letrozole / Generic mfg. 
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 114 Diseases   361 Trials   361 Trials   7200 News 


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  • ||||||||||  imatinib / Generic mfg., letrozole / Generic mfg., bicalutamide / Generic mfg.
    PREVALENCE AND PROGNOSTIC VALUE OF TARGETABLE RECEPTORS IN EXTRA-UTERINE LEIOMYOSARCOMA () -  Sep 9, 2022 - Abstract #CTOS2022CTOS_427;    
    In most cases, all four receptors did not show frequent or strong staining. In addition, survival analysis did not show any statistically significant differences between receptor expression and OS.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Ileocolitis Associated With the Checkpoint Inhibitor Palbociclib (PAL) (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_1931;    
    Case Description/ A 30-year-old female with biopsy confirmed stage IV ER+, PR+, HER2- ductal breast carcinoma with metastasis to liver and bone presented with abdominal pain, diarrhea, and hematochezia 2 months into therapy with letrozole and PAL...PAL was held and the patient was started on prednisone taper with resolution of symptoms after 1 month...Checkpoint inhibitor induced ileitis/colitis should be considered in a patient with new onset hematochezia and diarrhea after initiation of these agents. Figure: Image 1: Erythema, friability, congestion, erosions, and ulceration in the terminal ileum
  • ||||||||||  letrozole / Generic mfg., raloxifene hydrochloride / Generic mfg.
    Breast Cancer With Synchronous Endoluminal Upper and Lower GI Metastases (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_1060;    
    She started raloxifene and underwent surveillance MRI and mammogram at regular intervals...She continued letrozole and pablociclib...Our patient survived and had stable disease for more than 3 years. Figure: Figure 1: Duodenum examined using Narrow-Band Imaging (NBI) showing metastatic deposits (circled in yellow).
  • ||||||||||  Verzenio (abemaciclib) / Eli Lilly
    An Unusual Site of Colonic Metastasis From Hormone Positive Breast Cancer (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_925;    
    Case Description/ We describe a case of a 65-year-old postmenopausal female with a past medical history of Stage III, pT2pN3Mx, grade I, ER positive 74%, PR positive 37%, HER-2 negative, Ki-67 of 30%, 45/46 lymph node positive, invasive breast cancer diagnosed 7 years ago, status post bilateral mastectomy, adjuvant chemotherapy, radiation, adjuvant letrozole therapy and a history of stage IA non-small cell carcinoma status post lobectomy...She started with a few cycles of systemic chemotherapy followed by hormone therapy with faslodex and abemaciclib...Immunohistochemical staining of the metastatic lesion is essential to evaluate the benefit of anti-hormonal therapy. Surgical resection should be reserved as a final treatment option as surgical resection has not been shown to improve overall survival.
  • ||||||||||  letrozole / Generic mfg.
    Review, Journal:  A synopsis of the 2021 International Society of Fertility Preservation bi-annual meeting. (Pubmed Central) -  Sep 3, 2022   
    Presentations included talks on ovarian stem cell therapy for premature ovarian insufficiency, practical aspects of oocyte vitrification, ovarian stimulation for patients with breast cancer, in vitro maturation of oocytes at the time of ovarian tissue harvesting, male fertility preservation, and uterine transplantation. These presentations are summarized below and can be viewed in their entirety at www.isfp-fertility.org.
  • ||||||||||  Verzenio (abemaciclib) / Eli Lilly
    Enrollment closed, Combination therapy, Metastases:  GOG-3039: Abemaciclib and Letrozole to Treat Endometrial Cancer (clinicaltrials.gov) -  Sep 2, 2022   
    P2,  N=50, Active, not recruiting, 
    Initiation date: Aug 2022 --> Oct 2022 Recruiting --> Active, not recruiting
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Enrollment closed, Trial completion date, Trial primary completion date:  To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH) (clinicaltrials.gov) -  Sep 1, 2022   
    P2,  N=144, Active, not recruiting, 
    Trial completion date: Sep 2022 --> Sep 2023 | Trial primary completion date: Sep 2022 --> Sep 2023 Recruiting --> Active, not recruiting | Trial completion date: Aug 2022 --> Nov 2022 | Trial primary completion date: Apr 2022 --> Nov 2022
  • ||||||||||  progesterone / Generic mfg., letrozole / Generic mfg., clomifene citrate / Generic mfg.
    Review, Journal:  Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse. (Pubmed Central) -  Aug 31, 2022   
    We are uncertain if IM progesterone improves ongoing pregnancy rates or decreases miscarriage rate when compared to vaginal progesterone. Regarding the other reported comparisons, neither oral progesterone nor any other medication appears to be associated with an improvement in pregnancy outcomes (very low-certainty evidence).
  • ||||||||||  metformin / Generic mfg., letrozole / Generic mfg.
    Preclinical, Journal:  Effects of berberine on LPS /NF-κB and MAPK signaling pathways in PCOS model rats (Pubmed Central) -  Aug 30, 2022   
    Berberine significantly decreased serum triglyceride (TG), insulin level and insulin index (P＜0.05), increased serum SHBG level and decreased serum LPS level (P＜0.05), which were similar to those of metformin. Berberine can regulate sex hormone disorder and insulin resistance (IR) in PCOS rats by down-regulating the expressions of p38-MAPK and NF-κB protein in ovarian tissues and decreasing the serum content of LPS.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial primary completion date:  Impact of Omega 3 Fatty Acid Supplementation on Aromatase in Obese Subjects (clinicaltrials.gov) -  Aug 29, 2022   
    P1,  N=60, Recruiting, 
    Berberine can regulate sex hormone disorder and insulin resistance (IR) in PCOS rats by down-regulating the expressions of p38-MAPK and NF-κB protein in ovarian tissues and decreasing the serum content of LPS. Trial primary completion date: Jun 2022 --> Jun 2023
  • ||||||||||  letrozole / Generic mfg.
    Journal:  Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism. (Pubmed Central) -  Aug 24, 2022   
    In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP...In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
  • ||||||||||  Journal:  Synthesis of trans N-Substituted Pyrrolidine Derivatives Bearing 1,2,4-triazole Ring. (Pubmed Central) -  Aug 24, 2022   
    PJE ameliorated PCOS accompanying endometrial histological alterations through its antioxidant, anti-inflammatory, anti-fibrotic, anti-proliferative, and anti-androgenic effects most probably due to its polyphenols content. Eight novel amides (6a-h) and six amines (8a-f) derivatives were synthesized using 1-(4- methoxypyrrolidin-3-yl)-1H-1,2,4-triazole 4 salt with substituted benzoyl chlorides and benzyl bromides.
  • ||||||||||  progesterone / Generic mfg., letrozole / Generic mfg.
    Retrospective data, Journal:  Letrozole Supplementation and the Increased Risk of Elevated Progesterone Levels on Trigger Day. (Pubmed Central) -  Aug 22, 2022   
    In the PSM 2 cohort, progesterone levels on the trigger day increased by 0.05 ng/mL with an increase in every retrieved oocyte in the LE GnRH-ant group (β 0.05 ng/mL [95% CI 0.04, 0.06], P < 0.001), whereas an increase of 0.02 ng/mL was observed in the GnRH-a group (β 0.02 ng/mL [95% CI 0.01, 0.03], P < 0.001), with P for interaction being 0.0002. LE supplementation on the antagonist protocols may increase progesterone levels in the late follicular stage.
  • ||||||||||  letrozole / Generic mfg., clomifene citrate / Generic mfg.
    DEMOGRAPHIC DIFFERENCES IN OVULATION INDUCTION PRESCRIBING PRACTICES AMONG INFERTILE PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME (Anaheim Convention Center - Poster Hall in Expo Hall) -  Aug 21, 2022 - Abstract #ASRM2022ASRM_1278;    
    Further work is needed to elucidate factors mediating these differences to promote equity in access to fertility care for patients with PCOS. IMPACT STATEMENT: There are potential clinically relevant racial differences in OI prescription rates among infertile patients with PCOS that may not be fully explained by income or insurance type.
  • ||||||||||  letrozole / Generic mfg., clomifene citrate / Generic mfg.
    MORE RISK THAN REWARD: A COST ANALYSIS OF THE AMIGOS TRIAL (Anaheim Convention Center - Poster Hall in Expo Hall) -  Aug 21, 2022 - Abstract #ASRM2022ASRM_1160;    
    GN IUI cycles do not increase the chance of singleton live birth compared CC or LTZ IUI but do increase the chance of multiple gestations which have higher complication rates and maternal/neonatal costs. Therefore, GN IUI is not an optimal treatment for unexplained infertility.
  • ||||||||||  letrozole / Generic mfg.
    WHAT IS THE IDEAL LETROZOLE REGIMEN FOR OVULATION INDUCTION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME? (Anaheim Convention Center - Poster Hall in Expo Hall) -  Aug 21, 2022 - Abstract #ASRM2022ASRM_689;    
    This may shorten time to ovulation and potentially to pregnancy by allowing patients to complete more OI cycles as well as decrease direct costs for patients. IMPACT STATEMENT: Letrozole 2.5mg for 5 days for OI is associated with a lower response rate, thus there may be benefit to starting at a higher dose or for a longer duration without increasing rates of multifollicular development.