or extrinsic compression, in addition with dysphonia, raise the hypothesis of pseudoachalasia in relation to neurologic paraneoplastic syndrome. Trial primary completion date: Jun 2021 --> Feb 2022
  • ||||||||||  Trial completion date, Trial initiation date, Trial primary completion date:  SMMART Adaptive Clinical Treatment (ACT) Trial (clinicaltrials.gov) -  Jul 14, 2022   
    P2,  N=131, Not yet recruiting, 
    Adjuvant letrozole co-administration in intra-cytoplasmic sperm injection cycles following GnRH antagonist protocol appears to improve implantation, clinical pregnancy and live birth delivery rates in women with POSEIDON group 3 expected poor ovarian response. Trial completion date: Mar 2025 --> Mar 2026 | Initiation date: Apr 2022 --> Dec 2022 | Trial primary completion date: Mar 2025 --> Mar 2026
  • ||||||||||  Mekinist (trametinib) / Novartis
    Trametinib Use in Low-Grade Serous Ovarian Cancer – A Multi-Centre Experience () -  Jul 12, 2022 - Abstract #BGCS2022BGCS_40;    
    100% (n=14) received letrozole/anti-oestrogens...Toxicity is common, but manageable with dose reductions. Hopefully, incorporating trametinib into LGSOC treatment paradigms with translate to improved OS for this historically difficult to treat population.
  • ||||||||||  letrozole / Generic mfg.
    Trial completion date, Trial primary completion date:  Letrozole as a Prophylaxis From GTN for Complete Mole Patients (clinicaltrials.gov) -  Jul 12, 2022   
    P2/3,  N=200, Active, not recruiting, 
    Hopefully, incorporating trametinib into LGSOC treatment paradigms with translate to improved OS for this historically difficult to treat population. Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Apr 2022 --> Dec 2022
  • ||||||||||  letrozole / Generic mfg.
    Trial completion date, Trial primary completion date:  Evaluation of IM Letrozole ISM (clinicaltrials.gov) -  Jul 8, 2022   
    P1,  N=120, Active, not recruiting, 
    Aiming ovulation induction, letrozole in comparison to clomiphene citrate was found to have significantly better efficacy among women having anovulatory PCOS. Trial completion date: Apr 2022 --> Jul 2022 | Trial primary completion date: Apr 2022 --> Jul 2022
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Trial completion, HEOR, Combination therapy, Real-world evidence, Real-world, Metastases:  Real-world Treatment Patterns and Effectiveness of Palbociclib and AI Therapy (clinicaltrials.gov) -  Jul 8, 2022   
    P=N/A,  N=1, Completed, 
    Trial completion date: Apr 2022 --> Jul 2022 | Trial primary completion date: Apr 2022 --> Jul 2022 Active, not recruiting --> Completed
  • ||||||||||  letrozole / Generic mfg., leuprolide acetate for depot suspension / Generic mfg.
    Journal:  Fertility preservation in transgender men without discontinuation of testosterone. (Pubmed Central) -  Jul 8, 2022   
    This is the first published case report demonstrating the proof of concept of COS without cessation of high-dose testosterone therapy in two transgender men. Future studies with larger sample sizes should be performed to confirm these findings.
  • ||||||||||  letrozole / Generic mfg.
    Preclinical, Journal:  The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice. (Pubmed Central) -  Jul 1, 2022   
    The LET-treated group did not develop endocrine or metabolic abnormalities, but polycystic ovaries were seen. Since the HF/HFr diet can cause substantial metabolic and reproductive dysregulation in both LET-treated and placebo mice, food items rich in simple sugar-particularly fructose-and saturated fat, which have the potential to lead to PCOS progression, should be eliminated from the diet of young females.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Enrollment closed, Trial completion date, Trial primary completion date, HEOR, Combination therapy, Real-world evidence, Real-world, Metastases:  Real-world Treatment Patterns and Effectiveness of Palbociclib and AI Therapy (clinicaltrials.gov) -  Jun 30, 2022   
    P=N/A,  N=1, Active, not recruiting, 
    GH and letrozole combination can enhance AH in pubertal boys with short stature. Unknown status --> Active, not recruiting | Trial completion date: Oct 2021 --> Dec 2022 | Trial primary completion date: Oct 2021 --> Dec 2022
  • ||||||||||  Kisqali (ribociclib) / Novartis
    Journal:  Optimizing hormone therapy for breast cancer: Translating gains to the early-stage setting. (Pubmed Central) -  Jun 29, 2022   
    First-line CDK4/6 inhibitor ribociclib plus letrozole improves survival in the metastatic setting, but lack of accrual of African American women is a shortcoming. Predicting benefit in the early-stage setting and diverse enrollment in trials need to be priorities..