allopurinol / Generic mfg. 
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  • ||||||||||  tranexamic acid oral / Generic mfg., propranolol / Generic mfg., allopurinol / Generic mfg.
    Preclinical, Journal:  Postinjury Treatment to Mitigate the Effects of Aeromedical Evacuation After TBI in a Porcine Model. (Pubmed Central) -  Sep 24, 2022   
    Allopurinol, propranolol, and TXA, following TBI, do not induce adverse changes in systemic or cerebral hemodynamics during or after a simulated postinjury flight. While transient changes were noted in systemic cytokines and p-tau accumulation, further investigation will be needed to determine any persistent neurological effects of injury, flight, and pharmacologic treatment.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  Anserine beneficial effects in hyperuricemic rats by inhibiting XOD, regulating uric acid transporter and repairing hepatorenal injury. (Pubmed Central) -  Sep 24, 2022   
    Hyperuricemic rats were induced with a combination of 750 mg per kg bw d potassium oxazinate (PO) and 200 mg per kg bw d hypoxanthine for a week, and the rats were separately orally administered anserine (20, 40, 80 mg kg) and allopurinol (10 mg kg) for three weeks...Moreover, the gene expressions of xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and glucose transporter type 9 (GLUT9) were downregulated by anserine administration, and the gene expressions of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) were upregulated at the same time. These findings suggest that hepatorenal injury was repaired by anserine, which further regulated the expression of hepatic XOD and renal URAT1, GLUT9, ABCG2, OAT1 and OAT3 to relieve hyperuricemia in rats.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Allopurinol and prostate cancer survival in a Finnish population-based cohort. (Pubmed Central) -  Sep 23, 2022   
    Allopurinol users had lower OS but there were no significant differences by duration or intensity of allopurinol use. Allopurinol use may not have anticancer effects against prostate cancer; instead, it may be a surrogate for metabolic problems causing shorter OS among men with PCa.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia. (Pubmed Central) -  Sep 21, 2022   
    After treatment with different doses of NAY (low dose: 10 mg/kg, medium dose: 20 mg/kg, and high dose: 40 mg/kg) and allopurinol (positive drug, 10 mg/kg), observe the levels of uric acid (UA), creatinine (CRE), and urea nitrogen (BUN) in urine and serum, respectively, and detect the activities of xanthine oxidase in the liver...On the one hand, it can inhibit the formation of UA by inhibiting xanthine oxidase inhibitors activity, and on the other hand, it can promote the excretion of UA by regulating the UA transporter. It provides new ideas for the development of hyperuricemia drugs in the future.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Journal:  Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. (Pubmed Central) -  Sep 20, 2022   
    However, there were no differences in change of the composite cognitive score between groups (adjusted between-group difference for PT ≥ 75 vs. PNT: 0.144, 95%CI - 0.075 to 0.363, p = 0.196; PT < 75 vs. PNT: 0.103, 95%CI - 0.148 to 0.353, p = 0.421). Use of ULT was not associated with reduced cognitive decline over a 5-year follow-up among community-dwelling older adults at risk of dementia.
  • ||||||||||  Retrospective data, Journal:  Modelling and assessing one- and two-drug dose titrations. (Pubmed Central) -  Sep 20, 2022   
    Here, we propose a language to model dose titration procedures. The language was used to formalize one- and two-drug titration of chronic and acute cases, and to perform retrospective analysis of the drug titration processes on 253 patients diagnosed of diabetes mellitus type 2 and treated with metformin, 321 patients treated of chonic heart failure with furosemide, 155 patients with hyperuricemia treated with allopurinol as initial drug and febuxostat as alternative drug, and 187 hyperuricemia patients with primary drug allopurinol and supplementary drug probenecid, in order to identify different types of drug titration deviations from standard DT methods.
  • ||||||||||  carvedilol / Generic mfg., trimetazidine / Generic mfg., allopurinol / Generic mfg.
    Review, Journal:  A Potential Route to Reduce Ischemia/Reperfusion Injury in Organ Preservation. (Pubmed Central) -  Sep 18, 2022   
    In fact, these drugs are already in clinical use, and it is a question of repositioning them for this novel use, without additional risk. This new strategy of including them would allow us to shift from cold storage solutions to cold preservation solutions including multitarget pharmacological components, offering protection against IRI and thus protecting today's more vulnerable organs.
  • ||||||||||  allopurinol / Generic mfg.
    Prevalence of HLA B*5801 Allele Among African American Patients with Gout in an Academic Health Center (Virtual Poster Hall) -  Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_2963;    
    Both patients who developed SCAR while on allopurinol were found to be HLA B*5801 positive when admitted to the hospital, thus reinforcing the strong association between this risk allele and SCARs. In our study, the incidence of AHS was 1 in 104 African American allopurinol users, which was also higher than 1 in 1972 users as reported in the study by Keller et al.
  • ||||||||||  Patient Factors Influencing Recruitment in a Telemedicine Randomized Clinical Trial (Virtual Poster Hall) -  Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_2755;    
    P=N/A
    We found that patients who enrolled in the EVOLVE RCT of telemedicine vs. in-person visits were younger and lived closer to the rheumatology clinic. Our findings suggest that older individuals and those living further from our academic medical center may be underrepresented in this telemedicine trial, however enrollment is ongoing.
  • ||||||||||  allopurinol / Generic mfg.
    Changes in Tophus Composition During Urate-Lowering Therapy: A Dual Energy CT Study (Virtual Poster Hall) -  Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_1213;    
    While both urate and soft tissue volumes reduce over time, the chronic inflammatory soft tissue within the tophus is slower to respond than the MSU crystals.Figure 1. Example of an individual tophus measurement and change in the tophus composition over timeFigure 2.
  • ||||||||||  allopurinol / Generic mfg.
    Retrospective data, Journal:  Allopurinol Use and the Risk of Type 2 Diabetes Mellitus: A Meta-Analysis of Cohort Studies. (Pubmed Central) -  Sep 14, 2022   
    Because there are not enough eligible studies, the strength of evidence in our meta-analysis is weak. More cohort studies are needed to determine an association between use of allopurinol and the probability of T2DM for individuals with gout and/or hyperuricemia.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  A new immunochemotherapy schedule for visceral leishmaniasis in a hamster model. (Pubmed Central) -  Sep 14, 2022   
    The purpose of the present study was to evaluate the efficacy of the treatment with a recombinant cysteine proteinase from Leishmania, rldccys1, associated with allopurinol or miltefosine on Leishmania (Leishmania) infantum chagasi-infected hamsters...Neither hepatotoxicity nor nephrotoxicity was observed among controls and treated groups. These findings open perspectives to further explore this immunochemotherapeutic schedule as an alternative for treatment of visceral leishmaniasis.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  Allopurinol attenuates repeated traumatic brain injury in old rats: A preliminary report. (Pubmed Central) -  Sep 12, 2022   
    In neurobehavioral analyses, time spent in closed arms, in the corner of the open field, swimming latency, and distance were impaired in injured rats; however, all of them were significantly improved by allopurinol therapy. To sum up, this study demonstrated that ALL may mitigate rTBI-induced damage in aged rats, which suggests ALL as a potential therapeutic strategy for the treatment of recurrent TBI.
  • ||||||||||  TOO HOT TO GET DRESSED? (Convention Center Exhibit Hall: Poster Area) -  Sep 11, 2022 - Abstract #CHEST2022CHEST_4086;    
    On hospital day 5 patient fevered to 103 and was started on Vancomycin and Cefepime for possible sepsis...Cefepime was changed to Aztreonam for possible drug reaction...Based on the clinical presentation, patient's medication list (oxcarbazepine, cefepime, and allopurinol), and skin biopsy findings, a diagnosis of severe DRESS was made... This case demonstrates the importance of maintaining a high index of suspicion for DRESS when alternative, more common etiologies of multi-organ failure are not found and illustrates the heterogenous way in which it can present.