allopurinol / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 0 Diseases   61 Trials   61 Trials   3860 News 


«12345678910111213...5758»
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Korean Red Ginseng Ameliorates the Level of Serum Uric Acid via Downregulating URAT1 and Upregulating OAT1 and OAT3. (Pubmed Central) -  Nov 18, 2024   
    Animal study using with ICR mice was composed of control, potassium oxonate-induced hyperuricemia, allopurinol, and 3 Korean red ginseng water extract (KRGWE) treatment groups (62.5; 125, and 500?mg/kg)...KRGWE improved liver and kidney functioning. KRGWE improved liver/kidney functioning and is promising anti-hyperuricemic agent which can control serum uric acid via downregulating URAT1 and upregulating OAT1 and OAT3.
  • ||||||||||  allopurinol / Generic mfg.
    Enrollment closed, Phase classification, Enrollment change, Trial completion date, Trial primary completion date, Combination therapy:  Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial) (clinicaltrials.gov) -  Nov 17, 2024   
    P1,  N=17, Active, not recruiting, 
    Thus, our study shows maintaining low sUA levels with ULT was significantly associated with a decreased risk of CKD progression in patients with gout. Recruiting --> Active, not recruiting | Phase classification: P1/2 --> P1 | N=36 --> 17 | Trial completion date: Jun 2026 --> Nov 2024 | Trial primary completion date: Dec 2025 --> Nov 2024
  • ||||||||||  Yescarta (axicabtagene ciloleucel) / Gilead
    Journal, CAR T-Cell Therapy:  Toxic epidermal necrolysis-like cutaneous toxicity following chimeric antigen receptor T-cell therapy in recurrent large B-cell lymphoma. (Pubmed Central) -  Nov 17, 2024   
    We present a case of a 69-year-old man with diffuse large B-cell lymphoma treated with axicabtagene-ciloleucel CAR-T therapy, who developed a rare and severe cutaneous toxicity resembling toxic epidermal necrolysis (TEN)...Notably, allopurinol-induced TEN was considered with the patient's recent exposure to allopurinol, although the onset and minimal mucosal involvement did not align with typical presentations of allopurinol-induced cases...This case expands the spectrum of CAR-T therapy-related cutaneous toxicities, highlighting the need for early recognition of histopathology and tailored management by dermatologists. Further understanding of these reactions is crucial for optimizing the safety profile of this groundbreaking immunotherapy.
  • ||||||||||  allopurinol / Generic mfg.
    Trial completion, Enrollment change:  Obesity and Uric Acid Stones Study (clinicaltrials.gov) -  Nov 13, 2024   
    P3,  N=22, Completed, 
    Further studies are needed to confirm our findings. Active, not recruiting --> Completed | N=40 --> 22
  • ||||||||||  imatinib / Generic mfg., hydroxyurea / Generic mfg., allopurinol / Generic mfg.
    Case report: chronic myeloid leukemia in childhood () -  Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_48;    
    They sent for BCR-ABL which displayed a positive level more than upper Loq. The patient was started on Hydroxyurea 500 mg for five days after availability of BCR-ABL, imatinib was added on day 10, his WBC reduced; hydroxyurea was stopped, patient continue only on imatinib 400 mg...The present case is 15-year-old male who presented with joint pain, fever, splenomegaly, TLC of 305 x 10
  • ||||||||||  carbamazepine / Generic mfg.
    Review, Journal:  Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature. (Pubmed Central) -  Nov 7, 2024   
    This report adds to the scientific literature by highlighting the potential dangers associated with anticonvulsant therapies and the necessity for personalized medicine approaches in preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening and vigilant monitoring in the management of patients requiring anticonvulsant medications to prevent serious adverse reactions.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Modulation of cutaneous vasodilation by reactive oxygen species during local and whole-body heating in young and older adults. (Pubmed Central) -  Nov 6, 2024   
    The main takeaway is the pivotal role of genetic screening and vigilant monitoring in the management of patients requiring anticonvulsant medications to prevent serious adverse reactions. ROS derived from NADPH oxidase and xanthine oxidase attenuate cutaneous vasodilation in older adults during passive whole-body heating, but not during local skin heating, with negligible effects on their young counterparts for either heating modality.
  • ||||||||||  thioguanine / Generic mfg., allopurinol / Generic mfg.
    Allopurinol Add-on Treatment - Promising Approach to Opitimize Maintenance Therapy for Acute Lymphoblastic Leukemia in Children (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_2628;    
    P2
    DNA-TG/e-TGN ratio was unchanged indicating that DNA incorporation of TGN was not significantly affected during allopurinol treatment. The 46 % rise in DNA-TG, together with our previously published data with higher proportion of ANC levels within target, lower ALT and no increase in SAE, indicate that addition of allopurinol could be an effective strategy to optimize ALL MT.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Cost-Effectiveness of Febuxostat 120/80 Mg as a Second-Line After Allopurinol 100/300MG in Gout Patients in Algeria () -  Nov 4, 2024 - Abstract #ISPOREU2024ISPOR_EU_2603;    
    Molecular docking and molecular dynamic simulations were carried out to get insight into the key interactions of the inhibitors bound to the xanthine oxidase active site. In Algeria, Febuxostat 120/80 mg as a second-line treatment after allopurinol 100/300mg in gout patients is associated with improved clinical and reasonable economic outcomes compared to allopurinol 100/300mg only.
  • ||||||||||  allopurinol / Generic mfg.
    Urate Lowering Therapy in Patients With Subcutaneous Tophi () -  Nov 4, 2024 - Abstract #ISPOREU2024ISPOR_EU_635;    
    A large percent of patients with subcutaneous tophi are not being treated with a ULT, and of those treated, nearly half do not achieve sUA <6 mg/dL or the recommended <5 mg/dL. New treatments and/or treatment strategies are needed to improve care for patients with subcutaneous tophi.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Novel pyrimidine derivatives and black cumin as xanthine oxidase inhibitors: Synthesis, docking study and formulation. (Pubmed Central) -  Nov 4, 2024   
    On the other hand, new pyrimidine and triazolopyrimidine derivatives were prepared in an attempt to mimic the pyrazolpyrimidine structure of allopurinol (a well-known xanthine oxidase inhibitor drug)...To further understand the approach of binding between synthesized compounds 6a-c and xanthine oxidase, a molecular docking investigation was conducted. These findings highlight the discovery of a novel group of xanthine oxidase inhibitors with the potential to improve the state-of-the-art treatment for gout.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  The Impact of Uric Acid-Lowering Therapy on the Progression of Non-dialysis Chronic Kidney Disease: A Prospective Cohort Study. (Pubmed Central) -  Oct 30, 2024   
    There was a moderate inverse correlation between the difference in serum uric acid and the difference in estimated glomerular filtration rate (eGFR) after treatment (r = -0.5, p = 0.001). Conclusions The effective management of hyperuricemia by combining nonpharmacological (changing diet) and/or pharmacological (allopurinol) therapies may meaningfully improve the glomerular filtration rate in non-dialysis CKD patients with hyperuricemia.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Design, synthesis, and evaluation of chalcone derivatives as xanthine oxidase inhibitors. (Pubmed Central) -  Oct 27, 2024   
    Conclusion The use of febuxostat was neither associated with a decreased risk of cardiovascular events or deaths nor with the timing of starting kidney replacement therapy compared to the use of allopurinol in patients with CKD. All the 35 derivatives exhibited higher XO inhibition activities (IC50
  • ||||||||||  clindamycin phosphate / Generic mfg.
    Journal:  Severe Cutaneous Reaction Induced by Clindamycin: A Case Report of Toxic Epidermal Necrolysis. (Pubmed Central) -  Oct 25, 2024   
    However, lincosamide antibiotics like clindamycin are rarely associated with precipitating SJS or TEN. This report highlights the treatment and prognostic challenges faced throughout the patient's clinical course and seeks to highlight the importance of recognizing the development of SJS/TEN following novel drug administration and promptly addressing the management of the condition to improve long-term patient outcomes.
  • ||||||||||  WHEN A FRIEND BECOMES A FOE ? CIRCUMVENTING IVIG REACTIONS (Monitor 02; Hall A) -  Oct 24, 2024 - Abstract #ACAAI2024ACAAI_1288;    
    Cefdinir and home allopurinol were discontinued...Ig replacement therapy was discontinued and he was diagnosed with drug-induced psoriasis requiring 6-month treatment of apremilast and phototherapy with subsequent resolution...Our case emphasizes potential severe cutaneous adverse effects from IVIG where alternative options are clinically warranted. Generalized peeling and scaling of the skin
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Iatrogenic risk in elderly patients. (Pubmed Central) -  Oct 23, 2024   
    Allopurinol and febuxostat are similarly efficacious and well-tolerated in the treatment of gout in people with CKD when used in a treat-to-target regimen with lower incidence of gout flares in participants randomized to allopurinol. Through this study, we noted a predominance of delayed drug hypersensitivity reactions as well as an increased involvement of anti-infectives and allopurinol in the occurrence of adverse effects in the elderly population.
  • ||||||||||  allopurinol / Generic mfg.
    Trial completion date, Trial primary completion date:  Allopurinol Improves Heart Function in African Americans With Resistant Hypertension (clinicaltrials.gov) -  Oct 15, 2024   
    P2,  N=50, Recruiting, 
    While our findings should be interpreted with caution owing to the small number of studies and substantial heterogeneity, proactive prevention, recognition, and management of inappropriate drug dosing in this population is warranted. Trial completion date: May 2025 --> May 2026 | Trial primary completion date: Mar 2025 --> Oct 2025
  • ||||||||||  carbamazepine / Generic mfg., abacavir / Generic mfg., allopurinol / Generic mfg.
    Journal:  Implementation of HLA-related genotype-guided prescribing in Singapore. (Pubmed Central) -  Oct 15, 2024   
    The cost-effectiveness of such measures may change over time with new data (eg, allele frequencies, test costs, drug prices, genotyping approach) and should be evaluated periodically and locally. Implementation of preemptive pharmacogenomics panel testing as part of routine clinical care may shift the threshold for cost-effectiveness and brings promise of further optimization of pharmacotherapy through precision medicine.
  • ||||||||||  Savaysa (edoxaban) / Daiichi Sankyo
    Journal:  Diagnostic Complexities and Management of Gouty Arthritis With Suspected Seronegative Rheumatoid Arthritis and Malignancy in an Elderly Male. (Pubmed Central) -  Oct 8, 2024   
    This case involves a 77-year-old male with chronic gout, hypertension, chronic atrial fibrillation on edoxaban, diastolic congestive heart failure, and chronic kidney disease stage 3B, presenting with left knee pain and limited mobility...The patient was managed with allopurinol, prednisolone, and colchicine and referred to rheumatology for further evaluation...This case highlights the complexity of diagnosing gouty arthritis mimicking seronegative RA, especially in elderly patients where the risk of malignancy must be considered. It underscores the need for comprehensive clinical and imaging evaluations and personalized treatment plans in managing patients with multiple comorbidities.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Journal, Machine learning:  A consensual machine-learning-assisted QSAR model for effective bioactivity prediction of xanthine oxidase inhibitors using molecular fingerprints. (Pubmed Central) -  Oct 3, 2024   
    In this work, 249 XOIs belonging to 16 scaffolds were collected and were integrated into a consensual dataset by introducing the concept of IC50 values relative to allopurinol (RIC50)...Besides, an external validation of 43 XOIs and a case study on febuxostat also provide satisfactory results, indicating the powerful generalization of our predictor...The absorption, distribution, metabolism, excretion and toxicity (ADMET) prediction results further enhanced the potential of these novel XOIs as drug candidates. Overall, this work presents a QSAR model for accurate prediction of IP of XOIs, and is expected to provide new insights for further structure-guided design of novel XOIs.
  • ||||||||||  febuxostat / Generic mfg.
    STEVENS-JOHNSON SYNDROME CAUSED BY FEBUXOSTAT (Monitor 2; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1216;    
    Current diagnostic testing for SJS is lacking, making diagnosis difficult. Further investigation into diagnostic modalities to identify causative agents and treatment options when a causative agent is required to treat disease is needed.