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42 Trials |
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42 Trials |  |
2742 News |  |
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- || Review, Journal: Antimicrobial treatment of skin and soft tissue infections. (Pubmed Central) - Dec 5, 2023
The bacterial species most frequently implicated in children are Staphylococcus aureus and Streptococcus pyogenes. Given the low incidence of methicillin-resistant S. aureus in France (<10%), the first-line antibiotic treatment is amoxicillin-clavulanate, to which an anti-toxin treatment such as clindamycin may be added for patients with overt toxin signs.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Trends in penicillin dispensing during an acute rheumatic fever prevention programme. (Pubmed Central) - Dec 4, 2023
Given the low incidence of methicillin-resistant S. aureus in France (<10%), the first-line antibiotic treatment is amoxicillin-clavulanate, to which an anti-toxin treatment such as clindamycin may be added for patients with overt toxin signs. During the RFPP an increase in amoxicillin dispensing was seen in regions participating in the programme and regions outside of the programme, indicating the programmatic approach led to improved adherence to recommended first-line antibiotics.
- | fosfomycin tromethamine / Generic mfg.
Journal: Occurrence of plasmid-mediated fosfomycin resistance (fos genes) among Escherichia coli isolates, Portugal. (Pubmed Central) - Dec 4, 2023
The prevalence of fosfomycin-resistant E. coli isolates is still low in Portugal. Notably, 15% of fosfomycin-resistant isolates harbour a transferable fosA gene, among which there is a high rate of ESBL producers, turning traditional empirical therapeutical options used in Portugal (fosfomycin and amoxicillin-clavulanic acid) ineffective.
- | Journal: Frequency of Urinary Tract Infection Among Patients Undergoing Implant Fixation for Acute Trauma. (Pubmed Central) - Dec 4, 2023
Urinary tract infection is common in patients undergoing orthopedic implant fixation for hip fractures, which can lead to potentially serious outcomes. Overall, hygiene, prompt treatment, and standard protocol should be utilized to treat those infected and minimize the spread.
- | Journal: Antibiogram of uropathogens and associated risk factors among asymptomatic female college students in Dessie town, Northeast Ethiopia. (Pubmed Central) - Dec 3, 2023
A significant prevalence of uropathogens, and high resistance of bacterial isolates to the commonly prescribed drugs were detected. Therefore, routine UTI screening, regular health education on the risk of asymptomatic infectious diseases for reproductive age group females, and antimicrobial susceptibility testing should be practiced to avoid the progression of an asymptomatic infection into a symptomatic UTI.
- | Trial completion date, Trial primary completion date: Early Antibiotics After Aspiration in ICU Patients (clinicaltrials.gov) - Nov 30, 2023
P4, N=100, Recruiting, Sponsor: UConn Health
Therefore, routine UTI screening, regular health education on the risk of asymptomatic infectious diseases for reproductive age group females, and antimicrobial susceptibility testing should be practiced to avoid the progression of an asymptomatic infection into a symptomatic UTI. Trial completion date: Apr 2023 --> Dec 2024 | Trial primary completion date: Apr 2023 --> Dec 2024
- | cisplatin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: What if amoxicillin/clavulanic acid reduces the cisplatin anticancer impact on oral cancer treatment? (Pubmed Central) - Nov 28, 2023
Due to amx/cla-cisp combination on both cells but significantly on SCC-15 recovered the sole cisplatin effect, we believe that there might be a second thought when prescribing antibiotics while treating cancer patients. Not only the antibiotic's type but also the cancer type might interact to lessen the chemotherapeutic agent's impact which is clinically a dilemma to focus on.
- | Journal: BACTERIAL PROFILE, ANTIMICROBIAL RESISTANCE, AND FACTORS ASSOCIATED WITH URINARY TRACT INFECTION AMONG PREGNANT WOMEN AT HOSANNA TOWN HEALTH FACILITIES, CENTRAL ETHIOPIA. (Pubmed Central) - Nov 27, 2023
The gram-positive bacteria were susceptible to gentamicin (86.4%), erythromycin (81.8%), and nitrofurantoin (77.3%): whereas they showed a high level of resistance to penicillin (72.7%), doxycycline (54.5%), trimethoprim-sulfamethoxazole (52.9%), and cefoxitin (52.9%)...Therefore, regularly, culture-based bacterial identification and antibiotic susceptibility testing should be performed. Alternatively, empiric antibiotic therapy should consider the prevalence of antibiotic-resistant uropathogens and the factor that may increase the urinary tract infection occurrence due to multi-drug resistant uropathogens.
- | ampicillin / Generic mfg., tetracycline / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: Prevalence and characterization of antimicrobial-resistant Escherichia coli isolated from veterinary staff, pets, and pet owners in Thailand. (Pubmed Central) - Nov 27, 2023
This implies that these sources of E. coli could potentially be reservoirs for antibiotic resistance, thereby increasing the risk of harm to both humans and animals. These findings highlight the importance of implementing effective AMR control measures in veterinary practices, as bacteria resistant to commonly used antimicrobials are present in humans and animals.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Multidrug antibiotic resistance in hospital wastewater as a reflection of antibiotic prescription and infection cases. (Pubmed Central) - Nov 27, 2023
These findings highlight the importance of implementing effective AMR control measures in veterinary practices, as bacteria resistant to commonly used antimicrobials are present in humans and animals. The antimicrobial sensitivity testing (AST) showed that 57.6
- | Journal: Antibiotics resistance as a major public health concern: A pharmaco-epidemiological study to evaluate prevalence and antibiotics susceptibility-resistance pattern of bacterial isolates from multiple teaching hospitals. (Pubmed Central) - Nov 27, 2023
Previous studies reported the high prevalence of E. coli and S. aureus in clinical samples of Pakistani hospitals including hospitals in Peshawar and thus our findings are in agreement with the previous reports. Pharmacists being experts can play their role by promoting the optimal use of antimicrobial agents and educating healthcare professionals, patients and the public.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Dynamics of Pediatric Antibiotic Use Differ between High- and Low-Prescribing Clinics After Pneumococcal Conjugate Vaccines. (Pubmed Central) - Nov 27, 2023
PCVs are a powerful tool in reducing outpatient antibiotic consumption among young children, especially in HPC, resulting in partial closure of DAPR gap between HPC and LPC. The higher impact on HPC suggests that PCV-associated declines of respiratory disease may strongly contribute to a judicious antibiotic approach in clinics with high antibiotic consumption.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Fever and Challenging Cutaneous Mimicked-Urticaria Reaction to Amoxicillin-Clavulanate in two Children. (Pubmed Central) - Nov 27, 2023
The higher impact on HPC suggests that PCV-associated declines of respiratory disease may strongly contribute to a judicious antibiotic approach in clinics with high antibiotic consumption. No abstract available
- || Review, Journal: The Impact of Antibiotics and Steroids on the Nasal Microbiome in Patients with Chronic Rhinosinusitis: A Systematic Review According to PICO Criteria. (Pubmed Central) - Nov 25, 2023
The impact that therapies can have on the nasal microbiome of CRS patients is very varied. Further studies are needed to understand the role of the nasal microbiome, prevent CRS, and improve therapeutic tools for personalized medicine tailored to the individual patient.
- | Journal: Genome Analysis of Klebsiella pneumoniae Reveals International High-Risk Pandemic MDR Clones Emerging in Tertiary Healthcare Settings in Uganda. (Pubmed Central) - Nov 25, 2023
There was high resistance to piperacillin (90.91%), cefuroxime (86.96%), ceftazidime (84.62%), cefotaxime (84.00%), amoxicillin/clavulanate (75%), nalidixic acid (73.68%), and nitrofurantoin (71.43%) antibiotics among K. pneumoniae isolates...Chromosomal fosA (for fosfomycin) and oqxAB efflux pump genes were detected in all isolates...Our study demonstrated genetically diverse populations of K. pneumoniae, low levels of carbapenem resistance among the isolates, and no convergence of MDR and hypervirulence. Emerging high-risk international pandemic clones (ST11, ST14, ST147, ST 86 and ST307) were detected in these healthcare settings which are difficult to treat.
- | Retrospective data, Journal: Invasive and Non-Invasive Human Salmonellosis Cases Admitted between 2015 and 2021 in Four Suburban Hospitals in the Metropolitan Area of Milan (Italy): A Multi-Center Retrospective Study. (Pubmed Central) - Nov 25, 2023
Resistance was, in general, less common in the O:9 serogroup, while amikacin resistance was significantly more common...In conclusion, our study highlights a high burden of NTS infections, leading to severe or fatal outcomes in frail patients. Furthermore, AMR shows an increasing trend with a concerning high prevalence of cephalosporine resistance compared to the rest of Europe.
- || Review, Journal: Actinobacillus ureae may be a critical pathogen in patients with predispositions: A case report and review of the literature. (Pubmed Central) - Nov 25, 2023
Currently, A. ureae may be susceptible to penicillin, ampicillin, and third-generation cephalosporins. Other antibacterial agents, such as tetracycline, amoxicillin/clavulanic acid, and aminoglycosides also respond well and can be a choice in the treatment of A. ureae infections.
- || amoxycillin/clavulanate / Generic mfg.
Review, Journal: Dog and Cat Bites: Rapid Evidence Review. (Pubmed Central) - Nov 24, 2023
Antibiotic prophylaxis, with amoxicillin/clavulanate as the first-line choice, should be considered for all bites, particularly for those at increased risk of infection...Primary closure of bite wounds may be performed if there is low risk of infection. The need for tetanus vaccination and rabies postexposure prophylaxis should be evaluated for each patient; bites that do not break the skin generally do not require rabies postexposure prophylaxis.
- | Journal: Assessing the colony morphotypes and antibiotic susceptibility profile of Malaysian clinical Burkholderia pseudomallei to support the use of EUCAST disk diffusion breakpoints to determine antibiotic resistance. (Pubmed Central) - Nov 24, 2023
EUCAST DD interpretative criterion is suitable to interpret B. pseudomallei CAZ, MEM, AMC and DOX resistance. Increasing AMC MIC in B. pseudomallei is a concern.
- | Journal: Focusing on Gordonia Infections: Distribution, Antimicrobial Susceptibilities and Phylogeny. (Pubmed Central) - Nov 24, 2023
sputi and G. bronchialis stand out as the prevalent species causing infections in Spain. Resistance against cefoxitin and other antimicrobials should be considered.
- | Retrospective data, Journal: Antimicrobial susceptibility testing of anaerobic bacteria causing bacteremia: A 13-year (2010-2022) retrospective study in a tertiary hospital. (Pubmed Central) - Nov 21, 2023
showed low susceptibility to penicillin (20?%), amoxicillin (20?%), and clindamycin (40?%). The study contributes valuable data for monitoring and improving anaerobic bacteremia treatment.
- | Journal: Salmonella enterica serotypes isolated for the first time in laying hens, and their susceptibility to antibiotics. (Pubmed Central) - Nov 19, 2023
A total of 56 Salmonella isolates were tested for susceptibility to amoxicillin-clavulanic acid, cefepime, azithromycin, cefoxitin, and trimethoprim/sulfamethoxazole by the disk diffusion method. While 10% of
- | Journal: Molecular epidemiological investigation of carbapenem resistant Klebsiella pneumoniae isolated from intensive care unit patients of six geographical regions of Turkey. (Pubmed Central) - Nov 17, 2023
In Turkey, a polyclonal population of CC14 throughout the country and inter-hospital spread were indicated. The use of molecular typing tools will highlight understanding the transmission dynamics.
- | Journal: Prevalence and characterization of quinolone-resistant Escherichia coli isolated from retail raw beef and poultry meat in Egypt. (Pubmed Central) - Nov 16, 2023
The high prevalence of antimicrobial-resistant E. coli, with concern for QR strains harboring different resistance mechanisms in poultry meat and beef, threatens the public's health. Thus, standard manufacturing procedures and adequate hygiene conditions must be followed in all phases of meat preparation, production, and consumption, and public knowledge should be improved.
- | Journal: Gut acquisition of Extended-spectrum ?-lactamases-producing Klebsiella pneumoniae in preterm neonates: Critical role of enteral feeding, and endotracheal tubes in the neonatal intensive care unit (NICU). (Pubmed Central) - Nov 11, 2023
Our finding supposes that the enteral feeding tube and endotracheal tube might have a critical role in colonizing the intestinal tract of preterm infants. This highlights the current status of both practices that will require updated procedures in the NICU.
- | Journal: Genotyping and antibiotic susceptibility of Campylobacter species isolated from raw milk samples in Qazvin, Iran. (Pubmed Central) - Nov 11, 2023
These findings underscore the role of raw milk as a reservoir for Campylobacter spp. and highlight the substantial antibiotic resistance and genetic diversity within the species population.
- | Journal: Association between use of fluoroquinolones and risk of mitral or aortic valve regurgitation: a nationwide cohort study. (Pubmed Central) - Nov 6, 2023
Results were similar when fluoroquinolones were compared to extended-spectrum cephalosporins (HRs of 0.96 [95% CI, 0.82-1.12], 1.05 [95% CI, 0.86-1.28], and 0.88 [95% CI, 0.75-1.03], respectively). This large-scale cohort study did not find a higher risk of MR/AR with different types of fluoroquinolones in adult population.
- | ampicillin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: Evaluation of antibiotic resistance, toxin-antitoxin systems, virulence factors, biofilm-forming strength and genetic linkage of Escherichia coli strains isolated from bloodstream infections of leukemia patients. (Pubmed Central) - Nov 5, 2023
Our results demonstrate that highly diverse, resistant and pathogenic E. coli clones are circulating among leukemia patients in Iranian hospitals. More attention should be paid to the treatment and management of E. coli bloodstream infections in patients with leukemia.
- | ampicillin / Generic mfg., tetracycline / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: Virulence genotype and phenotype of two clinical isolates of Arcobacter butzleri obtained from patients with different pathologies. (Pubmed Central) - Nov 5, 2023
Motility and urease tests confirmed the genetic differences between strains, but no genetic marker related to the inability of HC-2 to adhere and invade was identified. This inability could be conditioning the patient's pathology.
- | rafamin (MMH-407) / Materia Medica
Preclinical, Journal: Efficacy of Raphamin against Pneumococcal Infection: a Preclinical Study. (Pubmed Central) - Nov 3, 2023
Raphamin monotherapy significantly decreased bacterial load in the lungs in comparison with placebo (p<0.05) which was comparable to the effect in antibiotic alone or combined with Raphamin. Raphamin prevented reproduction of Streptococcus pneumoniae in the lower respiratory tract and its combination with the antibiotic was safe and did not reduce the efficacy of amoxicillin/clavulanic acid.
- | Preclinical, Journal: In Vitro antibiotic combinations of Colistin, Meropenem, Amikacin, and Amoxicillin/clavulanate against multidrug-resistant Klebsiella pneumonia isolated from patients with ventilator-associated pneumonia. (Pubmed Central) - Nov 3, 2023
Raphamin prevented reproduction of Streptococcus pneumoniae in the lower respiratory tract and its combination with the antibiotic was safe and did not reduce the efficacy of amoxicillin/clavulanic acid. The results revealed that combinations of amoxicillin/clavulanate with colistin, meropenem, or amikacin in the planktonic mode and colistin with amoxicillin/clavulanate, meropenem, or amikacin in the biofilm mode could effectively inhibit CRKP isolates, and thus could be further explored for the treatment of CRKPs.
- Optimizing Immunoglobulin Replacement Therapy for Patients with B-Cell Malignancies and Hypogammaglobulinemia: The Investigator-Initiated, International, Randomized Phase II/III Rational Pla... (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_1694;
The results revealed that combinations of amoxicillin/clavulanate with colistin, meropenem, or amikacin in the planktonic mode and colistin with amoxicillin/clavulanate, meropenem, or amikacin in the biofilm mode could effectively inhibit CRKP isolates, and thus could be further explored for the treatment of CRKPs. In the RATIONALISE (
- | Journal: Pasteurella multocida Pneumonia with Hemoptysis in an Immunocompetent Case (Pubmed Central) - Oct 31, 2023
Although Pasteurella multocida pneumonia is not commonly observed, the presence of underlying bronchiectasis in this patient facilitated the establishment of the bacteria. In order not to miss the diagnosis of pneumonia due to P.multocida, microbiological evaluation and molecular typing should be performed in the samples taken from the respiratory tract in patients with chronic respiratory diseases such as bronchiectasis.
- | Journal: Investigation of Virulence Factors, Phylogenetic Group Features, and the Presence of ST131 Clone in Escherichia coli Isolates, a Urinary Tract Infection Agent in Children (Pubmed Central) - Oct 31, 2023
In recurrent UTI agents, resistance rates were higher for cefotaxime (n= 29, 29%), trimethoprim-sulfamethoxazole (n= 35, 35%) and cefepime (n= 25, 25%) and in O25b/ST131 isolates (n= 67) the rates were higher for amikacin (n= 3, 4.5%), gentamicin (n= 10, 14.9%) and ciprofloxacin (n= 17, 25.4%) when compared to the first UTI agents and non-O25b/ ST131 isolates (p< 0.05)...Thirty-three isolates belonging to 15 patients were evaluated with PFGE, and it was observed that the latter isolate and the first isolate of eight patients (53%) had the same band profile. Focusing on surveillance, diagnostic testing, treatment algorithms, and preventive measures for E.coli and especially for ST131 clone, which is frequently observed as causative agent in childhood UTIs, will help to manage challenging E.coli infections.
- | Journal: Trends in antimicrobial resistance of Shigella species in Peru, 2011-2020. (Pubmed Central) - Oct 30, 2023
sonnei was the most frequent species, which have a large proportion of strains resistant to trimethoprim/sulfamethoxazole, and a growing trend of resistance to ciprofloxacin and nalidixic acid. This increase in resistance to commonly used antibiotics in treatments is alarming, threatening the control and management of these currently treatable infections.
- | Journal, Nontuberculous mycobacteria: Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential. (Pubmed Central) - Oct 28, 2023
All tested isolates were susceptible to amikacin and moxifloxacin...No significant resistance differences between domestic and wild animals were found. The established significant frequency of resistance highlights the significant zoonotic potential posed by circulating rapidly growing NTM strains, which could lead to challenges in the treatment of these infections.
- | Journal: Antimicrobial Resistance of Actinobacillus pleuropneumoniae, Streptococcus suis, and Pasteurella multocida Isolated from Romanian Swine Farms. (Pubmed Central) - Oct 28, 2023
For S. suis, the highest rates of resistance were observed for streptomycin (98%), tetracycline (75%), oxytetracycline (72%), doxycycline (52%), and erythromycin (51%)...Bacteria isolates maintained high susceptibility against antimicrobial agents usually used against the mainly respiratory tract pathogens of swine. Resistance for streptomycin, tetracycline, oxytetracycline, and tilmicosin was high for all the tested pathogens.
- | Journal: Antimicrobial Susceptibility of Commensal E. coli Isolated from Wild Birds in Umbria (Central Italy). (Pubmed Central) - Oct 27, 2023
The highest prevalence of resistance was observed for ampicillin (85%) and amoxicillin/clavulanic acid (47%), probably due to their extensive use in human and veterinary medicine...Resistance to ciprofloxacin, cefotaxime and ceftazidime exhibited values of 18%, 17% and 15%, respectively...was not isolated. Resistance to third-generation cephalosporins, also detected in long-distance migratory birds, suggests the need for monitoring studies to define the role of wild birds in antimicrobial resistance circuits.
- | Journal: Molecular Characterisation of Antimicrobial Resistance in E. coli Isolates from Piglets in the West Region of Romania. (Pubmed Central) - Oct 27, 2023
The result of phenotypic antibiotic resistance testing may indicate the presence of plasmid-borne resistance, with a diagnostic odds ratio of a positive phenotypic resistance for tetK being 4.52. As a management decision, the maximum penetrance admitted for using a specific antibiotic for E. coli infections in pigs is recommended to be less than 20%.
- ||||| sulopenem (CP-70429) / Iterum
Enrollment closed, Trial completion date, Trial primary completion date: REASSURE: Oral Sulopenem Versus Amoxicillin/Clavulanate for Uncomplicated Urinary Tract Infection in Adult Women (clinicaltrials.gov) - Oct 27, 2023
P3, N=2229, Active, not recruiting, Sponsor: Iterum Therapeutics, International Limited
As a management decision, the maximum penetrance admitted for using a specific antibiotic for E. coli infections in pigs is recommended to be less than 20%. Recruiting --> Active, not recruiting | Trial completion date: Mar 2024 --> Nov 2023 | Trial primary completion date: Mar 2024 --> Nov 2023
- | Invanz (ertapenem) / Merck (MSD)
Journal: Transrenal Mycobacterium tuberculosis DNA in pulmonary tuberculosis patients during the first 14 days of treatment. (Pubmed Central) - Oct 26, 2023
We found that the method tested was able to detect bacterial killing by active antibiotics that disrupt the cell wall and lead to fragmentation of bacteria. However, the assay can't detect inactive bacteria or bacteria that are active with an intact cell wall.
- | Journal: Helicobacter cinaedi Infection Presenting with Myalgia and Cellulitis. (Pubmed Central) - Oct 24, 2023
We suspected pyomyositis and cellulitis and started oral administration of amoxicillin-clavulanate...On day 24, antibiotic therapy was changed to intravenous ampicillin, and symptoms improved...Myalgia can be caused by pyogenic myositis because of bacteremia. In cases of myalgia or cellulitis of unknown etiology, blood cultures can be useful when bacteremia is suspected; blood samples should be monitored over an extended period.
- | NN1213 / Novo Nordisk
Enrollment closed, Trial completion date, Trial primary completion date: APAC: Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children (clinicaltrials.gov) - Oct 23, 2023
P4, N=302, Active, not recruiting, Sponsor: Ramon Gorter
In cases of myalgia or cellulitis of unknown etiology, blood cultures can be useful when bacteremia is suspected; blood samples should be monitored over an extended period. Recruiting --> Active, not recruiting | Trial completion date: Jul 2024 --> Dec 2024 | Trial primary completion date: Jul 2024 --> Dec 2024
- | amoxycillin/clavulanate / Generic mfg.
Journal, Combination therapy: d,l-Methionine in combination with amoxicillin-clavulanic acid successfully dissolves spontaneously occurring infection-induced struvite urocystoliths in dogs: a pilot study. (Pubmed Central) - Oct 23, 2023
Infection-induced struvite urolithiasis is 1 of the 2 most common minerals occurring in canine uroliths. Results of this study supported the use of d,l-methionine and amoxicillin-clavulanic acid without changing diet for dissolution of infection-induced struvite urocystoliths in dogs.
- | Invanz (ertapenem) / Merck (MSD)
Journal: Prevalence and characterization of ESBL-producing Escherichia coli in healthy pregnant women and hospital environments in Benin: an approach based on Tricycle. (Pubmed Central) - Oct 22, 2023
However, most isolates remained susceptible to ertapenem, amoxicillin-clavulanate, and imipenem...The identification of prevalent ESBL-encoding genes contributes to understanding the genetic basis of ESBL resistance in the studied population. Further research is warranted to explore the mechanisms of transmission and potential interventions to mitigate the spread of ESBL-producing Enterobacterales.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Quality of amoxicillin/clavulanic acid oral formulations for intended veterinary use in the UK, Malaysia, Serbia and Thailand. (Pubmed Central) - Oct 22, 2023
Antimicrobial formulations of substandard quality have negative consequences for efficacy in patients and potentially promote antimicrobial resistance. There was evidence of substandard formulations in all countries, not only for amoxicillin but especially for clavulanate; this could compromise equitable access to acceptable quality essential veterinary medicines worldwide.
- | cefazolin / Generic mfg., tetracycline / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: Detection of Antimicrobial Resistance and Biofilm Production Among Staphylococcus pseudintermedius from Canine Skin Lesions. (Pubmed Central) - Oct 19, 2023
Resistance to penicillin, amoxicillin-clavulanic acid, and cefazolin were higher than other antimicrobials...Among tetracycline-resistant strains, the frequency of tetK and tetM determinants were 19 (90.47%) and 21 (100%), respectively...Furthermore, the presence of icaA/D genes was detected in 35 (100%) and 29 (82.85%) of S. pseudintermedius strains, respectively. The high rates of antimicrobial resistance and biofilm production ability among S. pseudintermedius isolates, emphasize the urgent need to use more effective infection control policies and guidelines for antimicrobial use.
- | levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date, Head-to-Head: Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis (clinicaltrials.gov) - Oct 19, 2023
P=N/A, N=100, Not yet recruiting, Sponsor: University of Louisville
The high rates of antimicrobial resistance and biofilm production ability among S. pseudintermedius isolates, emphasize the urgent need to use more effective infection control policies and guidelines for antimicrobial use. Trial completion date: Dec 2024 --> Dec 2025 | Initiation date: May 2023 --> Nov 2023 | Trial primary completion date: Jul 2024 --> Nov 2025
- | Journal: Colibacillosis in lambs and kids in Egypt: Prevalence, serogroups, antibiogram profile, virulence genes distribution and antimicrobial resistance genes. (Pubmed Central) - Oct 16, 2023
For tetracycline, we detected the tetA in all examined isolates. The wide spread of atypical E. coli strains among diarrheic lambs and kids with marked resistance to several antibiotics of interest and the detection of major resistance genes assess the potential risk of this pathogen to animal and public health.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Cryptic susceptibility to penicillin/?-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages. (Pubmed Central) - Oct 15, 2023
On the other hand, we also show that methicillin-resistant S. epidermidis is capable of developing increased resistance to amoxicillin/clavulanic acid during long-term in vitro exposure to these drugs. These findings suggest that penicillin/?-lactamase inhibitor combinations could be a promising therapeutic candidate for treatment of a high proportion of methicillin-resistant S. epidermidis infections, although the in vivo risk of resistance development needs to be further addressed before they can be incorporated into clinical trials.