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7 Diseases |  |
1 Trial |
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1 Trial |  |
445 News |  |
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- || Natroba (spinosad) / Royalty
Review, Journal: Drugs for head lice. (Pubmed Central) - Jun 21, 2024
No abstract available
- Natroba (spinosad) / Royalty
Enrollment open: PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - Nov 28, 2023
P4, N=50, Recruiting, Sponsor: ParaPRO LLC
No abstract available Active, not recruiting --> Recruiting
- Natroba (spinosad) / Royalty
Trial completion date, Trial primary completion date: PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - Oct 19, 2023
P4, N=50, Active, not recruiting, Sponsor: ParaPRO LLC
Active, not recruiting --> Recruiting Trial completion date: Jun 2023 --> Mar 2026 | Trial primary completion date: Jun 2023 --> Nov 2025
- | ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Journal: In brief: OTC ivermectin for head lice. (Pubmed Central) - Jun 24, 2023
Trial completion date: Jun 2023 --> Mar 2026 | Trial primary completion date: Jun 2023 --> Nov 2025 No abstract available
- Natroba (spinosad) / Royalty
Enrollment closed, Trial completion date, Trial primary completion date: PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - Apr 28, 2023
P4, N=50, Active, not recruiting, Sponsor: ParaPRO LLC
No abstract available Recruiting --> Active, not recruiting | Trial completion date: Feb 2023 --> Jun 2023 | Trial primary completion date: Aug 2022 --> Jun 2023
- | Natroba (spinosad) / Royalty
Journal: Spinosad topical suspension (0.9%): a new topical treatment for scabies. (Pubmed Central) - Sep 12, 2022
Here the pharmacology, clinical efficacy and tolerability of this drug are discussed. As the first single dose scabicide the formulated 0.9% topical Spinosad solution shows significant efficacy, little systemic absorption and no serious adverse reactions, making it a promising treatment for classical scabies in patients older than four years.
- || Natroba (spinosad) / Royalty
Clinical, Journal: Spinosad 0.9% in the Treatment of Scabies: Efficacy Results from Two Multicenter, Randomized, Double-Blind, Vehicle-Controlled Studies. (Pubmed Central) - Apr 15, 2022
As the first single dose scabicide the formulated 0.9% topical Spinosad solution shows significant efficacy, little systemic absorption and no serious adverse reactions, making it a promising treatment for classical scabies in patients older than four years. Spinosad 0.9% was effective in the treatment of scabies in these studies of subjects ≥ 4 years of age following 1 application of study drug.
- | Natroba (spinosad) / Royalty
New P4 trial: PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - Apr 4, 2022
P4, N=50, Recruiting, Sponsor: ParaPRO LLC
- Natroba (spinosad) / Royalty
[VIRTUAL] New ligands for the control of human head lice, Pediculus humanus capitis (Room: Zoom Room 01) - Aug 13, 2021 - Abstract #ACSFall2021ACS_Fall_1806;
Natroba™ is a pediculicide for the topical treatment with 0.9 % spinosad (a 5:1 mixture of spinosyn A and spinosyn D) as the active ingredients...Dimethicone-based medical devices for the treatment of head louse infestations (e.g., Nix ULTRA, LiceMD, NYDA) are dimethylsiloxane polymers, which have high surface spreading characteristics and act as suffocants on eggs and crawling lice. Recent regulatory, legal and production actions will be discussed in terms of how they have impacted effective and sustainable head louse control in the US.
- | Natroba (spinosad) / Royalty
Preclinical, Journal: The effects of spinosad on antioxidant system and cognitive performance of mice. (Pubmed Central) - Jul 29, 2021
From the biochemical point of view, while BDNF and NGF levels were significantly lower in the spinosad applied group (p .05). These results show that spinosad disrupts cognitive functions at the doses we used in our study and this negative effect may be related to the decrease in neurotrophic factors.
- | Natroba (spinosad) / Royalty
Journal: New insights on the effects of spinosad on the development of Helicoverpa armigera. (Pubmed Central) - Jul 14, 2021
These results suggested that sublethal spinosad caused hormonal disorders in larvae, which directly affect insect development. Our study serves as a reference and basis for the toxicity evaluation of spinosad on molting and pupation in insect metamorphosis, which may contribute to identifying targets for effective control of cotton bollworm.
- || Natroba (spinosad) / Royalty
Clinical, Journal: Susceptibility of Brazilian Populations of Anastrepha fraterculus, Ceratitis capitata (Diptera: Tephritidae), and Drosophila suzukii (Diptera: Drosophilidae) to Selected Insecticides. (Pubmed Central) - Jul 10, 2021
These differences represent the natural variation in population susceptibility and not due to insecticide selection pressure. The diagnostic concentrations defined here should be used in future resistance monitoring programs in Brazil.
- || Natroba (spinosad) / Royalty
Review, Journal: The Spinosyns, Spinosad, Spinetoram, and Synthetic Spinosyn Mimics - Discovery, Exploration, and Evolution of a Natural Product Chemistry and the Impact of Computational Tools. (Pubmed Central) - Jul 7, 2021
The most recent of these synthetic spinosyn mimics show promise as insecticides targeting lepidopteran insect pests as demonstrated by field studies wherein the efficacy has been shown to be comparable to spinosad and spinetoram. These and a range of other aspects related to the exploration of the spinosyns over the past 30 years are reviewed herein.
- | Natroba (spinosad) / Royalty
Journal: Inhibiting the proteasome reduces molecular and biological impacts of the natural product insecticide, spinosad. (Pubmed Central) - Jul 7, 2021
These and a range of other aspects related to the exploration of the spinosyns over the past 30 years are reviewed herein. Based on these data, we propose that exposure to spinosad leads to degradation of the α6-like target protein, a potentially novel element in the mode of action of spinosyns that may contribute to their toxicity towards insects.
- | Natroba (spinosad) / Royalty
Journal: SELECTIVE ACTIONS OF INSECTICIDES ON DESENSITIZING and NON-DESENSITIZING NICOTINIC ACETYLCHOLINE RECEPTORS IN COCKROACH (Periplaneta americana) NEURONS. (Pubmed Central) - Jul 7, 2021
Nicotinic acetylcholine receptor competitive modulators (IRAC Group 4) and nicotinic acetylcholine receptor allosteric modulators, site II (hexatoxins, IRAC Group 32) are selective for nAChD receptors, while nicotinic acetylcholine receptor allosteric modulators, site I (spinosyns, IRAC Group 5) are selective for nAChN receptors. It is proposed that IRAC Groups 5 and 32 be re-named non-desensitizing nicotinic acetylcholine receptor allosteric modulators and desensitizing nicotinic acetylcholine receptor allosteric modulators, respectively.
- | Natroba (spinosad) / Royalty
Journal: Sublethal concentration of insecticide amplifies interference competition in a tortrix moth. (Pubmed Central) - Jul 2, 2021
Many organisms (pest and non-target species) compete through interference and theory predicts that a change in interference can substantially change dynamics. Our finding therefore reveals the importance of assessing the effect of insecticides on the mechanisms of competition when predicting their impact on populations.
- || Natroba (spinosad) / Royalty
Clinical, Journal: Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults. (Pubmed Central) - Jun 24, 2021
P=N/A
Our finding therefore reveals the importance of assessing the effect of insecticides on the mechanisms of competition when predicting their impact on populations. Estimated dietary pesticide exposures appeared to vary across the clusters and to be related to OF proportion in the diet.
- || Natroba (spinosad) / Royalty
Clinical, Journal: Efficacy of extended release formulations of Natular™ (spinosad) against larvae and adults of Anopheles mosquitoes in western Kenya. (Pubmed Central) - Jun 22, 2021
Estimated dietary pesticide exposures appeared to vary across the clusters and to be related to OF proportion in the diet. The extended release granular formulation and the dispersible tablet formulations of spinosad are effective against larval Anopheles mosquitoes for up to four weeks and may be an effective tool as part of larval source management programmes for reducing adult mosquito density and malaria transmission.
- | Natroba (spinosad) / Royalty
Journal: Sensitive, Simple and Fast Voltammetric Determination of Pesticides in Juice Samples by Novel BODIPY-Phthalocyanine-SWCNT Hybrid Platform. (Pubmed Central) - Jun 16, 2021
Also, the developing non-enzymatic sensor exhibited good repeatability (RSD= 2.3% for 10 electrodes) and stability (85.30% for 30 days). Validation guidelines by HPLC and statistical analysis showed that the proposed voltammetric method were precise, accurate, sensitive, and can be used for the routine quality control of methyl parathion determination in juice samples.
- | Natroba (spinosad) / Royalty
Preclinical, Journal: Quantification of spinosyn A and spinosyn D in animal-derived products using multiwalled carbon nanotubes coupled with liquid chromatography-tandem mass spectrometry for analysis. (Pubmed Central) - May 22, 2021
The developed method was successfully applied for monitoring market samples collected throughout the Korean Peninsula and none of the samples tested positive for the target analytes. It has therefore been shown that dehydration and acidification were effective to extract spinosad from animal-derived products.
- | Natroba (spinosad) / Royalty
Journal: Insights into How Spinosad Seed Treatment Protects Onion From Onion Maggot (Diptera: Anthomyiidae). (Pubmed Central) - May 22, 2021
Spinosad was detected in the soil and in both aboveground and belowground plant tissue, indicating that spinosad translocates into foliage, but declines in plant tissue and soil as plant mortality from D. antiqua feeding increases. Together, these results provide valuable insight into how spinosad protects onion seedlings and reveal key areas in need of further investigation.
- | Natroba (spinosad) / Royalty
Journal: Transcriptomic identification and characterization of genes commonly responding to sublethal concentrations of six different insecticides in the common fruit fly, Drosophila melanogaster. (Pubmed Central) - May 20, 2021
Furthermore, genes related to eggshell formation and motion were also under-transcribed, which may indicate a possible energy trade-off for xenobiotic stress. In summary, most of the differentially expressed genes were not directly related to well-known detoxification genes, suggesting that the roles of commonly expressed tolerance-related genes are not likely related to direct metabolic detoxification, but rather are associated with restoration of homeostasis.
- | Natroba (spinosad) / Royalty
Aber Bienensterben mit Spinosad ist OK? (Twitter) - May 19, 2021
- | Natroba (spinosad) / Royalty
Journal: Comparison of novaluron, pyriproxyfen, spinosad and temephos as larvicides against Aedes aegypti in Chiapas, Mexico. (Pubmed Central) - May 15, 2021
The poor performance of temephos may be indicative of reduced susceptibility in Ae. aegypti populations in Chiapas.
- | Natroba (spinosad) / Royalty
Journal: A Spinosad-Based Formulation Reduces the Survival and Alters the Behavior of the Stingless Bee Plebeia lucii. (Pubmed Central) - Apr 29, 2021
Bee locomotion-walking and flight-was reduced in accordance with the increase in spinosad concentrations; however, body mass and respiration rate were not altered. Our results show that the use of Tracer® in ecosystems visited by P. lucii can reduce forager bee survival and reduce their locomotion, generating a negative impact on pollination services provided by these bees.
- | Natroba (spinosad) / Royalty
Journal: Geographic Variation in Dominance of Spinosad Resistance in Colorado Potato Beetles (Coleoptera: Chrysomelidae). (Pubmed Central) - Apr 24, 2021
None of the populations sampled in 2010 were significantly different from additive resistance, but the Long Island population sampled in 2012 was not significantly different from fully recessive. Recessive inheritance of high-level resistance may help manage its increase.
- | Natroba (spinosad) / Royalty
Journal: Monitoring the Resistance of the Beet Armyworm (Lepidoptera: Noctuidae) to Four Insecticides in Southern China from 2014 to 2018. (Pubmed Central) - Apr 24, 2021
Spinosad remains an effective insecticide for the management of S. exigua. To avoid the rapid development of insecticide resistance, rotations of insecticides with low levels of resistance and different modes of action based on the resistance patterns of S. exigua should be performed in southern China.
- | Natroba (spinosad) / Royalty
Journal: Management of Onion Thrips (Thrips tabaci) in Organic Onion Production Using Multiple IPM Tactics. (Pubmed Central) - Apr 7, 2021
While spinosad + neem oil reduced thrips numbers and increased yield alone, none of the treatment combinations were effective at suppressing populations of thrips. Future T. tabaci management in organic onions will require optimization of the available effective biopesticides.
- | Natroba (spinosad) / Royalty
Journal: Coprecipitation-based synchronous pesticide encapsulation with chitosan for controlled spinosad release. (Pubmed Central) - Apr 2, 2021
The primary interaction between spinosad and chitosan has been found to be physical adsorption and adhesion, with the release dynamics following Fickian diffusion mechanism of Ritger-Peppas model. This work contributes to the development of pesticide carrier system of natural polymer materials, with a great potential for insect pest control.
- | Natroba (spinosad) / Royalty
Journal: RNA-Seq-Based Transcriptomic Analysis of Saccharopolyspora spinosa Revealed the Critical Function of PEP Phosphonomutase in the Replenishment Pathway. (Pubmed Central) - Apr 2, 2021
The replenishment of phosphoenol pyruvate in S. spinosa provides the substrate for the production of spinosad. We envision that these transcriptomic analysis results will contribute to the further study of secondary metabolites in actinomycetes.
- | Natroba (spinosad) / Royalty
Journal: Inheritance, stability, cross-resistance, and life history parameters of a clothianidin-selected strain of house fly, Musca domestica Linnaeus. (Pubmed Central) - Mar 21, 2021
These insecticides could be alternated with clothianidin as an insecticide resistance management tool to sustain its efficacy for a longer time period. These results shall be utilized to devise a proactive resistance management strategy for use of clothianidin against M. domestica that will be helpful to alleviate the allied threats to environmental and human health.
- || Natroba (spinosad) / Royalty
Clinical, Journal: Lethal and sublethal effects of the natural and healthy spinosad-based formulation Tracer™ on tadpoles of two neotropical species. (Pubmed Central) - Mar 19, 2021
The effects demonstrated here are not consistent with those expected since spinosad is supposed to be an environmental healthy alternative. This paper provides useful and necessary information to implement regulations on the use of new compounds entering the market and its associated risks.
- | Natroba (spinosad) / Royalty
Journal: Evaluating Behavioral Responses of Selected Stink Bugs (Hemiptera: Pentatomidae) to Spinosad. (Pubmed Central) - Mar 18, 2021
In paired (treated or untreated soybean seed) feeding preference experiments, southern green stink bug showed no preference for any treatment, whereas redbanded stink bug fed more on Entrust- and Tracer-treated seed. From these results, spinosad appears to have an arrestant and phagostimulant effect on redbanded stink bug in the laboratory.
- | Natroba (spinosad) / Royalty
Journal: Forficula auricularia (Dermaptera) in orchards: monitoring seasonal activity, the effect of pesticides, and the perception of European fruit growers on its role as a predator or pest. (Pubmed Central) - Mar 18, 2021
The highest seasonal activity of European earwigs coincides with applications of insecticides in orchards. This could disturb the earwigs' potential to suppress pest populations because several insecticides widely used in orchards have lethal and sublethal effects on earwigs even though they seem to develop some degree of pesticide resistance over time.
- | Natroba (spinosad) / Royalty
Journal: Identification of the Aedes aegypti nAChR gene family and molecular target of Spinosad. (Pubmed Central) - Mar 18, 2021
CRISPR/Cas9 introduced truncated Aaeα6 receptor in Ae. aegypti resulted in an increased level of resistance to spinosad, suggesting that the conserved nAChR α6 subunit is the target for spinosad insecticide.
- | Natroba (spinosad) / Royalty
Journal: Two ABC transporters are differentially involved in the toxicity of two Bacillus thuringiensis Cry1 toxins to the invasive crop-pest Spodoptera frugiperda (J. E. Smith). (Pubmed Central) - Feb 24, 2021
aegypti resulted in an increased level of resistance to spinosad, suggesting that the conserved nAChR α6 subunit is the target for spinosad insecticide. We provide functional evidence that in S. frugiperda these two ABCC transporters serve as receptors of Bt Cry1Fa and Cry1Ab toxins.
- | Natroba (spinosad) / Royalty
Journal: Focussed assessment of certain existing MRLs of concern for Spinosad. (Pubmed Central) - Feb 23, 2021
In order to identify the MRLs of potential concern that require a more detailed assessment, EFSA screened the existing MRLs for spinosad considering the new toxicological reference values and an acute risk could not be excluded for six commodities. Fall-back MRLs for all six commodities were proposed on the basis of the data received under the present assessment.
- | Natroba (spinosad) / Royalty
Journal: Managing Allium Leafminer (Diptera: Agromyzidae): An Emerging Pest of Allium Crops in North America. (Pubmed Central) - Feb 11, 2021
Spinosad applied to bare-root and plug-tray transplants immediately before transplanting reduced P. gymnostoma damage in the field by >90%. Implications of using these insecticides and application strategies are discussed within the context of developing a sustainable IPM program.
- | Natroba (spinosad) / Royalty
Journal: A Laboratory Bioassay Method to Assess the Use of Toxic Bait on Anastrepha fraterculus (Weidemann 1830). (Pubmed Central) - Jan 30, 2021
However, with 24 h of food deprivation, they had a higher susceptibility (LT = 46.48 h). Five-day-old A. fraterculus adults fed an artificial diet before being deprived of food for 12 or 24 h, then exposed to toxic bait for 4 h in the absence of a food source, are considered optimum conditions to evaluate the toxicity of toxic bait.
- | Natroba (spinosad) / Royalty
Journal: A De Novo Transcriptomics Approach Reveals Genes Involved in Thrips Tabaci Resistance to Spinosad. (Pubmed Central) - Jan 17, 2021
This research provides a novel genetic resource for onion thrips and a comprehensive molecular examination of resistant populations to spinosad. Those resources are important for future studies concerning thrips and resistance in insect pests regarding agriculture.
- | Natroba (spinosad) / Royalty
Journal: Oral and Topical Insecticide Response Bioassays and Associated Statistical Analyses Used Commonly in Veterinary and Medical Entomology. (Pubmed Central) - Jan 16, 2021
Results were consistent with previous reports of spinosad exhibiting little cross-resistance. For both spinosad and spinetoram, LC50 values were not greatly different between the pyrethroid-resistant strain and the susceptible strain.
- | Natroba (spinosad) / Royalty
Journal: Progress Toward an Attract-and-Kill Device for Asian Citrus Psyllid (Hemiptera: Liviidae) Using Volatile Signatures of Citrus Infected With Huanglongbing as the Attractant. (Pubmed Central) - Jan 16, 2021
Psyllid populations were not statistically affected at a deployment rate of four dollops per tree. Our results indicate that an AK formulation incorporating spinosad and a volatile blend signature of citrus greening into a slow-release matrix may be useful to suppress D. citri populations.
- | Natroba (spinosad) / Royalty
Journal: RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters. (Pubmed Central) - Jan 14, 2021
RedEx was also applied for seamless deletion of the rhamnose 3'-O-methyltransferase gene in the spinosad gene cluster to produce rhamnosyl-3'-desmethyl derivatives. The advantages of RedEx in seamless mutagenesis will facilitate rational design of complex DNA sequences for diverse purposes.
- | Natroba (spinosad) / Royalty
Journal: Avoidance behavior of juvenile common toads (Bufo bufo) in response to surface contamination by different pesticides. (Pubmed Central) - Jan 5, 2021
We showed that one data point every 15 or 60 minutes results in a risk of overlooking a weak avoidance behavior, but still allows to verify the absence/presence of an avoidance for six out of seven formulations. Our findings are important for an upcoming pesticide risk assessment for amphibians and could be a template for future standardized tests.
- | Natroba (spinosad) / Royalty
Journal: Engineering the Erythromycin-Producing Strain Saccharopolyspora erythraea HOE107 for the Heterologous Production of Polyketide Antibiotics. (Pubmed Central) - Dec 29, 2020
Our study demonstrated that the engineered Sac. erythraea strains SLQ185, LJ161, and LJ162 are good hosts for the expression of heterologous antibiotics and should aid in expression-based genome-mining approaches for the discovery of new and cryptic antibiotics from Streptomyces and rare actinomycetes.
- | Natroba (spinosad) / Royalty
Journal: Insecticide residue longevity for on-site screening of Drosophila suzukii (Matsumura) resistance. (Pubmed Central) - Dec 23, 2020
However, the toxicities of spinosad, zeta-cypermethrin and phosmet were less consistent. Hence, vials treated with these insecticides should be freshly made to be effective for screening D. suzukii field populations for resistance.
- | Natroba (spinosad) / Royalty
Journal: CRISPR-mediated gene knockout reveals nicotinic acetylcholine receptor (nAChR) subunit α6 as a target of spinosyns in Helicoverpa armigera. (Pubmed Central) - Dec 23, 2020
Our results provide in vivo functional evidence for Haα6 as a target of spinosyns in H. armigera, and little or no role of Haα7 in mediating toxicity of spinosyns. The results are valuable to the development of resistance monitoring and management methods for spinosyn resistance in H. armigera.
- | Natroba (spinosad) / Royalty
Journal: Inheritance of polygenic but stable pyriproxyfen resistance in a bio-control agent Chrysoperla carnea (Neuroptera: Chrysopidae): Cross-resistance and realized heritability. (Pubmed Central) - Dec 23, 2020
Releasing pyriproxyfen-resistant Chrysoperla carnea in a multi-sprayed cropping environment would help to keep pest population below economic threshold level. It would also minimize risk of insecticide resistance development in pests surviving even after several insecticide applications.
- | Natroba (spinosad) / Royalty
Journal: Regional differences in gene regulation may underlie patterns of sensitivity to novel insecticides in Leptinotarsa decemlineata. (Pubmed Central) - Dec 23, 2020
Our results suggest a mechanism for geographic variation in rates of adaptation to insecticides, whereby baseline levels of gene expression determine a population's response to novel insecticides. These findings have implications for the regional development of insecticide resistance management strategies and for the fundamental question of what determines the rate of adaptation to insecticides.
- || Natroba (spinosad) / Royalty
Clinical, Journal: Cross-resistance and the underlying mechanisms of clothianidin resistant population of Frankliniella occidentalis to insecticides (Pubmed Central) - Dec 21, 2020
Compared with the sensitive population, the CL populations had significantly increased activities of mixed-functional oxidases P(3.6-fold), b(2.9-fold) and O-demethylase (4.9-fold), and carboxylesterase (2.5-fold), with no significant difference in the activities of glutathione S-transferases among CL and S populations. The results highlight the role of increasing mixed-functional oxidases and carboxylesterase in the resistance of F. occidentalis to clothianidin.