Ongoing

4

300

Europe

Powder for solution for infusion, Solution for infusion, Powder and solvent for solution for infusion, ZYVOXID*1SACCA INF 2MG/ML, PIPERACILLINA DOROM*FL 1G+F2ML, PENSTAPHO*IM IV 1FL+F 1G, MERREM*EV POLV 10FL 1000MG, UNASYN*EV 1FL 1G+2G, COLIMICINA*IM FL 1000000U4ML+F, GLAZIDIM VENA 1*1FL 1G+1F 10ML

AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI, AIFA (bandi per la ricerca indipendente)

Ventilator Associated Pneumonia Polmonite da ventilazione meccanica, Ventilator Associated Pneumonia Polmonite da ventilazione meccanica, Diseases [C] - Bacterial Infections and Mycoses [C01]

 

 

Ongoing

4

40

Europe

ZYVOXID, ZYVOXID

POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI

ventilator associated pneumoniae

 

 

Ongoing

4

100

Europe

Rifampicin, minocycline, Zyvoxid 600mg, Rifampicin, minocycline, Zyvoxid, Zyvoxid

European Commission, Hellenic Institute for the Study of Sepsis, European Commisssion, Hellenic Institute for the Study of Sepsis

Complicated Skin and Skin Structure infections caused by Methicillin Resistant Staphylococcus Aureus

 

 

Not yet recruiting

4

64

Europe

Capsule, Tablet, Capsule, hard, Film-coated tablet, Rimactan, Fucidin, Dalacin, Tavanic, Zyvoxid, Bactrim forte

Sahlgrenska University Hospital, Västra Götalandsregionen, Centre for Antibiotic Resistance Research (CARe)

Periprosthetic hip or knee joint infections, Infections in hip or knee joint with a hip or knee replacement implant, Diseases [C] - Bacterial Infections and Mycoses [C01]

 

 

Not yet recruiting

4

284

Europe

Ciprofloxacin, ampicilin, vancomycin, linezolid, daptomycin, amoxicillin / clavulanic acid, piperacillin / tazobactam, amoxicilin, Film-coated tablet + pessary, Suspension for injection, Powder and solvent for solution for infusion, Solution for injection/infusion, Powder and solvent for solution for injection/infusion, Film-coated tablet, Tablet, Ciprofloxacin, ampicilin, vancomycin, linezolid, daptomycin, amoxicillin / clavulanic acid, piperacillin / tazobactam, amoxicilin

Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI), Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación

Adult patients with uncomplicated bacteremia caused by E. faecalis or E. faecium. Pacientes adultos con bacteriemias no complicadas causadas por E. Faecalis o E. faecium., Adult patients with infections that produce the passing of certainbacteria to the bloodstream. Pacientes adultos con infecciones que producen el paso de ciertasbacterias al torrente sanguíneo., Diseases [C] - Bacterial Infections and Mycoses [C01]

 

 

Not yet recruiting

4

120

Europe

Linezolid, Coated tablet, Solution for injection, Zyvoxid

UCLouvain, Louvain Drug Research Institute

All infections treated with the antibiotic linezolid, All infections treated with the antibiotic linezolid, Diseases [C] - Bacterial Infections and Mycoses [C01]

 

 

Ongoing

3

25

Europe

Solution for infusion, Zyvoxid

Helena Barrasa, Helena Barrasa

Infection Infecciones causadas por microorganismos gran positivos multirresistentes, Infection in the intensive care unit Infecciones en las unidades de cuidados intensivos, Diseases [C] - Bacterial Infections and Mycoses [C01]

 

 

Not yet recruiting

3

378

Europe

Ampicillim, amoxicillin/clavulanic, Cefazolin, Cefepime, Ceftazidime, CEFTRIAXONE, cloxacillin, daptomycin, Meropenem, Teicoplanin, Vancomycin, Amoxicillin, Amoxicillin / clavulanic acid, Ciprofloxacin, Levofloxacin, Linezolid, Moxifloxacin, Rifampicin, Powder and solvent for solution for infusion, Powder and solvent for solution for injection, Powder for solution for injection, Powder and solvent for suspension for injection, Powder for solution for injection/infusion, Tablet, , Capsule, Ampicillim, Amoxicillin/Clavulanic, Cefazolin, Cefepime, ceftazidime, CEFTRIAXONE, cloxacillin, daptomycin, Meropenem, Teicoplanin, Vancomycin, Amoxicillin, Amoxicillin / clavulanic acid, Ciprofloxacin, Clindamycin, Sulfametoxazol trimetoprim, Levofloxacin, Linezolid, Moxifloxacin, Rifampicin

Fundación Pública Andaluza para la Gestión de la Investigación, Instituto de Salud Carlos III. Ministerio de Ciencia e

Patients with long bone fractures who have had osteosynthesis material implanted to stabilize and assist fracturehealing and meet the criteria for Infections associated with osteosynthesis material Pacientes con fracturas de huesos largos a quienes se les ha implantado material de osteosíntesis para estabilizar y ayudar a la curación de la fractura y que cumplen con los criterios de Infecciones asociadas con el material de osteosíntesis., Patients with infections due to the implant used to stabilize a long bone fracture Pacientes con infecciones debidas al implante usado para estabilizar una fractura de hueso largo, Diseases [C] - Bacterial Infections and Mycoses [C01]

 

 

Completed

3

402

RoW

Bedaquiline Oral Tablet, Sirturo, Linezolid Oral Tablet, Zyvox, Delamanid in Oral Dosage Form, Deltyba, Clofazimine Oral Product, Lamprene, Levofloxacin Oral Tablet, Isoniazid Oral Product, INH, Ethambutol Oral Product, Pyrazinamide Oral Product

Wits Health Consortium (Pty) Ltd, Regents of the University of California, University of Cape Town, Perinatal HIV Research Unit of the University of the Witswatersrand

Tuberculosis, Pre-XDR-TB, Extensively Drug-Resistant Tuberculosis, Multi Drug Resistant Tuberculosis, Rifampicin Resistant Tuberculosis

04/24

04/24

Recruiting

3

290

RoW

Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid, Bactrim, Dalacin, Ospexin, Zyvox, IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline, Cloxacillin Sodium, Cefazolin Sandoz, Vancotex, Zinforo

Clinical Research Centre, Malaysia

Staphylococcus Aureus Bacteremia

05/25

06/25

Not yet recruiting

3

690

RoW

Bedaquiline, Sirturo, Linezolid, Zyvox, Pretomanid, Pretamyl, Moxifloxacin, Avelox, Control Arm FQ-S MDR/RR-TB regimen, designed according to latest WHO guidelines

University of California, San Francisco, Johns Hopkins University

Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant, Tuberculosis, MDR

Completed

2/3

552

RoW

Bedaquiline, Sirturo, R207910, TMC207, Pretomanid, PA-824, Moxifloxacin, Avelox, Linezolid, Zyvox, Clofazimine, Lamprene, Locally accepted standard of care which is consistent with the WHO recommendations for the treatment of M/XDR-TB.

Medecins Sans Frontieres, Netherlands, London School of Hygiene and Tropical Medicine, Global Alliance for TB Drug Development, University College, London, Drugs for Neglected Diseases, Swiss Tropical & Public Health Institute, eResearch Technology, Inc., Ministry of Health, Republic of Uzbekistan, World Health Organization, Ministry of Public Health, Republic of Belarus, THINK TB & HIV Investigative Network, University of Liverpool, Wits Health Consortium (Pty) Ltd, Rutgers, The State University of New Jersey, University of California, San Francisco

Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Tuberculosis, Pulmonary

08/22

08/22

Completed

2/3

137

RoW

Bedaquiline, Sirturo, R207910, TMC207, Pretomanid, PA-824, Moxifloxacin, Avelox, BAY 12-8039, Linezolid, Zyvox, Clofazimine, Lamprene, Directly observed therapy (DOT)

Medecins Sans Frontieres, Netherlands, University of Sussex, London School of Hygiene and Tropical Medicine, THINK TB & HIV Investigative Network, Wits Health Consortium (Pty) Ltd, Ministry of Public Health, Republic of Belarus, Ministry of Health, Republic of Uzbekistan

Multidrug Resistant Tuberculosis

05/22

05/22

Not yet recruiting

2

300

Europe

Amikacin, Tigecycline, Imipenem and Cilastatin, Cefoxitin, Azithromycin, Clofazimine, Ethambutol, Clarithromycin, Linezolid, Trimethoprim and Sulfamethoxazole, Doxycycline, Moxifloxacin, Bedaquiline, Rifabutin, Solution for injection, Powder for solution for infusion, Film-coated tablet, Powder for oral suspension, Capsule, Tablet, Capsule, hard, Clofazimine "Lamprene", Trimethoprim and Sulfamethoxazole "SAD"

University of Queensland, Medical Research Futures Fund, Cystic Fibrosis Foundation, Anonymous Donor, Thoracic Society of Australia and New Zealand, The University of Queensland, Children's Hospital Foundation

Mycobacterium abscessus pulmonary disease, Nontuberculous mycobacterium (NTM) are a group of bacteria. These bacteria can cause significant lung damage in both healthy people and those with underlying lung disease., Diseases [C] - Respiratory Tract Diseases [C08]

 

 

Active, not recruiting

2

309

RoW

TBAJ-876, Pretomanid, PA-824, Dovprela, Linezolid, Zyvox, Bedaquiline, Sirturo, TMC207, HRZE, HR

Global Alliance for TB Drug Development

Pulmonary TB, Pulmonary Tuberculosis, Drug Sensitive Tuberculosis

06/26

Recruiting

2

60

Europe

Tedizolid arm (SIVEXTRO®), Linezolid arm (ZYVOXID®), Standard quadruple therapy arm

Assistance Publique - Hôpitaux de Paris

Tuberculosis, Multidrug Resistant Tuberculosis

04/26

05/26

Recruiting

1

48

 

The first cycle on an empty stomach with test product; The second cycle taken on an empty stomach reference preparations; ;The first cycle on an empty stomach with reference product; The second cycle taken on an empty stomach test product ;The first cycle on an fed condation with test product; The second cycle taken on fed condation reference preparations； ;The first cycle on an fed condation with reference product; The second cycle taken on an empty stomach test product;

The First Hospital of Jilin University; Jiangsu Hansoh Pharmaceutical Group, Jiangsu Hansoh Pharmaceutical Group

NA

 

 

Recruiting

1

48

 

Subjects take one tablet of R medication in the first cycle and one tablet of T medication in the second cycle on an empty stomach ;Subjects take one tablet of T medication in the first cycle and one tablet of R medication in the second cycle on an empty stomach ;After taking a high-fat meal, the subjects took one tablet of T-medication in the first cycle and one tablet of R-medication in the second cycle ;After taking a high-fat meal, the subjects took one tablet of R-medication in the first cycle and one tablet of T-medication in the second cycle

Huzhou Central Hospital, Zhejiang Province; Haikou Pharmaceutical Factory Co., Ltd, Haikou Pharmaceutical Factory Co., Ltd.

Antibacterial

 

 

Recruiting

N/A

140

RoW

Linezolid, zyvox

Ain Shams University

Treatment Efficacy

12/23

12/23

Not yet recruiting

N/A

20

 

Take linezolid tablets 600 mg orally once daily ;Take contizolid tablets 800 mg twice daily.

Beijing Chest Hospital Affiliated to Capital Medical University; Beijing Chest Hospital Affiliated to Capital Medical University, Capital health development scientific research project

Tuberculosis