- |||||||||| goserelin acetate / Generic mfg.
Journal: Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans. (Pubmed Central) - Apr 6, 2022 Six months of goserelin-induced MC lead to significant bone loss associated with increased bone turnover and changes in the expression of bone-related miRNAs, changes that are only partially reversed at 6 m after MR. We conclude that endogenous T sufficiency has a central role in the up-regulation of molecular transducers of RET-induced muscle hypertrophy in humans that cannot be overcome by muscle mechano-transduction alone.
- |||||||||| goserelin acetate / Generic mfg., anastrozole / Generic mfg., exemestane / Generic mfg.
Trial completion: SEAT: Safety of OFS Combined With AI Endocrine Therapy in Chinese Premenopausal Breast Cancer Patients (clinicaltrials.gov) - Apr 6, 2022 P2, N=116, Completed, We conclude that endogenous T sufficiency has a central role in the up-regulation of molecular transducers of RET-induced muscle hypertrophy in humans that cannot be overcome by muscle mechano-transduction alone. Recruiting --> Completed
- |||||||||| Kisqali (ribociclib) / Novartis
Trial completion date, Trial primary completion date: Roll-over Study to Allow Continued Access to Ribociclib (clinicaltrials.gov) - Apr 6, 2022 P4, N=137, Not yet recruiting, Trial completion date: Feb 2022 --> Jul 2022 | Trial primary completion date: Feb 2022 --> Jul 2022 Trial completion date: Nov 2027 --> Feb 2028 | Trial primary completion date: Oct 2027 --> Jan 2028
- |||||||||| bicalutamide / Generic mfg.
Journal, Adverse events: Analysis of adverse event of interstitial lung disease in men with prostate cancer receiving hormone therapy using the FDA adverse event reporting system. (Pubmed Central) - Mar 30, 2022 Based on this FAERS pharmacovigilance analysis, the association between ILD events and hormone therapy drugs, including bicalutamide, flutamide, nilutamide, goserelin, degarelix and apalutamide, should not be ignored, especially in Japanese population. Lung function of prostate cancer patients should be monitored when receiving hormone therapy drugs mentioned above, especially the first year post medication.
- |||||||||| leuprorelin depot / Generic mfg.
Clinical, Journal: Effects of Gonadotropin-Releasing Hormone Analogs on Ovarian Function Against Chemotherapy-Induced Gonadotoxic Effects in Premenopausal Women With Breast Cancer in China: A Randomized Clinical Trial. (Pubmed Central) - Mar 15, 2022 P3 This randomized clinical trial, conducted at the Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital and Zhejiang Cancer Hospital in China, was an open-label trial involving premenopausal women aged 18 to 49 years with operable stage I to III breast cancer for which treatment with adjuvant or neoadjuvant cyclophosphamide-containing chemotherapy was planned in 2 parallel groups: treatment with chemotherapy with or without GnRHa...In patients randomized to receive GnRHa, 3.6 mg of goserelin or 3.75 mg of leuprorelin was injected subcutaneously once every 28 days from 1 to 2 weeks before the first cycle of chemotherapy to 4 weeks after the last cycle of chemotherapy...This randomized clinical trial found that administering GnRHa in treatment with chemotherapy for premenopausal patients with breast cancer reduces the risk of POI, which promotes the recovery of ovarian function. ClinicalTrials.gov Identifier: NCT02518191.
- |||||||||| Herceptin (trastuzumab) / Roche
Clinical, Journal: Ovarian tissue cryopreservation in a patient with breast cancer during pregnancy: a case report. (Pubmed Central) - Feb 26, 2022 OTC for fertility preservation in patients with PrBC does not delay breast surgery, radiotherapy or chemotherapy, which is essential for effective treatment of breast cancer. We assess this method as a promising fertility preservation method which was used here for the first time worldwide in a patient who developed breast cancer during pregnancy.
- |||||||||| Kisqali (ribociclib) / Novartis
A Case Report of Ribociclib-Induced Pneumonitis (Area F, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_991; Ribociclib was discontinued and the patient improved symptomatically with return to baseline level of function.Reports of CDK 4/6 inhibitor drug-associated lung injury are limited There has been only one case report outside of clinical trials of Ribociclib pneumonitis.7 As these drugs become more commonly used, it is important for clinicians to be aware of this potentially fatal drug associated lung injury. Treatment with drug cessation has varying responses from recovery like in our patient to death.
- |||||||||| Firmagon (degarelix) / Astellas, Ferring
Enrollment closed, Monotherapy: High-Dose Brachytherapy in Treating Patients With Prostate Cancer (clinicaltrials.gov) - Feb 16, 2022 P1/2, N=163, Active, not recruiting, Eventually, the proposed method was used for the extraction and quantification of target therapeutic peptides in plasma and urine samples, and satisfactory relative recoveries were achieved in the range of 90.6-110.3%. Suspended --> Active, not recruiting
- |||||||||| Ibrance (palbociclib) / Pfizer, gedatolisib (PF-05212384) / Celcuity
Enrollment closed, Trial completion date, Trial primary completion date: Phase I Study of Combination of Gedatolisib With Palbociclib and Faslodex in Patients With ER+/HER2- Breast Cancer (clinicaltrials.gov) - Feb 9, 2022 P1, N=18, Active, not recruiting, HME-O/W method is potential to establish long-acting PLGA microspheres (loading water-soluble drug) , exhibiting stable drug serum concentration in vivo, and without large concentration fluctuation or serious pain/side effects. Recruiting --> Active, not recruiting | Trial completion date: Sep 2020 --> Mar 2022 | Trial primary completion date: Sep 2020 --> Feb 2022
- |||||||||| Suprefact (buserelin acetate) / Sanofi, Erleada (apalutamide) / J&J, Firmagon (degarelix) / Astellas, Ferring
Enrollment open, Trial completion date: Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (clinicaltrials.gov) - Feb 3, 2022 P3, N=2478, Recruiting, Recruiting --> Active, not recruiting | Trial completion date: Sep 2020 --> Mar 2022 | Trial primary completion date: Sep 2020 --> Feb 2022 Suspended --> Recruiting | Trial completion date: Dec 2038 --> Dec 2033
- |||||||||| Xtandi (enzalutamide capsule) / Pfizer, Astellas, Eligard (leuprolide acetate) / Tolmar, Sanofi, Recordati
Enrollment closed, HEOR, Real-world evidence, Real-world, Metastases: A Study Called AWARENESS Using Data From Men in Alberta to Observe Treatment Patterns for Metastatic Castration-sensitive Prostate Cancer (clinicaltrials.gov) - Feb 2, 2022 P=N/A, N=400, Active, not recruiting, Suspended --> Recruiting | Trial completion date: Dec 2038 --> Dec 2033 Not yet recruiting --> Active, not recruiting
- |||||||||| goserelin acetate / Generic mfg.
Enrollment open, Real-world evidence, Real-world: Zoladex (clinicaltrials.gov) - Jan 25, 2022 P=N/A, N=1000, Recruiting, Trial primary completion date: Dec 2021 --> Dec 2022 Not yet recruiting --> Recruiting
- |||||||||| Xtandi (enzalutamide capsule) / Pfizer, Astellas, Eligard (leuprolide acetate) / Tolmar, Sanofi, Recordati
Trial completion date, Trial primary completion date, HEOR, Real-world evidence, Real-world, Metastases: A Study Called AWARENESS Using Data From Men in Alberta to Observe Treatment Patterns for Metastatic Castration-sensitive Prostate Cancer (clinicaltrials.gov) - Jan 19, 2022 P=N/A, N=400, Not yet recruiting, Active, not recruiting --> Completed Trial completion date: Jul 2022 --> Sep 2022 | Trial primary completion date: Jul 2022 --> Sep 2022
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