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- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal: A mouse model of immunosuppression facilitates oral Candida albicans biofilms, bacterial dysbiosis and dissemination of infection. (Pubmed Central) - Feb 4, 2025
Here, we used a mouse model of oropharyngeal candidiasis (OPC) with cortisone acetate injection on alternate days and a continuous supply of C. albicans in drinking water for three days, resulting in immunosuppression...Targeted 16S rRNA and ITS2 amplicon sequencing of microbes from the fecal samples of mice confirmed the above results in the stool samples and revealed an inverse correlation of beneficial microbes in the dysbiosis condition. Our study shows that mucosal-oral infection of C. albicans under immunosuppressed conditions causes tissue damage and invasion in local and distant organs; the invasion may be aided by the overgrowth of the resident endogenous Enterobacteriaceae and other members, including the opportunistic pathogen Enterococcus faecalis.
- | hydrocortisone / Generic mfg.
Journal: Conventional steroids vs. dual-release hydrocortisone on metabolic, cardiovascular and bone outcomes in adrenal insufficiency: a 10-year study. (Pubmed Central) - Sep 5, 2024
P3
Our study shows that mucosal-oral infection of C. albicans under immunosuppressed conditions causes tissue damage and invasion in local and distant organs; the invasion may be aided by the overgrowth of the resident endogenous Enterobacteriaceae and other members, including the opportunistic pathogen Enterococcus faecalis. In patients with treatment-naive AI, 10 years of conventional GC treatment is associated with a worsening of metabolic, insulin-sensitivity, cardiac, and bone outcomes, while DR-HC had no impact on them achieving a lower risk of developing comorbidities.
- | Journal, Metastases: IMPACT OF SYSTEMIC TREATMENTS FOR ADVANCED THYROID CANCER ON THE ADRENAL CORTEX. (Pubmed Central) - May 9, 2024
Our data confirm that systemic treatments for advanced thyroid cancer can lead to an impaired cortisol secretion. A reduction in the other hormones secreted by the adrenal cortex has been firstly reported and should be considered in the more appropriate management of these fragile patients.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Monitoring adrenal insufficiency through salivary steroids: a pilot study. (Pubmed Central) - Apr 22, 2024
SalE, SalF, and Z-score may be useful markers for monitoring and comparing different GRTs. Excess glucocorticoid in early afternoon best associated with depressive symptoms and worse life and sleep quality.
- | hydrocortisone / Generic mfg.
New P3 trial: Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency (clinicaltrials.gov) - Feb 15, 2024
P3, N=88, Completed, Sponsor: University of Palermo
- Cortone (cortisone acetate) / Merck (MSD)
First clinical experience of STRIDE regimen for Advanced HCCs in our hospital. (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_1919;
Conclusions STRIDE resimens for 2nd a3rd line regimen was effective for 40% of Advanced HCC. But irAE managements on STRIDE were important for HCC patients.
- | hydrocortisone / Generic mfg.
Journal: Effects of Dual-Release Hydrocortisone on Bone Metabolism in Primary and Secondary Adrenal Insufficiency: A 6-Year Study. (Pubmed Central) - Dec 13, 2023
TBS decline is more likely due to an age-related derangement of bone microarchitecture rather than a glucocorticoid effect. Our data confirm the safety of DR-HC replacement on bone health in both PAI and SAI patients.
- | triamcinolone acetonide / Generic mfg.
Journal: Development of a UPLC-ESI-MS/MS method for the determination of triamcinolone acetonide in human plasma and evaluation of its bioequivalence after a single intramuscular injection in healthy volunteers. (Pubmed Central) - Jul 27, 2023
Bioequivalence was evaluated through variance analysis and a double unilateral test, and the 90% confidence intervals of AUC , C , and AUC were 92.8%-113.4%, 99.1%-109.1%, and 89.7%-110.9%, respectively (all p > 0.05). These results met the bioequivalence criteria set by the NMPA, indicating that the developed UPLC-ESI-MS/MS method accurately determined TA concentrations in the plasma of healthy Chinese volunteers and that the test and reference formulations exhibited bioequivalence in these individuals.
- | hydrocortisone / Generic mfg.
Journal: Tissue glucocorticoid metabolism in adrenal insufficiency: a prospective study of dual-release hydrocortisone therapy. (Pubmed Central) - Jun 20, 2023
Using comprehensive in-vivo techniques, we have demonstrated abnormalities in corticosteroid metabolism in patients with primary and secondary AI receiving IR-HC. This dysregulation of pre-receptor glucocorticoid metabolism results in enhanced glucocorticoid activation in adipose tissue, which was ameliorated by treatment with DR-HC.
- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal: Age-associated features of norovirus infection analysed in mice. (Pubmed Central) - Jun 5, 2023
Interestingly, viral uptake depended on passive ileal absorption of luminal virus, a process blocked by cortisone acetate administration, which prevented ileal viral RNA accumulation...Together, our findings reveal developmentally associated aspects of persistent MNoV infection, including distinct tissue and cellular tropism, mechanisms of interferon regulation and severity of infection in the absence of interferon signalling. These emphasize the importance of defining viral pathogenesis phenotypes across the developmental spectrum and highlight passive viral uptake as an important contributor to enteric infections in early life.
- Cortone (cortisone acetate) / Merck (MSD)
Ambulatory 24-Hour Tissue Microdialysis of Cortisol and Metabolites, a Tool for Precision Management in Addison's Disease (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1584;
The 24-hour profiles of free cortisol and cortisone differs between patients with AD and healthy volunteers. Ambulatory 24-hour microdialysis samplings may provide a novel dynamic tool to monitor GRT in AD providing opportunity for individual dose adjustment.
- SPI-62 / Sparrow Pharma, Cortone (cortisone acetate) / Merck (MSD)
Intracellular Cortisol Control: An Approach to Reduce Cushing's Syndrome Morbidity With Minimal Adrenal Insufficiency Risk? (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1563;
In situations that require GC rescue dosing during HSD-1 inhibitor administration, prodrug GCs (i.e., cortisone acetate, prednisone) will not be effective a. s they require HSD-1 for activation. Those patients require active agents (e.g., hydrocortisone, prednisolone).
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Analysis of the effect of triclosan on gonadal differentiation of zebrafish based on metabolome. (Pubmed Central) - May 7, 2023
Moreover, SDMs were significantly enriched in Steroid hormone biosynthesis in the 2??g/L TCS group, which included Dihydrotestosterone, Cortisol, 11beta-hydroxyandrost-4-ene-3, 17-dione, 21-Hydroxypregnenolone, Androsterone, Androsterone glucuronide, Estriol, Estradiol, 19-Hydroxytestosterone, Cholesterol, Testosterone, and Cortisone acetate...Retinol metabolism, metabolism of xenobiotics by cytochrome P450, and cortisol synthesis and secretion may also participate in TCS-mediated sex differentiation. These findings reveal the molecular mechanisms of TCS-induced sex differentiation, and provide theoretical guidance for the maintenance of water ecological balance.
- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal: Development of a corticosteroid-immunosuppressed mouse model to study the pathogenesis and therapy of influenza-associated pulmonary aspergillosis. (Pubmed Central) - Apr 14, 2023
Early antifungal treatment with liposomal amphotericin B was pivotal to improve IAPA outcomes in CA-immunosuppressed mice, even after prior antiviral therapy with oseltamivir. In summary, our model recapitulates key clinical features of IAPA and provides a robust preclinical platform to study the pathogenesis and treatment of IAPA.
- Cortone (cortisone acetate) / Merck (MSD)
Determine the Extent and Type of Tissue Injury Caused by Mucorales in Lungs Using Pneumonia Mouse Model (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7054;
CD-1 male mice were immunosuppressed with cyclophosphamide (200?mg/kg) and cortisone acetate (500?mg/kg) on days ?2 and +3, relative to infection. Rhizopus infection causes lung tissue injury characterized by decreased AT2 cell markers and compromised endothelial cells during early infection consistent with clinical angioinvasion which likely contribute to bad prognosis.
- Cortone (cortisone acetate) / Merck (MSD)
Immunotherapy With Pam2+ODN Improves Morbidity and Mortality Against Influenza-associated Pulmonary Aspergillosis in a Corticosteroid-immunosuppressed Murine Model (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7053;
Immunomodulatory treatment with Pam2+ODN significantly improved influenza- and IAPA-associated morbidity and mortality. Detailed studies of the mechanistic underpinnings of this effect are in progress.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Effects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency. (Pubmed Central) - Feb 10, 2023
In our experience, patients shifted from CA to equivalent doses of MRH do not show significant glycometabolic modifications but blood pressure control and symptoms of over-or undertreatment may improve. The lack of amelioration in glucose metabolism and total cortisol daily exposure could suggest the need for a dose reduction when shifting from CA to MRH, due to their different pharmacokinetics.
- Efficacy assessment of SF001, a third generation polyene antifungal, in the neutropenic mouse model of pulmonary mucormycosis (D / 08) - Feb 4, 2023 - Abstract #ECCMID2023ECCMID_3797;
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Construction of automated high-throughput screening method for finding efficient 3-ketosteroid 1,2-dehydrogenating strains. (Pubmed Central) - Oct 27, 2022
By further process optimization, a high conversion (94.34% within 20 h) with high substrate (85 g/L cortisone acetate) was achieved...• "Mutation bottleneck" of single ARTP mutagenesis was surpassed by complex mutagenesis. • A high substrate (85 g/L CA) and high transformation rate craft (94.34% within 20 h) were built.
- | hydrocortisone / Generic mfg.
Journal, HEOR: Benefits of dual-release hydrocortisone treatment on central adiposity and health-related quality of life in secondary adrenal insufficiency. (Pubmed Central) - Oct 18, 2022
• A high substrate (85 g/L CA) and high transformation rate craft (94.34% within 20 h) were built. DR-HC treatment provides some benefits in patients with SAI, reducing central adiposity and improving HRQoL; however, worsening of HDL cholesterol is observed during treatment with DR-HC.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: An intestinal Candida albicans model for monomicrobial and polymicrobial biofilms and effects of hydrolases and the Bgl2 ligand. (Pubmed Central) - Jun 15, 2022
Rats were injected subcutaneously with cortisone acetate (225 mg/kg) as an immunosuppressant on day 5...There is a strong association between C. albicans and E. coli in the formation of polymicrobial biofilms. The combination of glucosamine and the A. fulica enzyme can reduce the single microbial biofilm ECM; however, it is ineffective in the polymicrobial model.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Unusual manifestations of adrenal insufficiency: A case report of hypopituitarism and Well's syndrome after apoplexy of a silent pituitary gonadotropic adenoma. (Pubmed Central) - Jun 14, 2022
The combination of glucosamine and the A. fulica enzyme can reduce the single microbial biofilm ECM; however, it is ineffective in the polymicrobial model. This case highlights that eosinophilia, pruritic skin rash and fever can be manifestations of adrenal insufficiency, and that they may initially be regarded as cellulitis.
- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal, PD(L)-1 Biomarker, IO biomarker: Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis. (Pubmed Central) - May 6, 2022
PD-L1 inhibition yielded more favorable immune responses and more consistent protection from IPM-associated morbidity and mortality than PD-1 blockade. Future dose-effect studies are needed to define the "sweet spot" between ICI-induced augmentation of antifungal immunity and potential immunotoxicities.
- Nucala (mepolizumab) / GSK
Use of Mepolizumab in the treatment of eosinophilic pneumonia: a case report () - Apr 30, 2022 - Abstract #EAACI2022EAACI_987;
Conclusion Although the drug is off-label for the treatment of CEP, the administration of Mepolizumab in the context of multiple steroid-dependent comorbidities represented a therapeutic choice. The steroid sparing capacity allowed the reduction of daily GC and limited the impact on comorbidities and of other potential side effects.
- ||| lenvatinib / Generic mfg.
Journal, Adverse events: Cortisol deficiency in Lenvatinib treatment of thyroid cancer: an underestimated, common adverse event. (Pubmed Central) - Mar 23, 2022
In this context, early diagnosis of PAI is essential, especially since glucocorticoid replacement therapy can induce a significant improvement in fatigue, without the need to reduce the dosage of lenvatinib. However, further studies are required to confirm these preliminary findings.
- | hydrocortisone / Generic mfg.
Trial completion date, Trial primary completion date: CareOnTIME: Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment (clinicaltrials.gov) - Mar 22, 2022
P4, N=150, Recruiting, Sponsor: Federico II University
However, further studies are required to confirm these preliminary findings. Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
- | dexamethasone / Generic mfg.
Journal: Hyperinsulinemic-euglycaemic clamp strengthens the insulin resistance in nonclassical congenital adrenal hyperplasia. (Pubmed Central) - Mar 3, 2022
Using the gold standard method, the hyperinsulinemic-euglycemic clamp, insulin resistance was present in NC-CAH patients and related to prolonged use and long-acting glucocorticoid treatment. Glucocorticoid replacement and cardiometabolic risks should be monitored regularly in NC-CAH.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Prediction of diabetes mellitus induced by steroid overtreatment in adrenal insufficiency. (Pubmed Central) - Feb 25, 2022
Family history of DM and VAI can be predictors of the development of DM in patients with SAI and need to be investigated during steroid replacement therapy. Interestingly, the type and the dose of replacement steroid do not impact on diabetes mellitus.
- || Cortone (cortisone acetate) / Merck (MSD)
Clinical, Journal: What factors have impact on glucocorticoid replacement in adrenal insufficiency: a real-life study. (Pubmed Central) - Nov 7, 2021
Our real-life study demonstrated the influence of etiology of AI on the type of GC used, a weight-based tailoring in sAI, a likely overdosage of GC treatment in pAI women at the start of treatment and the possibility to successfully increase FCA avoiding GC over-treatment. These observations could inform the usual clinical practice.
- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal: Corticosteroids alter alveolar macrophage control of Lichtheimia corymbifera spores in an ex vivo mouse model. (Pubmed Central) - Nov 6, 2021
The aim of this study was to describe the impact of corticosteroids on alveolar macrophage (AM) capacities to control Mucorales growth in a new murine ex vivo model. Corticosteroids enhanced fungal growth of L. corymbifera through AM phagocytosis inhibition and burst oxidative decrease.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Genomewide Transcriptome Responses of Arthrobacter simplex to Cortisone Acetate and its Mutants with Enhanced Δ-Dehydrogenation Efficiency. (Pubmed Central) - Nov 6, 2021
Finally, an optimal strain was created by coexpressing three genes, achieving 46.8 and 70.6% increase in PA amount and productivity compared to the initial values, respectively. Our study expanded the understanding of the Δ-dehydrogenation mechanism and offered an effective approach for excellent steroid-transforming strains.
- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal: Vaccine-Induced Protection in Two Murine Models of Invasive Pulmonary Aspergillosis. (Pubmed Central) - Oct 22, 2021
The lung fungal burden was inversely correlated with the peak anti-AF.KEX1 IgG titer achieved following vaccination. These studies provide the basis for further evaluation of a novel vaccine strategy to protect individuals at risk of invasive aspergillosis due to immunosuppressive treatments.
- || Cortone (cortisone acetate) / Merck (MSD)
Clinical, Journal: Preliminary results from whole-genome expression analysis in patients with secondary adrenal insufficiency treated with modified-release hydrocortisone. (Pubmed Central) - Jul 10, 2021
These studies provide the basis for further evaluation of a novel vaccine strategy to protect individuals at risk of invasive aspergillosis due to immunosuppressive treatments. MOD may restore a normal gene expression profile as soon as 1 month after switching from CONV.
- || Cortone (cortisone acetate) / Merck (MSD)
Clinical, Journal: Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia. (Pubmed Central) - Jun 22, 2021
AI patients on conventional treatment display cardiovascular abnormalities that could be related to hypovolemia. Switch to OD-HC seems to have beneficial effect on blood pressure profile, but no effect on cardiovascular structure and function.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Identification of glucocorticoid receptor in Drosophila melanogaster. (Pubmed Central) - May 27, 2021
Switch to OD-HC seems to have beneficial effect on blood pressure profile, but no effect on cardiovascular structure and function. This study identifies a D. melanogaster gene that structurally resembles vertebrate GR and is functionally necessary for the steroid-mediated immunosuppression to fungal infections.
- fosmanogepix (APX001) / Pfizer
[VIRTUAL] Combination treatment of fosmanogepix and liposomal amphotericin B is synergistic in treating experimental invasive pulmonary aspergillosis and mucormycosis () - May 20, 2021 - Abstract #ECCMID2021ECCMID_3513;
Combination of FMGX plus LAMB demonstrated high survival and fungal burden reduction in severe animal models of invasive mold infections, at drug exposures in mice similar to those achieved clinically . These impressive results warrant further investigation of FMGX plus LAMB combination treatment for severely ill patients with IPA and IM.
- | dexamethasone / Generic mfg.
Retrospective data, Journal, Real-world evidence: Real-world impact of glucocorticoid replacement therapy on bone mineral density: retrospective experience of a large single-center CAH cohort spanning 24 years. (Pubmed Central) - Mar 19, 2021
These impressive results warrant further investigation of FMGX plus LAMB combination treatment for severely ill patients with IPA and IM. Even though a low CA regimen during growth periods in addition to MC replacement appears to have an influence on BMD at femoral sites, interestingly a low dexamethasone one does not seem to be deleterious for bone health in adulthood.
- Cortone (cortisone acetate) / Merck (MSD)
[VIRTUAL] AUTOIMMUNE POLYGLANDULAR SYNDROME IN A POSTMENOPAUSAL WOMAN AFTER COVID-19 INFECTION () - Feb 24, 2021 - Abstract #ICE2021ICE_455;
The clinical features of adrenal insufficiency overlap with the recently described “long COVID” syndrome making the differential diagnosis challenging. It is of utmost importance to recognize the potential adrenal involvement as if left untreated may lead to serious health complications and be life-threating.
- | Cortone (cortisone acetate) / Merck (MSD)
Preclinical, Journal: Potency of gastrointestinal colonization and virulence of Candida auris in a murine endogenous candidiasis. (Pubmed Central) - Jan 21, 2021
It is of utmost importance to recognize the potential adrenal involvement as if left untreated may lead to serious health complications and be life-threating. Invasive strains showed higher colonization capability and rates of dissemination from gastrointestinal tracts under cortisone acetate immunosuppression than non-invasive strains, although the mortality rates caused by C. auris were lower than those caused by C. albicans.
- || prednisolone / Generic mfg., hydrocortisone / Generic mfg.
Review, Journal: The Use of Prednisolone versus Dual-Release Hydrocortisone in the Treatment of Hypoadrenalism. (Pubmed Central) - Jan 16, 2021
Although there is emerging evidence of both treatments offering better cardiometabolic outcomes than standard glucocorticoid replacement regimens, there is a paucity of evidence involving very low dose prednisolone (2-4 mg daily) compared to the larger doses (~7.5 mg) historically used. Data from upcoming clinical studies on prednisolone will therefore be of key importance in informing future practice.
- | cyclophosphamide intravenous / Generic mfg.
Preclinical, Journal: Impact of Candida auris infection in a neutropenic murine model. (Pubmed Central) - Dec 18, 2020
These models use a combination of cyclophosphamide and cortisone acetate that suppress both innate and adaptive immunity. Here we compare C. auris infection in two neutrophil depleted (ND) murine models, where innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.
- || Cortone (cortisone acetate) / Merck (MSD)
Clinical, Journal: Metabolic Effects of Cortisone Acetate vs Hydrocortisone in Patients With Secondary Adrenal Insufficiency. (Pubmed Central) - Nov 28, 2020
Mean body fat increased in the switch group but not in the CA control group (-0.7 kg; P < .05). A switch from CA to an equivalent dose of HC was associated with a worsened metabolic profile, suggesting that HC has a more powerful metabolic action than CA based on the assumption that 20 mg HC equals 25 mg CA.
- | Cortone (cortisone acetate) / Merck (MSD)
Journal: Sodium dodecyl sulfate-multi-walled carbon nanotubes-coated-membrane solid phase extraction of glucocorticoids in aqueous matrices. (Pubmed Central) - Oct 23, 2020
The intra-day repeatability was between 1.77 and 3.56% while the inter-day reproducibility was between 2.69 and 9.53%, respectively. The method was used to analyse glucocorticoids as contaminants in the canal water samples.
- | Berinert (C1 esterase inhibitor (human) IV) / CSL Behring
Trial completion: Randomized, Double-blind, Two Arms, Multicenter, Phase III Study of Berinert for Treatment of ACE Induced Angioedema (clinicaltrials.gov) - Oct 22, 2020
P3, N=31, Completed, Sponsor: Technische Universit
The method was used to analyse glucocorticoids as contaminants in the canal water samples. Suspended --> Completed
- | cyclophosphamide intravenous / Generic mfg.
Preclinical, Journal: Comparative immunopathogenesis in a murine model of inhalative infection with the mucormycetes Lichtheimia corymbifera and Rhizopus arrhizus. (Pubmed Central) - Aug 27, 2020
Clinical, immunological and inflammation parameters as well as efficacy of posaconazole prophylaxis were monitored over 14 days...Key parameters such as virulence and immunopathogenesis vary strongly according to fungal species and underlying risk group. Selected neutropenia is no sufficient risk factor for onset of inhalative mucormycosis.
- Cabometyx (cabozantinib tablet) / Takeda, Exelixis, Ipsen
[VIRTUAL] Primary Adrenal Insufficiency During Tyrosine Kinase Inhibitors Treatment in Advanced Thyroid Cancer Patients () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_2264;
The appearance of fatigue, the typical symptom of PAI, could be multifactorial in these pts due also to the direct effect of TKIs treatment. Thus, in these cases is very difficult to recognize the cause of fatigue and to decide the appropriate treatment (cortisone acetate replacement therapy vs TKIs dose reduction).
- Decadron (dexamethasone) / Merck (MSD)
[VIRTUAL] Giant Adrenal Myelolipoma Associated with Prolonged ACTH Elevation in a Patient with Congenital Adrenal Hyperplasia (CAH) () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_376;
The role of ACTH in development of myelolipomas is supported by the increased incidence in patients with Addison’s disease, Nelson’s syndrome and ACTH dependent Cushing Disease. Our case supports the role of ACTH as the myelipoma developed after the reduction of patient’s glucocorticoid treatment and ACTH levels were high for years.
- methylphenidate tablet / Generic mfg., sertraline / Generic mfg.
[VIRTUAL] Long-Term Outcomes of Two Siblings with X-Linked Congenital Adrenal Hypoplasia Due to a Mutation in NR0B1 (DAX1) Gene: Reproductive and Neuropsychiatric Aspects () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_327;
Pubertal development of patients with CAH due to NR0B1 mutations can be heterogeneous. However, the intriguing neuropsychiatric features in two siblings may suggest a role of NR0B1 in neuropsychological development or other still unknown underlying genetic defect.
- | irinotecan / Generic mfg.
Journal: Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules. (Pubmed Central) - Jun 12, 2020
In vitro testing of the in silico identified inhibitors using purified enzyme proved that irinotecan, argatroban, cortisone acetate and sorafenib inhibit EhArg with IC value (mM) of 1.99, 2.40, 0.91 and 2.75 respectively as compared to the known inhibitors L-NOHA and L-norvaline with IC value (mM) of 1.57 and 17.9 respectively. Identification of structure-based non-amino acid inhibitory molecules against arginase will be constructive in design and discovery of novel chemical modulators for treating amebiasis by directed therapeutics.
- | Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance, hydrocortisone / Generic mfg., Cortone (cortisone acetate) / Merck (MSD)
Review, Journal: Central adrenal insufficiency: open issues regarding diagnosis and glucocorticoid treatment. (Pubmed Central) - Apr 2, 2020
Promising results have been obtained with modified-release hydrocortisone, especially regarding glucose metabolism in patients with primary adrenal insufficiency. Outlook An accurate clinical diagnosis and a careful individualized therapy are mandatory in patients with CAI.