- |||||||||| Unusual Cause Of Toxic Epidermal Necrolysis () - Jul 3, 2023 - Abstract #WCD2023WCD_5290;
Here, we report a case of TEN in a patient who had been treated with oral itraconazole...KEY MESSAGE: Allopurinol, carbamazepine, antibacterial sulphonamides, sulfasalazine, phenobarbital, phenytoin, nevirapine, and non-steroidal anti-inflammatory (NSAIDs) medications are medicines that having a significant risk of developing into severe cutaneous drug eruptions...As a dermatologists, we have to be aware of any potential adverse effects. Early diagnosis, immediate medication discontinuation and prompt supportive care commencement are crucial to reduce morbidity and mortality rate
- |||||||||| Stevens-Johnson Syndrome In An Infant Induced by Paracetamol : A Rare Case () - Jul 3, 2023 - Abstract #WCD2023WCD_5279;
By contrast with adults, allopurinol, oxicams and nevirapine are not identified as causative agents in infant, probably due to differences in drug prescriptions...The patient was treated with methylprednisolone injection 15 mg and zinc syrup daily...Therefore, clinicians must be more cautious while prescribing. Patients should also be educated regarding the adverse effects of NSAID.
- |||||||||| Purpura at electrocardiography probe sites: ECG sign in DRESS syndrome () - Jul 3, 2023 - Abstract #WCD2023WCD_5273;
OBSERVATION: Our first and second patients whom were receiving phenytoin treatment presented with maculopapular eruption...Our second and third patients presented with significant facial edema and erythematous papules and plaques with a tendency to merge on the trunk with a history of allopurinol treatment...Our last patient had a maculopapular eruption on the trunk after 14 days of piperacillin/tazobactam, and teicoplanin treatment due to diabetic foot...True incidence of this finding may be more frequent. No mortality was observed in our cases, and more extensive studies are needed in terms of prognostic indicators
- |||||||||| imatinib / Generic mfg.
Imatinib-induced lichenoid rash: Toxidermia or induced lichen () - Jul 3, 2023 - Abstract #WCD2023WCD_5257;
Lichen planus remains the main differential diagnosis. In our patient, the study of intrinsic and extrinsic imputability criteria, as well as the histology, plead in favor of the responsibility of imatinib in the development of this lichenoid dermatosis
- |||||||||| DRESS syndrome: Skin phenotype and visceral involvement () - Jul 3, 2023 - Abstract #WCD2023WCD_5241;
Allopurinol and aromatic antiepileptics are the most frequently incriminated molecules. Erythema multiforme is considered to be a poor clinical prognostic factor as it correlates with severe liver damage.
- |||||||||| allopurinol / Generic mfg.
Allopurinol induced DRESS in a Caucasian patient with HLA-B*58:01 genotype () - Jul 3, 2023 - Abstract #WCD2023WCD_5230;
KEY MESSAGE: DRESS has significant morbidity and mortality. Specific HLA genotyping associated with DRESS strongly considered in all high risk ethnic populations prior to starting drug therapy.A Medicare policy review should contemplate subsiding this test as a cost-effective measure to reduce DRESS associated hospital stay
- |||||||||| sildenafil / Generic mfg.
A rare systemic drug reaction induced by Sildenafil () - Jul 3, 2023 - Abstract #WCD2023WCD_5225;
50-year-old male with no known medical history, presented with a three-day widespread rash and asthenia. Physical examination showed a 38,6
- |||||||||| isotretinoin oral / Generic mfg.
A Patient with Acne Conglobata, Schizoaffective Disease- Depressive Type and Hyperlipidemia Successfully Treated by Low- Dose Oral Isotretinoin - a Case Report () - Jul 3, 2023 - Abstract #WCD2023WCD_4455;
Medication: bipropionum hydrochloricum, trazodonum hydrochloricum, quentiapinum fumaras, altrazolanum, haloperidol gtts on demand because of the psychiatric indication, rosurvastatinum, ramiprilinum, amlodipinum besilas, bisoprolol fumaras and allopurinol because of internal diseases and rupatadinum fumaras peroral and budesonid nasal spray due to the pollinosis...Later, only a local therapy with adapalene has been administered...Normally, the schizoaffective disease - depressive type and hyperlipidemia are relative contraindications for the isotretinoin treatment. However, with this casuistics, we want to prove that such a treatment is possible, but the low- doses of isotretinoin are preferred and a close cooperation with a psychiatrist and an internist is necessary
- |||||||||| Diagnostic Quandary: When Anca Raises A Dilemma As To The Etiology- Wegener () - Jul 3, 2023 - Abstract #WCD2023WCD_4424;
However, with this casuistics, we want to prove that such a treatment is possible, but the low- doses of isotretinoin are preferred and a close cooperation with a psychiatrist and an internist is necessary The offending drugs leading to Drug induced vasculitis are propylthiouracil, allopurinol, minocycline, linezolid etc. Diagnosis is based on clinical picture, ANCA and improvement after withdrawal of offending drug...Patient was treated with Linezolid, Febuxostat, Meropenem and Paracetamol for complaints of fever, cough and cold before ten days...Patient was admitted in surgery ward diagnosed as cellulitis and was again kept on Injection Linezolid for 4 days...Linezolid was omitted and patient was kept on Injection Piperacillin/ Tazobactam and Injection Dexamethasone 1.5cc intramuscular...ANCA is usually positive in Wegener
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen
Review, Journal, Immunomodulating: Drug-induced Stevens Johnson syndrome and toxic epidermal necrolysis: Interpreting the systematic reviews on immunomodulatory therapies. (Pubmed Central) - Jun 30, 2023
The evidence for improved survival with off-label use of corticosteroids plus intravenous immunoglobulins, ciclosporin plus intravenous immunoglobulins, and ciclosporin alone has not been demonstrated by network meta-analyses and meta-regression. In the real-world clinical setting, systemic corticosteroids (in SJS and overlap SJS/TEN), ciclosporin, and etanercept (in TEN) appear to be the off-label treatments currently most widely used.
- |||||||||| allopurinol / Generic mfg.
Journal: Effect of orange solid waste diet on flesh quality and metabolic profile of common carp (Cyprinus carpio). (Pubmed Central) - Jun 19, 2023
The results showed that SWC diet significantly enhanced specific growth rate, muscle sweetness (via sweet amino acids and sweet molecules), and the nutritional value of fish meat (increased protein, ?-vitamin E, and allopurinol)...In addition, SWC diet promoted biosynthesis of non-essential amino acids in muscle by enhancing glycolysis and the tricarboxylic acid cycle. In conclusion, SWC could be a cost-effective solution for providing nutritious and flavourful aquatic products.
- |||||||||| allopurinol / Generic mfg.
Journal, Adherence: Optimising adherence to allopurinol for gout: patients' perspectives. (Pubmed Central) - Jun 19, 2023
Patient perceptions of the effectiveness and necessity of allopurinol influenced intentional adherence during medication initiation, implementation and discontinuation. Strategies that inform patients of their urate control and provide accurate medical advice have the potential to improve adherence to allopurinol.
- |||||||||| allopurinol / Generic mfg.
Journal, Adherence: An allopurinol adherence tool using plasma oxypurinol concentrations. (Pubmed Central) - Jun 19, 2023
A tool to identify people with gout who require additional support to maintain adherence using plasma oxypurinol concentrations was developed and evaluated. The predictive performance of the tool is suitable for adherence screening in clinical trials and may have utility in some clinical practice settings.
- |||||||||| allopurinol / Generic mfg.
Journal: Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. (Pubmed Central) - Jun 14, 2023
Presentation of unconventional peptides by HLA-B*58:01 aided by allopurinol contributes to our fundamental understanding of drug-HLA interactions. The binding of peptides from endogenously available proteins such as self-protein lamin A/C and viral protein EBNA3B suggest that aberrant loading of unconventional peptides in the presence of allopurinol or oxypurinol may be able to trigger anti-self reactions that can lead to Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and Drug Reaction with
- |||||||||| allopurinol / Generic mfg.
Journal: Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome. (Pubmed Central) - Jun 13, 2023
The binding of peptides from endogenously available proteins such as self-protein lamin A/C and viral protein EBNA3B suggest that aberrant loading of unconventional peptides in the presence of allopurinol or oxypurinol may be able to trigger anti-self reactions that can lead to Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and Drug Reaction with SZF inhibits UA-induced renal tubular epithelial cell pyroptosis via by targeting NLRP3 to inhibit tubular inflammatory and prevent the progression of HUA-induced renal injury effectively.
- |||||||||| allopurinol / Generic mfg.
Trial completion date, Trial primary completion date: Obesity and Uric Acid Stones Study (clinicaltrials.gov) - Jun 13, 2023
P3, N=40, Recruiting,
SZF inhibits UA-induced renal tubular epithelial cell pyroptosis via by targeting NLRP3 to inhibit tubular inflammatory and prevent the progression of HUA-induced renal injury effectively. Trial completion date: Apr 2023 --> Mar 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
- |||||||||| Journal: A Case Report of Leukocytoclastic Vasculitis: Diagnostic Approach and Treatment. (Pubmed Central) - Jun 3, 2023
Staining with antibodies to human IgG, IgA, IgM, C3, fibrinogen, and albumin was negative. CONCLUSIONS Leukocytoclastic vasculitis can be triggered by penicillins, cephalosporins, sulfonamides, phenytoin, and allopurinol acting as haptens and stimulating an immune response, resulting in development of vasculitis.
- |||||||||| Trial completion date, Trial primary completion date: TRUST: Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout (clinicaltrials.gov) - Jun 2, 2023
P=N/A, N=650, Not yet recruiting,
CONCLUSIONS Leukocytoclastic vasculitis can be triggered by penicillins, cephalosporins, sulfonamides, phenytoin, and allopurinol acting as haptens and stimulating an immune response, resulting in development of vasculitis. Trial completion date: Jun 2026 --> Sep 2026 | Trial primary completion date: Jun 2026 --> Sep 2026
- |||||||||| allopurinol / Generic mfg.
Preclinical, Journal: Fatty Acid-Rich Extract from Holothuria atra for Hyperuricemia via Expressions Modulation of GLUT9a and GLUT9b in Rat Model. (Pubmed Central) - May 31, 2023
The extraction was carried out using n-hexane solvent and then administered to potassium oxonate-induced hyperuricemic rats, with allopurinol acting as a positive control...The anti-hyperuricemic activity could be associated with the modulation of GLUT9 by the H. atra extract. In conclusion, the n-hexane extract from H. atra is a potential serum uric acid-lowering agent targeting GLUT9, where further investigations are crucially warranted.
- |||||||||| febuxostat / Generic mfg., allopurinol / Generic mfg.
Journal: ANMCO statement: Uric acid and cardiovascular disease: evidence and therapeutic approach (Pubmed Central) - May 29, 2023
This ANMCO statement provides an update on available evidence regarding the association between elevated plasma uric acid levels and cardiovascular disease risk and the safety and efficacy of uric acid lowering agents (allopurinol and febuxostat) used in patients with urate crystal deposits. In addition, it summarizes practical indications for the use of these drugs in at-risk patients or in patients with cardiovascular disease.
- |||||||||| allopurinol / Generic mfg.
Journal: A comprehensive analysis of the hub genes for oxidative stress in ischemic stroke. (Pubmed Central) - May 25, 2023
Drug-sensitive analysis targeting hub genes defined allopurinol and nickel sulfate as potential candidates for impairing the neural death caused by oxidative stress in IS...TLR4 was found to have excellent diagnostic value and a wide-spectrum interaction with other hub genes. Our research emphasized the impact of oxidative stress on ischemic stroke, which supports the idea that antioxidants hold great promise in ischemic stroke therapy.
- |||||||||| tigulixostat (LC350189) / LG Chem
Enrollment open: EURELIA2: Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients (clinicaltrials.gov) - May 23, 2023
P3, N=2542, Recruiting,
Our research emphasized the impact of oxidative stress on ischemic stroke, which supports the idea that antioxidants hold great promise in ischemic stroke therapy. Not yet recruiting --> Recruiting
- |||||||||| allopurinol / Generic mfg.
Journal: Feline leishmaniosis with focus on ocular manifestation: a case report. (Pubmed Central) - May 17, 2023
The cat was treated with allopurinol, responded well and was still alive at follow-up on day 288 after first presentation...SAA is valuable for monitoring. Regarding ophthalmology, uveitis and glaucoma may have a poor prognosis.
- |||||||||| acetylcysteine solution / Generic mfg., cholestyramine / Generic mfg., allopurinol / Generic mfg.
Journal: Successful Management of Severe Manganese Toxicosis in Two Dogs. (Pubmed Central) - May 15, 2023
The patients were managed with calcium ethylenediaminetetraacetic acid, paraaminosalicylic acid, allopurinol, Vitamin E, ginkgo biloba, and S-adenosylmethionine/silybin...A previous case report detailed the fatal manganese toxicosis in a dog; this case report describes the successful management of severe acute hepatic injury secondary to manganese toxicosis. The combination of medications used above may be used for successful treatment of manganese toxicosis in dogs.
- |||||||||| febuxostat / Generic mfg., allopurinol / Generic mfg.
Review, Journal: Hyperuricemia and kidney damage in patients with cardiovascular disease: A review (Pubmed Central) - May 15, 2023
Despite the fact that currently the guidelines for the treatment of CKD do not include a recommendation for the start of urate-lowering therapy, a large amount of data has been accumulated on the potential benefits of such treatment even in the absence of a diagnosis of gout. The preferred group of drugs for this group of patients are xanthine oxidase inhibitors, and for patients with eGFR below 30 ml/min/1.73 m, it seems that allopurinol currently has larger evidence base for the efficacy and safety of prescribing.
- |||||||||| lisinopril / Generic mfg., allopurinol / Generic mfg.
Management of Hypoglycemia in Von Gierke's Disease (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_702;
Due to the deficiency of G6P, treatment with a specialized hypoglycemic regimen is warranted. A D10
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Jaypirca (pirtobrutinib) / Eli Lilly
Enrollment open, Trial initiation date, IO biomarker: Pirtobrutinib and Venetoclax in Waldenstr (clinicaltrials.gov) - May 10, 2023
P2, N=42, Recruiting,
A D10 Not yet recruiting --> Recruiting | Initiation date: Aug 2023 --> May 2023
- |||||||||| allopurinol / Generic mfg.
Trial completion, Trial completion date: Allopurinol to Prevent Cirrhosis Related Morbidities (clinicaltrials.gov) - May 9, 2023
P2/3, N=100, Completed,
Allopurinol use in older adults with gout is associated with a reduced risk of persistent physical disability but not associated with risk of frailty. Recruiting --> Completed | Trial completion date: Aug 2023 --> Mar 2023
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