2016-004772-21: Dual-release hydrocortisone compared to immediate-release glucocorticoid replacement therapy in patients with adrenal insufficiency and diabetes mellitus. Differenze fra terapia con glucorticoidi a breve emivita e con idrocortisone a rilascio modificato nei pazienti con insufficienza surrenalica e diabete mellito |
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| Not yet recruiting | 4 | 16 | Europe | Plenadren, CORTONE ACETATO, Modified-release tablet, Tablet, PLENADREN - 20 MG - COMPRESSA A RILASCIO MODIFICATO - USO ORALE -FLACONE (HDPE) - 50 COMPRESSE, CORTONE ACETATO - 25 MG COMPRESSE20 COMPRESSE, Hydrocortisone Roussel 10mg Comprim¿ | AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA VERONA, Universit¿ degli studi di Verona | adrenal insufficienty insufficienza surrenalica, adrenal insufficienty insufficienza del surrene, Diseases [C] - Hormonal diseases [C19] | | | | |
| Recruiting | 4 | 150 | Europe | Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone), Dual release hydrocortisone (plenadren) | Federico II University | Congenital Adrenal Hyperplasia | 12/23 | 12/23 | | |
NCT06260462: Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency |
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| Completed | 3 | 88 | NA | dual-release hydrocortisone, Plenadren, Conventional glucocortidois, hydrocortisone, cortisone acetate | University of Palermo | Adrenal Insufficiency | 09/22 | 12/23 | | |
ChiCTR2300078524: Perioperative safety assessment of steroid-sparing protocol in neuroendoscopic resection for pituitary adenoma: A prospective, randomized, controlled clinical study |
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| Recruiting | N/A | 382 | | 200 mg Hydrocortisone (HC) was given by intravenous injection (iv) during the operation.200 mg of hydrocortisone was administered intravenously in the first 24 hours after surgery (Post-operative day 1, POD 1), For the second 24 hours (POD 2), intravenous administration of hydrocortisone 100 mg; POD 3 HC 50 mg iv; POD 4 HC 25 mg iv; POD 5-14 Cortisone acetate (CA) 25 mg oral (po).; Steroid hormones were not used during surgery and were grouped according to POD 1 plasma Cortisol (COR) levels at 8:00 AM (0800) : A, group SAI (COR < 5 μg/dL, or COR 5-15 μg/dL, with clinical symptoms of adrenal insufficiency (hypotension, bradycardia, nausea, fatigue, severe headache, persistent vomiting, or severe hyponatraemia (< 125 mmol/L)): POD 1 HC 100 mg iv, POD 2 HC 50 mg iv, POD 3 25 mg iv, POD 4-7 CA 25 mg po; B, group NOSAI (COR ≥ 5 μg/dL and no clinical symptoms of adrenal cortical dysfunction) : no steroid hormones. | Shanghai East Hospital, School of Medicine, Tongji University; Shanghai East Hospital, School of Medicine, Tongji University, 2022 Shanghai East Hospital Clinical Research Project | Pituitary adenoma | | | | |
