letrozole / Generic mfg. 
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  • ||||||||||  Review, Journal:  Research advances in drug therapy of endometriosis. (Pubmed Central) -  Jul 7, 2023   
    Letrozole improved the fertility of patients with mild endometriosis. For endometriosis patients with infertility, oral GnRH antagonists and aromatase inhibitors are promising drugs, especially Elagolix and Letrozole.
  • ||||||||||  letrozole / Generic mfg., anastrozole / Generic mfg.
    Journal:  The genomic landscape associated with resistance to aromatase inhibitors in breast cancer. (Pubmed Central) -  Jul 7, 2023   
    Pathway analysis revealed HSD3B1 to be involved in estrogen biosynthesis. This study reveals the involvement of key genes that might be associated with the development of AI resistance in ER-positive breast cancers and hence may act as a potential prognostic and diagnostic biomarker for these patients.
  • ||||||||||  Kisqali (ribociclib) / Novartis
    Trial completion, Enrollment change, Metastases:  AMICA: Anti-hormonal Therapie With Ribociclib in HR-positive / HER2- Negative Metastatic Breast Cancer (clinicaltrials.gov) -  Jul 7, 2023   
    P2,  N=56, Completed, 
    This study reveals the involvement of key genes that might be associated with the development of AI resistance in ER-positive breast cancers and hence may act as a potential prognostic and diagnostic biomarker for these patients. Active, not recruiting --> Completed | N=150 --> 56
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Review, Journal:  Bilateral Lacrimal Gland Mantle Cell Lymphoma in 11-Year Follow-Up: Case Report and Review of 48 Cases With Ocular Adnexal Presentation in the Literature. (Pubmed Central) -  Jul 5, 2023   
    She showed hepatic lymphadenopathy and splenomegaly, and so received 2 cycles of alternating Hyper-CVAD therapy and high-dose methotrexate with cytarabine, combined with rituximab, in 2 months, leading to complete remission...Next year, the left rib resection revealed the metastasis of breast adenocarcinoma, leading to daily oral letrozole...She underwent 2 courses of bendamustine and rituximab, resulting in complete remission but died of metastatic breast cancer at the age of 74 years. Clinical features in 48 previous cases with ocular adnexal MCL in the literature were summarized in this study.
  • ||||||||||  Verzenio (abemaciclib) / Eli Lilly
    Trial completion, Combination therapy, Metastases:  A Study of Abemaciclib in Indian Women With Advanced Breast Cancer (clinicaltrials.gov) -  Jul 5, 2023   
    P4,  N=200, Completed, 
    Clinical features in 48 previous cases with ocular adnexal MCL in the literature were summarized in this study. Recruiting --> Completed
  • ||||||||||  letrozole / Generic mfg.
    Journal, Immunomodulating:  Immunomodulatory effects of testosterone and letrozole during Plasmodium berghei ANKA infection. (Pubmed Central) -  Jul 3, 2023   
    In conclusion, free testosterone plays an essential role in pathogenesis in male mice by increasing CD8+ and decreasing Mac3+ cells and mainly reducing IL-17A levels, which is critical in the development of anaemia. Our results are important for understanding the mechanisms that regulate the exacerbated inflammatory response in infectious diseases and would be useful for the future development of alternative therapies to reduce the mortality generated by inflammatory processes.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Trial primary completion date:  Combined Immunotherapies in Metastatic ER+ Breast Cancer (clinicaltrials.gov) -  Jul 3, 2023   
    P2,  N=102, Recruiting, 
    Our results are important for understanding the mechanisms that regulate the exacerbated inflammatory response in infectious diseases and would be useful for the future development of alternative therapies to reduce the mortality generated by inflammatory processes. Trial primary completion date: Oct 2023 --> Oct 2024
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Bullous Symmetrical Drug-Related Intertriginous and Flexural Exanthema Induced by Doxorubicin () -  Jul 3, 2023 - Abstract #WCD2023WCD_5234;    
    Antibiotics for example amoxicillin, penicillin, and ceftriaxone are among the most common causative agents of SDRIFE...The lesions appeared after the third cycle of chemotherapy with pegylated liposomal doxorubicin hydrochloride for her breast cancer...Her chemotherapy regimen was changed into palbociclib combined with letrozole without new lesions appeared...Chemotherapeutic drugs including doxorubicin might be the causative agent. Further investigation is needed to determine the etiology of doxorubicin-induced bullous-SDRIFE
  • ||||||||||  letrozole / Generic mfg.
    Preclinical, Journal:  Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats. (Pubmed Central) -  Jun 28, 2023   
    Female forebrain neuronal aromatase knockout (FBN-ARO-KO) rats and letrozole-treated rats were also employed...Notably, hippocampal-dependent spatial learning and memory was impaired in juvenile (1 Mon) and adulthood (6 Mon) KO rats. Taken together, we demonstrated that BDE2 plays a pivotal role for hippocampal neurogenesis, as well as learning and memory during female aging, especially in juvenile and middle age.
  • ||||||||||  letrozole / Generic mfg., anastrozole / Generic mfg., tamoxifen / Generic mfg.
    Review, Journal, HEOR:  Health-related quality of life of women with breast cancer being treated with hormone therapy: A scoping review. (Pubmed Central) -  Jun 19, 2023   
    We believe that trastuzumab, leuprorelin, letrozole, and palbociclib is a feasible and effective treatment for HER2-positive and HR-positive metastatic breast cancer in premenopausal patients who cannot tolerate first-line chemotherapy. In recent years there has been an increase in studies focused on health-related quality of life, and the evidence pointed to relevant information on health-related quality of life and the use of endocrine therapy, tamoxifen in combination with aromatase inhibitors, as well as aromatase inhibitor alone and the use of cyclin-dependent kinase 4 and 6.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Retrospective data, Journal, HEOR, Real-world evidence, Real-world, Metastases:  Real-world comparative effectiveness of palbociclib plus letrozole versus letrozole in older patients with metastatic breast cancer. (Pubmed Central) -  Jun 16, 2023   
    By upregulating the expression of PM20D1, quercitrin activated the PI3K/Akt signaling pathway, improved adipocyte catabolism, corrected reproductive and metabolic abnormalities, and had a therapeutic effect on PCOS-IR. This analysis demonstrates the effectiveness of palbociclib combination therapy as standard-of-care for older patients with HR+/HER2- MBC in the first-line setting.
  • ||||||||||  letrozole / Generic mfg., anastrozole / Generic mfg.
    Enrollment closed, Enrollment change, Trial primary completion date:  Anastrozole and Letrozole After Surgery for the Treatment of Stage I-III Breast Cancer (clinicaltrials.gov) -  Jun 15, 2023   
    P2,  N=161, Active, not recruiting, 
    Trial completion date: Sep 2023 --> Sep 2024 Recruiting --> Active, not recruiting | N=29 --> 161 | Trial primary completion date: Jun 2023 --> Jan 2024
  • ||||||||||  letrozole / Generic mfg., menotropin / Generic mfg.
    Journal:  Factors Influencing the Pregnancy Outcome of Intrauterine Insemination and Follow-up Treatment. (Pubmed Central) -  Jun 12, 2023   
    Furthermore, there were 240 couples who not pregnant received one or more cycles of in vitro fertilisation/intracytoplasmic sperm injection/ pre-implantation genetic technology treatment, and another 182 couples forgo follow-up treatment. The results of the present study demonstrate that the clinical IUI pregnancy rate is correlated with the factors of female AMH, EMT and OS protocol; more studies and samples are necessary to evaluate whether other factors affect pregnancy rate.
  • ||||||||||  hydrocortisone / Generic mfg., flutamide / Generic mfg.
    Trial primary completion date, Combination therapy:  Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia (clinicaltrials.gov) -  Jun 12, 2023   
    P4,  N=62, Active, not recruiting, 
    The results of the present study demonstrate that the clinical IUI pregnancy rate is correlated with the factors of female AMH, EMT and OS protocol; more studies and samples are necessary to evaluate whether other factors affect pregnancy rate. Trial primary completion date: Jun 2022 --> Dec 2024
  • ||||||||||  letrozole / Generic mfg.
    Trial completion date, Trial primary completion date:  Evaluation of IM Letrozole ISM (clinicaltrials.gov) -  Jun 7, 2023   
    P1,  N=120, Active, not recruiting, 
    pathway and improving intestinal barrier function to act as a cure for PCOS. Trial completion date: Mar 2023 --> Sep 2023 | Trial primary completion date: Mar 2023 --> Sep 2023
  • ||||||||||  hydrocortisone / Generic mfg., flutamide / Generic mfg.
    Phase classification, Trial completion date, Trial primary completion date, Combination therapy:  Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia (clinicaltrials.gov) -  Jun 5, 2023   
    P4,  N=62, Active, not recruiting, 
    Our findings suggest that dalpiciclib plus letrozole or anastrozole could be a novel standard first-line treatment for patients with hormone receptor-positive, HER2-negative advanced breast cancer, and is an alternative option to the current treatment landscape. Phase classification: P2 --> P4 | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Jun 2022