allopurinol / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 0 Diseases   61 Trials   61 Trials   3860 News 


«12...1920212223242526272829...5758»
  • ||||||||||  allopurinol / Generic mfg.
    Biomarker, Review, Journal:  Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases. (Pubmed Central) -  Feb 8, 2022   
    Oxidative stress, a key pathogenic factor in the development of endothelial dysfunction has been also pointed out as an important factor of lithogenesis. Special attention must be paid to cardiovascular morbidities associated with urolithiasis in order to take advantage of pleiotropic effects of statins, angiotensin receptor blockers and allopurinol.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., allopurinol / Generic mfg.
    Single-cell multi-omic approaches define common molecular and cellular signals of domit antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage. () -  Feb 4, 2022 - Abstract #AAAAI2022AAAAI_2130;    
    Blister fluid was obtained from patients with clinically-defined sulfamethoxazole-trimethoprim (SMX-TMP)- (n=7), allopurinol- (n=9) or lamotrigine-(n=1) induced SJS/TEN for 10x 5’ single-cell (sc)TCR-RNA-CITE sequencing, providing paired TCR, transcriptome, and surface proteome (137 validated lineage and activation markers) of each cell, respectively. Multi-dimensional single-cell sequencing from SJS/TEN blister fluid across different drugs and patients defines activated, cytotoxic, and dominantly-expanded TCR+ CD8+ T-cell populations that express markers of tissue residency, and relevant cell-cell interactions that define a distinct immunopathogenesis to help drive strategies for prevention, early diagnosis, and targeted therapy.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the FDA Adverse Event Reporting System (FAERS) from 1995-2020 (Convention Center, North Building, 100 Level, Room 120A) -  Feb 4, 2022 - Abstract #AAAAI2022AAAAI_1371;    
    Overall, 30,202 (0.15%) of 20,406,852 adverse drug events reported in FAERS were “SJS”, “SJS/TEN”, or “TEN”  with a median age of 51 years, 57% were female, and 21% were fatal.  The top 4 drugs associated with SJS/TEN (lamotrigine, phenytoin, sulfamethoxazole-trimethoprim and allopurinol) were unchanged over 15 years, and accounted for 8,418 (28%) of cases.  All except phenytoin showed increasing reports over time. Over 15 years of FAERS reports, the same high-risk drugs still account for a high proportion of SJS/TEN cases.  Newer causes of SJS/TEN such as ICI have emerged as more common causes over the last 7 years with a differing epidemiology and higher mortality than the prevalent small molecule causes.
  • ||||||||||  ibuprofen / Generic mfg.
    Review, Journal:  Honorary Professor Garry Graham. (Pubmed Central) -  Feb 3, 2022   
    These results suggest a need to identify kidney stone patients who benefit from 24-hour urine testing. An appreciation of the contribution of Professor Gary Graham to anti-inflammatory and antirheumatic pharmacology and clinical pharmacology.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Journal:  Update on gout management: what is old and what is new. (Pubmed Central) -  Feb 1, 2022   
    Although there have been significant advances in understanding of risk factors and treatment approaches, gout remains suboptimally managed. There is substantial need for improving gout management efforts and gout education among patients and clinicians.
  • ||||||||||  colchicine / Generic mfg., allopurinol / Generic mfg.
    Health literacy and gout characteristics in a primary care cohort () -  Jan 30, 2022 - Abstract #BSR2022BSR_447;    
    Frequent flares and a history of oligo/polyarticular flares were associated with poor health literacy in people with gout in primary care. Our findings provide further evidence to counter the common misconception that gout is a ‘rich man’s disease’ and highlight the importance of considering health literacy when providing information and education to all people with gout.
  • ||||||||||  allopurinol / Generic mfg.
    Clinical, Review, Journal:  Oxidative Stress Markers among Obstructive Sleep Apnea Patients. (Pubmed Central) -  Jan 29, 2022   
    The administration of certain compounds, like vitamins A, C, and E as well as N-acetylcysteine and allopurinol, can decrease oxidative stress markers. However, their role in the treatment of OSA remains unclear.
  • ||||||||||  allopurinol / Generic mfg.
    Retrospective data, Journal:  Network Meta-Analysis of Drug Therapies for Lowering Uric Acid and Mortality Risk in Patients with Heart Failure. (Pubmed Central) -  Jan 27, 2022   
    It is available to develop SCE as food supplemental applications for hyperuricemia and nephritic inflammation. Results suggested that allopurinol therapy was not associated with a significantly improved prognosis in terms of mortality but could potentially counteract the adverse effects associated with longstanding hyperuricemia in HF patients.
  • ||||||||||  allopurinol / Generic mfg.
    Clinical, Journal:  Allopurinol for fibromyalgia pain in adults: a randomized controlled trial. (Pubmed Central) -  Jan 27, 2022   
    Although previous findings indicated that allopurinol could present intrinsic analgesic effects in both animals and humans, this study showed no benefit of the use of oral allopurinol as an adjuvant strategy during 30 days in women displaying fibromyalgia. However, considering previous promising results, new prospective studies are still valid to further investigate allopurinol and more selective purine derivatives in the management of pain syndromes.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Genotyping for HLA Risk Alleles to Prevent Drug Hypersensitivity Reactions: Impact Analysis. (Pubmed Central) -  Jan 26, 2022   
    Genotyping before initiating antiepileptic drugs or flucloxacillin is not cost-effective. Our results confirm the need for mandatory testing of HLA-B*5701 in abacavir initiators, as indicated in the drug label, and show genotyping of HLA-B*5801 in allopurinol initiators should be considered.
  • ||||||||||  allopurinol / Generic mfg.
    THE PREVALENCE OF HYPERURICEMIA IN PATIENTS WITH URINARY STONES AND HYPERURICOSURIA OR NORMAL URICOSURIA (Poster Area (Virtual)) -  Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1034;    
    We did not find any evidence that supports treatment of hyperuricemia in patients with urinary stones. Further studies, including cohort prospective studies, are required to observe the rate of urinary stones among patients with hyperuricemia and with hyperuricosuria or without it and the efficacy of treatment of hyperuricemia in these different conditions.
  • ||||||||||  colchicine / Generic mfg., allopurinol / Generic mfg.
    Journal, Adverse events:  Gout and levodopa: an unknown adverse effect? (Pubmed Central) -  Jan 18, 2022   
    Despite few cases of recovery after reduced doses of levodopa, the above described case of positive reintroduction was an argument in favor of the role of levodopa in gout flare. This study highlights a potential association between levodopa and gout through an analysis of the cases reported in the WHO pharmacovigilance database.
  • ||||||||||  allopurinol / Generic mfg.
    Review, Journal:  Leishmaniosis caused by Leishmania infantum in ferrets: Update review. (Pubmed Central) -  Jan 15, 2022   
    Two different therapeutic protocols have been described to treat domestic ferrets with leishmaniosis: meglumine antimoniate plus allopurinol protocol or miltefosine plus allopurinol protocol...Different proposed diagnostic algorithms have been included for domestic ferrets with suspected leishmaniosis, clinically healthy domestic ferrets and animals as blood donors. In this sense, the present review provides updated data on scientific knowledge of leishmaniosis in ferrets.
  • ||||||||||  allopurinol / Generic mfg.
    Biomarker, Journal:  Integrating disease and drug-related phenotypes for improved identification of pharmacogenomic variants. (Pubmed Central) -  Jan 11, 2022   
    Using genome-wide association studies summary statistics from the UK Biobank, European Bioinformatics Institute-genome-wide association studies catalog and the Pharmacogenomics Research Network, we validated pleiotropy at the ABCG2 locus between allopurinol response and gout and identified novel pleiotropy between antihypertensive-induced new-onset diabetes, Crohn's disease and inflammatory bowel disease at the IL18RAP/SLC9A4 locus. New mechanistic insights and genetic loci can be uncovered by identifying pleiotropy between disease and drug-related traits.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  Ameliorative effect and mechanism of Yi-Suan-Cha against hyperuricemia in rats. (Pubmed Central) -  Jan 11, 2022   
    It is concluded that ALP activates the Nrf2/p62 pathway to ameliorate oxidative stress and liver injury in diabetic rats. Yi-Suan-Cha may lower uric acid level by downregulating URAT1/GLUT9 expression and upregulating ABCG2/OAT1 expression.
  • ||||||||||  Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / Eisai, AbbVie
    Journal:  P053 Interstitial Nephritis from IBD: Complicated Conclusions. (Pubmed Central) -  Jan 11, 2022   
    TIN secondary to aminosalicylates is well-documented, but there are few reports of adalimumab-induced granulomatous TIN and only one report of vedolizumab-induced TIN. Each of our patients had well-controlled IBD and multiple confounding variables that could impact kidney function or cause TIN, including hypertension and multiple potential culprit medications, illustrating the dilemma of determining the etiology of renal injury in IBD patients.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  All-cause mortality and allopurinol use. (Pubmed Central) -  Jan 8, 2022   
    This meta-analysis is technically sound and the data support the conclusions. Some points are discussed.