| allopurinol / Generic mfg. |
ACTRN12612000434897: To compare the efficacy & safety profile of Febuxostat with Allopurinol in
local Pakistani hyperuricemic patients. |
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| Recruiting | 4 | 120 | | | PharmEvo (Pvt.) Ltd., PharmEvo (Pvt.) Ltd. | Hyperuricemia, Gout | | | | |
ACTRN12612001188820: Safety and efficacy of immediate versus delayed allopurinol treatment for the prevention of gout flares in pacific, maori and other people |
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| Recruiting | 4 | 200 | | | Department of General Practice and Primary Health Care, School of Population Health, University of Auckland, Pacific Perspectives Limited | Gout | | | | |
2016-004112-35`ACTRN12620001086954: A comparison between standard treatment with azathioprine and a modified treatment with a lower dose of azathioprine in combination with allopurinol for patients with inflammatory bowel disease |
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| Ongoing | 4 | 120 | Europe | Azathioprine, Allopurinol, NA, Tablet, Imurel, Allopurinol | SOIBD (The Swedish Organisation for the study of Inflammatory Bowel Diseases), SOIBD, Umeå University, Västerbotten County Council | Premature birth at less than 32 weeks gestational age, Neonatal resuscitation, Respiratory distress syndrome | | | | |
| Recruiting | 4 | 380 | | | University of Otago, Health research Council of New Zealand | Gout | | | | |
2014-004122-18: Allopurinol in Functional Impairment (ALFIE) Trial ‘Improving muscle strength’ |
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| Ongoing | 4 | 124 | Europe | ALLOPURINOL, N/A, Capsule, hard | University of Dundee, Tayside Clinical Trials Unit | FUNCTIONAL IMPAIRMENT, decreased exercise capacity, Diseases [C] - Musculoskeletal Diseases [C05] | | | | |
| Ongoing | 4 | 72 | Europe | Allopurinol, n/a, Capsule, hard | University of Dundee/ NHS Tayside | right ventricular hypertrophy associated with COPD or Interstitial Lung Disease and pulmonary hypertension, COPD or Interstitial Lung Disease with enlarged right side of heart, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2005-000551-15: Effect of folic acid supplementation and allopurinol on endothelial function in patients with rheumatoid arthritis treated with methotrexate |
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| Ongoing | 4 | 80 | Europe | Allopurinol, Folic acid, Allopurinol, Folic acid, | University of Dundee | Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory polyarthritis associated with excess cardiovascular (CV) mortality. Hyperhomocysteinaemia is recognized as an independent CV risk factor and homocysteine levels are frequently elevated in RA patients.Endothelial dysfunction is considered a marker of early atherosclerotic disease and seems to correlate well with future increase CV risk. RA patients are known to have endothelial dysfunction. | | | | |
2005-003081-42: EXPLORING THE THERAPEUTIC POTENTIAL OF XANTHINE OXIDASE INHIBITORS IN CORONARY ARTERY DISEASE |
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| Ongoing | 4 | 124 | Europe | Allopurinol, PL 0142/0147, | University of DUndee | Ishaemic heart disease; Angina, acute myocardial infarction | | | | |
2005-001670-27: Reversibility of cerebrovascular endothelial dysfunction in diabetes: the role of allopurinol. |
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| | 4 | 24 | Europe | Allopurinol, Allopurinol, Allopurinol, Allopurinol | Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship | Type Two Diabetes Mellitus | | | | |
2005-001669-33: New therapeutic targets in stroke prevention: the effect of allopurinol on the cerebral vasculature of patients with subcortical stroke |
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| Ongoing | 4 | 80 | Europe | Allopurinol, Allopurinol, Allopurinol, Allopurinol | Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship | Subcortical Ischaemic Stroke | | | | |
2006-004611-21: Does allopurinol (a xanthine oxidase inhibitor) have clinically useful anti-ischaemic effects in angina pectoris? - A randomised, double-blind, placebo-controlled trial |
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| Ongoing | 4 | 60 | Europe | Allopurinol, Allopurinol | University of Dundee | Angina Pectoris | | | | |
2008-004224-23: The effect of allopurinol on carotid ultrasound intima-media thickness and markers of endothelial function in patients with recent stroke - a pilot study. |
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| Ongoing | 4 | 80 | Europe | Allopurinol, | University of Glasgow / NHS Greater Glasgow and Clyde | Ischaemic stroke or transient ischaemic attack (TIA) (ICD Classification Code I63.0-9 and G45.0-1). | | | | |
| Ongoing | 4 | 4706 | Europe | Feboxostat Trade Name: Adenuric, Allopurinol, Adenuric, Allopurinol, Adenuric, Allopurinol | University of Dundee, , Menarini | Chronic symptomatic hyperuricaemic | | | | |
2012-001858-25: A clinical study on the therapeutic efficacy and safety of Febuxostat and Allopurinol on serum urate concentration in subjects suffering from hyperuricemia and gout |
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| Ongoing | 4 | 330 | Europe | Febuxostat, Allopurinol, Colchicine, ADENURIC, ZYLORIC, Colchicina Lirca, ADENURIC, ZYLORIC, Colchicina Lirca | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A., MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A., MIOL - Menarini International Operations Luxembourg S.A. | hyperuricemia and gout | | | | |
2013-003559-39: Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease (ALL-HEART) |
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| Ongoing | 4 | 5215 | Europe | Allopurinol, | The University of Dundee, NHS TAYSIDE, NIHR HTA, | Ischaemic Heart Disease (IHD), angina or myocardial infarction | | | | |
2013-003404-39: The effect of sodium nitrite on kidney salt and water regulation, blood pressure regulating hormones and blood pressure in healthy subjects during inhibition of various enzyme systems. Effekten af natriumnitrit på nyrernes vand- og saltregulering, blodtryksregulerende hormoner og blodtryk hos raske forsøgspersoner under samtidig hæmning af forskellige enzymsystemer |
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| Ongoing | 4 | 20 | Europe | Allopurinol, Enalapril, Acetazolamid, Allopurinol, Enalapril, Acetazolamid | Department of Medical Research, Regional Hospital Holstebro, Medicinsk Forskningsafsnit, Regionshospitalet Holstebro, Hospitalsenheden Vest | The normal physiological responses in healthy subjects Normale fysiologiske effekter hos raske forsøgspersoner | | | | |
2016-000164-42: investigating the use of allopurinol as treatment for allergic asthma |
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| Ongoing | 4 | 18 | Europe | Allopurinol, Capsule, Allopurinol | Tayside Medical Sciences Centre on behalf of University of Dundee | Asthma, Asthma, Diseases [C] - Respiratory Tract Diseases [C08] | | | | |
| Not yet recruiting | 4 | 66 | Europe | ALLOPURINOL, n/a, Capsule, hard | University of Dundee/NHS Tayside, British Heart Foundation Grant Funding | Left ventricular hypertrophy in hypertension, Enlarged heart associated with previous high blood pressure, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR-IPR-17011837: The urate-lowering efficacy and safety of febuxostat versus allopurinol in Chinese asymptomatic hyperuricemic patients with chronic kidney disease |
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| Recruiting | 4 | 100 | | febuxostat ;allopurinol | the Affiliated Hospital of Qingdao University; the Affiliated Hospital of Qingdao University, raise independently | Hyperuricemia | | | | |
ChiCTR1800020310: The effects of febuxostat versus allopurinol on oxidative stress in Chinese asymptomatic hyperuricemic patients with chronic kidney disease |
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| Recruiting | 4 | 371 | | febuxostat ;allopurinol ;none | the Affiliated Hospital of Qingdao University; the Affiliated Hospital of Qingdao University, raise independently | Hyperuricemia | | | | |
2020-005730-15: Research into continuation or cessation of urate lowering therapies in gout patients in remission. Onderzoek met urinezuurverlagende therapie bij jicht. Levenslang doorgaan of is (tijdelijk) stoppen mogelijk? |
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| Ongoing | 4 | 310 | Europe | Tablet, Allopurinol, Desuric, Adenuric | Sint Maartenskliniek, ZonMw /ZE&GG, Sint Maartenskliniek | Gout, arthritis urica, Gout, Diseases [C] - Musculoskeletal Diseases [C05] | | | | |
ChiCTR1900024963: Clinical study for the effect of allopurinol in different doses on the gout flares |
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| Recruiting | 4 | 195 | | The dosage of Allopurinol will increased gradually from 50 mg/d in the first four weeks，100 mg/d in the next four weeks, and to 200 mg/d to the end. ;Allopurinol 200mg/d + Colchicine 0.5 mg/d. ;Allopurinol 200mg/d | Anqing Hospital Affiliated to Anhui Medical University; Anqing Hospital Affiliated to Anhui Medical University, Scientific research foundation of anhui medical university | gout | | | | |
ChiCTR2100044828: Effects of different types of uric acid lowering drugs on gout flare |
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| Recruiting | 4 | 150 | | febuxostat(40mg/d,4 weeks) or allopurinol (200mg/d, 4 weeks) ;benzbromarone(50mg/d,4 weeks) | The First Affiliated Hospital of University of Science and Technology of China; The First Affiliated Hospital of University of Science and Technology of China, The patient bears the cost of the test | Gout | | | | |
ChiCTR1800019389: A single-center, prospective, randomized, double-blind, controlled trial for the effect of allopurinol sustained-release capsules on the stability of coronary plaques in patients with acute coronary syndrome |
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| Not yet recruiting | 4 | 162 | | Allopurinol Sustained-reease Capsules ;placebo capsules | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, None | acute coronary syndrome | | | | |
ChiCTR2000035778: Long-term safety of urate-lowering drugs and their protective effects on important organs |
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| Not yet recruiting | 4 | 450 | | Allopurinol is recommended to start at 100mg and 50mg for patients with renal insufficiency ;Febuxostat start at 20mg ;Benzbromarone start at 25mg | Huashan Hospital, Fudan University; Huashan Hospital, Fudan University, Shanghai Shenkang Hospital Development Center | Gout/Hyperuricemia | | | | |
2021-002185-40: Allopurinol and Febuxostat Treatment in Patients with Adenine Phosphoribosyltransferase Deficiency: A Clinical Trial |
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| Ongoing | 4 | 10 | RoW | Tablet, Uloric, Allopurinol Alvogen | Landspitali - The National University Hospital of Iceland, Icelandic Research Fund | Adenine phosphoribosyltransferase deficiency, Adenine phosphoribosyltransferase deficiency is a hereditary disorder causing kidney stones and kidney failure in untreated patients., Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
| Enrolling by invitation | 4 | 2 | RoW | Febuxostat 80 MG Oral Tablet or Allopurinol 300 MG Oral Tablet | Medical Practice Prof D. Ivanov | Gout, CKD Stage 1-4, SUA Level (>8 mg/dL; 480 µmol/L) | 12/22 | 12/22 | | |
NCT05474560: Febuxostat Versus Allopurinol on Hepatic Steatosis in MAFLD Patients |
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| Completed | 4 | 90 | RoW | Allopurinol (100 mg/day) plus lifestyle intervention, Allopurinol group, Febuxostat 40 mg plus lifestyle intervention, Febuxostat group, Life style intervention | Ain Shams University | Non-Alcoholic Fatty Liver Disease, Hyperuricemia | 01/23 | 01/23 | | |
ChiCTR1900024152: The effect of allopurinol on the prognosis of patients with acute myocardial infarction with hyperuricemia |
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| Not yet recruiting | 4 | 520 | | Allopurinol ;placebo | Xiamen Cardiovascular Hospital Xiamen University; Xiamen Cardiovascular Hospital Xiamen University, Xiamen science and technology plan project | acute myocardial infarction with hyperuricemia | | | | |
NCT05540184: Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients |
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| Recruiting | 4 | 124 | RoW | Trimetazidine 35 mg, Vastarel MR, Allopurinol 300 MG, Zyloric 300mg, Normal saline, 0.9 NS | Beni-Suef University, Cairo University | AKI - Acute Kidney Injury | 09/25 | 09/25 | | |
| Recruiting | 4 | 650 | US | Allopurinol, Aloprim, Zyloprim, Naproxen 250 MG, Prophylaxis, Colchicine 0.6 mg, Colchicine 1.2 mg, Flare, Naproxen 500 Mg, Prednisone 40 mg | Massachusetts General Hospital, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Gout | 09/28 | 10/28 | | |
ChiCTR2200056659: Allopurinol in the treatment of cyclosporine-induced hyperuricemia in children with aplastic anemia：a randomized controlled study |
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| Not yet recruiting | 4 | 40 | | Receive allopurinol tablets ;Receive placebo | The Seventh Affiliated Hospital, Sun Yat-sen University; The Seventh Affiliated Hospital, Sun Yat-sen University, The Seventh Affiliated Hospital, Sun Yat-sen University Clinical Research 735 Program” | hyperuricemia | | | | |
ACTRN12613001347752: De novo combination allopurinol-thiopurine vs standard thiopurine in inflammatory bowel disease (IBD) patients escalating to immunomodulators: a randomized controlled trial |
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| Recruiting | 3/4 | 140 | | | Eastern Health, Gastrenterological Society of Australasia Ferring IBD clinician establishment grant | Inflammatory Bowel Disease | | | | |
2013-004235-77: Allopurinol, brain lesions, heart size and blood pressure after ischaemic stroke |
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| Not yet recruiting | 3 | 464 | Europe | Allopurinol, Tablet, Allopurinol | NHS Greater Glasgow & Clyde, University of Glasgow, Stroke Association / British Heart Foundation, | Ischaemic stroke or transient ischaemic attack (TIA) (ICD Classification Code I63.0-9 and G45.0-1), Stroke due to blood clots or mini strokes., Diseases [C] - Nervous System Diseases [C10] | | | | |
2011-000619-16: Estudio para valorar el efecto sobre las plaquetas del tratamiento con Alopurinol en pacientes diabéticos |
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| Ongoing | 3 | 68 | Europe | Tablet | Fundación Investigación Biomedica. Hospital Clinico San Carlos, Fundación Investigación Biomedica. Hospital Clinico San Carlos | Hipótesis: el tratamiento con alopurinol (600 mg/día) en pacientes diabéticos resistentes a aspirina con enfermedad coronaria establecida podría favorecer el efecto antiplaquetario de la aspirina e inducir cambios en el perfil de expresión proteico de estas células Hypothesis: treatment with allopurinol (600 mg/day) in diabetic patients resistant to aspirin with established coronary disease could enhance the antiplatelet effect of aspirin and induce changes in its protein expression profile | | | | |
2016-002433-30: Effect of azathioprine and allopurinol compared to azaothioprine monotherapy in ulcerative colitis |
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| Ongoing | 3 | 84 | Europe | Tablet, Imurel, Allopurinol | Hvidovre Hospital, Regionernes medicinpulje | Ulcerative Colitis, Ulcerative colitis, Diseases [C] - Digestive System Diseases [C06] | | | | |
2016-000222-19: A European trial to evaluate the effect of Allopurinol administered very early after birth on brain injury in children with oxygen deficiency during birth |
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| Ongoing | 3 | 846 | Europe | Allokid, Allopurinol, Powder for solution for injection, ACEPURIN | University Hospital Tuebingen, UMC Utrecht, Oslo University Hospital, European Union, EU, European Union Horizon 2020 framework program | Perinatal Asphyxia, hypoxic-ischemic brain injury, oxygen deficiency during birth, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
CRUCIAL, NCT04217421 / 2017-004596-31: Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass |
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| Recruiting | 3 | 236 | Europe | Allopurinol, Mannitol | dr. M.J.N.L. Benders, ZonMw: The Netherlands Organisation for Health Research and Development, University Medical Center Groningen, Erasmus Medical Center, University Medical Center Nijmegen, ACE Pharmaceuticals BV | Congenital Heart Disease in Children, Neuroprotection | 10/26 | 12/28 | | |
2022-003573-32: Allopurinol as a preventive drug in patients with high and very high cardiovascular risk, taking into account the presence of the long-COVID syndrome. Allopurynol jako lek prewencyjny u pacjentów wysokiego i bardzo wysokiego ryzyka sercowo-naczyniowego z uwzględnieniem obecności zespołu long-COVID. |
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| Not yet recruiting | 3 | 1116 | Europe | Milurit (Allopurinolum), Tablet, Milurit (Allopurinolum) 200mg | Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Medical Research Agency | hyperuricemia, hypertension, ischemic stroke, intracerebral haemorrhage, TIA, heart failure, peripheral arterial disease, atrial fibrillation, diabetes mellitus hiperurykemia, nadciśnienie tętnicze, udar niedokrwienny, krwawienie domózgowe, TIA, niewydolność serca, choroba tętnic obwodowych, migotanie przedsionków, cukrzyca, hyperuricemia, hypertension, ischemic stroke, intracerebral haemorrhage, TIA, heart failure, peripheral arterial disease, atrial fibrillation, diabetes mellitus hiperurykemia, nadciśnienie tętnicze, udar niedokrwienny, krwawienie domózgowe, TIA, niewydolność serca, choroba tętnic obwodowych, migotanie przedsionków, cukrzyca, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Completed | 3 | 22 | US | Phentermine / Topiramate Oral Product, Citrate Salts, Allopurinol, Diet | University of Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Obesity, Uric Acid Stones, Type 2 Diabetes Mellitus in Obese, Pre-Diabetes | 11/24 | 11/24 | | |
NCT04956432: A Multicentre, Randomized, Double-blind, Allopurinol Controlled Study to Evaluate the Efficacy and Safety of SHR4640 in Subjects With Gout |
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| Active, not recruiting | 3 | 780 | RoW | SHR4640, Allopurinol | Jiangsu HengRui Medicine Co., Ltd. | Gout | 07/24 | 07/24 | | |
| Recruiting | 3 | 2542 | US | Tigulixostat, LC350189, Allopurinol, Placebo | LG Chem | Gout, Hyperuricemia, Gout Flare, Tophi | 07/25 | 12/25 | | |
| Recruiting | 3 | 760 | Europe | Allopurinol, Mannitol | University Hospital Tuebingen, Technische Universität Dresden, UMC Utrecht, KU Leuven, University of Zurich, University of Vienna, Fundación para la Investigación del Hospital Clínico de Valencia, Universidade do Porto, Oslo University Hospital, Università degli Studi di Udine, Helsingin Ja Uudenmaan Sairaanhoitopiirin, University of Helsinki, Poznan University of Medical Sciences, Tartu University Hospital, ACE Pharmaceuticals BV | Encephalopathy, Hypoxic-Ischemic, Infant, Newborn, Diseases | 01/26 | 01/26 | | |
ALL-VASCOR, NCT05943821: The Effect of Allopurinol on the Risk of Cardiovascular Events in Patients with Cardiovascular Risk |
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| Recruiting | 3 | 1116 | Europe | Allopurinol 200 mg, Allopurinol, Optional intervention, Please describe in more detail | Poznan University of Medical Sciences | Cardiovascular Diseases, Uric Acid | 07/28 | 07/28 | | |
| Recruiting | 2/3 | 40 | RoW | Allopurinol 300 MG, Zyloric, Placebo oral tablet, Placebo | Ministry of Health, Brazil, Fundação de Amparo à Pesquisa do Estado de São Paulo, InCor Heart Institute | Refractory Angina | 09/21 | 12/21 | | |
NCT05828836: Allopurinol and Quality of Life in Liver Cirrhosis |
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| Completed | 2/3 | 100 | RoW | Allopurinol Tablet, Placebo | Tanta University | Cirrhosis, Liver | 01/23 | 03/23 | | |
NCT05545670: Allopurinol to Prevent Cirrhosis Related Morbidities |
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| Completed | 2/3 | 100 | RoW | Placebo, Allopurinol 300 MG | Tanta University | Cirrhosis | 02/23 | 03/23 | | |
| Terminated | 2/3 | 43 | US, RoW | ABP-671, Allopurinol | Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd. | Gout | 09/24 | 09/24 | | |
NCT05511766: Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis |
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| Recruiting | 2/3 | 150 | RoW | Allopurinol 300 MG, zyloric, Atorvastatin 20mg, Placebo | Tanta University | Cirrhosis, Hepatic Encephalopathy, Ascites, Varices, SBP - Spontaneous Bacterial Peritonitis | 04/24 | 01/25 | | |
NCT05818085: Phase 2b/3 Study to Assess ABP-671 a Novel URAT1 Inhibitor in Participants With Gout |
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| Active, not recruiting | 2/3 | 580 | US, RoW | ABP-671, Allopurinol, Placebo | Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd. | Gout | 08/25 | 08/25 | | |
ACTRN12611000182998: Effect of allopurinol on prevention of pancreatitis after Endoscopic Retrograde Cholangio Pancreatography(ERCP) |
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| Active, not recruiting | 2 | 500 | | | Mohammad Abbasinazari, Shahid Beheshti University of Medical Sciences | pancreatitis | | | | |
2006-001084-27: Phase I/II study of prevention of Colorectal Cancer CRC with Allopurinol in High-Risk Subjects |
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| Ongoing | 2 | 75 | Europe | ZYLORIC*30CPR 300MG, ZYLORIC*30CPR 300MG | AZIENDA OSPEDALIERA OSPEDALI GALLIERA | CHEMOPREVENTION OF COLORECTAL CANCER | | | | |
2016-003409-33: Allopurinol in maintenance therapy of acute lymphoblastic leukemia in childhood |
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| Ongoing | 2 | 60 | Europe | Allopurinol, Allopurinol, Tablet, Allopurinol Teva, Puri-nethol, Methotrexate orion | Västra Götaland Regionen, Queen Silvias Childrens and Adolescents Hospital, Västra Götaland Regionen, Region Skåne, Stockholms Läns Landsting, Region Östergötland, Landstinget i Uppsala, Västerbottens läns landsting, Region Hovedstaden, Region Midt, Helse Sör-Öst, Helse Vest, Helse Midt-Norge, Helse Nord, Ministry of Welfare, Hospital district of Helsinki University Central Hospital, Hospital district of Tampere University Central Hospital, Hospital district of Kuopio University Central Hospital, Hospital district of Oulo University Central Hospital, Hospital district of Turku University Central Hospital, Queen Silvias Childrens and Adolescents Hospital | Acute lymphoblastic leukemia diagnosed at age 0-18 in children, Acute lymphoblastic leukemia diagnosed at age 0-18 in children, Diseases [C] - Cancer [C04] | | | | |
2017-005060-18: The Role of Uric Acid Metabolism in Anaphylaxis: the Effect of Allopurinol on Allergic Reactions to Peanut in Peanut Allergic Adults. |
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| Not yet recruiting | 2 | 20 | Europe | Allopurinol, Capsule, Allopurinol | Manchester University NHS Foundation Trust | Determination of the Lowest Observed Adverse Event level dose (LOAEL)of peanut in individual suffering with peanut allergy, after treatment with allopurinol., Allergy to peanut, Body processes [G] - Immune system processes [G12] | | | | |
2019-004862-16: Study of verinurad and allopurinol in heart failure with preserved ejection fraction |
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| Not yet recruiting | 2 | 435 | Europe, RoW | Verinurad, Allopurinol 100 mg, Allopurinol 300 mg, RDEA3170, Prolonged-release capsule, hard, Tablet, Allopurinol | AstraZeneca AB, AstraZeneca AB | Heart Failure Patients with Preserved Ejection Fraction (HFpEF) and hyperuricaemia, Heart failure with a normally contracting heart, but the heart is too stiff to fill properly, combined with elevated levels of uric acid in the blood circulation, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Completed | 2 | 156 | US | Allopurinol, Zyloprim, Fludarabine, Fludara, Cyclophosphamide, Cytoxan, ATG, Anti-thymocyte globulin, TBI, Total body irradiation, Tacrolimus, Prograf, MMF, Mycophenolate Mofetil, Peripheral Blood Stem Cells, Related or Unrelated Bone Marrow Cells | Masonic Cancer Center, University of Minnesota | Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Plasma Cell Leukemia, Myelodysplastic Syndromes, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, B-Cell Lymphoma, Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Mantle-Cell Lymphoma, Prolymphocytic Leukemia, Lymphoblastic Lymphoma, Burkitt's Lymphoma, Non-Hodgkin's Lymphoma, Multiple Myeloma, Myeloproliferative Syndromes, Hematological Diseases | 04/23 | 05/23 | | |
NCT05665699: Phase II Study to Evaluate Efficacy and Safety of D-0120 in Combination With Allopurinol in Subjects With Gout |
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| Recruiting | 2 | 80 | US | D-0120, Allopurinol | InventisBio Co., Ltd | Gout | 07/25 | 12/25 | | |
NCT05253833: Phase 2 to Assess Efficacy and Safety in AR882 Alone or in Combination With Allopurinol in Patients With Tophaceous Gout |
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| Completed | 2 | 42 | US, RoW | AR882 Dose 1, AR882 Dose 2, Allopurinol Tablet | Arthrosi Therapeutics | Gout, Arthritis, Gouty, Hyperuricemia, Gout Chronic | 08/24 | 10/24 | | |
BEAM, NCT03570983: A Trial Comparing Single Agent Melphalan to Carmustine, Etoposide, Cytarabine, and Melphalan () as a Preparative Regimen for Patients With Multiple Myeloma Undergoing High Dose Therapy Followed by Autologous Stem Cell Reinfusion |
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| Recruiting | 2 | 100 | US | Allopurinol, Carmustine, Etoposide, Cytarabine, Melphalan | Swedish Medical Center | Multiple Myeloma | 06/24 | 12/24 | | |
RESIST, NCT05888233: Allopurinol Improves Heart Function in African Americans With Resistant Hypertension |
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| Recruiting | 2 | 50 | US | Allopurinol | VA Office of Research and Development | Heart Failure Preserved Ejection Fraction, Resistant Hypertension | 10/25 | 05/26 | | |
NCI-2022-07625, NCT05536349: Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT) |
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| Recruiting | 2 | 60 | US | Pirtobrutinib, Obinutuzumab, GA101, Gazyva, RO5072759, Venetoclax, ABT-199, GDC-0199, Valacyclovir, Allopurinol | M.D. Anderson Cancer Center, Loxo Oncology, Inc., The Leukemia and Lymphoma Society | Leukemia | 04/25 | 04/25 | | |
ChiCTR2400086523: A multicenter, randomized, double-blind, double-dummy, positive drug parallel controlled phase II clinical study evaluating the treatment of gout with hyperuricemia with topiramate tablets |
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| Not yet recruiting | 2 | 160 | | Topirast tablets 160 mg/day + allopurinol simulation tablet; Topirast tablets 200 mg/day + allopurinol simulation tablet; Topirast tablets 240 mg/day + allopurinol simulation tablet; Allopurinol tablets + topirast simulation tablet | The Affiliated Hospital of Qingdao University; The Affiliated Hospital of Qingdao University, Shandong Xinhua Pharmaceutical Co., Ltd | Gout with hyperuricemia | | | | |
NCT05805605: Allo HSCT Using RIC and PTCy for Hematological Diseases |
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| Recruiting | 2 | 56 | US | Peripheral Blood Stem Cell Transplant, Allopurinol 300 MG, Fludarabine, Cyclophosphamide, Bone Marrow Cell Transplant, Total Body Irradiation, Sirolimus Pill, Mycophenolate Mofetil, (MMF) | Masonic Cancer Center, University of Minnesota | Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Biphenotypic Acute Leukemia, Undifferentiated Leukemia, Prolymphocytic Leukemia, Chronic Myelogenous Leukemia, Plasma Cell Leukemia, Myelodysplastic Syndromes, Leukemia, Myeloid, Myelodysplastic Syndrome With Excess Blasts-1, Burkitt Lymphoma, Relapsed T-Cell Lymphoma, Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Marginal Zone Lymphoma, Follicular Lymphoma, Myeloproliferative Neoplasm, Myelofibrosis | 10/27 | 10/28 | | |
NCT05734495: Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia |
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| Recruiting | 2 | 42 | US | Pirtobrutinib, LY3527727, LOXO-305, Venetoclax, ABT-199, A-1195425.0, GDC-0199, RO5537382, Venclexta, and Venclyxto. | Dana-Farber Cancer Institute, Eli Lilly and Company | Waldenstrom Macroglobulinemia | 01/29 | 01/33 | | |
NCT06056570: Open Label PK, PD and DDI of Dotinurad and Allopurinol in Gout Patients with Hyperuricemia |
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| Completed | 1/2 | 20 | US | dontinurad, dotinurad + allopurinol, allopurinol | Urica Therapeutics Inc. | Gout, Hyperuricemia | 06/24 | 07/24 | | |
ChiCTR2300072577: An evidence-based evaluation study of integrated Chinese and Western medicine treatment for the preclinical phase of gout |
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| Not yet recruiting | 1/2 | 513 | | Yunpi Quzhuo Granule + Allopurinol Tablet ;Yunpi Quzhuo Granule + Allopurinol Tablet Simulator ;Allopurinol Tablet + Yunpi Quzhuo Granule Simulator | The First Affiliated Hospital of Hu'nan University of Chinese Medicine; Hu'nan University of Chinese Medicine, the National Key Research and Development Program of the Ministry of Science and Technology | hyperuricemia | | | | |
NCT05360628: Evaluation of PK and Safety of D-0120 and Allopurinol |
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| Completed | 1 | 20 | US | D-0120 in combination with Allopurinol | InventisBio Co., Ltd | Healthy | 02/22 | 07/22 | | |
CLAMP, NCT05049863: Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate ( Trial) |
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| Terminated | 1 | 17 | US | Mycophenolate Mofetil, MMF, Cellcept, Allopurinol, Zyloprim, Aloprim, Irinotecan, Onivyde, Camptosar | Washington University School of Medicine | Small-cell Lung Cancer, Small Cell Lung Carcinoma | 11/24 | 11/24 | | |
| Recruiting | 1 | 165 | US | Allopurinol, Zyloprim, Dietary Intervention | Wake Forest University Health Sciences, National Heart, Lung, and Blood Institute (NHLBI) | Salt; Excess, Blood Pressure Disorders | 06/25 | 06/25 | | |
ChiCTR-TRC-12001933: The serum urate-lowering effect and safety profile of "Yellow-dragon Wonderful-Seed" formula in the treatment of gout：a randomised controlled trial |
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| Completed | N/A | 72 | | Yellow-dragon Wonderful-Seed formula (+Gypsum) ;"Yellow-dragon Wonderful-Seed" formula (-Gypsum) ;allopurinol | Teaching Hospital of Chengdu University of Traditional Chinese Medicine; Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Physician Investigator Foundation of Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus of China | gout | | | | |
ChiCTR-RCC-12002927: A case-control study of relationship between genotyping and severe cutaneous adverse reactions |
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| Completed | N/A | 500 | | Nil | Institute of Clinical Pharmacology, Central South University; Level of the institution：, 863 project | severe cutaneous adverse reactions caused by allopurinol | | | | |
NCT04699383: Documentation of Patient Outcomes for SSG/Allopurinol Combination Treatment in Ethiopia |
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| Completed | N/A | 105 | RoW | Sodium Stibogluconate with allopurinol | Institute of Tropical Medicine, Belgium, Wollo University, Boru Meda Hospital, University of Gondar | Cutaneous Leishmaniasis | 12/22 | 12/22 | | |
ChiCTR2200062286: A randomized controlled trial of taurine intervention in hyperuricemia with hypercholesterolemia |
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| Not yet recruiting | N/A | 60 | | Taurine, allopurinol ;Placebo, allopurinol | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine; The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin Municipal Bureau of Science and Technology | Hyperuricemia with hypercholesterolemia | | | | |
NCT05601271: Effect of Allopurinol on Markers of Mineral and Bone Metabolism |
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| Active, not recruiting | N/A | 50 | RoW | Allopurinol | University of Sao Paulo General Hospital | Chronic Kidney Diseases, Osteodystrophy, Uric Acid Concentration, Serum, Quantitative Trait Locus 7 | 12/23 | 04/24 | | |
NCT04746989: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - (DREAM) Probenecid vs Allopurinol |
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| Active, not recruiting | N/A | 294878 | US | Probenecid, Allopurinol | Brigham and Women's Hospital, National Institute on Aging (NIA), Rutgers University, Johns Hopkins University | Gout | 12/23 | 12/23 | | |
ChiCTR2300077715: Study on the evidence-based evaluation of integrated traditional Chinese and western medicine treatment for the chronic arthritis stage of gout |
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| Not yet recruiting | N/A | 684 | | Huazhuo Sanjie Zhubi granules + allopurinol tablets; Allopurinol tablets + Huazhuo Sanjie Zhubi Granule mimics; Huazhuo Sanjie Zhubi granules + allopurinol tablets mimics | Dongzhimen Hospital, Beijing University of Chinese Medicine; Dongzhimen Hospital, Beijing University of Chinese Medicine, National Key Research and Development Program | gout | | | | |
ChiCTR1900028684: Follow-up study for the curative effect of uric acid-reducing treatment in patients with hyperuricemia |
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| Recruiting | N/A | 600 | | Treatment with benzbromarone; Treatment with febuxostat; Treatment with allopurinol | Shanghai Tenth People's Hospital affiliated to Tongji University; Shanghai Tenth People's Hospital affiliated to Tongji University, No funding involved | hyperuricemia | | | | |
| Not yet recruiting | N/A | 10 | | | Professor Robert Walker, Otago Medical Research Foundation Laurenson Award | Gout; Chronic kidney disease | | | | |
ACTRN12607000295448: Treatment of cutaneous leishmaniasis with meglumine antimoniate and allopurinol. |
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| Recruiting | N/A | 620 | | | Dr Amer Ejaz, combined military hospital | cutaneous leishmaniasis | | | | |
ACTRN12607000477426: Effects of aspirin and a blood pressure medicine on the blood concentrations of allopurinol, a common treatment for gout |
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| Active, not recruiting | N/A | 8 | | | Professor Richard Day, St Vincent?s Clinical Trials Account and Professor Richard Day General Purpose Fund, St Vincent's Hospital Sydney Ltd | Potential drug interaction(s) between low-dose aspirin, hydrochlorothiazide (HCT) and allopurinol | | | | |
ACTRN12621001730897: The effect of self-monitoring urate concentrations on adherence to allopurinol in people with gout |
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| Completed | N/A | 30 | | | UNSW Sydney, Arthritis Australia | Gout | | | | |
| Completed | N/A | 10 | | | Professor Robert Walker, Otago Medical Research Foundation Laurenson Award | Gout, Chronic kidney disease | | | | |
NCT05193838: Effect of Allopurinol on Left Ventricular Function in Children With Dilated Cardiomyopathy |
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| Not yet recruiting | N/A | 100 | NA | Allopurinol Tablet | Assiut University | Dilated Cardiomyopathy | 05/23 | 07/23 | | |
