Completed

4

440

 

rabeprazole 10 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and clarithromycin 500 mg b.i.d. ;rabeprazole 10 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and tetracycline 750 mg b.i.d. ;rabeprazole 20 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and clarithromycin 500 mg b.i.d. ;rabeprazole 20 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and tetracycline 750 mg b.i.d

The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University, the Chinese Study Group on Helicobacter pylori, Chinese Society of Gastroenterology

helicopter pylori and duodenal ulcer

 

 

Recruiting

4

245

 

SOMAC ;Pantoloc ;Takepron ;Nexium ;Pariet ;SOMAC+probiotic ;none

Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Z hejiang University; Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Z hejiang University, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University

Helicobacter pylori infection

 

 

Completed

4

362

 

flupentixol and melitracen + nizatidine ;flupentixol and melitracen + rabeprazole ;flupentixol and melitracen ;nizatidine ;rabeprazole

The Third Xiangya Hospital, Central South University; Digestive System Department, The Third Xiangya Hospital, Central South University, the New Xiangya Talent Project of the Third xiangya hosipital of Central South University (20180304); Hunan Provincial Natural Science Foundation of China(2020JJ4853), etc.

functional dyspepsia

 

 

Recruiting

4

360

 

bismuth quadruple therapy ;Amoxicillin dual therapy ;Furazolidone dual therapy

Henan Provincial People's Hospital; Henan Provincial People's Hospital, Henan Provincial Medical Science and Technology Research Project

helicobacter pylori infection

 

 

Recruiting

4

80

 

On the basis of proton pump inhibitor (rabeprazole 20mg, orally, 1 day), agomelatine 25mg/d was added, orally before bedtime ;On the basis of proton pump inhibitor (rabeprazole 20mg, orally, 1/ day) treatment, soothing agents were added, orally before bedtime

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Jiangsu Hansoh Pharmaceutical Group Co. Ltd

Gastroesophageal reflux disease (GERD)

 

 

Recruiting

4

240

 

vonoprazan 20mg,2 times a day for 7days ;vonoprazan 20mg,2 times a day for 14 days ;rabeprazole 10mg,2 times a day for 14 days

Department of Gastroenterology, Jinshan Hospital of the First Affiliated Hospital of Chongqing Medical University; Jinshan Hospital of the First Affiliated Hospital of Chongqing Medical University, Postgraduate funding

Helicobacter pylori infection

 

 

Recruiting

4

242

RoW

Rabeprazole, Bismuth potassium citrate, Metronidazole, Doxycycline, Tetracycline

Shanghai Zhongshan Hospital

Helicobacter Pylori Infection

12/22

12/22

Recruiting

4

393

RoW

Vonoprazan, Rabeprazole, Amoxicillin, Clarithromycin, Colloidal bismuth pectin

Second Affiliated Hospital, School of Medicine, Zhejiang University

Helicobacter Pylori Infection

08/23

08/23

Recruiting

4

1404

RoW

Rabeprazloe+bismuth+amoxicillin+clarithromycin, Vonoprazan+amoxicillin+clarithromycin 14 days, Vonoprazan+amoxicillin+clarithromycin 7 days, Vonoprazan+tetracycline+furazolidone 14 days, Vonoprazan+tetracycline+furazolidone 7 days, Vonoprazan+amoxicillin+furazolidone 7 days, Vonoprazan+amoxicillin+tetracycline 14 days, Vonoprazan+amoxicillin 7 days, Vonoprazan+amoxicillin 14 days

Xijing Hospital of Digestive Diseases

the Eradication Rates of Helicobacter Pylori

11/24

12/24

Not yet recruiting

4

500

 

The treatment lasted for 10 days, including vonoprazan 20mg twice a day, amoxicillin 1g three times a day ;The treatment lasted for 10 days, including vonoprazan 20mg twice a day, amoxicillin 1g three times a day, furazolidone 100mg twice a day ;The treatment lasted for 14 days, including vonoprazan 20mg twice a day, amoxicillin 1g three times a day ;Amoxicillin 1g twice a day, clarithromycin sustained-release tablet 0.5g twice a day, rabeprazole sodium enteric-soluble capsule 20mg twice a day, colloidal bismuth 0.3g twice a day. Patients were treated for 14 days

Xuzhou First People's Hospital; Xuzhou First People's Hospital, None

Helicobacter pylori infection

 

 

Not yet recruiting

4

500

 

On the basis of basic treatment, the patients were given rabeprazole sodium enteric-coated tablets (Jichuan Pharmaceutical Group Co., Ltd., GYZZ H20040916, specification: 10mg/tablet), 10 mg/time, twice a day, for 28 days; If accompanied by Helicobacter pylori infection, the patient should be treated with quadruple antibiotic (Rabeprazole 10mg bid, amoxicillin potassium clavulanic acid 5 pills bid, clarithromycin 0.5 bid, bismuth potassium citrate 220 mg bid) for 14 days. Stop taking medication for 14 days and undergo gastroscopy and Helicobacter pylori examination. ;On the basis of basic treatment, the patient was given Qiruiweishu capsule, 4 capsules at a time, twice a day; Rabeprazole sodium enteric-coated tablets (Jichuan Pharmaceutical Group Co., Ltd., GYZZ H20040916, specification: 10mg/tablet), 10 mg/time, twice a day. Take it continuously for 28 days. In the same way, the patients with Helicobacter pylori infection were treated with quadruple antimicrobial therapy (rabeprazole 10 mg bid, amoxicillin potassium clavulanic acid 5 pills bid, clarithromycin 0.5 bid, bismuth potassium citrate 220 mg bid) for 14 days in the first week. Stop taking medication for 14 days and undergo gastroscopy and Helicobacter pylori examination.

Jiangsu Second Hospital of Traditional Chinese Medicine; Jiangsu Second Hospital of Traditional Chinese Medicine, Jianmin Pharmaceutical Group Co., Ltd.

chronic gastritis

 

 

Recruiting

4

702

RoW

High-dose dual therapy (rabeprazole, amoxicillin), Proton pump inhibitor, Rabeprazole, Pariet®, Antibiotics, Amoxicillin ,Amoxicillin®, Bismuth High-dose dual therapy (rabeprazole, amoxicillin, tripotassium dicitrate bismuthate), Colloidal Bismuth, Tripotassium dicitrate bismuthate, KCB®, Amoxicillin-Metronidazole Bismuth quadruple therapy, Antibiotics, Amoxicillin, Amoxicillin®, Antibiotics, Metronidazole, Flagyl®

National Taiwan University Hospital, Ministry of Science and Technology, Taiwan

Helicobacter Pylori Infection

09/24

12/24

Not yet recruiting

4

300

 

Berberine hydrochloride tablets 200mg + Vonoprazan fumarate tablets 20mg + amoxicillin capsule 1g, berberine hydrochloride tablets 3 times a day and all the rest of the medicines were given twice a day for 14 days.; Berberine hydrochloride tablets 300mg + Vonoprazan fumarate tablets 20mg + amoxicillin capsule 1g, berberine hydrochloride tablets 3 times a day, and all the rest of the medicines were given twice a day for 14 days.; Colloidal bismuth pectin capsules 200mg + Rabeprazole sodium enteric-coated tablets 20mg + amoxicillin capsules 1g + clarithromycin tablets 0.5g, all medications were given twice a day for 14 days.

Qianxinan People's Hospital; Qianxinan People's Hospital, self-funded

Helicobacter pylori infection

 

 

Not yet recruiting

4

364

 

Rabeprazole+Amoxicillin; Vonoprazan + Amoxicillin

Nanjing First Hospital; Nanjing First Hospital, Self-raised

Helicobacter

 

 

Not yet recruiting

4

130

 

Given Rabeprazole sodium enteric-coated tablets (10 mg/time, twice/day), bismuth potassium citrate capsules (300 mg/time, twice/day), amoxicillin (1,000 mg/time, twice/day) + furazolidone tablets (100mg/time, twice/day) + Wei Chang Hao (2,000 mg/time, three times/day), take it for 14 days. After antibiotic bunching, Wei Chang Hao was continued to be taken (2,000 mg/time, 3 times/day) for 4 weeks. Note: Antibiotics should be taken at a two-hour interval. ;Rabeprazole sodium enteric-coated tablets (10 mg/time, twice a day), bismuth potassium citrate capsules (300 mg/time, twice a day), amoxicillin (1,000 mg/time, twice a day) and furazolidone tablets (100 mg/time, twice a day) were given for 14 days. ;N/A

The First Hospital of Nanchang; The First Hospital of Nanchang, The First Hospital of Nanchang

Helicobacter pylori infection

 

 

Not yet recruiting

4

219

 

Amoxicillin 1g/ twice/day + vonoprazan 20mg/ twice/day (14 days); Amoxicillin 750mg/ time 4 times/day + vonoprazan 20mg/ time 2 times/day (14 days); Amoxicillin 750mg/ time 4 times/day + Rabeprazole 20mg/ time 2 times/day (14 days)

Guangzhou First People’s Hospital; Guangzhou First People’s Hospital, self-financing

Helicobacter pylori

 

 

Not yet recruiting

4

224

 

Tegoprazan 50mg twice a day and amoxicillin 1.0g three times a day for 10 days; Rabeprazole 20mg twice a day, amoxicillin 1.0g twice a day, Furazolidone 0.1g twice a day, colloidal bismuth pectin 200mg twice a day for 10 days

Chengdu Xinhua Hospital; Chengdu Xinhua Hospital, In-hospital research projects

Helicobacter pylori infection

 

 

Not yet recruiting

4

600

 

Rabeprazole enteric-coated capsule + Amoxicillin capsule + Tetracycline tablet + Compound Eosinophil-Lactobacillus Tablets capsules were taken for 14 days; Rabeprazole enteric-coated capsule + Amoxicillin capsule +Tetracycline tablet + Bismuth potassium citrate capsules + Compound Eosinophil-Lactobacillus Tablets capsules were taken for 10 days, while taking Compound Eosinophil-Lactobacillus Tablets until the 21d; Rabeprazole enteric-coated capsule + Amoxicillin capsule +Tetracycline tablet + Bismuth potassium citrate capsules were taken for 14 days

Peking University First Hospital; Peking University First Hospital, China Health Promotion Foundation

Helicobacter pylori positive chronic gastritis

 

 

Recruiting

4

3100

RoW

PPI, P-CAB 50

Duk-Woo Park, MD

Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction

09/26

12/27

Not yet recruiting

4

484

 

Rabeprazole 20 mg twice daily (Bid) + Amoxicillin 1 g Bid + Clarithromycin 500 mg Bid + Potassium Citrate Bismuth 220 mg Bid + Brachyspira Yeast 0.25; Control Group: Rabeprazole 20 mg Bid + Amoxicillin 1 g Bid + Clarithromycin 500 mg Bid + Potassium Citrate Bismuth 220 mg Bid.

The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University, Researcher-initiated Clinical Research Fund Project of the First Affiliated Hospital of Xiamen University

Helicobacter pylori

 

 

Completed

3

918

RoW

10d bismuth quadruple therapy, rabeprazole 20 mg bid, tripotassium dicitrate bismuthate 300mg qid, tetracycline 500 mg qid, metronidazole 250 mg qid, 14d hybrid therapy, amoxicillin 1 g bid, clarithromycin 500 mg bid, metronidazole 500 mg bid, 14D high-dose dual therapy, rabeprazole 20 mg qid, amoxicillin 750 mg qid

Kaohsiung Veterans General Hospital.

Helicobacter Pylori Infection

12/21

12/21

Not yet recruiting

3

700

 

TNP-2198 capsules, rabeprazole sodium enteric-coated tablets, amoxicillin capsules ;Amoxicillin capsules, clarithromycin tablets, rabeprazole sodium enteric-coated tablets, Bismuth potassium citrate capsules

Department of Gastroenterology, Peking Universsity Third Hospital; Department of Gastroenterology, Peking University Third Hospital, self-funded

helicobacter pylori infection

 

 

Completed

2

80

RoW

TNP-2198, Rifasutenizol, Rabeprazole Sodium, Amoxicillin

TenNor Therapeutics (Suzhou) Limited

Helicobacter Pylori Infection

09/22

09/22

Completed

1/2

40

RoW

TNP-2198, Rifasutenizol, Rabeprazole Sodium, Amoxicillin

TenNor Therapeutics (Suzhou) Limited

Helicobacter Pylori Infection

01/22

01/22

Completed

1

20

RoW

TNP-2092 capsules, Rifaquizinone, TNP-2092 capsules placebo, Rabeprazole sodium enteric-coated tablets

TenNor Therapeutics Inc.

Helicobacter Pylori Infection

11/17

11/17

Completed

1

14

US

ESK-001, Rabeprazole

Alumis Inc

Pharmacokinetics

06/22

09/22

Completed

1

Canada

Bellus Health Inc. - a GSK company

08/23

08/23

Completed

1

32

US

Maribavir Commercial Tablet Formulation, TAK-620, Maribavir Pediatric Powder-for-oral Suspension Formulation, Rabeprazole

Takeda

Healthy Volunteers

08/23

09/23

Completed

1

36

 

In the fasting state, the subjects took rabeprazole sodium enteric-coated tablets for 7 consecutive days, and then took the palbociclib reference preparation in the first cycle, and the second cycle was the same as before, and the pibociclib test preparation was taken in the second cycle; In the fasting state, the subjects took rabeprazole sodium enteric-coated tablets for 7 consecutive days, and took the palbociclib test preparation in the first cycle, and the reference preparation of palbociclib in the second cycle

Hebei General Hospital; CSPC Ouyi Pharmaceutical Co., Ltd, CSPC Ouyi Pharmaceutical Co., Ltd.

N/A

 

 

Completed

1

113

US

Single dose of PF-07220060 as first Tablet Formulation, Cohort 1, first Tablet Formulation, Fasted, Single dose of PF-07220060 as second Tablet Formulation, Cohort 2, second Tablet Formulation, Fasted, Cohort 3, first Tablet Formulation, Second Dose Level, Fasted, Cohort 4, second Tablet Formulation, Second Dose level, Fasted, Single dose of PF-07220060 as a Tablet Formulation, Cohort 5, Fed, Single dose of PF-07220060 as a Tablet formulation under Rabeprazole administration, Cohort 6, Fasted PPI, Cohort 7, Fed PPI, Single dose of PF-07220060 as third tablet formulation, Cohort 8, third tablet formulation

Pfizer

Healthy Participants

06/24

07/24

Completed

1

40

Europe

Sisunatovir, Rabeprazole 40 mg, Sisunatovir suspension, Rabeprazole 20 mg

Pfizer

Healthy

07/24

07/24

Completed

1

18

 

GRIN Therapeutics, Inc., GRIN Therapeutics, Inc.

Malformations of Cortical Development

 

 

Recruiting

1

74

 

According to the secondary prevention of coronary heart disease, patients were given health education, adjustment of lifestyle, control of risk factors, such as smoking cessation, control of blood pressure, blood sugar, blood lipids, etc. In terms of drug selection, single anti-platelet aggregation was given: aspirin 100mg qd or clopidogrel 75mg qd or ticagrelor 90mg bid po, lipid-stabilizing plaque: atorvastatin calcium tablet 20mg qn or rosuvastatin 10mg qn. The dosage of β-blocker was determined by the patient's blood pressure and resting heart rate, and CCB/ACEI/ARB was determined by the patient's blood pressure, blood potassium and kidney function. At the same time, gastric protection drugs were given: Iprrazole or rabeprazole enteric-coated tablets 10mg qd.; Western medicine treatment plan is the same as the control group, Chinese medicine plus Lengzhu granules (vinegar Sanling formula granules 1g, specifications: 1g granules /9g decoction pieces; Vinegar Zedoary (Guangxi Zedoary) formula granules 1g, specifications: 1g granules /8g decoction pieces; Ginger formula granule 6g, specification: 0.5g granule /6g decoction piece; Jujube formula granules 3g, specifications: 2.5g granules /3g decoction pieces; Glycyrrhiza formula granules 3g, specifications: 1g granules /3g decoction pieces; Drug production Company: Jiangyin Tianjiang Pharmaceutical Co., LTD.) Water infusion, 1 dose/day; The course of treatment is 40 days.

Guangdong Provincial Hospital of Chinese Medicine Zhuhai Hospital; Guangdong Provincial Hospital of Chinese Medicine, None

Coronary heart disease

 

 

Recruiting

N/A

500

 

rabeprazole vs control

Department of Gastroenterology and Hepatology, the Chinese PLA General Hospital, Beijing 100853, China.; Chinese PLA General Hospital, ministry of health

upper gastrointestinal bleeding

 

 

Not yet recruiting

N/A

260

 

Rabeprazole 10mg qid+Amoxicillin 750mg qid 14days ;Rabeprazole 20mg tid+Amoxicillin 750mg qid 14days ;Rabeprazole 20mg qid+Amoxicillin 750mg qid 14days ;Rabeprazole 20mg bid+Bismuth 220mg bid+Amoxicillin 1000mg bid+clarithromycin 500g bid 14days

Daping Hospital, the Third Military Medical University, Chongqing, China; Daping Hospital, the Third Military Medical University, Chongqing, China, National Natrural scientific funds(81171526,81472006)

diseases of upper digestive tract

 

 

Recruiting

N/A

543

 

Esomeprazole 20mg bid or Rabeprazole 20mg bid + bismuth 220mg bid + Amoxicillin 1g bid + tetracycline 750mg bid + furaxone 100mg bid, 14 days

Daping Hospital, the Third Military Medical University, Chongqing, China; Daping Hospital, the Third Military Medical University, Chongqing, China, optional research topic

diseases of upper digestive tract

 

 

Recruiting

N/A

690

 

10-day sequential therapy containing Rabeprazole ;10-day sequential therapy containing Omeprazole

Guangzhou Women and Children's Medical Center; Guangzhou Women and Children's Medical Center, NA

Helicobacter pylori infection in children

 

 

Not yet recruiting

N/A

240

 

TCM syndrome differentiation + PPI; Agreement prescription of traditional Chinese Medicine+PPI

Shanghai Yueyang Hospital; Shanghai Yueyang Hospital, Three year plan of action for promoting clinical skills and clinical innovation in municipal hospitals

refractory gastroesophageal reflux disease

 

 

Not yet recruiting

N/A

200

 

rabeprazole combined with mosapride ;none

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, self raise

chronic gastritis

 

 

Recruiting

N/A

56

 

Rabeprazole plus chloroquine ;Lopinavir + rabeprazole

Infection prevention and treatment center of The Fifth Affiliated Hospital of Sun Yat-Sen University; The Fifth Affiliated Hospital of Sun Yat-Sen University, government

Novel Coronavirus Pneumonia (COVID-19)

 

 

Not yet recruiting

N/A

112

 

fasting TRTR ;fasting RTRT ;TRTR after meal ;RTRT after meal

The Second Affiliated Hospital of Xingtai Medical College; Rundu Pharma, Rundu Pharma

Gastric ulcer, duodenal ulcer, anastomotic ulcer, reflux esophagitis, Zollinger-Ellison syndrome.

 

 

Completed

N/A

281

RoW

Histology，13C urea breath test，Stool antigen test，Serological antibody test for H.pylori and Serologic test with a current infection marker of H.pylori, Rabeprazole，Minocycline，Amoxicillin and Colloidal bismuth pectin

Second Affiliated Hospital, School of Medicine, Zhejiang University

Helicobacter Pylori Infection

01/22

01/23

Not yet recruiting

N/A

640

 

Rabeprazole (Zhuhai Rundu Pharmaceutical Co., LTD., Rainqing) 10mg/ time, 4 times/day ;Omeprazole high-dose dual therapy

Affiliated Hospital of Southwest Medical University; Affiliated Hospital of Southwest Medical University, None

helicobacter pylori (Hp) infection

 

 

Recruiting

N/A

190

 

Tonghua Liyan prescription ;Rabeprazole capsules

Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine; Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shenkang three-year Chinese medicine action plan subsidy

Gastroesophageal reflux disease

 

 

Recruiting

N/A

82

 

Tonghua Liyan granules combined with rabeprazole capsules ;Tonghua Liyan granules placebo combined with rabeprazole capsules

Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine; Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Technology Innovation Action Plan of Shanghai Science and Technology Commission (19401971800)

Gastroesophageal reflux disease

 

 

Not yet recruiting

N/A

60

 

ketorolac tromethamine + Rabeprazole ;ketorolac tromethamine + Rabeprazole + Mulberry cream formula

Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine; Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Dingjiwan Foundation of Meng Heding's Internal Medicine Department, Shanghai University of Traditional Chinese Medicine

Residual pain after vertebroplasty for osteoporotic thoracolumbar compression fractures

 

 

Recruiting

N/A

60

 

Qinggan Hewei Prescription Chinese medicine granule combined with rabeprazole sodium enteric-coated tablet ;Chinese medicine formula granule emulator combined with rabeprazole sodium enteric-coated tablet

Beijing Pinggu District Hospital of Traditional Chinese Medicine; Beijing Pinggu District Hospital of Traditional Chinese Medicine, Capital Health Development Scientific Research Project of Beijing Municipal Health Commission

Refractory gastroesophageal reflux disease

 

 

Not yet recruiting

N/A

70

 

Tongyang Xuanbi pilulas combined with rabeprazole capsules ;Tongyang Xuanbi pilulas placebo combined with rabeprazole capsules

Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine; Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Technology Innovation Action Plan of Shanghai Science and Technology Commission (19401971800)

Gastroesophageal reflux disease

 

 

Completed

N/A

120

 

1-8 weeks: Rabeprazole and probiotics; 9-12 weeks: probiotics; 1-8 weeks: Rabeprazole and probiotics placebo; 9-12 weeks: probioics placebo

The First Affiliated Hospital of Nanchang University; Jiangzhong Pharmaceutical Co. LTD, Jiangzhong Pharmaceutical Co. Ltd.

gastroesophageal reflux

 

 

Recruiting

N/A

68

 

Xuanfei Zhike pilulas placebo combined with rabeprazole capsules ;Xuanfei Zhike pilulas placebo combined with rabeprazole capsules

Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine; Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai High-level Talent Leading Program for Traditional Chinese Medicine (No.ZY (2021-2023)-043)

Gastroesophageal reflux disease