- |||||||||| idasanutlin (RG7388) / Roche, Gazyva (obinutuzumab) / Roche, Biogen, Nippon Shinyaku, Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Trial termination, Combination therapy: A Study of Idasanutlin in Combination With Obinutuzumab in Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and in Combination With Rituximab in R/R Diffuse Large B-Cell Lymphoma (DLBCL) Participants (clinicaltrials.gov) - Jun 24, 2019 P1/2, N=25, Terminated, CLL might have had a role in the response to therapy, but the associations might be considered in future trials. Active, not recruiting --> Terminated; Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2.
- |||||||||| Review, Journal: Novel agents for relapsed and refractory follicular lymphoma. (Pubmed Central) - Jun 22, 2019
Combination studies are currently underway with novel-novel combinations and with traditional chemotherapy regimens. This overview will discuss the results of several recent studies exploring activity of novel drugs in relapsed follicular lymphoma.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Gazyva (obinutuzumab) / Roche, Biogen
Clinical, Clinical Trial,Phase I, Clinical Trial,Phase II, Clinical Trial,Phase III, Journal, IO biomarker: Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions. (Pubmed Central) - Jun 22, 2019 P3 Among patients with untreated CLL and coexisting conditions, venetoclax-obinutuzumab was associated with longer progression-free survival than chlorambucil-obinutuzumab. (Funded by F. Hoffmann-La Roche and AbbVie; ClinicalTrials.gov number, NCT02242942.).
- |||||||||| Gazyva (obinutuzumab) / Biogen, Roche, Rituxan Hycela (rituximab/hyaluronidase) / Biogen, Roche, Halozyme Therapeutics
Review, Journal: A tale of two antibodies: obinutuzumab versus rituximab. (Pubmed Central) - Jun 15, 2019 The benefit conferred by obinutuzumab over rituximab may be context-specific and vary based on histological subtype and immune integrity. This comprehensive review will explore the preclinical differences, investigate the proposed pathogenesis of rituximab resistance, compare the employed dosing strategies and interrogate available clinical results to help inform practice.
- |||||||||| Gazyva (obinutuzumab) / Biogen, Roche, Rituxan (rituximab) / Roche, Biogen
Clinical, Journal: Management of patients with follicular lymphoma treated first line with obinutuzumab. (Pubmed Central) - Jun 6, 2019 As median overall survival approaches 20 years or more, the long-term effects and sequencing of any strategy should be considered. Here we discuss the considerations for selection of front-line therapy, based on evidence and local Australian clinician experience, in the management of first line follicular lymphoma.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Gazyva (obinutuzumab) / Roche, Biogen, Nippon Shinyaku
Trial suspension: Obinutuzumab, Venetoclax, and Lenalidomide in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov) - Jun 3, 2019 P1, N=60, Suspended, Here we discuss the considerations for selection of front-line therapy, based on evidence and local Australian clinician experience, in the management of first line follicular lymphoma. Recruiting --> Suspended
- |||||||||| Polivy (polatuzumab vedotin-piiq) / Roche, Gazyva (obinutuzumab) / Roche, Biogen, Nippon Shinyaku, Rituxan (rituximab) / Roche
Trial primary completion date, Combination therapy: GO29834: A Study of Obinutuzumab, Polatuzumab Vedotin, and Lenalidomide in Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab in Combination With Polatuzumab Vedotin and Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (clinicaltrials.gov) - May 28, 2019 P1, N=128, Recruiting, Trial primary completion date: Dec 2021 --> Jul 2019 Trial primary completion date: Feb 2022 --> Aug 2019
- |||||||||| Gazyva (obinutuzumab) / Roche, Biogen
Enrollment open, Trial primary completion date: OLYMP-1: Obinutuzumab in Marginal Zone Lymphoma (clinicaltrials.gov) - May 20, 2019 P2, N=56, Recruiting, N=25 --> 34 Not yet recruiting --> Recruiting | Trial primary completion date: May 2019 --> Oct 2019
|