- |||||||||| Zalain (sertaconazole) / Elder Pharma
Majocchi Granuloma of the knee : A rare clinical entity (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3944;
The patient was treated with oral terbinafine 250mg/day for 12 weeks aossociated with topical sertaconazole olamine twice daily... we report an unusual presentation of Majocchi
- |||||||||| Remicade (infliximab) / J&J
INFLIXIMAB TREATMENT FOR CROHN (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_892;
we report an unusual presentation of Majocchi Demodicosis should be taken into account in patients treated with biological medications and presenting atypical inflammatory skin lesions.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Three-step synthesis and antifungal analysis of novel benzo[b]thiophene ring structure derivatives | Poster Board #935 (In-person; Poster Board #935; Hall C (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_12604;
It is hypothesized that the remodeling of the C25 benzo[ b ]thiophene structure with varying substituents will lead to successful microbial inhibition. In conclusion, this project intends to assist in the search for potent antifungal compounds with extensive effectiveness against diverse fungi species.
- |||||||||| Zalain (sertaconazole) / Elder Pharma, Zyflo (zileuton) / Chiesi
Synthesis and antibacterial evaluation of novel benzo[b]thiophene derivatives | Poster Board #1814 (In-person; Poster Board #1814; Hall C (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_2999;
Preliminary results have indicated the addition of some groups may increase the antibacterial activity of the benzo[ b ]thiophene derivatives while addition of certain groups decrease the activity of the compounds. In conclusion, this project will give strides towards identifying more potent benzo[ b ]thiophene derivatives with broader efficacy against gram-positive and gram-negative bacteria.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Observational data, Journal: Species distribution and antifungal susceptibility profiles of yeasts isolated from onychomycosis: a cross-sectional study with insights into emerging species. (Pubmed Central) - Dec 28, 2023
Results obtained from antifungal susceptibility testing showed significant differences in MIC values of isoconazole, fenticonazole, and sertaconazole among different species...Moreover, there was a statistically significant difference in MICs of fenticonazole and clotrimazole between the two most prevalent causative species, C. parapsilosis complex and C. albicans. Correct identification of the causative agents of onychomycosis and performing susceptibility testing could be helpful in choosing the most appropriate antifungal therapy.
- |||||||||| isotretinoin oral / Generic mfg.
Recalcitrant tinea cruris in women: role of menstrual cups, isotretinoin and low level laser light therapy. () - Jul 3, 2023 - Abstract #WCD2023WCD_6015;
Therapeutic intervention consisted of a standardized oral anti-fungal regimen for four weeks with itraconazole 100 mg twice daily followed by additional two weeks of topical therapy with sertaconazole nitrate cream. This study provides a fresh insight on efficacious prevention of recurrence of tinea cruris in females, using multipronged approach
- |||||||||| Zalain (sertaconazole) / Elder Pharma, Vumon (teniposide) / BMS
Review, Journal: Therapeutic potential of thiophene compounds: a mini-review. (Pubmed Central) - Feb 7, 2023
However, there are some marketed formulations available such as Thiophenfurin, Teniposide, Cefoxitin, Ticaconazole, Sertaconazole, Suprofen, ketotifen, Brinzolamide, Dorzolamide, Tiotropium which contain thiophene nucleus. Thus, in a nutshell, gathering recent data is necessary to comprehend the present scenario of thiophene moiety for scientific research purposes and highlights a broad view of the biological potential of compounds having a thiophene nucleus.
- |||||||||| Zalain (sertaconazole) / Elder Pharma, Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Journal: Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation. (Pubmed Central) - Nov 19, 2022
The highly enantioselective hydrogenation of α-N-heteroaryl ketones was realized with a ruthenium-diphosphine-diamine catalyst, providing the corresponding chiral β-heteroaryl amino alcohols with up to 99% yield and up to >99% ee. The synthetic utilities of the current reaction were demonstrated by gram-scale synthesis of key intermediates of Sertaconazole and Cenobamate.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Journal: In Situ Swelling Formulation of Glycerol-Monooleate-Derived Lyotropic Liquid Crystals Proposed for Local Vaginal Application. (Pubmed Central) - Oct 21, 2022
The system consists of a precursor solution loaded with sertaconazole nitrate as a model drug, which is able to easily swell in a stable three-dimensional structure by absorbing simulated vaginal fluid...In vitro degradation studies showed a slow matrix erosion, consistent with data obtained from lipophilic drug release studies in simulated vaginal fluid. Therefore, the suggested cubic phase based on lyotropic liquid crystals could represent a valid proposal as a vaginal drug delivery system due to its characteristics of resistance, adhesion and the possibility of providing a slow and controlled release of drugs directly at the administration site.
- |||||||||| Clinical, Preclinical, Journal: In Vitro Activity of 23 Antifungal Drugs against 54 Clinical and Environmental Aspergillus oryzae isolates. (Pubmed Central) - Oct 12, 2022
In contrast, ketoconazole, terbinafine, econazole, tioconazole, ravuconazole, miconazole, nystatin, clotrimazole, griseofulvin, sertaconazole, natamycin, tolnaftate, and fluconazole had no or low activity. Further studies are required to determine how well this in vitro activity translates into in vivo efficacy.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
FDA event, Journal: Repositioning of FDA-Approved Antifungal Agents to Interrogate Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) in Ferroptosis. (Pubmed Central) - Oct 12, 2022
In addition, sertaconazole significantly reduced lipid peroxidation and ferroptosis in human differentiated dopaminergic neurons (Lund human mesencephalic LUHMES cells), demonstrating that it is a valuable chemical tool for further investigating the role of ACSL4 in ferroptosis. This study highlights phenethyl-imidazole scaffold as a novel and promising starting point for the development of anti-ferroptotic agents targeting ACSL4.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Clinical, Retrospective data, Journal: A Meta-Analysis on the Effectiveness of Sertaconazole 2% Cream Compared with Other Topical Therapies for Seborrheic Dermatitis. (Pubmed Central) - Sep 24, 2022
At 28 days since the beginning of the treatment, the sertaconazole regimen was associated with a significantly higher percentage of patients with mild SI and a lower percentage of patients with moderate or severe SI (odds ratio 0.51) than the other investigated treatments-hydrocortisone, ketoconazole, clotrimazole, metronidazole, pimecrolimus, and tacrolimus (odds ratio 1.95). In conclusion, treatment with sertaconazole 2% cream may represent an efficient alternative therapy for patients with SD.
- |||||||||| ciclopirox topical / Generic mfg.
Oral terbinafine in short course Versus Ciclopirox alamin in the treatement of tinea pedis (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_514;
Evolution : At the control of the 1st week:clinical improvement and regression of pruritus was reported in 57% of patients (n=11) in group B versus 25% (n=5) of patients in group A. At the control of the 2nd week:disappearance of the lesions was noted in 95% of patients (n=18) in group B, versus 25% (n=5) of patients in group A. At the control of the 3rd week: disappearance of the lesions was reported in 70% (n=14) of the patients in group A, while maintenance of the treatment for 4 weeks was necessary in 30% (n=6) of the patients to obtain complete healing. At the control of the 4th week: no relapse was noted in the patients of group B, and a total disappearance of the lesions was observed in all the patients of group A. Discussion the 2 antifungals seem effective in the treatment of tinea pedis , however in this study we noted a faster improvement in symptoms in the group treated with oral terbinafine, and better compliance this can be explained by the single daily dose versus 2 applications per day in the ciprox alamine group, moreover topical ciprox alamine has the advantage of being less expensive and offers the possibility of use in patients with renal or hepatic insufficiency and in breastfeeding women given the absence of systemic passage .
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Clinical, Journal: The Efficacy and Safety of Pimecrolimus 1% Cream versus Sertaconazole 2% Cream in the Treatment of Patients with Facial Seborrheic Dermatitis: A Randomized Blinded Trial. (Pubmed Central) - Apr 28, 2022
At the control of the 4th week: no relapse was noted in the patients of group B, and a total disappearance of the lesions was observed in all the patients of group A. Discussion the 2 antifungals seem effective in the treatment of tinea pedis , however in this study we noted a faster improvement in symptoms in the group treated with oral terbinafine, and better compliance this can be explained by the single daily dose versus 2 applications per day in the ciprox alamine group, moreover topical ciprox alamine has the advantage of being less expensive and offers the possibility of use in patients with renal or hepatic insufficiency and in breastfeeding women given the absence of systemic passage . Pimecrolimus is associated with faster response and fewer AEs than sertaconazole in patients with FSD.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Journal: Efficacy and Safety of Eberconazole vs Sertaconazole in Localised Tinea Infection. (Pubmed Central) - Jan 26, 2022
Intergroup comparison with respect to pruritus and scaling showed significant difference (P < 0.001), suggestive of better reduction of pruritus and scaling scores at 4 weeks with Sertaconazole when compared to Eberconazole. Sertaconazole was better than Eberconazole in relieving signs and symptoms of dermatophytoses, especially pruritus, thereby improving patients' quality of life.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Journal: Sertaconazole provokes proapoptotic autophagy via stabilizing TRADD in nonsmall cell lung cancer cells. (Pubmed Central) - Jan 4, 2022
Moreover, we found that TRADD suppression reverses sertaconazole-induced proapoptotic autophagy and relieves growth suppression, indicating the vital role of TRADD-regulated proapoptotic autophagy in the anti-NSCLC activity of sertaconazole. In summary, our findings suggest that sertaconazole could be a highly promising anti-NSCLC drug by triggering proapoptotic autophagy via stabilizing TRADD, which may provide a new potential therapeutic option for patients with NSCLC.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Journal: Sertaconazole induced toxicity in HeLa cells through mitotic arrest and inhibition of microtubule assembly. (Pubmed Central) - Dec 16, 2021
Sertaconazole significantly inhibited the migration of HeLa cells and showed synergistic antiproliferative potential with vinblastine. Collectively, the results suggest that sertaconazole which is already in clinical practice could be useful as a topical chemotherapy agent for the treatment of skin cancers in combination with other systemic anticancer agents.
- |||||||||| Zalain (sertaconazole) / Elder Pharma, Luzu (luliconazole) / Bausch Health
Clinical, Journal, HEOR: Comparison of efficacy, safety, and cost-effectiveness of sertaconazole and luliconazole cream in patients with dermatophytoses: A prospective, randomized, open-label study. (Pubmed Central) - Nov 16, 2021
Only one patient in the sertaconazole group showed allergic contact dermatitis. Sertaconazole was better than luliconazole in relieving signs and symptoms during the study and follow-up period, but cost-effectiveness wise, luliconazole was better than sertaconazole.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Clinical, Journal: Antifungal efficacy of liquid poloxamer 407-based emulsions loaded with sertaconazole nitrate. (Pubmed Central) - Mar 4, 2021
In both cases, formulations with low viscosity and high water content showed best results despite a lower solubility of sertaconazole nitrate, suggesting that the composition of the vehicle plays a major role in permeation through the membrane. In addition, an API content close to saturation solubility had a positive effect on permeation.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
FDA event, Journal: The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. (Pubmed Central) - Nov 6, 2020
While the anticoagulant ticlopidine and the antifungal sertaconazole caused both accumulations that resulted in distinct distortions of pharyngeal anatomy and lethality upon acute exposure, the proton-pump inhibitor dexlansoprazole caused molting defects and required exposure during larval development. Such easily detectable defects in a powerful genetic model system advocate the continued exploration of current medicines using a variety of model organisms to better understand drugs already prescribed to millions of patients.
- |||||||||| Zalain (sertaconazole) / Elder Pharma, clotrimazole topical / Generic mfg.
Journal: Optimization and application of in vitro and ex vivo models for vaginal semisolids safety evaluation. (Pubmed Central) - Aug 20, 2020
In this study, traditional and renewed methods were studied for toxicity assessment of vaginal semisolids upon products currently used in clinical practice as antimicrobials (Gino-Canesten, Sertopic, Dermofix, Gyno-Pevaryl, Lomexin, Gino Travogen, Dalacin V), containing estrogens (Ovestin, Blissel, Colpotrophine), and reference formulations (Replens, Universal Placebo)...15% variability in thickness and variation coefficients lower than 25% when testing negative and positive controls were achieved. These models can improve cost-efficiency in early steps of product development.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Biomarker, Journal: Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis. (Pubmed Central) - Aug 15, 2020
In the invivo study, the mucoadhesive liposomal gel showed a significant reduction in the microbial count with a subsequent reduction in inflammatory responses with the lowest histopathological change compared with conventional gel. The study confirmed the potentiality of employing mucoadhesive liposomes as a successful carrier for the vaginal delivery of antifungal drugs.
- |||||||||| Zalain (sertaconazole) / Elder Pharma, clotrimazole / Generic mfg., Sebifin (terbinafine HCL) / Generic mfg.
Journal: Low in vitro activity of sertaconazole against clinical isolates of dermatophyte. (Pubmed Central) - May 19, 2020
However, sertaconazole, a third-generation imidazole, did not show any significant effect. Furthermore, M. canis and E. floccosum showed the best response to the antifungal agents.
- |||||||||| Sebifin (terbinafine HCL) / Generic mfg.
Clinical, Journal: A case of Tinea Faciei caused by Trichophyton benhamiae: first report in China. (Pubmed Central) - May 6, 2020
Furthermore, M. canis and E. floccosum showed the best response to the antifungal agents. This rare dermatophytosis case highlights the importance of ITS sequencing in helping to recognize rare pathogenic fungi that can be easily misdiagnosed with a conventional morphological diagnosis.
- |||||||||| fluconazole / generics, clotrimazole / generics, terbinafine HCL / generics
Journal: Mutation in the Squalene epoxidase gene ofandassociated with allylamine resistance. (Pubmed Central) - Jun 22, 2019
...Antifungal susceptibility testing of the isolated Trichophyton species (n = 127) was carried out with 12 antifungal agents: fluconazole, voriconazole, itraconazole, ketoconazole, sertaconazole, clotrimazole, terbinafine, naftifine, amorolfine, ciclopirox olamine, griseofulvin, and luliconazole...This transition leads to the substitution of amino acid phenylalanine to leucine in 397position of the squalene epoxidase enzyme. In homology modelling the mutant residue was smaller than wild type and positioned in the dominant site of squalene epoxidase during drug interaction, which may lead to failure to block ergosterol biosynthesis pathway by the antifungal drug.
- |||||||||| Zalain (sertaconazole) / Elder Pharma
Trial completion: Sertaconazole 2% Cream to Improve Symptoms Associated With Atopic Dermatitis (clinicaltrials.gov) - May 20, 2015
P2, N=70, Completed,
In homology modelling the mutant residue was smaller than wild type and positioned in the dominant site of squalene epoxidase during drug interaction, which may lead to failure to block ergosterol biosynthesis pathway by the antifungal drug. Recruiting --> Completed
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