- |||||||||| febuxostat / Generic mfg.
Journal: Risk of Hematologic Events With Coadministration of Methotrexate and the Breast Cancer Resistance Protein Inhibitor Febuxostat. (Pubmed Central) - Jun 29, 2022
We analyzed the Japanese Adverse Drug Event Report database and compared the frequency of hematologic events in patients taking oral and intravenous MTX, with or without the concomitant use of febuxostat or allopurinol...The multivariate logistic analysis of intravenous MTX users showed that hematologic events were significantly associated with febuxostat use (P < 0.01) and age ≥ 60 years (P < 0.01). Our findings suggest that patients being treated with intravenous MTX who concomitantly use febuxostat may be at an increased risk of hematologic events, presumably due to BCRP-mediated drug-drug interaction.
- |||||||||| febuxostat / Generic mfg., allopurinol / Generic mfg.
Journal: POSSIBILITIES OF RENOPROTECTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERURICEMIA. (Pubmed Central) - Jun 28, 2022
In patients with pre-dialysis stages of CKD febuxostat demonstrates renoprotective abilities. Use of febuxostat in patients with CKD stage 3b-4 and in patients on hemodialysis is safe and more effective for target sUA level achievement than the use of allopurinol.
- |||||||||| allopurinol / Generic mfg.
Preclinical, Journal: Hypouricemic Effect of Submerged Culture of Ganoderma lucidum in Potassium Oxonate-Induced Hyperuricemic Rats. (Pubmed Central) - Jun 24, 2022
However, allopurinol (10 mg/kg b.w.) or GM treatment (200 or 400 mg/kg b.w) improved food intake (26.3 ± 2.7 g/day) and reduced the level of uric acid (4.45 ± 0.46 mg/dL)...These results clearly demonstrated the hypouricemic effect of submerged G. lucidum culture and their potential against hyperuricemia-associated renal and hepatic damage. GM was more potent to alleviate hyperuricemia, and GP was more potent to improve renal and hepatic function.
- |||||||||| colchicine / Generic mfg., allopurinol / Generic mfg.
Review, Journal: Distinguishing Periprosthetic Crystalline Arthropathy from Infection in Total Knee Arthroplasty: A Systematic Review. (Pubmed Central) - Jun 23, 2022
Commonly used markers of PJI fail to reliably distinguish periprosthetic crystalline arthropathy from infection. Though clinical judgement and consideration of the implications of delayed treatment for acute PJI remain paramount, in the setting of synovial crystals, surgeons may wish to consider this alternate etiology as the source of the patient's clinical symptoms.
- |||||||||| allopurinol / Generic mfg.
Journal: Fabrication and characterization of dissolving microneedles for transdermal drug delivery of allopurinol. (Pubmed Central) - Jun 23, 2022
Moreover, transepidermal water loss significantly increased to 49.50 ± 3.82 g/m·h after the application of DMNs and returned to normal levels (12.25 ± 0.21 g/m·h) after 8 h, indicating that the DMNs were well tolerated. These results suggest that transdermal drug delivery of AP by using DMNs is an efficient and safe alternative to currently available routes of administration.
- |||||||||| metformin / Generic mfg.
Journal: A nationwide wastewater-based assessment of metformin consumption across Australia. (Pubmed Central) - Jun 23, 2022
Greater metformin use was correlated with populations of lower education and income levels, while positive correlations were found between metformin consumption and consumption of allopurinol, caffeine and venlafaxine. Our study provides more evidence on the distribution of metformin use across Australia, which can be used to develop public health strategies to reduce the overall burden of type 2 diabetes in specific regions.
- |||||||||| allopurinol / Generic mfg.
Preclinical, Journal: In Vivo Effects of Orally Administered Different Concentrations of Silver Oxide Nanoparticles in Hyperuricemic Mice. (Pubmed Central) - Jun 22, 2022
The positive control was provided with the commercially available drug allopurinol to compare the effects of AgO-NPs and allopurinol...The lipid profile results showed that high concentration (20 µg/mL) of AgO-NPs decrease the lipid content significantly as compared to control. It was concluded from this study that the antioxidant, anti-inflammatory, and antilipidemic properties of AgO-NPs may improve the hyperuricemic condition in gouty arthritis mice.
- |||||||||| Journal: Epidermal necrolysis in the context of immuno-oncologic medication as well as kinase inhibitors and biologics. (Pubmed Central) - Jun 22, 2022
Fourteen cases were EN-like reactions: six bullous lichenoid drug eruptions (DE) to pembrolizumab (2), obinutuzumab, nivolumab, rituximab, infliximab/nivolumab, and eight multiforme-like DE to rituximab (2), adalimumab, ramucirumab, bevacizumab, vemurafenib, sorafenib (2)...A correct diagnosis is highly relevant in terms of prognosis and use of these drugs in malignoma treatment. Re-exposure is contraindicated in EN, but possible in other DE after rigorous risk-benefit evaluation.
- |||||||||| metformin / Generic mfg., acyclovir / Generic mfg., allopurinol / Generic mfg.
Fluconazole induced toxic epidermal necrosis in a HIV negative woman: a new case. (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_48;
Initially involving the trunk ,with marked lip and oral blisters ,the rash later spread peripherally to involve 80% of the body surface area , 2 days after introducing oral aciclovir...Discussion Drug induced toxic epidermal necrolysis (TEN) is more commonly associated with medications such as sulfonamides, penicillin, anticonvulsants, oxicam non-steroidal anti-inflammatory drugs, allopurinol and corticosteroids...TEN caused by fluconazole is rare ,and till now only few cases have been reported in the literature, mainly in patient with HIV infection. We reported a rare case of fuconazole induced TEN in a HIV négative woman.
- |||||||||| prednisone / Generic mfg., carbamazepine / Generic mfg., allopurinol / Generic mfg.
Difficulties in drug-induced hypersensitivity syndrome diagnosis (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_35;
Anticonvulsants (especially carbamazepine), antibiotics and allopurinol are thought to be among the most common causes of DIHS...In the treatment were used systemic corticosteroids (methylprednisolone, followed by prednisone) which improved the condition of the skin...The clinical picture and the histopathological examination of the skin indicated the diagnosis of DIHS. The diagnosis of DIHS constitutes a challenge due to the nonspecific symptoms and the difficulty in identifying the drug which is the cause of reaction.
- |||||||||| ruzinurad (SHR 4640) / Jiangsu Hengrui Pharma
Trial completion, Enrollment change, Trial primary completion date, Monotherapy: A Study of Evaluating the Efficacy and Safety of SHR4640 in Subjects With Gout (clinicaltrials.gov) - Jun 13, 2022
P3, N=594, Completed,
The diagnosis of DIHS constitutes a challenge due to the nonspecific symptoms and the difficulty in identifying the drug which is the cause of reaction. Recruiting --> Completed | N=880 --> 594 | Trial primary completion date: Mar 2021 --> Jul 2021
- |||||||||| carbamazepine / Generic mfg., allopurinol / Generic mfg.
Biomarker, Clinical, Review, Journal: Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health. (Pubmed Central) - Jun 11, 2022
G6PD deficiencies were most frequent in Africa, the Middle East and Southeast Asia with pronounced differences in variant composition. These variability data provide an important resource to inform cost-effectiveness modeling and guide population-specific genotyping strategies with the goal of optimizing the implementation of precision public health.
- |||||||||| trimetazidine / Generic mfg., allopurinol / Generic mfg.
Preclinical, Journal: BRETSCHNEIDER SOLUTION AND TWO ANTIANGINAL DRUGS PROTECT PERIPHERAL TISSUE IN AN ANIMAL MODEL OF HEMORRHAGIC SHOCK. (Pubmed Central) - Jun 9, 2022
Also, treatment with TMZ, ALO and HTK increased immunohisthochemical expression of thioredoxin-1 in heart [Control: 6.6 (5.6-7.4); TMZ: 9.5 (8.1-9.7); ALO: 9.1 (8.4-10.2); HTK: 14.2 (12.6-15); all p<0,05]; and kidney [Control: 4.6 (4-5.1); TMZ: 9.7 (9.3-9.9); ALO: 9.6 (9-9.9); HTK: 16.7 (16.1-17); all p<0,05]. In an experimental model of hemorrhagic shock, TMZ, ALO and HTK Solution attenuated cell damage in multiple parenchyma and increased antioxidant defenses.
- |||||||||| hydralazine hydrochloride / Generic mfg.
Journal, PARP Biomarker: Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy. (Pubmed Central) - Jun 9, 2022
While both hydralazine and allopurinol downregulated XO and NADPH oxidase expression, only hydralazine upregulated Nrf2/HO-1 renal expression, suggesting the additional effects of hydralazine independent of XO/ NADPH oxidase inhibition. In conclusion, hydralazine protected renal proximal tubular epithelial cells against the insults of high glucose and prevented renal damage via XO/NADPH oxidase inhibition and Nrf-2/HO-1 activation, suggesting the comprehensive antioxidation and anti-inflammation mechanisms for the management of DN.
- |||||||||| allopurinol / Generic mfg.
Journal: Why do patients with gout not take allopurinol? (Pubmed Central) - Jun 8, 2022
The major reasons behind the patient's decision not to take allopurinol relate to the desire to lead a normal life and the strategy of testing the treatment to see if they could reduce the dose without getting symptoms. These results provide some potentially modifiable targets for adherence interventions and some recommendations to clinicians about how to reframe ULT for patients in order to improve adherence.
- |||||||||| allopurinol / Generic mfg.
Journal: Therapeutic antigout and antioxidant activity of Piper betle L. in gout-induced broilers. (Pubmed Central) - Jun 4, 2022
Better feed conversion ratios (1.83 ± 0.001) and the restoration of the antioxidants superoxide dismutase, catalase and glutathione to normal levels were observed from birds fed P. betle 20 g/kg than with Allopurinol.4. The data showed that P. betle can be an effective treatment for gout in broiler chicken, as an alternative to Allopurinol.
- |||||||||| febuxostat / Generic mfg., allopurinol / Generic mfg.
Journal: Gout (Pubmed Central) - Jun 4, 2022
Therefore, guidelines call for consequent urate lowering strategies to bring serum urate levels to a target at least below 360 µmol/l. The following article summarizes the recent state of knowledge regarding the diagnosis and therapy of gout.
- |||||||||| verinurad (RDEA3170) / AstraZeneca
Trial completion: AMETHYST: Study of Verinurad in Heart Failure With Preserved Ejection Fraction (clinicaltrials.gov) - Jun 1, 2022
P2, N=159, Completed,
Older patients with CKD who started allopurinol at >100 mg/d versus ≤100 mg/d were twice as likely to visit a hospital with a severe cutaneous reaction in the next 180 days. Active, not recruiting --> Completed
- |||||||||| allopurinol / Generic mfg.
Journal: Generalized fixed drug eruption due to allopurinol (Pubmed Central) - May 29, 2022
Based on the medication safety, the therapeutic effects and the low price, with oral administration once daily, we suggest that benzbromarone should be the first drug of choice if clinicians are treating asymptomatic hyperuricemia. No abstract available
- |||||||||| pentoxifylline / Generic mfg., allopurinol / Generic mfg.
Review, Journal: A Systematic Review on the Role of Antioxidants in Thyroid Eye Disease. (Pubmed Central) - May 29, 2022
Se was the only recommended antioxidant based on one high-level randomized controlled trial. While different antioxidants could potentially be effective in the management of TED, no strong recommendation for any or combination of antioxidants could be made to be implemented in the daily practice.
- |||||||||| allopurinol / Generic mfg.
Journal: Synthesis and biological evaluation of thiazolidine-2-thione derivatives as novel xanthine oxidase inhibitors. (Pubmed Central) - May 26, 2022
The result shown that compound 6k behaved the strongest XO inhibitory activity with an IC50 value of 3.56 μmol/L, which was approximately 2.5-fold more potent than allopurinol...Additionally, the molecular docking results suggested that the 4-fluorophenyl-sulfonyl moiety could interact with Gly260 and Ile264 in the innermost part of the active pocket through 2 hydrogen bonds, while the thiazolidinethione moiety could form two hydrogen bonds with Glu263 and Ser347 in hydrophobic pockets. In summary, the results described above suggested that compound 6k could be a valuable lead compound for the treatment of hyperuricemia as a novel XO inhibitor.
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