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7 Diseases |  |
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1 Trial |  |
445 News |  |
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- | Natroba (spinosad) / Royalty
Preclinical, Journal: Simultaneous determination of spinosad, temephos, and piperonyl butoxide in animal-derived foods using LC-MS/MS. (Pubmed Central) - Jun 15, 2019
The applicability of the method was evaluated via evaluating samples collected from a large wholesale market located in Seoul, and none of the samples contained any of the target analytes. In conclusion, the current approach is simple, efficient, and reliable and can successfully determine the residual levels of spinosad, temephos, and piperonyl butoxide in complex animal-derived food products.
- | Natroba (spinosad) / Royalty
Journal: Cytochrome P450 monooxygenases-mediated sex-differential spinosad resistance in house flies Musca domestica (Diptera: Muscidae). (Pubmed Central) - Jun 14, 2019
It was found that with increased spinosad resistance, CYP4G2 and CYP6A5v2 were up-regulated in females, while both of them were down-regulated in males, and this suggested their involvement in the female-linked spinosad resistance of house flies. Taken together, our results provide valuable insight into the involvement of cytochrome P450 monooxygenases in the sex-differential spinosad resistance in house flies.
- | Natroba (spinosad) / Royalty
Journal: Functional characterization of CYP6A51, a cytochrome P450 associated with pyrethroid resistance in the Mediterranean fruit fly Ceratitis capitata. (Pubmed Central) - Jun 14, 2019
Toxicity bioassays indicated that CYP6A51 confers knock-down resistance to both λ-cyhalothrin and deltamethrin. Detection of CYP6A51 - associated pyrethroid resistance in field populations may be important for efficient Insecticide Resistance Management (IRM) strategies.
- | Natroba (spinosad) / Royalty
Für Spinosad wäre der Nachweis einfach. Steht in der Anwendungsvorschrift. (Twitter) - Jun 9, 2019
- | Natroba (spinosad) / Royalty
Fantastic! Anyone else out there for a mandatory label? Or maybe @NonGMOProject will develop a non-spinosad label. (Twitter) - Jun 8, 2019
- | Natroba (spinosad) / Royalty
Clinical, Journal: Experimental study on the action of larvicides in Aedes aegypti populations collected in the Brazilian municipality of Itabuna, Bahia, under simulated field conditions. (Pubmed Central) - Jun 7, 2019
Detection of CYP6A51 - associated pyrethroid resistance in field populations may be important for efficient Insecticide Resistance Management (IRM) strategies. the three larvicides demonstrated similar control; however, pyriprofyxen might give a false impression of breeding ground positivity as it acts at the pupal stage, compromising the indicators of infestation that are strategic parameters for control actions.
- | Natroba (spinosad) / Royalty
Journal: Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives. (Pubmed Central) - Jun 5, 2019
The structure activity relationship study indicated that lipophilicity has a great influence on the antiproliferative effects of these derivatives. The most active compound 11d exhibited remarkably enhanced OXPHS inhibition and apoptosis inducing ability than spinosyn A.
- | Natroba (spinosad) / Royalty
Clinical, Journal: Monitoring of Resistance in Field Populations of Scirtothrips dorsalis (Thysanoptera: Thripidae) and Diaphorina citri (Hemiptera: Liviidae) to Commonly Used Insecticides in Citrus in Central India. (Pubmed Central) - Jun 5, 2019
Our data show there may be a shift in resistance to neonicotinoid insecticides that are widely used among citrus growers in the study region. Results from this study indicate that the evolution of insecticide resistance and cross-resistance may be decelerated by the rotational use of insecticides with different modes of action.
- | Natroba (spinosad) / Royalty
Journal: Evaluation of Protein Bait Manufactured From Brewery Yeast Waste for Controlling Drosophila suzukii (Diptera: Drosophilidae). (Pubmed Central) - Jun 5, 2019
Moreover, we found that D. suzukii has a bimodal activity pattern in visiting protein bait, where maximum activity occurs during 8:00-10:00 a.m. and 14:00-16:00 p.m. The antennae and maxillary palpi played an important role in detecting the chemicals emitted from the protein bait, as the number of intact flies that responded to new protein bait was significantly higher than the number of flies without antennae that responded, but almost 15% of defective flies still responded to the protein bait. Our results suggested that the protein bait based on spent brewery yeast could be a promising alternative for D. suzukii population monitoring and for managing this pest when combined with bioinsecticides, providing guidance for using this protein bait as a component of integrated pest management.
- | Natroba (spinosad) / Royalty
Preclinical, Journal: Effects of Insecticides Used in Organic Agriculture on Anastatus reduvii (Hymenoptera: Eupelmidae) and Telenomus podisi (Hymenoptera: Scelionidae), Egg Parasitoids of Pestivorous Stink Bugs. (Pubmed Central) - Jun 5, 2019
When A. reduvii was fed insecticide-laced honey, all treatments except Neemix at 0.1× reduced adult longevity compared to the control. These studies demonstrated that insecticides commonly used in organic agriculture can negatively affect two common parasitoids of stink bugs; specifically, negative effects were most pronounced with Entrust, and variable with Neemix and Pyganic.
- | Natroba (spinosad) / Royalty
Journal: Alternative insecticides for larval control of the dengue vector Aedes aegypti in Lao PDR: insecticide resistance and semi-field trial study. (Pubmed Central) - May 29, 2019
These results suggest that Bti and diflubenzuron may be promising alternative larvicides for controlling dengue vectors in water-storage containers in Laos, especially against Ae. aegypti populations, in which resistance to temephos has been detected.
- | Natroba (spinosad) / Royalty
Journal: Genotoxic and mutagenic assessment of spinosad using bioassays with Tradescantia pallida and Drosophila melanogaster. (Pubmed Central) - May 22, 2019
However, SPN at the concentrations of 0.625; 1.25 and 2.5 g/L was able to induce high frequency of micronuclei in T. pallida. Under the experimental conditions of T. pallida in the present study, SPN caused genotoxic activity.
- | Natroba (spinosad) / Royalty
Journal: Spinosad-mediated effects on survival, overall group activity and the midgut of workers of Partamona helleri (Hymenoptera: Apidae). (Pubmed Central) - May 11, 2019
The brain, on the other hand, did not present significant alterations under the tested conditions. The data obtained demonstrate, therefore, that spinosad negatively affects individual survival, general group activity and the midgut epithelium of P. helleri.
- | Natroba (spinosad) / Royalty
Biomarker, Journal: Toxicity of the insecticides spinosad and indoxacarb to the non-target aquatic midge Chironomus riparius. (Pubmed Central) - May 1, 2019
Additionally, changes in lactate dehydrogenase and glutathione peroxidase activities were observed for both insecticides, and evidences of oxidative damage were found for spinosad. This study contributes to the growing knowledge on sublethal effects of novel insecticides on non-target aquatic invertebrates and strengthens the usefulness of biochemical biomarkers to support the interpretation of their potentially deleterious effects on aquatic insects near agricultural fields.
- | Natroba (spinosad) / Royalty
Clinical, Journal: Exposure to Insecticides Reduces Populations of Rhynchophorus palmarum in Oil Palm Plantations with Bud Rot Disease. (Pubmed Central) - Apr 25, 2019
...The effects of six neurotoxic insecticides (abamectin, carbaryl, deltamethrin, fipronil, imidacloprid and spinosad) were evaluated against SAPW for toxicity, survival, reproduction, and mortality...Mortality of SAPW populations caused by insecticides had similar effects in the laboratory and field conditions. The results suggest that carbaryl, deltamethrin, fipronil, and imidacloprid caused significantly higher mortality as compared to the control in SAPW and may be used to control its populations in oil palm trees where bud rot appears as the key disease for SAPW attraction and infestation.
- | Natroba (spinosad) / Royalty
Review, Journal: Strategies for Enhancing the Yield of the Potent Insecticide Spinosad in Actinomycetes. (Pubmed Central) - Apr 21, 2019
Thus, the combining multi-omics analysis with high-throughput screening of chemical elicitors would be a promising approach in characterizing the regulatory and signal transduction mechanisms and improving spinosad production in Sa. Spinosa.
- | Natroba (spinosad) / Royalty
Clinical, Journal: Identification and risk assessment of spinosad resistance in a California population of Drosophila suzukii. (Pubmed Central) - Apr 19, 2019
These findings confirm that spinosad resistance is emerging in the Watsonville area and document the first known occurrence in the USA, presenting an urgent need for the development of alternative management strategies to control this pest. Additional work is needed to resolve the underlying molecular mechanism(s) that confers spinosad resistance in D. suzukii and assess the potential for this trait to spread into new populations.
- | Natroba (spinosad) / Royalty
Clinical, Journal: Insecticide dose and seasonal timing of trunk injection in apples influences efficacy and residues in nectar and plant parts. (Pubmed Central) - Apr 19, 2019
This study identified a broader list of possible trunk-injectable pesticides for apple trees. This study also shows that managing the seasonal timing of injection can reduce the risk of insecticide exposure to pollinators.
- | Natroba (spinosad) / Royalty
Journal: Use of mechanical and behavioural methods to eliminate female Aedes aegypti and Aedes albopictus for sterile insect technique and incompatible insect technique applications. (Pubmed Central) - Apr 12, 2019
With 100% separation, use of a spiked blood meal is a more effective method of sex separation than the mechanical methods. Application of the spiked blood meal approach as a second separation level for sexes, after applying the Fay-Morlan glass plate method, could achieve 100% sex separation of sexes whilst allowing a reduction in the amount of toxicants required.
- | Natroba (spinosad) / Royalty
Journal: Lethal and behavioral effects of synthetic and organic insecticides on Spodoptera exigua and its predator Podisus maculiventris. (Pubmed Central) - Apr 11, 2019
Application of the spiked blood meal approach as a second separation level for sexes, after applying the Fay-Morlan glass plate method, could achieve 100% sex separation of sexes whilst allowing a reduction in the amount of toxicants required. This work provides useful information on the combination of commercial insecticides with the predator P. maculiventris to controlling S. exigua in integrated pest management (IPM) programs.
- | Natroba (spinosad) / Royalty
Journal, Adverse events: Toxicity and side effects of some insecticides applied in cotton fields on Apis mellifera. (Pubmed Central) - Apr 3, 2019
...Results indicated that lambda-cyhalothrin was the most toxic-tested pesticide, recording the lowest LC and LC values at all tested periods and the lowest LT and LT at all tested concentrations, followed by abamectin, spinosad, chlorpyrifos, and emamectin benzoate...The tested pesticides significantly decreased bee foraging activities, i.e., number of foraging workers, number of worker collecting nectar, number of worker gathering pollen grains, area of broad workers, and honey bee yields. Dipel and pyridalyl were the most safety pesticides on honey bee workers in laboratory and field, so it could be introduced as a component in IPM programs of cotton pests.
- | Natroba (spinosad) / Royalty
Clinical, Journal: Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity. (Pubmed Central) - Mar 30, 2019
In addition, damage caused by spinosad led to a reduction in oviposition and egg viability of A. aegypti females. Finally, the exposure of mosquito larvae to sublethal concentrations of spinosad interfered with the development of the midgut, arresting the blood digestion and reproduction of adult females with blood digestion and reproduction difficulties.
- | Natroba (spinosad) / Royalty
Clinical, Journal: Assessing dengue transmission risk and a vector control intervention using entomological and immunological indices in Thailand: study protocol for a cluster-randomized controlled trial. (Pubmed Central) - Mar 27, 2019
The integration of multiple outcome measures will assist health authorities to better predict outbreaks for planning and applying focal and timely interventions. The trial outcomes will not only be important for Thailand, but also for the entire Southeast Asian region and further afield.
- ||||| Natroba (spinosad) / Royalty
Enrollment change: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jan 17, 2019
P3, N=280, Completed, Sponsor: ParaPRO LLC
The trial outcomes will not only be important for Thailand, but also for the entire Southeast Asian region and further afield. N=120 --> 280
- ||||| Natroba (spinosad) / Royalty
Enrollment change: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jan 17, 2019
P3, N=364, Completed, Sponsor: ParaPRO LLC
N=120 --> 280 N=120 --> 364
- | Natroba (spinosad) / Royalty
Trial completion: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Oct 25, 2018
P3, N=120, Completed, Sponsor: ParaPRO LLC
N=120 --> 364 Active, not recruiting --> Completed
- | Natroba (spinosad) / Royalty
Trial completion, Trial completion date, Trial primary completion date: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Oct 25, 2018
P3, N=120, Completed, Sponsor: ParaPRO LLC
Active, not recruiting --> Completed Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Jun 2018 | Trial primary completion date: Oct 2018 --> Jun 2018
- |||| Natroba (spinosad) / Royalty
Enrollment closed: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jul 3, 2018
P3, N=120, Active, not recruiting, Sponsor: ParaPRO LLC
Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Jun 2018 | Trial primary completion date: Oct 2018 --> Jun 2018 Recruiting --> Active, not recruiting
- |||| Natroba (spinosad) / Royalty
Enrollment closed: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jun 29, 2018
P3, N=120, Active, not recruiting, Sponsor: ParaPRO LLC
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- |||| Natroba (spinosad) / Royalty
Trial completion date, Trial primary completion date: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Mar 21, 2018
P3, N=120, Recruiting, Sponsor: ParaPRO LLC
Recruiting --> Active, not recruiting Trial completion date: Apr 2018 --> Jul 2018 | Trial primary completion date: Mar 2018 --> Jun 2018
- |||| Natroba (spinosad) / Royalty
P3 data, Trial primary completion date: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Nov 30, 2017
P3, N=120, Recruiting, Sponsor: ParaPRO LLC
Trial completion date: Apr 2018 --> Jul 2018 | Trial primary completion date: Mar 2018 --> Jun 2018 Trial primary completion date: Jan 2018 --> Jun 2018
- |||||| Natroba (spinosad) / Royalty
Enrollment open, P3 data: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - May 11, 2017
P3, N=120, Recruiting, Sponsor: ParaPRO LLC
Trial primary completion date: Jan 2018 --> Jun 2018 Not yet recruiting --> Recruiting
- |||||| Natroba (spinosad) / Royalty
Enrollment open: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - May 5, 2017
P3, N=120, Recruiting, Sponsor: ParaPRO LLC
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- ||||| Natroba (spinosad) / Royalty
P3 data, Enrollment change: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Mar 14, 2017
P3, N=120, Not yet recruiting, Sponsor: ParaPRO LLC
Not yet recruiting --> Recruiting N=75 --> 120 | Initiation date: Jun 2015 --> May 2017 | Trial primary completion date: Oct 2017 --> Jan 2018 | N=75 --> 120
- ||||| Natroba (spinosad) / Royalty
Enrollment change, Trial initiation date, Trial primary completion date: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Mar 14, 2017
P3, N=120, Not yet recruiting, Sponsor: ParaPRO LLC
N=75 --> 120 | Initiation date: Jun 2015 --> May 2017 | Trial primary completion date: Oct 2017 --> Jan 2018 | N=75 --> 120 N=75 --> 120 | Initiation date: Jun 2015 --> May 2017 | Trial primary completion date: Oct 2017 --> Jan 2018
- | Natroba (spinosad) / Royalty
P3 data: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jan 18, 2016
P3, N=75, Suspended, Sponsor: ParaPRO LLC
N=75 --> 120 | Initiation date: Jun 2015 --> May 2017 | Trial primary completion date: Oct 2017 --> Jan 2018 Trial primary completion date: Jan 2016 --> Oct 2017
- | Natroba (spinosad) / Royalty
Trial primary completion date: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jan 18, 2016
P3, N=75, Suspended, Sponsor: ParaPRO LLC
Trial primary completion date: Jan 2016 --> Oct 2017 Trial primary completion date: Dec 2015 --> Oct 2017
- || Natroba (spinosad) / Royalty
P3 data: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Dec 18, 2015
P3, N=75, Suspended, Sponsor: ParaPRO LLC
Trial primary completion date: Dec 2015 --> Oct 2017 Recruiting --> Suspended
- || Natroba (spinosad) / Royalty
Trial suspension: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Dec 18, 2015
P3, N=75, Suspended, Sponsor: ParaPRO LLC
Recruiting --> Suspended Recruiting --> Suspended
- |||| Natroba (spinosad) / Royalty
P3 data: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Oct 5, 2015
P3, N=75, Recruiting, Sponsor: ParaPRO LLC
Recruiting --> Suspended Trial primary completion date: Oct 2015 --> Jan 2016
- |||||| Natroba (spinosad) / Royalty
P3 data: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Aug 19, 2015
P3, N=75, Recruiting, Sponsor: ParaPRO LLC
Trial primary completion date: Oct 2015 --> Jan 2016 Active, not recruiting --> Recruiting
- |||||| Natroba (spinosad) / Royalty
Enrollment open: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Aug 19, 2015
P3, N=75, Recruiting, Sponsor: ParaPRO LLC
Active, not recruiting --> Recruiting Active, not recruiting --> Recruiting
- |||||||||| Natroba (spinosad) / Royalty
New P3 trial, P3 data: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jun 30, 2015
P3, N=75, Active, not recruiting, Sponsor: ParaPRO LLC
- |||||||||| Natroba (spinosad) / Royalty
New P3 trial: Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies (clinicaltrials.gov) - Jun 30, 2015
P3, N=75, Active, not recruiting, Sponsor: ParaPRO LLC
- | Natroba (spinosad) / Royalty
New P4 trial: Pharmacokinetic (PK) and Tolerance Study of Natroba Topical Suspension in Pediatrics With an Active Head Lice Infestation (clinicaltrials.gov) - Aug 6, 2012
P4, N=26, Completed, Sponsor: ParaPRO LLC