amoxycillin/clavulanate / Generic mfg. 
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  • ||||||||||  Journal:  Therapies Used by Children With Primary Ciliary Dyskinesia: A Natural History Study. (Pubmed Central) -  Nov 22, 2024   
    Older participants and those with inner dynein arm/microtubular disorganization defects reported more therapies likely due to disease progression and more severe phenotypes, respectively. We report that a wide range of therapies are used in PCD without disease-specific studies defining benefits and risks.
  • ||||||||||  Clinical, Journal:  Multidrug resistance in urinary E. coli higher in males compared to females. (Pubmed Central) -  Nov 18, 2024   
    A higher proportion of MDR E. coli were noted in urine samples from males compared with females, possibly due to the increased likelihood of prior treatment for UTIs in men. Antimicrobial stewardship interventions could be targeted towards this cohort to address increasing rates of AMR.
  • ||||||||||  amoxycillin/clavulanate / Generic mfg.
    Journal:  Thyroid Abscess: A Very Rare Entity in Child. (Pubmed Central) -  Nov 15, 2024   
    The management was medical including intravenous antibiotic therapy based on amoxicillin-clavulanic acid and exploration by nasofibroscopy completed by hypopharyngoscopy showed a fistula of the piriform sinus. The treatment is based on surgery by cauterization of the sinus.
  • ||||||||||  Journal:  Stability of antibiotics for use in the testing of immediate drug allergy reactions. (Pubmed Central) -  Nov 15, 2024   
    The treatment is based on surgery by cauterization of the sinus. This study has generated practical stability information for clinicians, allowing 15 parenteral antibiotics from 7 different classes to be aseptically prepared in advance for use in the testing of drug allergy reactions.
  • ||||||||||  Journal:  PNEUMONIA-ASSOCIATED ACUTE GLOMERULONEPHRITIS IN A NIGERIAN ADOLESCENT. (Pubmed Central) -  Nov 14, 2024   
    Initial management focused on empyema drainage and antibiotic coverage using intravenous amoxicillin-clavulanate but response was marginal...He was subsequently treated with furosemide, amlodipine, and ciprofloxacin with complete resolution of the symptoms (except haematuria), and discharged on the 30 day...Children with pneumonia who develop features of impaired renal function should be investigated for AGN. This report highlights this rare and unusual association as a possibility in our setting; and also brought up the difficulties with diagnostic procedures in resource constrained settings like ours, especially in light of widespread antimicrobial resistance and rational antibiotics use.
  • ||||||||||  amoxycillin/clavulanate / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  REPAIR: Oral Antibiotics After Obstetric Perineal Tear (clinicaltrials.gov) -  Nov 7, 2024   
    P4,  N=442, Active, not recruiting, 
    Finally, the inability to explain all resistance using existing knowledge highlights the importance of new target gene discovery. Recruiting --> Active, not recruiting | Trial completion date: Mar 2025 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Jan 2024
  • ||||||||||  Journal:  Pathogenicity potential of enterococci isolated from a Veterinary Biological Isolation and Containment Unit. (Pubmed Central) -  Nov 5, 2024   
    Furthermore, in terms of pathogenicity, three isolates (8.8%) were classified as high threats and two (5.9%) as moderate threats. The degree of resistance, production of virulence factors and the percentage of isolates classified as moderate or high threat means that a constant vigilance of such strains in veterinary units, but also in clinics and hospitals in general, is an important tool in terms of infection prevention and consequent reduction of HAIs.
  • ||||||||||  amoxycillin/clavulanate / Generic mfg., ceftazidime / Generic mfg., gentamicin sulfate / Generic mfg.
    Journal:  Identification of Burkholderia cepacia Complex: Comparing Conventional, Automated, and Molecular Methods in a Tertiary Care Center. (Pubmed Central) -  Nov 4, 2024   
    These results are essential for guiding antibiotic therapy and improving clinical outcomes, thus contributing to precision medicine and antimicrobial stewardship efforts. Samples that grew non-lactose fermenting colonies on MacConkey agar, which were resistant to polymyxin B 300 (PB300) units, were further identified using conventional biochemicals, and lysine decarboxylase test, ornithine decarboxylase test, arginine dihydrolase test, ortho-nitrophenyl-?-galactoside (ONPG) test, urea hydrolysis, triple disc screening test (polymyxin B 300 units, amoxicillin-clavulanic acid 20/10 mcg (AMC20/10), and gentamicin 10 mcg (GEN10)),
  • ||||||||||  sulopenem etzadroxil/probenecid (CP-70429) / Iterum
    P3 data, Journal:  A phase 3 randomized trial of sulopenem vs. ertapenem in patients with complicated intraabdominal infections. (Pubmed Central) -  Nov 4, 2024   
    P3
    This finding should be interpreted in the context of country regulations, as endpoint timing, primary analysis population and noninferiority margin may vary regionally. Both IV and oral sulopenem were well-tolerated; the oral formulation allowed patients with resistant pathogens to step down from IV therapy.
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Early Antibiotics After Aspiration in ICU Patients (clinicaltrials.gov) -  Oct 31, 2024   
    P4,  N=5, Terminated, 
    Both IV and oral sulopenem were well-tolerated; the oral formulation allowed patients with resistant pathogens to step down from IV therapy. Trial completion date: Dec 2024 --> Apr 2024 | Recruiting --> Terminated | Trial primary completion date: Dec 2024 --> Apr 2024 | N=100 --> 5; Under-enrollment
  • ||||||||||  Journal:  Prevalence of Antimicrobial Resistant Escherichia coli from Sinking Creek in Northeast Tennessee. (Pubmed Central) -  Oct 26, 2024   
    Significant differences in resistance to ceftriaxone and amoxicillin/clavulanic acid were observed between sampling sites...The most frequent MDR patterns (6.8%) included three antibiotics: ceftriaxone, ciprofloxacin, and nitrofurantoin. The high prevalence of AR E. coli in Sinking Creek poses a significant public health risk, highlighting the need for ongoing surveillance and intervention strategies to prevent the spread of AR bacteria.
  • ||||||||||  ampicillin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
    Retrospective data, Journal:  Antimicrobial Use in Cats in a University Veterinary Hospital in Central Italy: A Retrospective Study. (Pubmed Central) -  Oct 25, 2024   
    These results suggest room for improvement, particularly in increasing the use of antimicrobial susceptibility testing to ensure more targeted antimicrobial therapy. Given the importance of antimicrobial resistance and the One Health approach, the study also highlights the need to consider the broader impact of antimicrobial use in animals, including the potential contribution to resistance in bacteria that affect both animal and human health.
  • ||||||||||  Retrospective data, Review, Journal:  Antimicrobial Resistance of Environmental V. cholerae Non-O1/O139 Isolates: Systematic Review and Meta-analysis. (Pubmed Central) -  Oct 23, 2024   
    Consequently, there is a need to reassess the empiric antibiotic prescribed for the management of community-acquired peritonitis. The meta-analysis showed significant variability in antibiotic resistance patterns among environmental NOVC isolates across time and regions, emphasizing the need for tar-geted, time-specific, and country-specific approaches to address antibiotic resistance globally.
  • ||||||||||  amoxycillin/clavulanate / Generic mfg.
    Journal:  Unveiling the diverse bioactivity of cobalt oxide nanoparticles produced through carboxymethyl cellulose extraction. (Pubmed Central) -  Oct 12, 2024   
    These nanoparticles exhibited potent antioxidant properties and demonstrated safety for potential applications based on erythrocyte viability results. Additionally, Co3O4NPs displayed significant potency against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and showed promising ?-amylase enzyme inhibitory activity, highlighting their multifunctional therapeutic potential as antioxidant, antibacterial, anticancer, and alpha-amylase inhibition assay.
  • ||||||||||  Alecensa (alectinib) / Roche
    Journal:  Appendicitis while on alectinib for non-small cell lung cancer: a tale of two case reports. (Pubmed Central) -  Oct 11, 2024   
    Both patients remained on alectinib over the courses of appendicitis without interruption. While appendicitis has not been previously described as an adverse effect of alectinib, its incidence in two patients at our center within several months following the administration of alectinib raises its suspicion as a possible adverse effect.
  • ||||||||||  cefuroxime / Generic mfg., amoxycillin/clavulanate / Generic mfg.
    Prevalence of antimicrobial resistant enterobacteria's in a community and in the environment in Salvador, Brazil (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3205;    
    The prevalence of those bacteria in the environment, besides other associations, is related to the lack of basic sanitation and the traffic between humans and the river. Observing heightened resistance to Amoxicillin-clavulanic acid and intravenous Cefuroxime corresponds with the prevalence of the bla TEM gene in the samples, since this gene is related to resistance to cephalosporins and penicillin-like antibiotics.
  • ||||||||||  ciprofloxacin oral / Generic mfg., amikacin sulfate / Generic mfg.
    Role of AcrAB and OqxAB Efflux Pumps in Amikacin and Ciprofloxacin Resistance among Clinical Isolates of Klebsiella pneumoniae in Lima, Peru (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3037;    
    The 93.75% were resistant to ciprofloxacin and piperacillin/tazobactam; 87.5% were resistant to trimethoprim/sulfamethoxazole; 56.25% were resistant to fosfomycin; 25% were resistant to levofloxacin and 18.75% to amikacin...The prevalence of resistance genes show AcrA gene was detected in 43.75% isolates, the AcrB gene in 56.25%, OqxA in 31.25%, and OqxB in 25.00%. In conclusion, our findings suggest that efflux pumps are major mechanisms for ciprofloxacin and amikacin resistance in K. pneumoniae , with the AcrAB and OqxAB systems being significant contributors to this resistance
  • ||||||||||  Etiology of Postpartum Sepsis among recently delivered women in Pakistan (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2610;    
    Of the 10 most common pathogens, 67.6% were sensitive to combined clindamycin and gentamycin, 53.2% were sensitive to imipenem, 35.6% were sensitive to combined amoxicillin-clavulanic acid and metronidazole, and 19.4% were sensitive to combined ampicillin and metronidazole. Pakistan's high postpartum sepsis rates necessitate treatment guidelines based on common pathogen susceptibility, preventive strategies are imperative to improve the outcomes of postpartum women and reduce maternal mortality in Pakistan.
  • ||||||||||  Increase of antimicrobial resistance in post COVID-19 patients in Bolivia (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1816;    
    No correlation was found between AMR and sociodemographics, or WASH conditions, or COVID-19 severity. These findings revealed a high prevalence of AMR E. coli circulating in post-COVID-19 patients, which can be potentially considered an important reservoir for AMR.
  • ||||||||||  Journal:  First Case Report of Mycotic Abdominal Aortic Aneurysm Caused by Campylobacter fetus in Serbia. (Pubmed Central) -  Sep 29, 2024   
    Campylobacter fetus associated with abdominal aortic aneurysms represents a life-threatening condition, posing a significant challenge in vascular surgery. Due to the lack of clear guidelines on antibiotic susceptibility testing and the treatment of infections associated with this pathogen, enhanced surveillance of Campylobacter fetus is necessary in both human and veterinary medicine.
  • ||||||||||  IKZF1-RELATED COMBINED IMMUNODEFICIENCY DIAGNOSED DUE TO PNEUMOCYSTIS JIROVECII PNEUMONIA (Monitor 10; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1182;    
    He was started on oral amoxicillin without improvement after three days, prompting a switch to amoxicillin-clavulanate...After three weeks of trimethoprim/sulfamethoxazole treatment, he improved...In this case, a diagnosis of PJP pneumonia prompted early genetic diagnosis of a severe form of IKZF1/IKAROS deficiency. Table 1: Immunologic lab work of our patient diagnosed with IKZF1- related combined immunodeficiency.