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Journal: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation. (Pubmed Central) - Dec 16, 2021 Thus, umami foods induce obesity and metabolic syndrome by engaging the same purine nucleotide degradation pathway that is also activated by fructose and salt consumption. We suggest that the three tastes-sweet, salt and umami-developed to encourage food intake to facilitate energy storage and survival but drive obesity and diabetes in the setting of excess intake through similar mechanisms.
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Review, Journal: The role and transformative potential of IL-19 in atherosclerosis. (Pubmed Central) - Dec 16, 2021 Several other drugs have also been investigated in clinical trials as anti-inflammatory agents; the development of some of these agents has been terminated (canakinumab, darapladib, varespladib, losmapimod, atreleuton, setileuton, PF-04191834, veliflapon, and methotrexate), but others remain in development (ziltivekimab, tocilizumab, Somalix, IFM-2427, anakinra, mesenchymal stem cells (MSCs), colchicine, everolimus, allopurinol, and montelukast)...We propose that IL-19 is a promising biomarker and target for the diagnosis and treatment of atherosclerosis. This review considers the role and mechanism of action of IL-19 in atherosclerosis and discusses whether IL-19 is a potential therapeutic target for this condition.
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Review, Journal: Dietary supplements for chronic gout. (Pubmed Central) - Dec 16, 2021 Randomized clinical trials are warranted and should further investigate allopurinol and more selective purine derivatives in the management of acute or chronic pain conditions. While dietary supplements may be widely used for gout, this review found no high-quality that supported or refuted the use of glycomacropeptide-enriched skim milk powder or vitamin C for adults with chronic gout.
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Clinical, Review, Journal: Tumor Lysis Syndrome in Patients With Hepatocellular Carcinoma: A Systematic Review of Published Case Reports. (Pubmed Central) - Dec 5, 2021 Considering the kaleidoscope of novel therapies and diverse pathogenesis of HCC, it is crucial for clinicians to recognize the clinicolaboratory derangements suggestive of TLS and initiate appropriate management. The present review highlights the need for clinicians to consider TLS within differentials when caring for patients with HCC.
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Biomarker, Journal: Impact and applicability of pharmacogenomics in rheumatology: an integrated analysis. (Pubmed Central) - Dec 2, 2021 Pharmacogenomic genotyping could inform prescribing for the majority of rheumatology patients and may prevent a subset of ADRs/IRs. These findings justify prospective evaluation of pharmacogenomic testing including assessment of cost-effectiveness in selected rheumatology populations to further understand impact on therapy-related toxicities and treatment outcomes.
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Journal: A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa. (Pubmed Central) - Nov 29, 2021 On the molecular level, qRT-PCR proved that allopurinol showed a significant downregulating effect on all tested QS-encoding genes that regulate virulence factor production. In summary, allopurinol is a promising QS inhibitor that may be useful in the future treatment of P. aeruginosa infection.
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Journal, IO biomarker: Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. (Pubmed Central) - Nov 25, 2021 CGA or allopurinol was given to mice with HUA induced by hypoxanthine and potassium oxonate...Also, CGA increased the relative abundance of SCFA-producing bacteria, including Bacteroides, Prevotellaceae UGC-001, and Butyricimonas, and it reversed the purine metabolism and glutamate metabolism functions of gut microbiota. In conclusion, CGA may be a potential candidate for relieving the symptoms of HUA and regulating its associated inflammatory responses and intestinal homeostasis.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Feasibility of Outpatient CAR T Cell Therapy: Experience of a Single Institution () - Nov 24, 2021 - Abstract #ASH2021ASH_6231; All patients received fludarabine and cyclophosphamide as lymphodepletion (LD) therapy day -5 to -3...Patients subsequently followed up in clinic daily for 2 weeks and were started on allopurinol, ciprofloxacin, fluconazole, acyclovir and levetiracetam...Conclusion Outpatient administration of Tisagenlecleucel is feasible with low risk of hospital admission within 3 days of infusion. Adoption of outpatient CAR T cell therapy may increase patient access for treatment of DLBCL and diseases such as multiple myeloma while reducing administration costs for this novel therapy.
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Preclinical, Journal: Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice. (Pubmed Central) - Nov 24, 2021 The extracts of P. capitata herba possessed pronounced antihyperuricemia and antigouty arthritis effects and were, therefore, promising natural medicines for hyperuricemia-related disorders and gouty arthritis. The use of P. capitata herba for the treatment of urinary calculus may be, at least to some degree, related to its potential as an antihyperuricemia and antigouty arthritis drug.
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Enrollment open: Allopurinol in Acute Coronary Syndrome (clinicaltrials.gov) - Nov 19, 2021 P4, N=162, Recruiting, In short, the present study identified cleroda-4(18),13-dien-15,16-olide as novel potential XO inhibitors, which can be potentially used for the treatment of gout. Not yet recruiting --> Recruiting
- |||||||||| colchicine / Generic mfg., allopurinol / Generic mfg.
Journal, HEOR: Colchicine Prophylaxis of Gout Flares When Commencing Allopurinol is Very Cost Effective. (Pubmed Central) - Nov 17, 2021 It also holds promise for use in rapid quality testing of medicinal herbs, intermediate products, and preparations of traditional Chinese medicines. Colchicine prophylaxis to prevent gout flares whilst commencing allopurinol in gout is very cost effective.
- |||||||||| probenecid / Generic mfg., allopurinol / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - (DREAM) Probenecid vs Allopurinol (clinicaltrials.gov) - Nov 15, 2021 P=N/A, N=294878, Completed, Overall, our study provides new insights into the pathogenic mechanisms of obesity-associated periodontal disease and the development of new therapeutic options for the disease. Active, not recruiting --> Completed | Trial completion date: Feb 2022 --> Aug 2021 | Trial primary completion date: Feb 2022 --> Aug 2021
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Trial completion date, Trial primary completion date: AMETHYST: Study of Verinurad in Heart Failure With Preserved Ejection Fraction (clinicaltrials.gov) - Nov 15, 2021 P2, N=159, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Feb 2022 --> Aug 2021 | Trial primary completion date: Feb 2022 --> Aug 2021 Trial completion date: Nov 2022 --> Apr 2022 | Trial primary completion date: Nov 2022 --> Apr 2022
- |||||||||| colchicine / Generic mfg., etoricoxib / Generic mfg., allopurinol / Generic mfg.
The doubtful gout () - Nov 7, 2021 - Abstract #APLAR2021APLAR_611; Gout of the hip is extremely rare but must not be overlooked. Joint aspiration with synovial fluid analysis for crystal identification under polarized light microscopy and a negative synovial fluid culture may aid the diagnosis.
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Multicenter prospective study on gouty arthritis and predictors of outcomes among filipino patients on anti-tuberculosis treatment () - Nov 7, 2021 - Abstract #APLAR2021APLAR_532; The proper management of the patients through prompt administration of these drugs with close observation of the symptoms and laboratory work ups and correct lifestyle made possible to continue the anti-tuberculous therapy without withdrawing the anti-TB medications. The timely strict monitoring and management of notified adverse effects which includes patient education, clinical examination, and serial laboratory tests are essential.
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