- |||||||||| Invanz (ertapenem) / Merck (MSD)
A Rare Case of Recurrent Pylephlebitis Secondary to Diverticulitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3001;
She was discharged on oral ciprofloxacin and metronidazole...Treatment consisted of 3 months of apixaban therapy and 4 weeks of parenteral ertapenem...Patient was transitioned to a 1-week oral amoxicillin/clavulanate antibiotic therapy and continued her lifetime apixaban therapy...In the absence of underlying liver disease or more recent infections, we speculate that the patient
- |||||||||| amoxycillin/clavulanate / Generic mfg.
Find That Bleed! A Case of Hemobilia Due to Cystic Artery Pseudoaneurysm in a Patient With Persistent Melena (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2563;
He was hospitalized one-week prior due to a similar episode at which point he was found to have a dieulafoy lesion in the transverse colon and CT angiography incidentally revealing cholecystitis, which was managed conservatively with amoxicillin/clavulanate for 7 days...Thus, it is important to have a high index of suspicion and include visceral artery aneurysms in the differential for patients presenting with GI bleeding. Figure: Laparoscopic view of the bleeding cystic artery and the gallbladder wall.
- |||||||||| Tasigna (nilotinib) / Novartis, Inhibikase
A Rare Case of Infectious Esophagitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2347;
Of note, he recently underwent a bilateral iliofemoral thrombendarteriectomy with stent placement for critical limb ischemia and was subsequently placed on apixaban...He was treated with amoxicillin-clavulanate for 14 days with plans for endoscopic surveillance in 8 weeks...In conclusion, bacterial esophagitis is a rare but important consideration in immunocompromised patients with infectious esophagitis. Figure: Mid-esophageal ulcer and esophagitis
- |||||||||| A Perforated Appendix Masquerading as Crohn (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2160;
He was discharged on a course of amoxicillin-clavulanate, and the abscess drain was removed after two weeks...Unique to this case, symptoms were prolonged over a two-week period, appendix was normal on initial CT scan, and TI inflammation with fistulizing abscess formation. Although, complicated appendicitis rarely presents as terminal ileitis with fistulizing abscess formation, it should be included in the differential diagnosis of such a presentation, as prompt recognition would improve patient care, decrease further complications, and decrease patient stress of being misdiagnosed with CD.
- |||||||||| Fetus and Maternal Outcomes in Primary Sclerosing Cholangitis With Choledocholithiasis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2021;
ERCP is safest if performed in the second trimester with intraprocedural fetal heart rate monitoring. Additionally, fluoroscopy time should be minimized as able to decrease radiation exposure to the fetus, and caution should be taken when using indomethacin for post-ERCP pancreatitis prophylaxis.
- |||||||||| Perforation After Radiation: HCC in the Gallbladder (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_1582;
Leukocytosis resolved and he was discharged with amoxicillin-clavulanate to complete 14 days of antibiotics...To our knowledge, this is the first known case in which a patient presented with HCC perforation through the gallbladder shortly after initiation of radiation therapy. Figure: An 8.2 cm mass extending into the gall bladder fossa with a defect in the enhancing wall of the tumor indicating rupture into the gall bladder lumen.
- |||||||||| Beyond the Yellow Haze: Navigating Gilbert Syndrome and Hepatitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_1579;
Amoxicillin-clavulanate is a common cause of drug-induced liver injury (DILI), along with other medications such as chlorpromazine, macrolides, tetracyclines, and antiepileptics...EBV can cause self-limiting hepatitis in immunocompetent individuals, while CMV is typically associated with hepatitis in immunocompromised individuals and rarely affects immunocompetent individuals. Although hepatitis in individuals with Gilbert syndrome may present with more significant hyperbilirubinemia, the overall course and prognosis of the condition are similar to those without Gilbert syndrome.
- |||||||||| A Unique Case of Spyglass Cholangioscopy-Associated Bacteremia (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_1344;
She started on IV Vancomycin 1g daily and IV ampicillin-sulbactam 3g every six hours based on culture results and sensitivities...She was discharged on oral amoxicillin-clavulanic acid 875-25mg for ten days...Since bacteremia is a significant complication of this procedure, future studies can be performed to analyze outcomes of bacterial translocation in patients treated with antibiotics either before or after this procedure. Thus, our case demonstrates the importance of further research into approaches to mitigate the associated risk of bacteremia following spyglass cholangioscopy.
- |||||||||| Incidental Finding of an Appendiceal Abscess on Screening Colonoscopy (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_707;
She denied tobacco or alcohol use, and her only medications were vitamin D and trazodone for sleep...The patient was started on a 10-day course of amoxicillin-clavulanate and referred to a surgeon...In addition to an abscess, the differential diagnosis of a mucinous appendiceal lesion includes simple mucoceles, serrated polyps, low-grade or high-grade appendiceal mucinous neoplasms, and mucinous adenocarcinomas; thus, surgical resection of any localized appendiceal mucinous lesion is recommended to rule out a potentially malignant lesion. Figure: A protruding appendiceal lesion with white pus noted on colonoscopy exam.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Journal: Bifidobacterium breve PRL2020: Antibiotic-Resistant Profile and Genomic Detection of Antibiotic Resistance Determinants. (Pubmed Central) - Jul 29, 2023
Recently, a strain of B. breve (PRL2020) has shown to be resistant to amoxicillin and amoxicillin-clavulanate (AC) by applying the microdilution protocol according EFSA guidelines...The results of our tests demonstrated that the strain PRL2020 is indeed endowed with amoxicillin- and AC-resistant properties and that it is also insensitive to ampicillin...The similarity among the AR determinants found was studied through nucleotide sequence alignment, and it was possible to verify not only the absence of genes explaining these features in the flanking regions but also the presence of genetic sequences (rpoB and erm(X)) putatively responsible for rifampicin and erythromycin resistance...Analysis of the flanking regions of these genes revealed possible mobile elements upstream and downstream only in the case of the erm(X) gene, but the features of the Insertion Sequences (IS) are described as not to cause horizontal transfer. Our findings on strain PRL2020 demonstrate that its AR profile is compatible with antibiotics when taken with the aim of reducing the risk of dysbiosis.
- |||||||||| amoxycillin/clavulanate / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Antibacterial and Antibiofilm Effects of Different Samples of Five Commercially Available Essential Oils. (Pubmed Central) - Jul 29, 2023
Peppermint and Clove oils recorded the most significant differences regarding chemical composition and antibacterial/antibiofilm activities. All registered differences could be due to different places for harvesting the raw plant material, various technological processes through which these essential oils were obtained, the preservation conditions, and complex interactions between constituents.
- |||||||||| vancomycin / Generic mfg., nystatin oral / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Antibiotic Treatment causes Depletion of Gut Microbiome and induces adaptive immunological Response in murine TBI (South: Hall F) - Jul 20, 2023 - Abstract #ASA2023ASA_694;
Intestinal expression of tight junction markers is altered and adaptive immune system in circulating blood cells is induced. Signs of reduced perilesional astrogliosis after TBI and antibiotic treatment might indicate potential neuroprotective effects, which require further investigations.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: Application of new indicators to assess the quality of antimicrobial use in Intensive Care Units. (Pubmed Central) - Jul 18, 2023
The use of these novel indicators provides additional information to the current analysis of DDD. Its implementation is feasible and has led to the detection of patterns that agree with local guidelines and cumulative antibiogram reports and foster targeted improvement actions within antimicrobial stewardship programs.
- |||||||||| amoxycillin/clavulanate / Generic mfg.
Journal: Diagnostic low-dose X-ray radiation induces fluoroquinolone resistance in pathogenic bacteria. (Pubmed Central) - Jul 12, 2023
Furthermore, a significant decrease in the inhibition zone was detected for amoxicillin and amoxicillin/clavulanic acid (AMC)...Specifically, low-dose X-rays made Staphylococcus aureus resistant to marbofloxacin and increased its resistance to penicillin. Similarly, Salmonella Enteritidis became resistant to both marbofloxacin and enrofloxacin, and showed reduced sensitivity to amoxicillin and AMC.
- |||||||||| cefuroxime / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: Less Is More: When to Repeat Antimicrobial Susceptibility Testing. (Pubmed Central) - Jul 12, 2023
This approach saves money, time, and will reduce laboratory waste. Further studies are needed to determine whether these savings are in balance with the small possibility of treating patients with inadequate antibiotics.
- |||||||||| Journal: A national study confirms that Escherichia coli from Australian commercial layer hens remain susceptible to critically important antimicrobials. (Pubmed Central) - Jul 11, 2023
Resistance was observed for amoxicillin-clavulanate (9.1%), ampicillin (16.2%), ciprofloxacin (2.7%), florfenicol (2.4%), gentamicin (1.0%), streptomycin (4.7%), tetracycline (37.8%) and trimethoprim/sulfamethoxazole (9.5%)...Two MCR E. coli isolates with ciprofloxacin-resistance were found to be carrying known resistance genes including aadA1, dfrA1, strA, strB, sul1, sul2, tet(A), blaTEM-1B, qnrS1 and tet(A). Overall, this study found that E. coli from layer hens in Australia have low rates of AMR, likely due to strict control on antimicrobial usage achieved by the sum of regulation and voluntary measures.
- |||||||||| Preclinical, Journal: Effects of Repeated in-vitro Exposure to Saudi Honey on Bacterial Resistance to Antibiotics and Biofilm Formation. (Pubmed Central) - Jul 10, 2023
The data highlight the positive impact of prolonged in-vitro exposure to Saudi honey (Sumra and Sider) for wound-associated bacteria since they displayed a significant increase in their sensitivity profiles to the tested antibiotic and a reduction in their ability to form biofilm. The increased bacterial sensitivity to antibiotics and a limited tendency toward biofilm formation would suggest the great potential therapeutic use of this Saudi honey (Sumra and Sidr) to treat wound infections.
- |||||||||| Silverzine Tulle (Silver Sulfadiazine) / MinaPharm
Single Monkeypox Lesion In An Immunocompetent Young Man () - Jul 3, 2023 - Abstract #WCD2023WCD_7599;
KEY MESSAGE: A clinical presentation of Monkeypox in an immunocompetent young man. Important to highlight this clinical record and assist in clinical and epidemiological diagnosis.
- |||||||||| Dermatitis Artefacta: A Rare And Challenging Dermatosis () - Jul 3, 2023 - Abstract #WCD2023WCD_6966;
Three weeks prior to our visit, she has been on Acyclovir, Prednisolone, Clindamycin, Amoxicillin and Clavulanic acid and Mupirocin ointment...She was treated with normal saline for dressing, amitriptyline and cognitive behavioral therapy was given...She did not admit responsibility for the creation of the lesions hence making management more difficult. The management of this patient required a detailed Dermatologic and Psychiatric assessment
- |||||||||| Edematous Stria Distensae Secondary to Infection () - Jul 3, 2023 - Abstract #WCD2023WCD_5457;
Our patient did not have any of these disorders apart from local skin infection over her abdomen. To our knowledge, this is the first reported case of edematous SD secondary to localised skin infection.
- |||||||||| amoxycillin/clavulanate / Generic mfg.
Sweet Syndrome Induced By Amoxicillin-Clavulanate () - Jul 3, 2023 - Abstract #WCD2023WCD_5281;
One case of histiocytoid SS has been reported induced by Levofloxacin and AC. A case of SS have been reported associated with upper respiratory infection and amoxicillin use but no case of SS have been reported induced by AC.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Extremely Severe Atopic Dermatitis In Patient Affected By Hyper-Ige Syndrome Immediately Responsive To Dupilumab () - Jul 3, 2023 - Abstract #WCD2023WCD_3856;
She also underwent a therapy with topical clobetasol and systemic cetirizine without benefit...Laboratory test showed a stability of IgE and eosinophils (IgE 54391, 1400 eosinophils/?l). KEY MESSAGE: Dupilumab treatment is effective not only in a very rapid improvement of AD lesions, itch and quality of life in patients affected by H-IgE-S, but it could be also helpful in resolving skin abscesses which are typical of this condition.
- |||||||||| Journal: Community-Acquired Methicillin-Resistant Staphylococcus aureus in Hospitals: Age-Specificity and Potential Zoonotic-Zooanthroponotic Transmission Dynamics. (Pubmed Central) - Jun 28, 2023
Antibiograms showed high beta lactam resistances, including amoxicillin-clavulanate (83%), oxacillin (84%), cefoxitin FOX (100%), penicillin and ampicillin (~100%), as well as high resistance (82%) to carbapenem...A similar pattern was seen in MCH except for a low resistance pattern to gentamicin CN, clindamycin CD, erythromycin E, and tobramycin TOB; 34%, 31%, 39%, and 41%, respectively, except for fusidic acid...Clinical- and lineage-profiles imply host-selection and zoonotic-zooanthroponotic transmission dynamics. Future molecular typing, sequencing, and characterization of dominant clone(s) is imperative.
- |||||||||| Journal: Whole Genome Sequencing and Phenotypic Analysis of Antibiotic Resistance in Filifactor alocis Isolates. (Pubmed Central) - Jun 28, 2023
The genetic surroundings of the detected genes suggested their inclusion in mobile genetic elements that might be transferrable to other bacteria. These findings suggest that, despite showing high susceptibility to several antibiotics, F. alocis might obtain new antimicrobial resistance traits due to its acceptance of mobile genetic elements with antibiotic resistance genes in their genome.
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