goserelin acetate / Generic mfg. 
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  • ||||||||||  goserelin acetate / Generic mfg.
    Journal:  Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans. (Pubmed Central) -  Apr 6, 2022   
    Six months of goserelin-induced MC lead to significant bone loss associated with increased bone turnover and changes in the expression of bone-related miRNAs, changes that are only partially reversed at 6 m after MR. We conclude that endogenous T sufficiency has a central role in the up-regulation of molecular transducers of RET-induced muscle hypertrophy in humans that cannot be overcome by muscle mechano-transduction alone.
  • ||||||||||  goserelin acetate / Generic mfg., anastrozole / Generic mfg., exemestane / Generic mfg.
    Trial completion:  SEAT: Safety of OFS Combined With AI Endocrine Therapy in Chinese Premenopausal Breast Cancer Patients (clinicaltrials.gov) -  Apr 6, 2022   
    P2,  N=116, Completed, 
    We conclude that endogenous T sufficiency has a central role in the up-regulation of molecular transducers of RET-induced muscle hypertrophy in humans that cannot be overcome by muscle mechano-transduction alone. Recruiting --> Completed
  • ||||||||||  Kisqali (ribociclib) / Novartis
    Trial completion date, Trial primary completion date:  Roll-over Study to Allow Continued Access to Ribociclib (clinicaltrials.gov) -  Apr 6, 2022   
    P4,  N=137, Not yet recruiting, 
    Trial completion date: Feb 2022 --> Jul 2022 | Trial primary completion date: Feb 2022 --> Jul 2022 Trial completion date: Nov 2027 --> Feb 2028 | Trial primary completion date: Oct 2027 --> Jan 2028
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg.
    Review, Journal:  Gonadotropin-releasing hormone agonists in prostate cancer: A comparative review of efficacy and safety. (Pubmed Central) -  Apr 5, 2022   
    Goserelin appears to be the most convenient of all the GnRH-A for administration. Lack of conclusive comparative evidence makes it imperative to have a holistic approach of considering the patient profile and the disease characteristics to select the appropriate GnRH-A for ADT in prostate cancer.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Clinical, Journal:  Effects of Gonadotropin-Releasing Hormone Analogs on Ovarian Function Against Chemotherapy-Induced Gonadotoxic Effects in Premenopausal Women With Breast Cancer in China: A Randomized Clinical Trial. (Pubmed Central) -  Mar 15, 2022   
    P3
    This randomized clinical trial, conducted at the Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital and Zhejiang Cancer Hospital in China, was an open-label trial involving premenopausal women aged 18 to 49 years with operable stage I to III breast cancer for which treatment with adjuvant or neoadjuvant cyclophosphamide-containing chemotherapy was planned in 2 parallel groups: treatment with chemotherapy with or without GnRHa...In patients randomized to receive GnRHa, 3.6 mg of goserelin or 3.75 mg of leuprorelin was injected subcutaneously once every 28 days from 1 to 2 weeks before the first cycle of chemotherapy to 4 weeks after the last cycle of chemotherapy...This randomized clinical trial found that administering GnRHa in treatment with chemotherapy for premenopausal patients with breast cancer reduces the risk of POI, which promotes the recovery of ovarian function. ClinicalTrials.gov Identifier: NCT02518191.
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring
    Enrollment change:  Degarelix in the Treatment of Endometriosis Recurrence (clinicaltrials.gov) -  Feb 28, 2022   
    P3,  N=360, Completed, 
    Phase classification: P=N/A --> P4 N=100 --> 360
  • ||||||||||  Herceptin (trastuzumab) / Roche
    Clinical, Journal:  Ovarian tissue cryopreservation in a patient with breast cancer during pregnancy: a case report. (Pubmed Central) -  Feb 26, 2022   
    OTC for fertility preservation in patients with PrBC does not delay breast surgery, radiotherapy or chemotherapy, which is essential for effective treatment of breast cancer. We assess this method as a promising fertility preservation method which was used here for the first time worldwide in a patient who developed breast cancer during pregnancy.
  • ||||||||||  Kisqali (ribociclib) / Novartis
    A Case Report of Ribociclib-Induced Pneumonitis (Area F, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_991;    
    Ribociclib was discontinued and the patient improved symptomatically with return to baseline level of function.Reports of CDK 4/6 inhibitor drug-associated lung injury are limited There has been only one case report outside of clinical trials of Ribociclib pneumonitis.7 As these drugs become more commonly used, it is important for clinicians to be aware of this potentially fatal drug associated lung injury. Treatment with drug cessation has varying responses from recovery like in our patient to death.
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring
    Enrollment closed, Monotherapy:  High-Dose Brachytherapy in Treating Patients With Prostate Cancer (clinicaltrials.gov) -  Feb 16, 2022   
    P1/2,  N=163, Active, not recruiting, 
    Eventually, the proposed method was used for the extraction and quantification of target therapeutic peptides in plasma and urine samples, and satisfactory relative recoveries were achieved in the range of 90.6-110.3%. Suspended --> Active, not recruiting
  • ||||||||||  Ibrance (palbociclib) / Pfizer, gedatolisib (PF-05212384) / Celcuity
    Enrollment closed, Trial completion date, Trial primary completion date:  Phase I Study of Combination of Gedatolisib With Palbociclib and Faslodex in Patients With ER+/HER2- Breast Cancer (clinicaltrials.gov) -  Feb 9, 2022   
    P1,  N=18, Active, not recruiting, 
    HME-O/W method is potential to establish long-acting PLGA microspheres (loading water-soluble drug) , exhibiting stable drug serum concentration in vivo, and without large concentration fluctuation or serious pain/side effects. Recruiting --> Active, not recruiting | Trial completion date: Sep 2020 --> Mar 2022 | Trial primary completion date: Sep 2020 --> Feb 2022
  • ||||||||||  goserelin acetate / Generic mfg.
    Trial primary completion date, Metastases:  Goserelin 10.8mg Injection in Treatment of Advanced Prostate Cancer (clinicaltrials.gov) -  Jan 27, 2022   
    P3,  N=94, Recruiting, 
    Not yet recruiting --> Active, not recruiting Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  goserelin acetate / Generic mfg.
    Enrollment open, Real-world evidence, Real-world:  Zoladex (clinicaltrials.gov) -  Jan 25, 2022   
    P=N/A,  N=1000, Recruiting, 
    Trial primary completion date: Dec 2021 --> Dec 2022 Not yet recruiting --> Recruiting