allopurinol / Generic mfg. 
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  • ||||||||||  colchicine / Generic mfg., febuxostat / Generic mfg., allopurinol / Generic mfg.
    Gout Prevalence and Management Strategies among Patients with Moderate to Advanced CKD (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2275;    
    Gout affects a substantial proportion of the non-dialysis CKD population, with differing management and monitoring strategies between the US and Brazil. Further examination of the effectiveness of gout diagnosis and treatment practices between countries may provide an important opportunity to improve patient outcomes.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Association between Urate-Lowering Therapy and Kidney Failure in Patients with CKD (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1067;    
    Real-world data from the CKD-REIN cohort show that ULTs do not slow the progression of CKD. Thus, in patients with asymptomatic hyperuricemia, ULT should not be prescribed for the purpose of slowing down CKD progression.
  • ||||||||||  Krystexxa (pegloticase) / Amgen
    Journal:  Controversies and practical management of patients with gout and chronic kidney disease. (Pubmed Central) -  Sep 21, 2024   
    We believe that kidney specialists should consider gout as a major complication of CKD and actively manage it in their patients. Here, we present insights from nephrologists and rheumatologists on a team approach to gout management that includes the nephrologist.
  • ||||||||||  ABP-671 / Jiangsu Atom Bioscience and Pharma
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  ABP-671-302: Extension Study of ABP-671 in Participants With Gout (clinicaltrials.gov) -  Sep 20, 2024   
    P2/3,  N=43, Terminated, 
    No abstract available N=580 --> 43 | Trial completion date: Jul 2025 --> Sep 2024 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2025 --> Sep 2024; Redesign of clinical development program for ABP-671: A new long-term safety study after the completion and analysis of Part 1 of ABP-671-301 (NCT05818085) is planned and will be conducted using the doses selected for the pivotal studies.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Empowering probiotics with high xanthine transport for effective hyperuricemia management. (Pubmed Central) -  Sep 20, 2024   
    Importantly, YES301 exhibited a therapeutic efficacy comparable to allopurinol, a conventional uric acid-lowering agent, and manifesting fewer adverse effects and enhanced biosafety. These findings highlight the promising potential of engineered probiotics in the management of hyperuricemia through reducing intestinal purine levels.
  • ||||||||||  ABP-671 / Jiangsu Atom Bioscience and Pharma
    Trial primary completion date:  Phase 2b/3 Study to Assess ABP-671 a Novel URAT1 Inhibitor in Participants With Gout (clinicaltrials.gov) -  Sep 20, 2024   
    P2/3,  N=580, Active, not recruiting, 
    These findings highlight the promising potential of engineered probiotics in the management of hyperuricemia through reducing intestinal purine levels. Trial primary completion date: Aug 2024 --> Aug 2025
  • ||||||||||  THE KNOWN TO THE UNKNOWN: A RARE CASE OF UPPER GI BLEEDING (Convention Center Exhibit Hall: Poster Area 2) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6562;    
    The patient received Dexamethasone and Allopurinol therapy and was discharged home with outpatient oncology follow-up...(3) Therapeutic advances in multiple myeloma management now include the use of antiangiogenic thalidomide and protease inhibitor bortezomib. Although rare in presentation, PCM should be considered in the differential diagnosis with GI bleeding and presence of systemic hematological malignancy.
  • ||||||||||  indomethacin / Generic mfg., furosemide / Generic mfg., allopurinol / Generic mfg.
    Preclinical, Journal:  Diuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats. (Pubmed Central) -  Sep 5, 2024   
    Geranyl acetate has demonstrated significant diuretic and anti-hyperuricemic effects, likely influenced by nitric oxide release and inhibition of enzymes, like xanthine oxidase and urease. The findings have suggested potential benefits for individuals with kidney ailments, hypertension, and gout.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Hyperuricemia drives intestinal barrier dysfunction by regulating gut microbiota. (Pubmed Central) -  Sep 3, 2024   
    Allopurinol was used to decrease uric acid level, and antibiotics were administered to mice to deplete gut microbiota...However, removing gut microbiota aggravated lipid metabolic dysfunction. Gut microbiota is a direct and specific cause for intestinal barrier dysfunction.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., allopurinol / Generic mfg.
    Toxic Epidermal Necrolysis in the Setting of Systemic Epstein-Barr Virus (Exhibit Hall, Cristal Ballroom) -  Aug 28, 2024 - Abstract #CAP2024CAP_494;    
    This case draws attention to a drug-induced TEN in the setting of profound immune activation with cytotoxic T-cell neoplasia and the importance of understanding this association with lymphoproliferative disorders. It also demonstrates the rare but rapid and extensive clinical presentation of systemic EBV-positive T-cell lymphoma of childhood.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Review, Journal:  Exercise and hyperuricemia: an opinion article. (Pubmed Central) -  Aug 26, 2024   
    Most of the previous evidence suggesting that exercise improves serum urate levels comes from intervention trials in other populations, and serum urate is only one of the outcomes observed. This opinion article analyses the causes of HUA, offers dietary and exercise guidance with the aim of furnishing a point of reference for individuals with HUA or fitness enthusiasts.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Identification of a novel xanthine oxidoreductase inhibitor for hyperuricemia treatment with high efficacy and safety profile. (Pubmed Central) -  Aug 24, 2024   
    It also showed favorable dose-dependent uric acid-lowering effects in two different XOR substrate-induced hyperuricemic mouse models, which was significantly superior than the current first-line drug, allopurinol...Notably, there was no obvious inhibition of CC15009 against cardiac ion channels, including hERG, Nav1.5, Cav1.2 at the concentration of 30??M, indicating its lower cardiovascular risk. Taken together, our results supported CC15009 as a candidate of high efficacy and safety profile to treat hyperuricemia through direct XOR inhibition.
  • ||||||||||  Elitek (rasburicase) / Sanofi
    Review, Journal:  Tumour lysis syndrome. (Pubmed Central) -  Aug 23, 2024   
    Xanthine, typically enzymatically converted to uric acid, can accumulate when xanthine oxidases, such as allopurinol, are administered during TLS management. Whether measurement of xanthine is clinically useful to optimize the use of allopurinol or rasburicase remains to be determined.
  • ||||||||||  Olmesartan-Induced Enteropathy Resulting in Hypokalemia-Induced Rhabdomyolysis (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_5525;    
    Home medications included allopurinol, gabapentin, olmesartan, and amlodipine...As o ur patient also improved after valsartan was substituted for olmesartan, OIE rose to the top of our differential diagnosis...Other characteristic findings include increase in intra-epithelial lymphocytes, noted on her outpatient endoscopy but not on repeat inpatient endoscopy (likely due to initiation of budesonide and mesalamine, lowering lymphocytic infiltrate biopsy yield). Clinical suspicion and a broad differential are key to diagnosing OIE; it often presents a diagnostic dilemma and improves if olmesartan is suspended.
  • ||||||||||  Ravicti (glycerol phenylbutyrate) / Immedica, Amgen, Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
    Think Outside the Box! Not All Hyperammonemia is Due to Liver Disease (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_5327;    
    Urea cycle disorders should be considered in patients who present with neuropsychiatric symptoms in the emergency room with hyperammonemia. A prompt recognition of symptoms will prevent permanent neurological damage or even death.
  • ||||||||||  DRESS is More: A Rare Case of Acalculous Cholecystitis (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_4104;    
    Prednisone was initiated for presumed DRESS and ultimately skin biopsy demonstrated lymphohistiocytic inflammation consistent with drug eruption (Figure 1C-D)...While rare, the association between DRESS and acalculous cholecystitis should promptly be recognized to facilitate timely intervention. Figure: Figure 1: A) Desquamating rash on palms, B) Erythematous, pruritic rash on upper extremities, C) H&E stain, magnification 200x, Spongiotic dermatitis from left upper arm skin biopsy, D) H&E stain, magnification 200x, lichenoid dermatitis with lymphohistiocytic reaction from left upper arm skin biopsy
  • ||||||||||  lovastatin / Generic mfg., allopurinol / Generic mfg.
    Hepatocellular Injury From Cyst Compression in Polycystic Kidney Disease (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_1890;    
    Allopurinol was stopped at this time as a potential agent of hepatic injury...Figure: Figure 1: A) MRI MRCP demonstrates prominent 12 x 9.7cm R renal cyst extending and compressing the right liver lobe. B) Coronal view demonstrating numerous right renal cysts and a left renal cyst.
  • ||||||||||  A Challenging Diagnosis of Hepatosplenic T-cell Lymphoma (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_1785;    
    He was given allopurinol for prophylaxis of tumor lysis syndrome and monitored...B. These abnormal T cells are immunoreactive for CD3 cells.( Immunohistochemical stain CD3, original magnification 400x), C. TIA shows cytotoxic granules (Immunohistochemical stain TIA, original magnification 400x), D. CD56 is highlighted by abnormal T cells (Immunohistochemical stain CD56, original magnification 400x).
  • ||||||||||  allopurinol / Generic mfg.
    Clinical, Retrospective data, Review, Journal:  Efficacy and Safety of Allopurinol on Chronic Kidney Disease Progression: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Aug 15, 2024   
    The purpose of this review is not only to examine the involvement of allopurinol in SJS/TEN but also to provide detailed information about the drug, allopurinol, and general features and characteristics of SJS/TEN and other associated drug reactions. Allopurinol treatment in patients with CKD and hyperuricemia slows the decline in eGFR as compared with placebo, without risk of increased adverse effects.
  • ||||||||||  ABP-671 / Jiangsu Atom Bioscience and Pharma
    Enrollment closed:  Phase 2b/3 Study to Assess ABP-671 a Novel URAT1 Inhibitor in Participants With Gout (clinicaltrials.gov) -  Aug 15, 2024   
    P2/3,  N=580, Active, not recruiting, 
    Allopurinol treatment in patients with CKD and hyperuricemia slows the decline in eGFR as compared with placebo, without risk of increased adverse effects. Recruiting --> Active, not recruiting
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Treatment of Canine Leishmaniasis with Meglumine Antimoniate: A Clinical Study of Tolerability and Efficacy. (Pubmed Central) -  Aug 10, 2024   
    Veterinarians must be vigilant regarding the potentially serious adverse effects associated with aNm and promptly stop drug administration if unexpected clinical manifestations occur. On the other hand, they should not discard its use for CanL treatment since it is confirmed that aNm in association with allopurinol is highly effective in controlling CanL.
  • ||||||||||  Retrospective data, Journal:  The Effectiveness of Measuring Thiopurine Metabolites in the Treatment of Autoimmune Hepatitis Patients. (Pubmed Central) -  Aug 8, 2024   
    The thiopurine drugs-azathioprine and mercaptopurine-are purine antimetabolites used for the treatment of autoimmune hepatitis...In 11 cases, levels of 6-thioguanine nucleotide were low; the dose was not changed in 3 of these, and the dose was increased in the remaining 8...In the remaining 3, the dose was decreased, and allopurinol was added...We showed that, in cases of suboptimal response to thiopurine treatment, measuring thiopurine metabolites had an important role in optimizing therapy. In most patients, changing the dose led to a significant improvement with no need to switch to secondline therapies.